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Browse the failure-mode index

102 real negative results, null findings, and replication failures in Dentistry. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessDentistry

Accuracy of four intraoral scanners in oral implantology: a comparative in vitro study

Mario Imburgia, Silvia Logozzo, Uli Hauschild et al. · 2017 · BMC Oral Health

BACKGROUND: Until now, only a few studies have compared the ability of different intraoral scanners (IOS) to capture high-quality impressions in patients with dental implants. Hence, the aim of this study was to compare the trueness and precision of four IOS in a partially edentulous model (PEM) with three implants and in a fully edentulous model (FEM) with six implants. METHODS: Two gypsum models were prepared with respectively three and six implant analogues, and polyether-ether-ketone cylinders screwed on. These models were scanned with a reference scanner (ScanRider®), and with four IOS (C

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Negative / Null Result ReportOpen accessDentistry

Incidence of impacted mandibular and maxillary third molars-a radiographic study in a Southeast Iran population

Maryam Alsadat Hashemipour, Mehrnaz Tahmasbi, Farnaz Fahimi Hanzaei · 2012 · Medicina oral, patología oral y cirugía bucal

OBJECTIVES: The aim of this study is to evaluate the position of impacted third molars based on the classifications of Pell & Gregory and Winter in a sample of Iranian patients. STUDY DESIGN: In this retrospective study, up to 1020…

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Negative / Null Result ReportOpen accessDentistry

Anti‐infective therapy of peri‐implantitis with adjunctive local drug delivery or photodynamic therapy: 12‐month outcomes of a randomized controlled clinical trial

Mario Bassetti, Dorothee Schär, Beat Wicki et al. · 2013 · Clinical Oral Implants Research

OBJECTIVE: The objective of the study is to compare the clinical, microbiological and host-derived effects in the non-surgical treatment of initial peri-implantitis with either adjunctive local drug delivery (LDD) or adjunctive photodynamic therapy (PDT) after 12 months. MATERIALS AND METHODS: Forty subjects with initial peri-implantitis, that is, pocket probing depths (PPD) 4-6 mm with bleeding on probing (BoP) and radiographic bone loss ≤2 mm, were randomly assigned to two treatment groups. All implants were mechanically debrided with titanium curettes and with a glycine-based powder airpoli

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Negative / Null Result ReportDentistry

In Vitro Biofilm Formation on Titanium and Zirconia Implant Surfaces

Stefan Roehling, Monika Astasov‐Frauenhoffer, Irmgard Hauser‐Gerspach et al. · 2016 · Journal of Periodontology

Background: It has been hypothesized that zirconia might have a reduced bacterial adhesion compared with titanium; however, results from experimental studies are rather controversial. The aim of the present study is to compare biofilm…

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Negative / Null Result ReportDentistry

Anti‐infective therapy of peri‐implantitis with adjunctive local drug delivery or photodynamic therapy: six‐month outcomes of a prospective randomized clinical trial

Dorothee Schär, Christoph A. Ramseier, Sigrun Eick et al. · 2012 · Clinical Oral Implants Research

OBJECTIVE: To compare the adjunctive clinical effects in the non-surgical treatment of peri-implantitis with either local drug delivery (LDD) or photodynamic therapy (PDT). MATERIAL AND METHODS: Forty subjects with initial…

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Negative / Null Result ReportOpen accessDentistry

Deep Learning for Automated Detection of Cyst and Tumors of the Jaw in Panoramic Radiographs

Hyunwoo Yang, Eun Jo, Hyung Jun Kim et al. · 2020 · Journal of Clinical Medicine

Patients with odontogenic cysts and tumors may have to undergo serious surgery unless the lesion is properly detected at the early stage. The purpose of this study is to evaluate the diagnostic performance of the real-time object detecting deep convolutional neural network You Only Look Once (YOLO) v2-a deep learning algorithm that can both detect and classify an object at the same time-on panoramic radiographs. In this study, 1602 lesions on panoramic radiographs taken from 2010 to 2019 at Yonsei University Dental Hospital were selected as a database. Images were classified and labeled into f

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Negative / Null Result ReportDentistry

Smoking, Diabetes Mellitus, Periodontitis, and Supportive Periodontal Treatment as Factors Associated With Dental Implant Survival: A Long-Term Retrospective Evaluation of Patients Followed for Up to 10 Years

Rachel Anner, Yoav Grossmann, Yael Anner et al. · 2010 · Implant Dentistry

OBJECTIVES: To evaluate the factors associated with long-term implant survival in a large cohort of patients in regular follow-up until data collection. METHODS: The study population consisted of 475 patients who were referred to a private…

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Negative / Null Result ReportDentistry

Subgingival Plaque Removal Using a New Air‐Polishing Device

Raphaël Moëne, Fabien Décaillet, E. Andersen et al. · 2010 · Journal of Periodontology

BACKGROUND: The purpose of this study is to evaluate the safety, patient acceptance, and short-term microbiologic effect of a new air-polishing device in subjects in maintenance care with residual pockets > or =5 mm. METHODS: This was an…

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Negative / Null Result ReportDentistry

Evaluation of Antioxidant Enzymes Activity and Malondialdehyde Levels in Patients With Chronic Periodontitis and Diabetes Mellitus

Shilpa Trivedi, Nand Lal, Abbas Ali Mahdi et al. · 2013 · Journal of Periodontology

BACKGROUND: The aim of this study is to investigate the impact of diabetes, a known risk factor for periodontitis, on activities of antioxidant enzymes superoxide dismutase (SOD), glutathione reductase (GR), and catalase (CAT) as well as…

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Negative / Null Result ReportDentistry

Peri‐implant evaluation of immediately loaded implants placed in esthetic zone in patients with diabetes mellitus type 2: a two‐year study

Antonio Aguilar‐Salvatierra, José Luis Calvo‐Guirado, Maximino González‐Jaranay et al. · 2015 · Clinical Oral Implants Research

OBJECTIVES: The aim of this study was to evaluate implant survival and primary stability parameters in patients with diabetes with different levels of glycosylated hemoglobin Alc (HbA1c) treated with immediate placement and…

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Negative / Null Result ReportOpen accessDentistry

Enamel Bond Strength of New Universal Adhesive Bonding Agents

DE McLean, EJ Meyers, VL Guillory et al. · 2015 · Operative Dentistry

PURPOSE: Universal bonding agents have been introduced for use as self-etch or etch-and-rinse adhesives depending on the dental substrate and clinician's preference. The purpose of this study was to evaluate the shear bond strength (SBS)…

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Negative / Null Result ReportDentistry

Effect of Non‐Surgical Periodontal Therapy on C‐Reactive Protein, Oxidative Stress, and Matrix Metalloproteinase (MMP)‐9 and MMP‐2 Levels in Patients With Type 2 Diabetes: A Randomized Controlled Study

Panagiotis A. Koromantzos, Konstantinos Makrilakis, Xanthippi Dereka et al. · 2011 · Journal of Periodontology

BACKGROUND: It is well accepted that glycemic control in patients with diabetes mellitus (DM) is affected by systemic inflammation and oxidative stress. The effect of periodontal therapy on these systemic factors may be related to…

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Negative / Null Result ReportDentistry

Efficacy of autogenous tooth roots for lateral alveolar ridge augmentation and staged implant placement. A prospective controlled clinical study

Frank Schwarz, Didem Hazar, Kathrin Becker et al. · 2018 · Journal Of Clinical Periodontology

OBJECTIVES: To assess and compare the efficacy and safety of autogenous tooth roots (TR) and autogenous bone blocks (AB) for lateral alveolar ridge augmentation and two-stage implant placement. MATERIAL AND METHODS: A total of 30 patients…

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Negative / Null Result ReportOpen accessDentistry

Assessment of the Stability of the Palatal Rugae in a 3D-3D Superimposition Technique Following Slow Maxillary Expansion (SME)

Valentina Lanteri, Gianguido Cossellu, Marco Farronato et al. · 2020 · Scientific Reports

The Palatal Rugae are considered a useful human identification marker for both orthodontists and forensic personnel. The principal aim of the present study was to evaluate the stability of palatal rugae with a 3D-3D superimposition procedure following Slow Maxillary Expansion (SME), in order to assess whether they kept their uniqueness and validity for human identification, even after a specific dental treatment. For this purpose, a sample of 27 digital dental models - belonging to growing patients (13 males and 14 females), aged between 8.5 and 15 years, who underwent SME therapy - was retros

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Negative / Null Result ReportOpen accessDentistry

Effect of distance learning on the quality of life, anxiety and stress levels of dental students during the COVID-19 pandemic

Zeynep Başağaoğlu Demirekin, Muhammed Hilmi Büyükçavuş · 2022 · BMC Medical Education

BACKGROUND: The long-term psychological effects of COVID-19 on dental students are unclear. The aim of this cross-sectional online study was to investigate the psychological effects of the COVID-19 pandemic on dental students. METHOD: The Quality of Life Scale (WHOQOL-BREF) was sent to all dental students through Google Forms to evaluate their quality of life (QoL), and the DASS-21 scale was used to evaluate their psychosocial status due to distance learning during the COVID-19 pandemic. The answers were analyzed both on the basis of year of education and type of education (online versus class

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Negative / Null Result ReportOpen accessDentistry

Spatial and contrast resolution of ultralow dose dentomaxillofacial CT imaging using iterative reconstruction technology

Gerlig Widmann, Alexander Bischel, Andreas Stratis et al. · 2017 · Dentomaxillofacial Radiology

OBJECTIVES: The objective of this study was to determine how iterative reconstruction technology (IRT) influences contrast and spatial resolution in ultralow-dose dentomaxillofacial CT imaging. METHODS: A polymethyl methacrylate phantom with various inserts was scanned using a reference protocol (RP) at CT dose index volume 36.56 mGy, a sinus protocol at 18.28 mGy and ultralow-dose protocols (LD) at 4.17 mGy, 2.36 mGy, 0.99 mGy and 0.53 mGy. All data sets were reconstructed using filtered back projection (FBP) and the following IRTs: adaptive statistical iterative reconstructions (ASIRs) (ASIR

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Negative / Null Result ReportDentistry

Toothpastes containing abrasive and chemical whitening agents: efficacy in reducing extrinsic dental staining.

Cristina Neves Girao Salgado Soares, Flávia Lucisano Botelho do Amaral, Marcelo Ferraz Mesquita et al. · 2017 · PubMed

This in vitro study evaluated the efficacy of toothpastes containing abrasive and chemical whitening agents in reducing the extrinsic discoloration of dental enamel. Sixty slabs of dentin from human teeth were sealed so that only the…

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Negative / Null Result ReportOpen accessDentistry

Antiseptics and microcosm biofilm formation on titanium surfaces

Georgia Verardi, Maximiliano Sérgio Cenci, Tamires Timm Maske et al. · 2016 · Brazilian Oral Research

Oral rehabilitation with osseointegrated implants is a way to restore esthetics and masticatory function in edentulous patients, but bacterial colonization around the implants may lead to mucositis or peri-implantitis and consequent implant loss. Peri-implantitis is the main complication of oral rehabilitation with dental implants and, therefore, it is necessary to take into account the potential effects of antiseptics such as chlorhexidine (CHX), chloramine T (CHT), triclosan (TRI), and essential oils (EO) on bacterial adhesion and on biofilm formation. To assess the action of these substance

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Negative / Null Result ReportOpen accessDentistry

Smear layer deproteinization with NaOCl and HOCl: Do application/wash-out times affect dentin bonding of one-step self-etch adhesives?

Kittisak Sanon, Takashi Hatayama, Antonín Tichý et al. · 2022 · Dental Materials Journal

This study investigated the influence of application/wash-out times of sodium hypochlorite (NaOCl) and hypochlorous acid (HOCl) on dentin bond strength of one-step self-etch adhesives (1-SEAs). Human coronal dentin discs with a…

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Negative / Null Result ReportOpen accessDentistry

Remineralization of Artificial Dentin Caries Using Dentin and Enamel Matrix Proteins

Katja Bächli, Patrick R. Schmidlin, Florian J. Wegehaupt et al. · 2019 · Materials

To assess the remineralizing potential of dentin matrix proteins and enamel matrix derivatives (DMPs and EMDs) after application on artificially induced dentin lesions, given the hypothesis that these materials increase the mineral uptake, binding, and mineralization. Forty-eight caries-free human premolars were used. Teeth were cut, polished, and embedded, leaving an open window on the root surface, of which one-third was covered with a flowable composite to preserve the healthy untreated dentin. Then, samples were demineralized in Buskes solution for 33 days. A micro-CT scan prior to treatme

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Negative / Null Result ReportOpen accessDentistry

BLOOD LIPID LEVELS RELATED TO ALLERGIC RHINITIS: A SIGNIFICANT ASSOCIATION?

Ignazio La Mantia, Claudio Andaloro, Pasquale Gianluca Albanese et al. · 2026 · EuroMediterranean Biomedical Journal

Allergic rhinitis is a common problem increasing greatly over the past three decades. Several studies have found a possible link between dyslipidem ia and allergic disease but the relating causal mechanisms remain elusive. The aim of this…

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Negative / Null Result ReportOpen accessDentistry

Unraveling the oral microbiome's role in Alzheimer's disease: From pathophysiology to therapeutic potential

Gilliana Rozenblum, Karima Ait‐Aissa, G. E. D. Zahran et al. · 2025 · Alzheimer s & Dementia

Oral dysbiosis contributes to Alzheimer's disease (AD) by promoting neuroinflammation. Pathobionts such as Porphyromonas gingivalis, Treponema denticola, and Fusobacterium nucleatum release virulence factors that induce amyloid beta aggregation and tau hyperphosphorylation, while the loss of commensals like Streptococcus salivarius and Neisseria spp. impairs anti-inflammatory protection, worsening neuronal damage. P. gingivalis is strongly linked to an increased risk of AD, especially in individuals with systemic conditions like diabetes, hypertension, and chronic kidney disease. Its presence

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Negative / Null Result ReportOpen accessDentistry

Adjunctive Therapies in Periodontitis: Current Concepts and the Future

Rafael Scaf de Molon, João Paulo Steffens, Érica Dorigatti de Ávila et al. · 2026 · Journal of Periodontal Research

Periodontitis is a chronic, host-mediated inflammatory disease in which microbial dysbiosis and dysregulated immune responses drive the destruction of tooth-supporting tissues. Although conventional therapy remains centered on mechanical biofilm control, persistent inflammation and alveolar bone loss in susceptible individuals underscore the need for adjunctive strategies. Translating preclinical discoveries into predictable clinical outcomes, however, remains a major challenge in periodontal research. This narrative review integrates two interrelated themes, translational research methodology

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Negative / Null Result ReportOpen accessDentistry

Efficacy of Propolis-Based Mouthwash on Generalized Chronic Gingivitis: A Randomized Controlled Clinical Trial

Naser Sargolzaie, Vahid Reza Askari, Maryam Najjar et al. · 2024 · Journal of Dental School

Objectives This study aimed to investigate the effect of propolis-based mouthwash on the gingival parameters of generalized chronic gingivitis cases in a randomized controlled clinical trial. Methods A total number of 69 patients with generalized chronic gingivitis were randomly assigned into three groups (N=23): propolis, chlorhexidine, or placebo mouthwash. The gingival and bleeding indices were evaluated before and after two weeks of mouthwash use. Data analyses were performed using Kruskal-Wallis test, one-way analysis of variance, and paired t-test at p<0 .05. Results The average gingival

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Negative / Null Result ReportOpen accessDentistry

Fracture resistance of pulpotomized primary molars restored with three types of composite resins with and without fiber-reinforcement

Zahra Bahrololoomi, Farnaz Farahat, Shirin Pajouhande et al. · 2025 · Journal of Dental Materials and Techniques

Objective: Coronal restoration of pulpotomized primary molars plays a vital role in ensuring the long-term success of the treatment. This study aimed to evaluate the effect of fiber reinforcement on the fracture resistance of pulpotomized primary molars restored with flowable or paste bulk-fill composite resins in comparison to a conventional composite resin.Methods: In this in vitro experimental study, 48 primary molars were randomly allocated into six groups (n=8). The teeth were pulpotomozed and restored with the following materials: Group 1: Conventional composite resin, Group 2: Fiber+ co

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