A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21155 results · page 1 of 706
Alexander A. Aarts · 2015 · Science
Reproducibility is a defining feature of science, but the extent to which it characterizes current research is unknown. We conducted replications of 100 experimental and correlational studies published in three psychology journals using…
Olvert A. Berkhemer, Puck Fransen, Debbie Beumer et al. · 2014 · New England Journal of Medicine
BACKGROUND: In patients with acute ischemic stroke caused by a proximal intracranial arterial occlusion, intraarterial treatment is highly effective for emergency revascularization. However, proof of a beneficial effect on functional…
Els van Nood, Anne Vrieze, Max Nieuwdorp et al. · 2013 · New England Journal of Medicine
BACKGROUND: Recurrent Clostridium difficile infection is difficult to treat, and failure rates for antibiotic therapy are high. We studied the effect of duodenal infusion of donor feces in patients with recurrent C. difficile infection.…
Thomas G. Brott, Robert W. Hobson, George Howard et al. · 2010 · New England Journal of Medicine
BACKGROUND: Carotid-artery stenting and carotid endarterectomy are both options for treating carotid-artery stenosis, an important cause of stroke. METHODS: We randomly assigned patients with symptomatic or asymptomatic carotid stenosis to…
The ACCORD Study Group · 2010 · New England Journal of Medicine
BACKGROUND: We investigated whether combination therapy with a statin plus a fibrate, as compared with statin monotherapy, would reduce the risk of cardiovascular disease in patients with type 2 diabetes mellitus who were at high risk for…
Mark R. Gilbert, James J. Dignam, Terri S. Armstrong et al. · 2014 · New England Journal of Medicine
BACKGROUND: Concurrent treatment with temozolomide and radiotherapy followed by maintenance temozolomide is the standard of care for patients with newly diagnosed glioblastoma. Bevacizumab, a humanized monoclonal antibody against vascular…
Bertram Pitt, Marc A. Pfeffer, Susan F. Assmann et al. · 2014 · New England Journal of Medicine
BACKGROUND: Mineralocorticoid-receptor antagonists improve the prognosis for patients with heart failure and a reduced left ventricular ejection fraction. We evaluated the effects of spironolactone in patients with heart failure and a…
Freddie C. Hamdy, Jenny Donovan, J. Athene Lane et al. · 2016 · New England Journal of Medicine
BACKGROUND: The comparative effectiveness of treatments for prostate cancer that is detected by prostate-specific antigen (PSA) testing remains uncertain. METHODS: We compared active monitoring, radical prostatectomy, and external-beam…
John B. Holcomb, Barbara C. Tilley, Sarah Baraniuk et al. · 2015 · JAMA
IMPORTANCE: Severely injured patients experiencing hemorrhagic shock often require massive transfusion. Earlier transfusion with higher blood product ratios (plasma, platelets, and red blood cells), defined as damage control resuscitation,…
Gregory G. Schwartz, Anders Olsson, Markus Abt et al. · 2012 · New England Journal of Medicine
BACKGROUND: In observational analyses, higher levels of high-density lipoprotein (HDL) cholesterol have been associated with a lower risk of coronary heart disease events. However, whether raising HDL cholesterol levels therapeutically…
Scott Marek, Brenden Tervo‐Clemmens, Finnegan J. Calabro et al. · 2022 · Nature
Abstract Magnetic resonance imaging (MRI) has transformed our understanding of the human brain through well-replicated mapping of abilities to specific structures (for example, lesion studies) and functions 1–3 (for example, task functional MRI (fMRI)). Mental health research and care have yet to realize similar advances from MRI. A primary challenge has been replicating associations between inter-individual differences in brain structure or function and complex cognitive or mental health phenotypes (brain-wide association studies (BWAS)). Such BWAS have typically relied on sample sizes approp
Joseph P. Broderick, Yuko Y. Palesch, Andrew M. Demchuk et al. · 2013 · New England Journal of Medicine
BACKGROUND: Endovascular therapy is increasingly used after the administration of intravenous tissue plasminogen activator (t-PA) for patients with moderate-to-severe acute ischemic stroke, but whether a combined approach is more effective…
Susumu Eguchi, Mitsuhisa Takatsuki, Akihiko Soyama et al. · 2011 · Hepatogastroenterology
BACKGROUND/AIMS: When right hemi-hepatectomy without middle hepatic vein (MHV) is performed in a living donor (LD), MHV tributaries such as V5 and V8 may be preserved during parenchymal transection to preserve liver function and reduce the…
G. Michael Felker, Kerry L. Lee, David A. Bull et al. · 2011 · New England Journal of Medicine
BACKGROUND: Loop diuretics are an essential component of therapy for patients with acute decompensated heart failure, but there are few prospective data to guide their use. METHODS: In a prospective, double-blind, randomized trial, we…
John Myburgh, Simon Finfer, Rinaldo Bellomo et al. · 2012 · New England Journal of Medicine
BACKGROUND: The safety and efficacy of hydroxyethyl starch (HES) for fluid resuscitation have not been fully evaluated, and adverse effects of HES on survival and renal function have been reported. METHODS: We randomly assigned 7000…
The HPS2-THRIVE Collaborative Group · 2014 · New England Journal of Medicine
BACKGROUND: Patients with evidence of vascular disease are at increased risk for subsequent vascular events despite effective use of statins to lower the low-density lipoprotein (LDL) cholesterol level. Niacin lowers the LDL cholesterol…
Frank Dudbridge · 2013 · PLoS Genetics
Polygenic scores have recently been used to summarise genetic effects among an ensemble of markers that do not individually achieve significance in a large-scale association study. Markers are selected using an initial training sample and used to construct a score in an independent replication sample by forming the weighted sum of associated alleles within each subject. Association between a trait and this composite score implies that a genetic signal is present among the selected markers, and the score can then be used for prediction of individual trait values. This approach has been used to
Brad H. Rovin, Richard Furie, Kevin Latinis et al. · 2012 · Arthritis & Rheumatism
OBJECTIVE: To evaluate the efficacy and safety of rituximab in a randomized, double-blind, placebo-controlled phase III trial in patients with lupus nephritis treated concomitantly with mycophenolate mofetil (MMF) and corticosteroids.…
Eric F. Morand, Richard Furie, Yoshiya Tanaka et al. · 2019 · New England Journal of Medicine
BACKGROUND: Anifrolumab, a human monoclonal antibody to type I interferon receptor subunit 1 investigated for the treatment of systemic lupus erythematosus (SLE), did not have a significant effect on the primary end point in a previous…
Samantha Budd Haeberlein, Paul Aisen, Frederik Barkhof et al. · 2022 · The Journal of Prevention of Alzheimer s Disease
BACKGROUND: Alzheimer's disease is a progressive, irreversible, and fatal disease for which accumulation of amyloid beta is thought to play a key role in pathogenesis. Aducanumab is a human monoclonal antibody directed against aggregated soluble and insoluble forms of amyloid beta. OBJECTIVES: We evaluated the efficacy and safety of aducanumab in early Alzheimer's disease. DESIGN: EMERGE and ENGAGE were two randomized, double-blind, placebo-controlled, global, phase 3 studies of aducanumab in patients with early Alzheimer's disease. SETTING: These studies involved 348 sites in 20 countries. PA
Christoph D. Spinner, Robert Gottlieb, Gerard J. Criner et al. · 2020 · JAMA
Importance: Remdesivir demonstrated clinical benefit in a placebo-controlled trial in patients with severe coronavirus disease 2019 (COVID-19), but its effect in patients with moderate disease is unknown. Objective: To determine the…
Armando E. Giuliano, Linda McCall, Peter D. Beitsch et al. · 2010 · Annals of Surgery
BACKGROUND AND OBJECTIVE: Sentinel lymph node dissection (SLND) has eliminated the need for axillary dissection (ALND) in patients whose sentinel node (SN) is tumor-free. However, completion ALND for patients with tumor-involved SNs…
Richard Klein, Kate A. Ratliff, Michelangelo Vianello et al. · 2014 · Social Psychology
Although replication is a central tenet of science, direct replications are rare in psychology. This research tested variation in the replicability of 13 classic and contemporary effects across 36 independent samples totaling 6,344…
Dominik Pfister, Nicolás Gonzalo Núñez, Roser Pinyol et al. · 2021 · Nature
Abstract Hepatocellular carcinoma (HCC) can have viral or non-viral causes 1–5 . Non-alcoholic steatohepatitis (NASH) is an important driver of HCC. Immunotherapy has been approved for treating HCC, but biomarker-based stratification of patients for optimal response to therapy is an unmet need 6,7 . Here we report the progressive accumulation of exhausted, unconventionally activated CD8 + PD1 + T cells in NASH-affected livers. In preclinical models of NASH-induced HCC, therapeutic immunotherapy targeted at programmed death-1 (PD1) expanded activated CD8 + PD1 + T cells within tumours but did n
Eduardo A. Cavallo, Sebastián Galiani, Ilan Noy et al. · 2013 · The Review of Economics and Statistics
Abstract We examine the average causal impact of catastrophic natural disasters on economic growth by combining information from comparative case studies. For each country affected by a large disaster, we compute the counterfactual by…
Marie Bakitas, Tor D. Tosteson, Zhigang Li et al. · 2015 · Journal of Clinical Oncology
PURPOSE: Randomized controlled trials have supported integrated oncology and palliative care (PC); however, optimal timing has not been evaluated. We investigated the effect of early versus delayed PC on quality of life (QOL), symptom…
Pierre Asfar, Ferhat Meziani, Jean‐François Hamel et al. · 2014 · New England Journal of Medicine
BACKGROUND: The Surviving Sepsis Campaign recommends targeting a mean arterial pressure of at least 65 mm Hg during initial resuscitation of patients with septic shock. However, whether this blood-pressure target is more or less effective…
Domenica A. Delgado, Bradley S. Lambert, Nickolas Boutris et al. · 2018 · JAAOS Global Research and Reviews
Background: The visual analog scale (VAS) is a validated, subjective measure for acute and chronic pain. Scores are recorded by making a handwritten mark on a 10-cm line that represents a continuum between “no pain” and “worst pain.”…
Katherine Baicker, Sarah Taubman, Heidi Allen et al. · 2013 · New England Journal of Medicine
BACKGROUND: Despite the imminent expansion of Medicaid coverage for low-income adults, the effects of expanding coverage are unclear. The 2008 Medicaid expansion in Oregon based on lottery drawings from a waiting list provided an…
G. L. Andriole, E. David Crawford, Robert L. Grubb et al. · 2012 · JNCI Journal of the National Cancer Institute
BACKGROUND: The prostate component of the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial was undertaken to determine whether there is a reduction in prostate cancer mortality from screening using serum…