Envelope-Specific Recognition Patterns of HIV Vaccine-Induced IgG Antibodies Are Linked to Immunogen Structure and Sequence
Yuka Nadai; Yuka Nadai; Kathrin Held; Kathrin Held; Sarah Joseph; Mohamed I. M. Ahmed; Mohamed I. M. Ahmed; Verena S. Hoffmann · 2019 · Frontiers in Immunology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Background: A better understanding of the parameters influencing vaccine-induced IgG recognition of individual antigenic regions and their variants within the HIV Envelope protein (Env) can help to improve design of preventive HIV vaccines.Methods: Env-specific IgG responses were mapped in samples of the UKHVC003 Standard Group (UK003SG, n = 11 from UK) and TaMoVac01 (TMV01, n = 17 from Tanzania) HIV vaccine trials. Both trials consisted of three immunizations with DNA, followed by two boosts with recombinant Modified Vaccinia Virus Ankara (MVA), either mediating secretion of gp120 (UK003SG) o
Abstract by Yuka Nadai; Yuka Nadai; Kathrin Held; Kathrin Held; Sarah Joseph; Mohamed I. M. Ahmed; Mohamed I. M. Ahmed; Verena S. Hoffmann, Frontiers in Immunology (2019) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.3389/fimmu.2019.00717