Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Meity Ardiana, Budi Pikir, Anwar Santoso et al. · 2021 · ARYA Atherosclerosis
BACKGROUND: The compounds in cigarette smoke are believed to cause oxidative stress, leading to endothelial dysfunction. Understanding the mechanism of endothelial dysfunction due to cigarette smoke is useful for the development of early and preventive therapy for cardiovascular diseases (CVDs) with smoking risk factors.METHODS: In this experimental study, a posttest-only control group design was used. 20 Wistar rats were divided into two groups: a smoking group (exposed to 40 cigarettes per day for 4 weeks) and a control group. After the exposure, the animals were sacrificed and aortas were r
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Long Peng, Qianlin Gu, Zhenhua Huang et al. · 2020 · Cardiology Research and Practice
Hyperhomocysteinemia (HHcy) induced endothelial dysfunction is associated with disturbance in circulating endothelial progenitor cells (EPCs). Nevertheless, whether this unfavorable effect of HHcy on circulating EPCs also exists in premenopausal women is still unknown. Therefore, this leaves an area for the investigation of the difference on the number and activity of circulating EPCs in premenopausal women with hyperhomocysteinemia and its underlying mechanism. The number of circulating EPCs was measured by fluorescence-activated cell sorter analysis, as well as DiI-acLDL and lectin fluoresce
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Davies Isabel R, Gavrilovic Jelena, Baugh Mark D et al. · 2003 · Cardiovascular Diabetology
Abstract Background Coronary plaque rupture may result from localised over expression of matrix metalloproteinases (MMPs) within the plaque by infiltrating monocyte – macrophages. As MMP expression can be promoted by the modified lipoproteins, oxidative stress and hyperglycaemia that characterises Type 2 diabetes, we hypothesised that peripheral monocytes in these patients, exposed to these factors in vivo, would demonstrate increased MMP production compared to controls. Methods We examined peripheral venous monocyte expression of MMP and tissue inhibitor of metalloproteinase-1 (TIMP-1) in 18
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Guozhong Wang, Quanming Zhao, Qing Cheng et al. · 2019 · BMC Cardiovascular Disorders
Abstract Background The rational length of stay following non-complicated percutaneous coronary intervention (PCI) for Non-ST elevation myocardial infarction (NSTEMI) patients remains controversial. Few studies have examined the impact of early discharge on short-term outcomes in NSTEMI patients, but short-time discharge is not uncommon in real world practice. This study examined the impact of short time discharge following non-complicated PCI on 30-day net adverse clinical events in NSTEMI patients. Methods This retrospective study enrolled 1424 consecutive patients with NSTEMI diagnoses who
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Waqas Akhtar, Charles Butcher, Andrew Morley‐Smith et al. · 2022 · ESC Heart Failure
Abstract Aims We present a single‐centre retrospective experience using oral milrinone in patients with a left ventricular assist device (LVAD) and concurrent refractory right ventricular failure. Methods and results All patients implanted with LVAD between January 2013 and July 2021 from a high‐volume advanced heart failure service were reviewed. Eight patients were initiated on oral milrinone during this period. Oral milrinone was started 1.5 [inter‐quartile range (IQR) 1–2.3] years after LVAD implantation and continued for 1.2 (IQR 0.5–2.8) years. Therapeutic milrinone levels were achieved
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Hatem El Atroush, Hassan Effat, Mohamed Shehata et al. · 2012 · The Egyptian Heart Journal
Objective: To investigate the clinical significance of reciprocal ST segment depression on the presenting electrocardiogram in patients with acute inferior myocardial infarction. Design and setting: A prospective, randomized, controlled single center study done in the critical care department, Cairo university Hospital. Subjects: Forty consecutive patients with acute inferior myocardial infarction were enrolled in this study divided into two groups, 20 patients with reciprocal ST depression (group 1) and 20 patients without such depression (group 2). Interventions: All patients were investigat
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Daegwang Yoo, Minsun Kang, Jaehun Jung · 2023 · Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Postpancreatectomy diabetes can be caused by resection of functioning pancreatic tissue and is associated with postoperative pancreatic islet cell mass loss and subsequent endocrine dysfunction. Diabetes is a well‐known risk factor for ischemic heart disease. However, no previous studies have investigated ischemic heart disease in patients with postpancreatectomy diabetes and pancreatic cancer. Methods and Results Rates of patients with diabetes diagnosed with pancreatic cancer who underwent pancreatectomy between 2002 and 2019 in South Korea were obtained from the Korean National H
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Rafigheh Ghiasi, Mustafa Mohammadi, Javad Ashrafi Helan et al. · 2015 · Journal of Cardiovascular and Thoracic Research
Introduction: The previous studies have suggested that alteration in oxidative stress and antioxidant defense depends on various factors, such as mode, intensity, frequency and duration of exercise. In this study, we compared the effects of two various durations of resistance exercise (1 month and 4 month) on oxidative stress and antioxidant status in cardiac tissue. Methods: Thirty Wistar male rats divided into 3 groups: control (sedentary), exercise-1 (regular exercise for 1 month) and exercise-2 group (regular exercise for 4 months). After the final to the experiment, the rats were anesthet
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Alexandre Pereira Tognon, Murilo Foppa, Vivian Cristine Luft et al. · 2015 · Arquivos Brasileiros de Cardiologia
Background: Echocardiography, though non-invasive and having relatively low-cost, presents issues of variability which can limit its use in epidemiological studies. Objective: To evaluate left ventricular mass reproducibility when assessed at acquisition (online) compared to when assessed at a reading center after electronic transmission (offline) and also when assessed by different readers at the reading center. Methods: Echocardiographers from the 6 ELSA-Brasil study investigation centers measured the left ventricular mass online during the acquisition from 124 studies before transmitting to
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Ahmed Alnajar, MD, MSPH, Subhasis Chatterjee, MD, Jacqueline K. Olive, MD et al. · 2024 · JTCVS Open
Objective: Isolated tricuspid valve surgery is uncommon and associated with high perioperative morbidity and mortality. We aimed to study the overall outcomes of patients who underwent minimally invasive right thoracotomy tricuspid valve surgery (Mini-TVS), consisting of either tricuspid valve repair (TVre) or replacement (TVR). Methods: We performed a retrospective analysis of all Mini-TVS procedures (2017-2022), through which we identified isolated tricuspid valve surgeries. We examined in-hospital outcomes, survival analysis over a 4-year period, and competing risk analysis for reoperative
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Hiroki Yagi, MD, PhD, Eisuke Amiya, MD, PhD, Masae Uehara, MD, PhD et al. · 2023 · CJC Open
Background: IgG4-related disease (IgG4-RD) is a systemic disease characterized by serum IgG4 upregulation, massive infiltration of IgG4-positive plasma cells, and storiform fibrosis, which results in nodules or thickening of the involved organs. Cardiologists have recently recognized that IgG4-RD can be complicated by coronary artery events (CAEs); however, the mechanisms and clinical characteristics of this phenomenon are unknown. We evaluated the clinical signs of patients with coronary periarteritis (CP), aortic periarteritis (AP), and pericardial thickening, which are complications of IgG4
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Fereshteh Baygi, Mostafa Qorbani, Mohammad Esmaeil Motlagh et al. · 2020 · BMC Cardiovascular Disorders
Abstract Background This study evaluated the association of frequency of potato and rice consumption with cardiometabolic risk factors in children and adolescents. Methods This nationwide cross-sectional survey was conducted on 14,400 children and adolescents. Fasting blood was obtained from a sub-sample of 4200 randomly selected students. Physical examination and laboratory tests were conducted under standard protocols. Metabolic Syndrome (Mets) was defined based on the Adult Treatment Panel III criteria modified for the pediatric age group. The self-reported frequency consumption of white ri
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Gonçalo Costa, Joana Delgado-Silva, Eric Monteiro et al. · 2022 · Revista Portuguesa de Cardiologia
Aims and objectives: Vitamin D deficiency is a common finding and there is a suggested association with hypertension. Resistant hypertension is a clinical problem observed in 5–30% of hypertensive patients. Renal denervation (RDN) has been used for patients with resistant hypertension and has proven to lower blood pressure. Our primary goal was to assess the vitamin D serum concentration as a predictor of blood pressure response to RDN in highly selected patients. Methods: This prospective, nonrandomized, single-center study included 24 patients treated with RDN. Based on their one-year respon
View details →Failed Experiment ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Nenonen Arja, Rinne Marjo, Groundstroem Kaj et al. · 2007 · Cardiovascular Ultrasound
Abstract Background Myocardial diastolic tissue velocities are reduced already in newly onset Type 2 diabetes mellitus (T2D). Poor disease control may lead to left ventricular (LV) systolic dysfunction and heart failure. The aim of this study was to assess the effects of exercise training on myocardial diastolic function in T2D patients without ischemic heart disease. Methods 48 men (52.3 ± 5.6 yrs) with T2D were randomized to supervised training four times a week and standard therapy (E), or standard treatment alone (C) for 12 months. Glycated hemoglobin (HbA 1c ), oxygen consumption (VO 2max
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
M. Sadaka, M. Loutfy, M. Sobhy · 2013 · The Egyptian Heart Journal
Aim: The purpose of this study was to compare the impact of incomplete revascularization (IR) plus optimal medical therapy (OMT) to OMT alone on 1 year clinical outcomes in patients with multivessel coronary artery disease (MVD) who were not eligible for coronary bypass graft surgery (CABG). Methods: This is a prospective randomized study conducted on 50 selected patients with chronic stable angina with documented MVD and CABG was refused by the surgeon due to poor distal vessel quality. Patients were randomized 1:1 into two groups, group (I): 25 patients were subjected to OMT alone and group
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Cassandra A. A. Locatelli, My-Anh Nguyen, Nadya M. Morrow et al. · 2026 · Cardiovascular Diabetology
Abstract Background The ketogenic diet (KD) is widely recognized for its potential benefits in individuals with type 2 diabetes, but findings from both human and animal studies remain inconsistent. Type 2 diabetes is often comorbid with liver steatosis and atherosclerosis which are characterized by inflammation and dysregulated lipid metabolism. Moreover, whereas KD has shown mixed, sometimes detrimental, effects on circulating cholesterol levels in humans, it is currently unclear the whole-body balance of risk and benefit across hepatic, atherosclerotic, and pancreatic effects. Methods We use
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
George D. Fulk, Regina Bell, Keenan Batts et al. · 2026 · Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Sleep–wake disruption is common after stroke and may impede recovery. The Sleep Regularity Index (SRI) quantifies the probability that an individual is in the same sleep or wake state at the same clock time on consecutive days. This study evaluates SRI during poststroke recovery, estimating associations with stroke outcomes and characterizing transitions between SRI states over time. Methods We analyzed data from 71 participants who were part of a larger ongoing study exploring the impact of nonobstructive sleep apnea sleep disorders post stroke. Data were collected at 10, 60, and 9
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Yinuo Li, Xi Liu, Qian Hong et al. · 2024 · Frontiers in Cardiovascular Medicine
BackgroundRecent epidemiological studies have indicated a correlation between platelet indices and pulmonary arterial hypertension (PAH), yet the causality between them remains unclear. To explore the causal relationship between four platelet indices and PAH, with the aim of providing a theoretical basis for clinical prevention and treatment.MethodsSingle-nucleotide polymorphisms (SNPs) associated with platelet-related traits were selected as exposure factors from published genome-wide association studies (GWAS), including: platelet count (PLT), plateletcrit (PCT), mean platelet volume (MPV),
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Masatake Kobayashi, Susan Stienen, Jozine M. terMaaten et al. · 2020 · ESC Heart Failure
Abstract Aims Activation of the renin–angiotensin–aldosterone system plays an important role in the pathophysiology of heart failure (HF) and has been associated with poor prognosis. There are limited data on the associations of renin and aldosterone levels with clinical profiles, treatment response, and study outcomes in patients with HF. Methods and results We analysed 2,039 patients with available baseline renin and aldosterone levels in BIOSTAT‐CHF (a systems BIOlogy study to Tailored Treatment in Chronic Heart Failure). The primary outcome was the composite of all‐cause mortality or HF ho
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Maja Ivanovski, Miha Mrak, Anja Zupan Mežnar et al. · 2022 · Journal of Cardiovascular Development and Disease
Conduction system pacing (CSP) modalities, including His-bundle pacing (HBP) and left bundle branch pacing (LBBP), are increasingly used as alternatives to biventricular (BiV) pacing in heart failure (HF) patients scheduled for pace and ablate strategy. The aim of the study was to compare clinical outcomes of HF patients with refractory AF who received either BiV pacing or CSP in conjunction with atrio-ventricular node ablation (AVNA). Fifty consecutive patients (male 48%, age 70 years (IQR 9), left ventricular ejection fraction (LVEF) 39% (IQR 12)) were retrospectively analysed. Thirteen pati
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Shyamal Patel, Lucy Rose Howroyd, Helen Bucknall et al. · 2025 · CVIR Endovascular
Abstract Background Bronchial artery embolisation (BAE) is considered the most effective non-surgical technique for management of moderate-massive haemoptysis. Associated risks include neurological compromise such as stroke and spinal cord ischaemia. We aim to evaluate post-procedural outcomes and complication rates. Materials and methods A single-centre retrospective observational study was conducted for BAE cases performed between January 2002-June 2022 in a London teaching hospital. Data was collected from electronic medical records and Picture Archiving Communications System (PACS). Primar
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Wioletta Sacharczuk, Rafał Dankowski, Stefan Ożegowski et al. · 2023 · Frontiers in Cardiovascular Medicine
We aimed to compare therapies of sacubitril/valsartan + spironolactone (S/V + S) with angiotensin-converting enzyme inhibitors + spironolactone (ACEI + S) on the left-sided cardiac reverse remodeling (L-CRR). The second objective was to analyze the usefulness of GLS and LVEF in response to therapy.Methods78 patients (mean age 63.4 years, 20 females) with symptomatic heart failure with reduced ejection fraction were randomized to groups of equal numbers, i.e., 39 patients, and started on therapy of S/V + S or ACEI + S. Second evaluations were made after 6–8 weeks of therapy.ResultsGLS changed f
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Barrak Alahmad, Taofik Oyekunle, Claire Strohmeyer et al. · 2025 · Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Arrhythmia, particularly atrial fibrillation, is on the rise globally. While increased surveillance, aging populations, and other risk factors partially explain this rise, emerging risks such as extreme heat from climate change are underexplored. Methods We used Product Surveillance Registry by Medtronic (2016–2023) in the United States to examine patients with implantable cardioverter‐defibrillator or cardiac resynchronization therapy defibrillator devices. We identified first arrhythmic episodes (atrial tachycardia/fibrillation [AT/AF] or ventricular tachycardia/fibrillation) reco
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Ce Zhou, You Zhou, Niannian Shuai et al. · 2024 · Frontiers in Cardiovascular Medicine
Background and aimEstimated glomerular filtration rate (eGFR) is a key indicator of kidney function and is associated with numerous health conditions. This study examines the association between eGFR and cardiovascular disease (CVD) risk in a representative cohort of the US adult population.MethodsA cross-sectional analysis was conducted using data from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018. The study included 31,020 participants aged 20 years and older. The eGFR estimates were calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Juan Duchesne, David McGreevy, Kristofer Nilsson et al. · 2020 · Journal of Endovascular Resuscitation and Trauma Management
Background: Resuscitative endovascular balloon occlusion of the aorta (REBOA) is becoming a standardized adjunct in the management of non-compressible hemorrhage. Ultrasound (US)-guided femoral access has been taught as the best practice for femoral artery cannulation. However, there is a lack of evidence to support its use in patients in extremis with severe hemorrhage. We hypothesize that no differences in outcome will exist between US-guided and to blind percutaneous or cutdown access methods. Methods: This was an international, multicenter retrospective review of all patients managed with
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Zahra Ojaghi-Haghighi, Atoosa Mostafavi, Hassan Moladoust et al. · 2015 · Journal of Tehran University Heart Center
Background: Left ventricular (LV) twist is due to oppositely directed apical and basal rotation and has been proposed as a sensitive marker of LV function. We sought to assess the impact of chronic pure mitral regurgitation (MR) on the torsional mechanics of the left human ventricle using tissue Doppler imaging. Methods: Nineteen severe MR patients with a normal LV ejection fraction and 16 non-MR controls underwent conventional echocardiography and apical and basal short-axis color Doppler myocardial imaging (CDMI). LV rotation at the apical and basal short-axis levels was calculated from the
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Takumi Osawa, Hitoshi Mori, Akane Kawai et al. · 2022 · Journal of Arrhythmia
Abstract Background Uninterrupted dabigatran during atrial fibrillation (AF) ablation is now established as the standard therapy. However, there are few reports on the effects of uninterrupted dabigatran on the intensity of anticoagulation during AF ablation. Methods We retrospectively analyzed 247 consecutive patients who underwent AF ablation in our hospital from January 2017 to December 2018. Patients who took warfarin or uninterrupted direct oral anticoagulants (DOACs) except for dabigatran were excluded. 89 patients underwent ablation with uninterrupted dabigatran (uninterrupted group, ma
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Tianyu Niu, Tianyu Niu, Zhishuo Liu et al. · 2025 · Frontiers in Cardiovascular Medicine
BackgroundThis study investigates the feasibility and early outcomes of early myocardial reperfusion in patients with type A aortic dissection (TAAD), evaluating its effectiveness and potential benefits compared to traditional cardioplegic arrest techniques.MethodsA retrospective analysis was conducted on 168 patients diagnosed with TAAD who underwent surgery at the General Hospital of the Northern Theater Command in China from January 2021 to July 2024. Patients were divided into two groups: early myocardial reperfusion (EMR group, n = 66) and cardioplegic arrest (CA group, n = 102). Perioper
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Cleusa Ema Quilici Belczak, José Maria Pereira de Godoy, Amélia Cristina Seidel et al. · 2018 · International Journal of Vascular Medicine
Background. Elastic compression stockings (ECS) are effective in preventing and reducing occupational edema (OE), but the optimal pressure according to the prevalent working position during the day is still controversial. Objective. To compare the effectiveness of ECS with different pressures (15–20 mmHg or 20–30 mmHg) for reducing OE in individuals working in different prolonged postures. Methods. This cross-sectional study comprised 116 lower limbs of 58 individuals divided into three groups according to their prevalent postures over the day (sitting, standing, or combination). Volumetric me
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Muzaffar Ali, Deepak Padmanabhan, Khalil Kanjwal et al. · 2021 · Journal of Arrhythmia
Abstract Background Fluoroscopic imaging involves exposure of the patients and the laboratory staff to ionizing radiation. One of the strategies that reduce such exposure in an electrophysiology laboratory is using a three‐dimensional electroanatomic mapping (3D EAM) system for performing these procedures. In this analysis, we have analyzed the effect of fluoroscopy frame rate on the radiation exposure and in‐hospital outcomes in ablation procedures performed under 3D EAM guidance. Methods We retrospectively analyzed all the ablation procedures performed under 3D EAM guidance at our institute
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