Negative / Null Result ReportOpen accessPharmacy and materia medica
So-Yeon Kim, Minji Hong, Ponnuvel Deepa et al. · 2023 · Scientia Pharmaceutica
This study aimed to elucidate the anti-inflammatory activity of C. tinctorius leaves by measuring inflammatory parameters such as nitric oxide (NO) production and mRNA expression of iNOS, interleukin-6 (IL-6), and IL-1β in lipopolysaccharide (LPS)-induced HaCaT cells. Further, the effect of C. tinctorius ethanol extract on the MAPKs/NF-κB signaling pathway was examined in HaCaT cells. The phytochemical profile of the ethanol extract of C. tinctorius leaves was determined using UPLC-QTOF-MS/MS. The results indicated that the ethanol extract of C. tinctorius effectively attenuated LPS-induced se
View details →Negative / Null Result ReportOpen accessPharmacy and materia medica
Comfort Nanbam Sariem, Maxwell Patrick Dapar, Nenman Musa Lenka et al. · 2022 · INNOVATIONS in Pharmacy
Background: The prolonged multi-drug treatment regimen for tuberculosis (TB) can lead to non-adherence and unsuccessful treatment outcomes. Educational and psychological health models can be used to design cognitive and behavioral interventions to improve adherence and treatment outcomes. Objective: To determine the effect of cognitive and behavioral interventions on TB treatment outcomes. Methods: The quasi-experimental study conducted in six TB treatment centers involved reinforced medication education and adherence counseling (MEAC), designed from a structured validated psychometric scale.
View details →Negative / Null Result ReportOpen accessPharmacy and materia medica
Mohammad Jalaluddin, Saurabh Sathe, Joyce Thomas et al. · 2021 · Journal of Pharmacy and Bioallied Sciences
Aim: The aim of the present study was to assess the implant stability in immediate implant placement using different bone grafting materials. Materials and Methods: Twelve patients (5 males, 7 females, range of 40–58 years) were included in the study. All patients were divided into two groups based on the graft material used. For Group 1, Xenograft bone grafting material was used, and for Group 2, Freeze-dried bone allograft was used. The patients were suggested to rinse with 0.2% chlorhexidine mouth wash for 1 min. Periotome was used for atraumatic tooth extraction, and necessary care was tak
View details →Negative / Null Result ReportOpen accessPharmacy and materia medica
Saeid Abbasi-Maleki, Hadi Yousefi*, Rahim Sharafkhani et al. · 2023 · Research Journal of Pharmacognosy
Background and objectives: Earlier researches have exhibited the antioxidant, antinociceptive, and antiepileptic effects of Ferula gummosa. Considering that antioxidants play a key role in the pathogenesis of depression, the antidepressant potential of the F. gummosa essential oil was assessed by using a mouse models. Methods:Lorke’s method was used to access the acute toxicity of the F. gummosa essential oil. The F. gummosa essential oil (5-40 mg/kg), standard agents, and vehicle were administered to animals. The forced-swimming test (FST), tail suspension test (TST), and open-field test (OFT
View details →Negative / Null Result ReportOpen accessPharmacy and materia medica
Maryam Hassan Al-Zahrani, Nawal Marzoog Almutairi · 2023 · Journal of Pharmacy and Bioallied Sciences
Background/Objective/Methods: Glutathione-S-transferase Mu1 (GSTM1) and glutathione peroxidase 1 (GPX1) are known antioxidant enzymes that help protect cells from the oxidative damage that occurs from smoking. This study explored the correlation between GSTM1 and GPX1 levels between a group of smokers with the GSTM1 and GPX1 genes in the Saudi population and a control group and investigated the genetic risk factors in the group of smokers. Results: The control and smokers' group (n = 50; aged 22.3 ± 3.1 years; BMI 24.6 ± 5.9 kg/m2) were genotyped using quantitative polymerase chain reaction (q
View details →Negative / Null Result ReportOpen accessPharmacy and materia medica
Bazigha K. Al –Temimy, Alaa A. Abdul –Rasool · 2017 · Iraqi Journal of Pharmaceutical Sciences
ABSTRACT: Salbutamol sulphate nebules is considered as the most rapid effective route of administration for treatment of acute attacks of asthma . This study was carried out to formulate a stable formula of salbutamol nebules containing 0.1% (2.5mg / 2.5ml) of the active ingredient in a buffered solution . Stability study in different buffers at pH 3 showed that the longest shelf life was equal to 3.5 years for formula F .In addition the bioequivalency of this formula incomparison to ventolin nebules was measured and it was equal to (± 5.2) %. Also it was found that there was no significant d
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