Negative / Null Result ReportOpen accessBiology (General)
Ionuț-Alexandru Chelaru, Ramona-Alexandra Ciausu, Alexandra Savuca et al. · 2026 · Biomolecules & Biomedicine
Active pharmaceutical ingredients (APIs) are increasingly entering aquatic environments due to human and veterinary use, wastewater discharges, and inadequate waste containment, raising significant concerns for both ecosystems and human health. Ibuprofen and valproic acid are among the pharmaceuticals detected in surface waters, primarily due to incomplete metabolism and the limited removal efficiency of conventional wastewater treatment systems. Ibuprofen, readily available over the counter, is frequently found in high concentrations, while valproic acid, which is available only by prescripti
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Iryna Raievska, Andrii Schogolev · 2024 · Біологічні студії
Background. Morphometric indicators are crucial for evaluating the development and productivity of soybeans. They are influenced by genetic and environmental factors. The use of nearly isogenic soybean lines is a convenient model for determining the impact of early maturity genes and daylength on growth indicators. The aim of this study was to determine the influence of different daylengths and early maturity genes on soybean morphometric indicators under conditions of the temperate zone (at the latitude of Kharkiv – 50° N). Materials and Methods. The study involved nearly isogenic soybean lin
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Peng Wang, Yu Yan, Yujing Bai et al. · 2021 · Cell Reports
Summary: Related to ABI3/VP1 (RAV) transcription factors have important roles in plant stress responses; however, it is unclear whether RAVs regulates oxidative stress response in cassava (Manihot esculenta). In this study, we report that MeRAV1/2 positively regulate oxidative stress resistance and catalase (CAT) activity in cassava. Consistently, RNA sequencing (RNA-seq) identifies three MeCATs that are differentially expressed in MeRAV1/2-silenced cassava leaves. Interestingly, MeCAT6 and MeCAT7 are identified as direct transcriptional targets of MeRAV1/2 via binding to their promoters. In a
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DWI SURYANTO, SITI PATONAH, ERMAN MUNIR · 2010 · Hayati Journal of Biosciences
Biological control of plant disease using antagonistic microorganism has been obtaining much attention and implemented for decades. One of the potential microorganisms used in this strategy is chitinolytic bacteria. Utilization of this bacteria ranges from cell life, enzymes, genes, or other metabolites. In this study, we examined the ability of chitinolytic bacteria as a biocontrol agent of Fusarium wilt of red chili (Capsicum annuum L.) seedlings. The ability of chitinolytic bacteria to suppress the disease was evaluated by soaking red chili seeds in the bacterial isolates solution for 30 mi
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Somayeh Faghih, Zabihollah Zamani, Reza Fatahi et al. · 2019 · Biological Research
Abstract Background Drought is one of the main serious problems for agriculture production which its intensity is increasing in many parts of the world, hence, improving water use efficiency is a main goal for sustainable agriculture. Results Growth indices including relative shoot length growth (SL), relative stem diameter increase (SD) and relative trunk cross sectional area growth (TCSA) measured at the start and end of the season decreased by reducing the irrigation level. Chlorophyll index (CI) was decreased at 70% crop evapotranspiration, however water use efficiency (WUE), leaf and frui
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Oxana Kolomiets, Irina Bakloushinskaya, Mark Pankin et al. · 2023 · Diversity
The basic causes of postzygotic isolation can be elucidated if gametogenesis is studied, which is a drastically different process in males and females. As a step toward clarifying this problem, we obtained an experimental inbred lineage of the eastern mole vole Ellobius tancrei , whose founder animals were animals with identical diploid numbers 2n = 50 but with different Robertsonian translocations (Rb), namely 2Rb4.12 and 2Rb9.13 in the female and 2Rb.2.18 and 2Rb5.9 in the male. Here, we analyzed strictly inbred hybrids (F1, fertile and F10, sterile) using immunocytochemical methods in order
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Dewi Sekarsari, Viskasari P. Kalanjati, Abdulloh Machin et al. · 2020 · Majalah Biomorfologi
Background: Various risk factors of epilepsy in children had been reported although differences were found amongst regions. Objective: To identify the profile of epilepsy patients and previous febrile seizure history in children aged 0-17 years at Pediatric Ward, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, in 2017. Materials and Methods: This was a cross-sectional retrospective study, using secondary data from medical records of epilepsy patients with febrile seizure history in children aged 0-17 years old at Pediatric Ward, Dr. Soetomo General Academic Hospital, Surabaya, Indo
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Rosa Aghdam, Taban Baghfalaki, Pegah Khosravi et al. · 2017 · Genomics, Proteomics & Bioinformatics
Deciphering important genes and pathways from incomplete gene expression data could facilitate a better understanding of cancer. Different imputation methods can be applied to estimate the missing values. In our study, we evaluated various imputation methods for their performance in preserving significant genes and pathways. In the first step, 5% genes are considered in random for two types of ignorable and non-ignorable missingness mechanisms with various missing rates. Next, 10 well-known imputation methods were applied to the complete datasets. The significance analysis of microarrays (SAM)
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Sahaana Chandran, Jan Vinjé, Kimberly Huynh et al. · 2026 · Applied and Environmental Microbiology
ABSTRACT Human intestinal enteroid (HIE) and zebrafish larva (ZF) models support the replication of certain strains of human norovirus (HuNoV), the leading cause of viral gastroenteritis worldwide. The replication of 17 HuNoV-positive stool specimens (nine genotypes) from patients ranging from 5 months to 83 years old was evaluated in both HIE and ZF models. The yolk of 3-day post-fertilization ZF larvae was microinjected with 3 nL 10% clarified stool suspension. Each day post-infection (dpi), 10 larvae were pooled as one sample, and two specimens were collected daily until 5 dpi. Viral RNA wa
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Farahnaz Joukar, Sara Manafi Afkham, Afshin Shafaghi et al. · 2023 · Journal of Current Biomedical Reports
N-acetyl cysteine (NAC) has recently been proposed as an adjunctive therapy for the eradication of Helicobacter pylori infection due to its mucolytic, antioxidant, and antimicrobial properties. This study aimed to evaluate the efficacy of adding NAC to the standard 4-drug regimen consisting of amoxicillin, clarithromycin, pantoprazole, and bismuth subcitrate. In this double-blind, randomized clinical trial, 92 patients with confirmed H. pylori infection were randomly assigned to either the intervention group or the control group (46 patients each) using a randomized block design. All patients
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Brajušković G., Nikolić Zorana, Kojić A. et al. · 2013 · Archives of Biological Sciences
Prostate cancer (PCa) is the second most commonly diagnosed cancer among men worldwide. Despite its high incidence rate, the molecular basis of PCa onset and its progression remains little understood. Genome-wide association studies (GWAS) have greatly contributed to the identification of single nucleotide polymorphisms (SNP) associated with PCa risk. Several GWAS identified 8q24 as one of the most significant PCa-associated regions. The aim of this study was to evaluate the association of SNP rs378854 at 8q24 with PCa risk in the Serbian population. The study population included 261 individua
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Aviad Schnapp, Moria Harel, Dalit Cayam-Rand et al. · 2022 · Biomedicines
Autism spectrum disorder (ASD) is often associated with debilitating sleep disturbances. While anecdotal evidence suggests the positive effect of cannabinoids, randomized studies are lacking. Here, we report the effects of cannabinoid treatment on the sleep of 150 children and adolescents with ASD, as part of a double-blind, placebo-controlled study that assessed the impact of cannabinoid treatment on behavior (NCT02956226). Participants were randomly assigned to one of the following three treatments: (1) whole-plant cannabis extract, containing cannabidiol (CBD) and Δ9-Tetrahydrocannabinol (T
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Muhammad Abba Isah Audu, Yusuf Idris, Muhammad Liman Muhammad et al. · 2022 · Botanica
The nutritional attributes of sesame, Sesamum indicum, vary substantially and are primarily influenced by the plant’s genetic makeup. This investigation accessed the biochemical composition of sesame mutants from two generations. Seeds of eleven M3 lines were planted in a Randomized Complete Block Design (RCBD) to raise M4 lines, which were advanced to M5 generation. The seeds were harvested at maturity, and their biochemical compositions were quantitatively determined following standard procedures. Results revealed significant differences (p 0.05) was observed in ash content of M4 and M5 muta
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Edilma Pereira Gonçalves, Edna Ursulino Alves, Riselane de Lucena Alcântara Bruno et al. · 2007 · Acta Scientiarum: Biological Sciences
O experimento foi realizado no Laboratório de Análise de Sementes do Centro de Ciências Agrárias da Universidade Federal da Paraíba, em Areia – Estado da Paraíba, com sementes de trapiá, a fim de estudar o uso de diferentes substratos para avaliação da qualidade fisiológica no teste de germinação. Os substratos consistiram de: vermiculita (T1), bioplant® (T2), bioclone® (T3), areia (T4), plugmix® (T5), rolo de papel (T6) e entre papel em gerbox (T7). Após a distribuição das sementes nos respectivos substratos, foram colocados em germinador a 25oC, sob fotoperíodo de oito horas. Foram computada
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Robert Stawski, Konrad Walczak, Ewelina Perdas et al. · 2021 · Biology
Numerous studies have shown that cf nDNA significantly rises in stress caused by exercise. However, during nuclear decondensation, released DNA is followed by histones. Histones are also a common disease marker. After PAD4 mediated hypercitrullination extracellular H3Cit exhibits high toxicity contributing to tissue damage which, in cases of systemic inflammation, may lead to multiorgan failure and finally to death. We tested whether circulating histones rise in response to strenuous exercise. Eleven average-trained men performed three treadmill exercise tests to exhaustion at speed correspond
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Yoshihide Usami, Yoshino Mizobuchi, Mai Ijuin et al. · 2022 · Marine Drugs
The enantiomers of 6-fluoro-, 6-bromo-, and 6-iodopericosine A were synthesized. An efficient synthesis of both enantiomers of pericoxide via 6-bromopericosine A was also developed. These 6-halo-substituted pericosine A derivatives were evaluated in terms of their antitumor activity against three types of tumor cells (p388, L1210, and HL-60) and glycosidase inhibitory activity. The bromo- and iodo-congeners exhibited moderate antitumor activity similar to pericosine A against the three types of tumor cell lines studied. The fluorinated compound was less active than the others, including perico
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Kevin Hoffseth, Emily Busse, Josue Jaramillo et al. · 2021 · Frontiers in Cell and Developmental Biology
Mouse digit amputation provides a useful model of bone growth after injury, in that the injury promotes intramembranous bone formation in an adult animal. The digit tip is composed of skin, nerves, blood vessels, bones, and tendons, all of which regenerate after digit tip amputation, making it a powerful model for multi-tissue regeneration. Bone integrity relies upon a balanced remodeling between bone resorption and formation, which, when disrupted, results in changes to bone architecture and biomechanics, particularly during aging. In this study, we used recently developed techniques to evalu
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Qiaoli Wang, Wenpei Wang, Yonghui Wang et al. · 2024 · Journal of Fungi
Manganese is one of the trace elements necessary for organisms to maintain normal biological activities and is also a cofactor for manganese superoxide dismutase (Mn-SOD) and manganese peroxidase (MnP). In order to find a simple and effective method to rejuvenate the degenerated V. volvacea strains, we explored the effect of the exogenous addition of MnSO 4 on the antioxidant vigour and productivity of degenerated strains of V. volvacea . The results showed that the exogenous MnSO 4 had no significant effect on the non-degenerated strain T0, but it could effectively increase the mycelial growt
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CHEN Zhong-yun, MIN Hang, WU Wei-xiang et al. · 2001 · 浙江大学学报. 农业与生命科学版
The populations of methane-oxidizing bacteria were analyzed in Huangsong soils with various plant-cover, using Hungate anaerobic technique and chromatographic monitoring method. The results showed that the population of methane-oxidizing bacteria ranged 10 7 -10 8 cfu/g dried soil with different plant-cover. The various plant-cover on soil seemed to have no significant effect on the population of methane-oxidizing bacteria, but to have noteworthy effect on the methane-oxidizing activity in soil sampies. The variation of the population of methane-oxidizing bacteria had no significant effect on
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Xinglin Zhang, Jie Ren, Na Li, Wenjuan Liu, Qingmin Wu · 2009 · International Journal of Biological Sciences
Brucella melitensis is a facultative intracellular pathogen. An operon composed of BMEI0066, which encodes a two-component response regulator CenR, and BMEI0067, which encodes a cAMP-dependent protein kinase regulatory subunit, has been predicted to exist in many bacterial species. However, little is known about the function of this operon. In order to characterize this operon and assess its role in virulence, we constructed a marked deletion mutant of BMEI0066. The mutant was less able to withstand hyperosmotic conditions than wild-type (16M), but showed no significant difference with 16M whe
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Sancar Aziz, Mankinen Richard W, Lee Daekee et al. · 2006 · Journal of Circadian Rhythms
Abstract Background Recent studies have implicated the epidermal growth factor receptor (EGFR) within the subparaventricular zone as being a major mediator of locomotor and masking behaviors in mice. The results were based on small cohorts of mice homozygous for the hypomorphic Egfr wa 2 allele on a mixed, genetically uncontrolled background, and on intraventricular infusion of exogenous EGFR ligands. Subsequenlty, a larger study using the same genetically mixed background failed to replicate the original findings. Since both previous approaches were susceptible to experimental artifacts relat
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