Negative / Null Result ReportOpen accessPathology
Brahim Jaime S, Adam Albert, Wang Xiao-Min et al. · 2010 · Molecular Pain
Abstract Background Kinins play an important role in regulation of pain and hyperalgesia after tissue injury and inflammation by activating two types of G-protein-coupled receptors, the kinin B 1 and B 2 receptors. It is generally accepted that the B 2 receptor is constitutively expressed, whereas the B 1 receptor is induced in response to inflammation. However, little is known about the regulatory effects of kinin receptors on the onset of acute inflammation and inflammatory pain in humans. The present study investigated the changes in gene expression of kinin receptors and the levels of thei
View details →Negative / Null Result ReportOpen accessPathology
Safa Mohammed Hussein, Huda Hasan Aziz, Wurood Hameed Abed et al. · 2024 · Human Pathology Reports
Background: Hematological parameters are significantly affected by both immediate and prolonged exposure to smoking. The objective of this investigation is to evaluate the influence of cigarette smoking on hematological parameters among male students enrolled at Basrah University in Iraq. Methods: The study comprised a total of seventy male participants, divided into two groups: smokers (n = 35) and nonsmokers (n = 35). Each participant provided a 5 ml venous blood sample to analyze the complete blood count using a hematology analyzer (Spinreact, Spincell 3). Results: Cigarette smokers exhibit
View details →Negative / Null Result ReportOpen accessPathology
Menk M, Graw JA, von Haefen C et al. · 2018 · Journal of Inflammation Research
Mario Menk, Jan Adriaan Graw, Clarissa von Haefen, Hendrik Steinkraus, Burkhard Lachmann, Claudia D Spies, David Schwaiberger Department of Anesthesiology and Operative Intensive Care Medicine, Charité – University Medicine Berlin, FreieUniversität Berlin, Humboldt-Universitätzu Berlin, and Berlin Institute of Health, Germany Purpose: Although the role of the angiotensin II type 2 (AT2) receptor in acute lung injury is not yet completely understood, a protective role of this receptor subtype has been suggested. We hypothesized that, in a rodent model of acute lung injury
View details →Negative / Null Result ReportOpen accessPathology
Yeganeh Shekari, Zahra Mahmoodi, Mohammadtaghi Ghorbani Hesari et al. · 2026 · Molecular Pain
Background: Chronic daily headache (CDH) is known to be a common and debilitating disease that is influenced by genetic, dietary, and lifestyle factors. Iron (Fe) plays a key role in energy metabolism and neurotransmitter synthesis, while the FTO gene polymorphism (rs9939609) may play a role in modulating nutritional responses and nutrient metabolism. This study aimed to determine the interaction between CDH odds, dietary iron intake, and FTO genotype. Methods: This case-control study was conducted on 150 CDH patients and 150 healthy individuals aged 40–80 years. Participants were assessed for
View details →