Charlson comorbidity index has no incremental value for mortality risk prediction in nursing home residents with COVID-19 disease
Anum Zahra; Maarten van Smeden; Petra J. M. Elders; Jan Festen; Jacobijn Gussekloo; Karlijn J. Joling; Anouk van Loon; Kim Luijken · 2025 · BMC Geriatrics
WASTE classifies this as Replication Failure · AI classification, approximate
A previously reported effect did not replicate here — verify it holds before you build on it.
Abstract
Abstract Background During the COVID-19 pandemic, nursing home (NH) residents faced the highest risk of severe COVID-19 disease and mortality. Due to their frailty status, comorbidity burden can serve as a useful predictive indicator of vulnerability in this frail population. However, the prognostic value of these cumulative comorbidity scores like the Charlson comorbidity index (CCI) remained unclear in this population. We evaluated the incremental predictive value of the CCI for predicting 28-day mortality in NH residents with COVID-19, compared to prediction using age and sex only. Methods
Abstract by Anum Zahra; Maarten van Smeden; Petra J. M. Elders; Jan Festen; Jacobijn Gussekloo; Karlijn J. Joling; Anouk van Loon; Kim Luijken, BMC Geriatrics (2025) — licensed CC BY 4.0.
About to run something similar?
Run an AI Precheck on your own design to catch failure modes like this one before you spend the time. Your first desk check is free.
Related failures
Safer cycling in older age (SiFAr): effects of a multi-component cycle training. a randomized controlled trial
Negative / Null Result ReportOne-Year Mortality Rates Before and After Implementing Quality-Improvement Initiatives to Prevent Inpatient Falls (2012–2016)
Negative / Null Result ReportStand if you can- A parallel, superiority cluster randomized controlled trial to improve gait speed for long term care residents
Negative / Null Result ReportThe Seniors’ Community Hub: An Integrated Model of Care for the Identification and Management of Frailty in Primary Care
Negative / Null Result ReportClinical Features of CINin ChineseVery Elderly Patients Undergoing Coronary Angiography Procedure With Hydration Treatment: A Three-Center, Prospective Study
Negative / Null Result ReportMifepristone Increases Life Span in Female Drosophila Without Detectable Antibacterial Activity
WASTE indexes this work — it does not host or republish it. Failure-type classification is automated and approximate.
Metadata source: DOAJ · DOI 10.1186/s12877-025-05721-2