Negative / Null Result ReportMedicine
Jia, Xu, Xu et al. · 2026 · Frontiers in surgery
The clinical results of a total knee arthroplasty (TKA) without patellar resurfacing for knee osteoarthritis have been reported; however, not regarding comparison patellofemoral joint (PFJ) clinical outcomes using different prosthesis…
View details →Negative / Null Result ReportMedicine
Plumarom, Singsuwit, Marsh et al. · 2026 · Bone & joint open
The aim of the study was to assess progression of fracture healing after locking plate osteosynthesis with hybrid fixation compared with non-hybrid fixation in the distal femur, using the modified Radiological Union Scale for Tibia…
View details →Negative / Null Result ReportMedicine
Lansley, McSweeney, Rutere et al. · 2026 · Medical teacher
Immersive extended reality (iXR) technologies are increasingly adopted within health professions education. However, existing evidence has largely focused on technical skill acquisition or learner satisfaction, with limited examination of…
View details →Negative / Null Result ReportMedicine
Moon, Cho, Kim et al. · 2026 · Ewha medical journal
Rectus sheath block (RSB) is a simple abdominal wall block that can be readily applied. This study evaluated the postoperative analgesic efficacy of ultrasound-guided bilateral RSB in robotic single-site gynecologic surgery. Sixty patients…
View details →Negative / Null Result ReportMedicine
Coates, Bak, Rajagopalan et al. · 2026 · World journal of surgery
As obesity becomes more common, understanding its risks in routine operations is increasingly important. This study assessed the impact of obesity on intraoperative complications during elective laparoscopic cholecystectomy. Retrospective…
View details →Negative / Null Result ReportMedicine
Barbalho, Brugger, Gratieri et al. · 2026 · European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Transfersomes are deformable lipid vesicles extensively evaluated for transdermal drug delivery. However, the ocular penetration mechanism of transfersomes is poorly understood as the effect of tear flow, which by altering osmotic…
View details →Negative / Null Result ReportMedicine
Kılıç, Turkgenc, Baltrak et al. · 2026 · Pediatric surgery international
Failures of testicular descent may result in the condition known as an undescended testis (UDT). While mechanical and hormonal causes have been researched quite extensively, not much is known about the underlying genetics. Developmental…
View details →Negative / Null Result ReportMedicine
Yang, Ye, Cao et al. · 2026 · BMC oral health
This study primarily aimed to identify prognostic factors for patients with recurrent/metastatic tongue squamous cell carcinoma (R/M TSCC) undergoing re-resection and to preliminarily explore the value of baseline metabolic parameters in…
View details →Negative / Null Result ReportMedicine
Bayram, Kirac, Yozgatli et al. · 2026 · BMC musculoskeletal disorders
Both partial rotator cuff repair (PRCR) and superior capsular reconstruction (SCR) are frequently performed arthroscopically to treat non-pseudoparalytic massive irreparable rotator cuff tears (MIRCT). The purpose of this study was to…
View details →Negative / Null Result ReportMedicine
Serrano, Gueugneau, Ravier · 2026 · Scientific reports
This study examined modulations of the cardiac autonomic nervous system, neuromuscular performance and psychological states during the menstrual cycle (MC) in naturally menstruating women. Fifteen healthy young females were tested during…
View details →Negative / Null Result ReportMedicine
Kitahara, Ohshima, Nakajima et al. · 2026 · Scientific reports
Full-endoscopic spine surgery performed under local anesthesia offers clinical advantages, particularly for elderly patients. However, its reliance on fluoroscopy raises concerns about occupational radiation exposure. Although several…
View details →Negative / Null Result ReportMedicine
da Silva, Alves, Jalkh et al. · 2026 · Dental materials : official publication of the Academy of Dental Materials
To evaluate microbial inhibition at the implant-abutment interface of 5Y-PSZ zirconia abutments coated with boron-doped soda-lime glass, with or without silver, and to evaluate the fatigue lifetime of boron-doped soda-lime glass-coated…
View details →Negative / Null Result ReportMedicine
Shang, Ma, Chen et al. · 2026 · Waste management (New York, N.Y.)
Ammonia (NH 3 ) is a key odorous gas emitted from livestock and poultry farming, and biofiltration has been widely used for NH 3 removal. Temperature plays a critical role in regulating microbial activity and greenhouse gas emissions in…
View details →Negative / Null Result ReportMedicine
Zhou, He, Cheng et al. · 2026 · CNS neuroscience & therapeutics
To compare the real-world effectiveness, surgical and economic outcomes of preoperative rapid antibody clearance therapy (RACT: lymphoplasmapheresis (LPE), efgartigimod (EFG)) versus oral immunosuppressants (Oral IS) in generalized…
View details →Negative / Null Result ReportMedicine
Fukuda, Blackwood, Kim et al. · 2026 · Journal of neurointerventional surgery
Combined delivery catheter systems (CDCS) with ledge-reducing obturators are designed to streamline aspiration-first mechanical thrombectomy, yet comparative multicenter data across platforms remain limited. To determine whether an…
View details →Negative / Null Result ReportMedicine
Giorgini, Xavier, da Silva et al. · 2026 · Topics in companion animal medicine
LINE-1 (long interspersed nuclear element-1) is a family of related class I transposable elements in the DNA that is dispersed throughout the entire genome and the study of its methylation pattern is used in the understanding of several…
View details →Negative / Null Result ReportMedicine
Tran, Padda, Sharma et al. · 2026 · Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
A major challenge in teaching slit-lamp biomicroscopy is providing adequate depth perception and anatomical detail; the Deep Reality Viewer (DRV) addresses this by enabling stereopsis. This study evaluated the utility of DRV for slit-lamp…
View details →Negative / Null Result ReportMedicine
Björkman, Malusek, Persson et al. · 2026 · European radiology experimental
The aim was to compare the image quality of photon-counting detector CT (PCD-CT) and energy-integrating detector CT (EID-CT) in patients with tibial plateau fractures treated with metallic osteosynthesis material, and to identify optimal…
View details →Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Hironori Sadamatsu, Yuki Kurihara, Koichiro Takahashi et al. · 2019 · Case Reports in Oncology
Paraneoplastic limbic encephalitis (PLE) is a rare neurologic disorder that can complicate various malignancies, including lung cancer. PLE is most frequently found the initial presentation of lung cancer. In this study, we reported the case of a 74-year-old Japanese woman who developed PLE after partial remission of small cell lung cancer (SCLC) by first-line systemic chemotherapy. Brain magnetic resonance imaging showed no metastatic tumor or cerebrovascular disease. Anti-glutamic acid decarboxylase (GAD) and anti-amphiphysin antibodies were detected in her serum. She was diagnosed as having
View details →Negative / Null Result ReportOpen accessVeterinary medicine
Luana D. Felizari, Luke K. Fuerniss, Jonathan L. Beckett et al. · 2025 · Veterinary Sciences
This study evaluates the effects of a proprietary tannin blend (BX), supplemented with or without sodium monensin (MON), on beef cattle performance, carcass traits, and health. Steers ( n = 2986; initial shrunk body weight (SBW) 254 ± 9.2 kg) were allocated into 48 pens (61–62 steers/pen; 12 pens/treatment) fed for 230 d. Treatments included: (1) no feed additives (CTL); (2) BX (7.95 g/animal daily); (3) MON + Tylosin phosphate (TYL; 437.52 mg MON/animal daily + 80 mg TYL/animal daily); or (4) MON + BX (437.52 mg MON/animal daily + 7.95 g BX/animal daily). Data were analyzed in R 4.2.1 using a
View details →Negative / Null Result ReportOpen accessDiseases of the genitourinary system. Urology
Kyle Hayes, Elizabeth Warner, Chris Bollinger et al. · 2020 · BMC Nephrology
Abstract Background Focal segmental glomerulosclerosis (FSGS) causes renal fibrosis and may lead to kidney failure. FSGS and its common complication, proteinuria, are challenging to treat. Corticosteroids are ineffective in many patients with FSGS, and alternative treatments often yield suboptimal responses. Repository corticotropin injection (RCI; Acthar® Gel), a naturally sourced complex mixture of purified adrenocorticotropic hormone analogs and other pituitary peptides, may have beneficial effects on idiopathic FSGS via melanocortin receptor activation. Methods Two studies in a preclinical
View details →Replication FailureOpen accessGeriatrics
Anum Zahra, Maarten van Smeden, Petra J. M. Elders et al. · 2025 · BMC Geriatrics
Abstract Background During the COVID-19 pandemic, nursing home (NH) residents faced the highest risk of severe COVID-19 disease and mortality. Due to their frailty status, comorbidity burden can serve as a useful predictive indicator of vulnerability in this frail population. However, the prognostic value of these cumulative comorbidity scores like the Charlson comorbidity index (CCI) remained unclear in this population. We evaluated the incremental predictive value of the CCI for predicting 28-day mortality in NH residents with COVID-19, compared to prediction using age and sex only. Methods
View details →Negative / Null Result ReportOpen accessMedicine
Michael R Gionfriddo, Yirui Hu, Bhumika Maddineni et al. · 2022 · JMIR Formative Research
BackgroundDespite routine review of medication lists during patient encounters, patients’ medication lists are often incomplete and not reflective of actual medication use. Contributing to this situation is the challenge of reconciling medication information from existing health records, along with external locations (eg, pharmacies, other provider/hospital records, and care facilities) and patient-reported use. Advances in the interoperability and digital collection of information provides a foundation for integration of these once disparate information sources. ObjectiveWe aim to evaluate th
View details →Negative / Null Result ReportOpen accessVeterinary medicine
Pei-Chih Lee, Yuqing Yang, Kaywalee Chatdarong et al. · 2026 · Frontiers in Veterinary Science
IntroductionDry-preservation of gametes offers a promising alternative to cryobanking by potentially storing cells at ambient temperatures; however, successful preservation of whole oocytes remains limited by dehydration-induced cellular damages. This study evaluated whether intracellular delivery of trehalose via a membrane-permeable derivative, trehalose hexaacetate (6-O-Ac-Tre), could enhance dehydration tolerance of domestic cat cumulus–oocyte complexes (COCs), a relevant model for mammalian fertility preservation.MethodsCat COCs were incubated with 0, 3, 10, or 30 mM of 6-O-Ac-Tre to asse
View details →Negative / Null Result ReportOpen access
Nurfitri Iriani Utami, Abd. Karman, Moh Syarifudin · 2022 · OIKONOMIKA : Jurnal Kajian Ekonomi dan Keuangan Syariah
The massive digital transformation was escalating due to the emergence of the Covid-19 Pandemic occurred in almost all industrial sectors including the banking sector. To respond to this challenge, banking presents an innovation that is…
View details →Replication FailureOpen accessDiseases of the genitourinary system. Urology
Wanqing Huang, Jiuxu Bai, Yanping Zhang et al. · 2024 · Renal Failure
Background Elderly hemodialysis (HD) patients have a high risk of death. The effect of different types of HD membranes on survival is still controversial. The purpose of this study was to determine the relationship between the use of low-flux or high-flux membranes and all-cause and cardiovascular mortality in elderly hemodialysis patients.Methods This was a retrospective clinical study involving maintenance hemodialysis patients which were categorized into low-flux and high-flux groups according to the dialyzer they were using. Propensity score matching was used to balance the baseline data o
View details →Negative / Null Result ReportOpen accessImmunologic diseases. Allergy
Yuka Nadai, Yuka Nadai, Kathrin Held et al. · 2019 · Frontiers in Immunology
Background: A better understanding of the parameters influencing vaccine-induced IgG recognition of individual antigenic regions and their variants within the HIV Envelope protein (Env) can help to improve design of preventive HIV vaccines.Methods: Env-specific IgG responses were mapped in samples of the UKHVC003 Standard Group (UK003SG, n = 11 from UK) and TaMoVac01 (TMV01, n = 17 from Tanzania) HIV vaccine trials. Both trials consisted of three immunizations with DNA, followed by two boosts with recombinant Modified Vaccinia Virus Ankara (MVA), either mediating secretion of gp120 (UK003SG) o
View details →Failed Experiment ReportOpen accessMedicine (General)
Andrew J. Klein, Mark Berlacher, Jesse A. Doran et al. · 2020 · MedEdPORTAL
Introduction The interpretation of electrocardiograms (ECGs) is a critical competency for internal medicine trainees, yet time and resources to foster proficiency are limited. Methods This resident-authored ECG email curriculum for first-year residents involved 129 first-year internal medicine residents at three major academic university hospitals. Residents either received the resident-authored ECG email curriculum (intervention group) or continued standard training (control group). The curriculum involved 10 multiple-choice ECG cases emailed biweekly over the 6-month study period. All partic
View details →Failed Experiment ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Nenonen Arja, Rinne Marjo, Groundstroem Kaj et al. · 2007 · Cardiovascular Ultrasound
Abstract Background Myocardial diastolic tissue velocities are reduced already in newly onset Type 2 diabetes mellitus (T2D). Poor disease control may lead to left ventricular (LV) systolic dysfunction and heart failure. The aim of this study was to assess the effects of exercise training on myocardial diastolic function in T2D patients without ischemic heart disease. Methods 48 men (52.3 ± 5.6 yrs) with T2D were randomized to supervised training four times a week and standard therapy (E), or standard treatment alone (C) for 12 months. Glycated hemoglobin (HbA 1c ), oxygen consumption (VO 2max
View details →Failed Experiment ReportOpen accessOrthopedic surgery
Karthikeyan Chinnakkannu MD, John E Femino MD, Natalie Glass PhD et al. · 2019 · Foot & Ankle Orthopaedics
Category: Ankle, Arthroscopy, Hindfoot, Sports Introduction/Purpose: Posterior ankle/hindfoot arthroscopy (PAHA) is an established surgical option for treating pathologies, of posterior ankle and subtalar joints, which otherwise would require open incisions. Arthroscopic procedures are less invasive, provide magnified visualization and allow earlier rehabilitation and return to activity. Many studies have reported outcomes after PAHA, however only two studies have reported complications in larger cohorts. Although posterior ankle impingement (PAI) is a common indication for PAHA, it is a non-s
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