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5 real negative results, null findings, and replication failures in Nutritional diseases. Deficiency diseases. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessNutritional diseases. Deficiency diseases

The effect of Cornus mas L. fruit extract supplementation on glycemic control, insulin resistance, and adiponectin levels in patients with metabolic dysfunction-associated steatotic liver disease: a double-blind randomized controlled clinical trial

Zohreh Sadat Sangsefidi, Abbas Ali Sangouni, Faezeh Yarhosseini et al. · 2026 · Journal of Health, Population and Nutrition

Abstract Background Available evidence regarding effect of Cornus mas L. fruit extract (CMFE) as an anthocyanins source on glycemic control, insulin resistance, and adiponectin levels among metabolic dysfunction-associated steatotic liver disease (MASLD) patients is limited and controversial. Thus, this study aimed to assess effect of CMFE on glycemic control, insulin resistance, and adiponectin levels in MASLD patients. Methods This double-blind, randomized controlled clinical trial was carried out among 50 MASLD patients for 12 weeks. The participants were randomly categorized into the CMFE

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Negative / Null Result ReportOpen accessNutritional diseases. Deficiency diseases

The Effect of Postpartum Vitamin A and Beef Liver supplementation on Infant Acute Respiratory Infection and Diarrhea

Arvina Dian Wahyu Permatasari, Didik Gunawan Tamtomo, Budiyanti Wiboworini · 2024 · International Journal of Nutrition Sciences

Background: In Indonesia, Acute respiratory infection (ARI) and diarrhea-related morbidity and mortality in children less than five years old still remain a significant public health concern. In this relation, energy, protein, zinc, and vitamins C, B, D, E, and A are essential nutrients to mitigate morbidity and mortality. Vitamin A was shown to play a crucial role in human development, growth, and immune function that can protect infants against infectious diseases such as ARI and diarrhea. So this study aimed to compare the effect of beef liver and vitamin A supplementation for breastfeeding

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Negative / Null Result ReportOpen accessNutritional diseases. Deficiency diseases

Cadmium and selenium blood levels in association with congestive heart failure in diabetic and prediabetic patients: a cross-sectional study from the national health and nutrition examination survey

Renyue Ji, Haisheng Wu, Hongli Lin et al. · 2025 · Diabetology & Metabolic Syndrome

Abstract Background Epidemiological research on the association between heavy metals and congestive heart failure (CHF) in individuals with abnormal glucose metabolism is scarce. The study addresses this research gap by examining the link between exposure to heavy metals and the odds of CHF in a population with dysregulated glucose metabolism. Method This cross-sectional study includes 7326 patients with diabetes and prediabetes from the National Health and Nutrition Examination Survey from 2011 to 2018. The exposure variables are five environmental heavy metals—cadmium (Cd), lead (Pb), mercur

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Negative / Null Result ReportOpen accessNutritional diseases. Deficiency diseases

Curcumin and/or omega-3 polyunsaturated fatty acids supplementation reduces insulin resistance and blood lipids in individuals with high risk of type 2 diabetes: a randomised controlled trial

Rohith N. Thota, Shamasunder H. Acharya, Manohar L. Garg · 2019 · Lipids in Health and Disease

Abstract Background Lowering insulin resistance and dyslipidaemia may not only enhance glycaemic control but also preserve the β-cell function, reducing the overall risk of developing type 2 diabetes (T2D). The current study was aimed to evaluate the effects of curcumin and/or long-chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) supplementation on glycaemic control and blood lipid levels in individuals at high risk of developing T2D. Methods This was a 2 × 2 factorial, randomised, double-blinded, placebo-controlled study. Participants were allocated to either double placebo (PL) or curcu

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Replication FailureOpen accessNutritional diseases. Deficiency diseases

Sex-specific associations between type 2 diabetes and muscle health in middle-aged adults

Yijia Wang, Songting Gao, Qiang Xu et al. · 2025 · Diabetology & Metabolic Syndrome

Abstract Background Type 2 diabetes mellitus (T2DM) and sarcopenia have emerged as significant public health challenges that disproportionately affect middle-aged adults. However, the relationship between T2DM and muscle parameters in this critical age remains inadequately elucidated. Methods We conducted a comprehensive analysis of cross-sectional data derived from 2,446 middle-aged participants (aged 40–59 years; 1,230 men and 1,216 women) enrolled in the National Health and Nutrition Examination Survey (NHANES) 2011–2014. T2DM was defined by physician-confirmed diagnosis and/or glycohemoglo

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