Repository corticotropin injection versus corticosteroids for protection against renal damage in a focal segmental glomerulosclerosis rodent model
Kyle Hayes; Elizabeth Warner; Chris Bollinger; Dale Wright; Richard M. Fitch · 2020 · BMC Nephrology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Background Focal segmental glomerulosclerosis (FSGS) causes renal fibrosis and may lead to kidney failure. FSGS and its common complication, proteinuria, are challenging to treat. Corticosteroids are ineffective in many patients with FSGS, and alternative treatments often yield suboptimal responses. Repository corticotropin injection (RCI; Acthar® Gel), a naturally sourced complex mixture of purified adrenocorticotropic hormone analogs and other pituitary peptides, may have beneficial effects on idiopathic FSGS via melanocortin receptor activation. Methods Two studies in a preclinical
Abstract by Kyle Hayes; Elizabeth Warner; Chris Bollinger; Dale Wright; Richard M. Fitch, BMC Nephrology (2020) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1186/s12882-020-01879-6