19,727 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Olvert A. Berkhemer, Puck Fransen, Debbie Beumer et al. · 2014 · New England Journal of Medicine
BACKGROUND: In patients with acute ischemic stroke caused by a proximal intracranial arterial occlusion, intraarterial treatment is highly effective for emergency revascularization. However, proof of a beneficial effect on functional…
View details →Els van Nood, Anne Vrieze, Max Nieuwdorp et al. · 2013 · New England Journal of Medicine
BACKGROUND: Recurrent Clostridium difficile infection is difficult to treat, and failure rates for antibiotic therapy are high. We studied the effect of duodenal infusion of donor feces in patients with recurrent C. difficile infection.…
View details →Thomas G. Brott, Robert W. Hobson, George Howard et al. · 2010 · New England Journal of Medicine
BACKGROUND: Carotid-artery stenting and carotid endarterectomy are both options for treating carotid-artery stenosis, an important cause of stroke. METHODS: We randomly assigned patients with symptomatic or asymptomatic carotid stenosis to…
View details →The ACCORD Study Group · 2010 · New England Journal of Medicine
BACKGROUND: We investigated whether combination therapy with a statin plus a fibrate, as compared with statin monotherapy, would reduce the risk of cardiovascular disease in patients with type 2 diabetes mellitus who were at high risk for…
View details →Bertram Pitt, Marc A. Pfeffer, Susan F. Assmann et al. · 2014 · New England Journal of Medicine
BACKGROUND: Mineralocorticoid-receptor antagonists improve the prognosis for patients with heart failure and a reduced left ventricular ejection fraction. We evaluated the effects of spironolactone in patients with heart failure and a…
View details →Freddie C. Hamdy, Jenny Donovan, J. Athene Lane et al. · 2016 · New England Journal of Medicine
BACKGROUND: The comparative effectiveness of treatments for prostate cancer that is detected by prostate-specific antigen (PSA) testing remains uncertain. METHODS: We compared active monitoring, radical prostatectomy, and external-beam…
View details →John B. Holcomb, Barbara C. Tilley, Sarah Baraniuk et al. · 2015 · JAMA
IMPORTANCE: Severely injured patients experiencing hemorrhagic shock often require massive transfusion. Earlier transfusion with higher blood product ratios (plasma, platelets, and red blood cells), defined as damage control resuscitation,…
View details →Joseph P. Broderick, Yuko Y. Palesch, Andrew M. Demchuk et al. · 2013 · New England Journal of Medicine
BACKGROUND: Endovascular therapy is increasingly used after the administration of intravenous tissue plasminogen activator (t-PA) for patients with moderate-to-severe acute ischemic stroke, but whether a combined approach is more effective…
View details →Susumu Eguchi, Mitsuhisa Takatsuki, Akihiko Soyama et al. · 2011 · Hepatogastroenterology
BACKGROUND/AIMS: When right hemi-hepatectomy without middle hepatic vein (MHV) is performed in a living donor (LD), MHV tributaries such as V5 and V8 may be preserved during parenchymal transection to preserve liver function and reduce the…
View details →G. Michael Felker, Kerry L. Lee, David A. Bull et al. · 2011 · New England Journal of Medicine
BACKGROUND: Loop diuretics are an essential component of therapy for patients with acute decompensated heart failure, but there are few prospective data to guide their use. METHODS: In a prospective, double-blind, randomized trial, we…
View details →John Myburgh, Simon Finfer, Rinaldo Bellomo et al. · 2012 · New England Journal of Medicine
BACKGROUND: The safety and efficacy of hydroxyethyl starch (HES) for fluid resuscitation have not been fully evaluated, and adverse effects of HES on survival and renal function have been reported. METHODS: We randomly assigned 7000…
View details →The HPS2-THRIVE Collaborative Group · 2014 · New England Journal of Medicine
BACKGROUND: Patients with evidence of vascular disease are at increased risk for subsequent vascular events despite effective use of statins to lower the low-density lipoprotein (LDL) cholesterol level. Niacin lowers the LDL cholesterol…
View details →Frank Dudbridge · 2013 · PLoS Genetics
Polygenic scores have recently been used to summarise genetic effects among an ensemble of markers that do not individually achieve significance in a large-scale association study. Markers are selected using an initial training sample and used to construct a score in an independent replication sample by forming the weighted sum of associated alleles within each subject. Association between a trait and this composite score implies that a genetic signal is present among the selected markers, and the score can then be used for prediction of individual trait values. This approach has been used to
View details →Brad H. Rovin, Richard Furie, Kevin Latinis et al. · 2012 · Arthritis & Rheumatism
OBJECTIVE: To evaluate the efficacy and safety of rituximab in a randomized, double-blind, placebo-controlled phase III trial in patients with lupus nephritis treated concomitantly with mycophenolate mofetil (MMF) and corticosteroids.…
View details →Samantha Budd Haeberlein, Paul Aisen, Frederik Barkhof et al. · 2022 · The Journal of Prevention of Alzheimer s Disease
BACKGROUND: Alzheimer's disease is a progressive, irreversible, and fatal disease for which accumulation of amyloid beta is thought to play a key role in pathogenesis. Aducanumab is a human monoclonal antibody directed against aggregated soluble and insoluble forms of amyloid beta. OBJECTIVES: We evaluated the efficacy and safety of aducanumab in early Alzheimer's disease. DESIGN: EMERGE and ENGAGE were two randomized, double-blind, placebo-controlled, global, phase 3 studies of aducanumab in patients with early Alzheimer's disease. SETTING: These studies involved 348 sites in 20 countries. PA
View details →Christoph D. Spinner, Robert Gottlieb, Gerard J. Criner et al. · 2020 · JAMA
Importance: Remdesivir demonstrated clinical benefit in a placebo-controlled trial in patients with severe coronavirus disease 2019 (COVID-19), but its effect in patients with moderate disease is unknown. Objective: To determine the…
View details →Armando E. Giuliano, Linda McCall, Peter D. Beitsch et al. · 2010 · Annals of Surgery
BACKGROUND AND OBJECTIVE: Sentinel lymph node dissection (SLND) has eliminated the need for axillary dissection (ALND) in patients whose sentinel node (SN) is tumor-free. However, completion ALND for patients with tumor-involved SNs…
View details →Eduardo A. Cavallo, Sebastián Galiani, Ilan Noy et al. · 2013 · The Review of Economics and Statistics
Abstract We examine the average causal impact of catastrophic natural disasters on economic growth by combining information from comparative case studies. For each country affected by a large disaster, we compute the counterfactual by…
View details →Marie Bakitas, Tor D. Tosteson, Zhigang Li et al. · 2015 · Journal of Clinical Oncology
PURPOSE: Randomized controlled trials have supported integrated oncology and palliative care (PC); however, optimal timing has not been evaluated. We investigated the effect of early versus delayed PC on quality of life (QOL), symptom…
View details →Pierre Asfar, Ferhat Meziani, Jean‐François Hamel et al. · 2014 · New England Journal of Medicine
BACKGROUND: The Surviving Sepsis Campaign recommends targeting a mean arterial pressure of at least 65 mm Hg during initial resuscitation of patients with septic shock. However, whether this blood-pressure target is more or less effective…
View details →Domenica A. Delgado, Bradley S. Lambert, Nickolas Boutris et al. · 2018 · JAAOS Global Research and Reviews
Background: The visual analog scale (VAS) is a validated, subjective measure for acute and chronic pain. Scores are recorded by making a handwritten mark on a 10-cm line that represents a continuum between “no pain” and “worst pain.”…
View details →Katherine Baicker, Sarah Taubman, Heidi Allen et al. · 2013 · New England Journal of Medicine
BACKGROUND: Despite the imminent expansion of Medicaid coverage for low-income adults, the effects of expanding coverage are unclear. The 2008 Medicaid expansion in Oregon based on lottery drawings from a waiting list provided an…
View details →G. L. Andriole, E. David Crawford, Robert L. Grubb et al. · 2012 · JNCI Journal of the National Cancer Institute
BACKGROUND: The prostate component of the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial was undertaken to determine whether there is a reduction in prostate cancer mortality from screening using serum…
View details →Martín Cowie, Holger Woehrle, Karl Wegscheider et al. · 2015 · New England Journal of Medicine
BACKGROUND: Central sleep apnea is associated with poor prognosis and death in patients with heart failure. Adaptive servo-ventilation is a therapy that uses a noninvasive ventilator to treat central sleep apnea by delivering…
View details →Mark S. George, Sarah H. Lisanby, David Avery et al. · 2010 · Archives of General Psychiatry
CONTEXT: Daily left prefrontal repetitive transcranial magnetic stimulation (rTMS) has been studied as a potential treatment for depression, but previous work had mixed outcomes and did not adequately mask sham conditions. OBJECTIVE: To…
View details →Nicholas J. Robert, Véronique Dièras, John A. Glaspy et al. · 2011 · Journal of Clinical Oncology
PURPOSE: This phase III study compared the efficacy and safety of bevacizumab (BV) when combined with several standard chemotherapy regimens versus those regimens alone for first-line treatment of patients with human epidermal growth…
View details →Carlos A. Morillo, José Antônio Marin‐Neto, Álvaro Avezum et al. · 2015 · New England Journal of Medicine
BACKGROUND: The role of trypanocidal therapy in patients with established Chagas' cardiomyopathy is unproven. METHODS: We conducted a prospective, multicenter, randomized study involving 2854 patients with Chagas' cardiomyopathy who…
View details →Richard Klein, Michelangelo Vianello, Fred Hasselman et al. · 2018 · Advances in Methods and Practices in Psychological Science
We conducted preregistered replications of 28 classic and contemporary published findings, with protocols that were peer reviewed in advance, to examine variation in effect magnitudes across samples and settings. Each protocol was…
View details →Andreas Wieland, Carl Marcus Wallenburg · 2013 · International Journal of Physical Distribution & Logistics Management
Purpose – The purpose of this research is to explore the resilience domain, which is important in the field of supply chain management; it investigates the effects relational competencies have for resilience and the effect resilience, in…
View details →Usha Satish, Mark J. Mendell, Krishnamurthy Shekhar et al. · 2012 · Environmental Health Perspectives
BACKGROUND: Associations of higher indoor carbon dioxide (CO2) concentrations with impaired work performance, increased health symptoms, and poorer perceived air quality have been attributed to correlation of indoor CO2 with concentrations of other indoor air pollutants that are also influenced by rates of outdoor-air ventilation. OBJECTIVES: We assessed direct effects of increased CO2, within the range of indoor concentrations, on decision making. METHODS: Twenty-two participants were exposed to CO2 at 600, 1,000, and 2,500 ppm in an office-like chamber, in six groups. Each group was exposed
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