Negative / Null Result ReportMaterials Science
Huan Zhang, Shicheng Zhao, Xin Yu et al. · 2019 · Journal of Polymer Science Part B Polymer Physics
ABSTRACT The physical properties of ultrahigh molecular weight polyethylene (UHMWPE) are generally highly dependent on its molecular weight. However, in our study, it was found that two UHMWPE samples of similar molecular weight, SLL‐5 and…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Toni Weinhage, Timo Wirth, Paula Schütz et al. · 2020 · Frontiers in Immunology
Background. The receptor for advanced glycation end products (RAGE) is a multiligand receptor involved in a number of processes and disorders. While it is known that RAGE-signaling can contribute to toxic liver damage and fibrosis, its role in acute inflammatory liver injury and septic multiorgan failure is yet undefined. We examined RAGE in lipopolysaccharide (LPS) induced acute liver injury of D-galN sensitized mice as a classical model for tumor necrosis factor alpha (TNF-α) dependent inflammatory organ damage. Methods. Mice (Rage-/- and C57BL/6) were intraperitoneally injected with D galN
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Delson Chikobvu, Retius Chifurira · 2015 · South African Journal of Science
We modelled the mean annual rainfall for data recorded in Zimbabwe from 1901 to 2009. Extreme value theory was used to estimate the probabilities of meteorological droughts. Droughts can be viewed as extreme events which go beyond and/or below normal rainfall occurrences, such as exceptionally low mean annual rainfall. The duality between the distribution of the minima and maxima was exploited and used to fit the generalised extreme value distribution (GEVD) to the data and hence find probabilities of extreme low levels of mean annual rainfall. The augmented Dickey Fuller test confirmed that r
View details →Negative / Null Result ReportOpen accessMedicine
Valery Matthys, Elena E. Gorbunova, Irina N. Gavrilovskaya et al. · 2011 · Journal of Virology
Hantaviruses primarily infect the endothelial cell lining of capillaries and cause two vascular permeability-based diseases. The ability of pathogenic hantaviruses to regulate the early induction of interferon determines whether…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Jorge Aníbal Restrepo Morales, Osmar Leandro Loaiza, Juan Gabriel Vanegas López · 2019 · Journal of Economics Finance and Administrative Science
Purpose This paper aims to study the influence of innovation on micro, small and medium-sized enterprises (MSME) performance in Colombia through the 403 MSMES survey analysis. In particular, this paper measures the effect of participation in R&D alliances, product innovation and process innovation on it. Design/methodology/approach MSME performance is measured through a composite index, estimated through principal components analysis using polychoric correlations, which is based on eight self-reported assessments of MSME performance. Then, this measure of performance is related to MSME par
View details →Negative / Null Result ReportOpen accessMedicine
Wouter Claeys, Lien Van Hoecke, Anja Geerts et al. · 2022 · Scientific Reports
Hepatic encephalopathy (HE) is a common complication of chronic liver disease, characterized by an altered mental state and hyperammonemia. Insight into the brain pathophysiology of HE is limited due to a paucity of well-characterized HE models beyond the rat bile duct ligation (BDL) model. Here, we assess the presence of HE characteristics in the mouse BDL model. We show that BDL in C57Bl/6j mice induces motor dysfunction, progressive liver fibrosis, liver function failure and hyperammonemia, all hallmarks of HE. Swiss mice however fail to replicate the same phenotype, underscoring the import
View details →Negative / Null Result ReportPsychology
Krista R. Mehari, Albert D. Farrell · 2013 · Journal of Research on Adolescence
This study examined the moderating effects of individual ethnicity and school ethnic composition on the relation between peer victimization and adolescents' well‐being. Participants were 4,593 sixth grade students attending 36 schools…
View details →Negative / Null Result ReportOpen accessMedicine
James West, Bryan Voss, Leo Pavliv et al. · 2016 · Pulmonary Circulation
Right ventricular (RV) failure is the primary cause of death in pulmonary arterial hypertension (PAH) and is a significant cause of morbidity and mortality in other forms of pulmonary hypertension. There are no approved therapies directed…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Josine L. Min, Jennifer M. Taylor, J. Brent Richards et al. · 2011 · PLoS ONE
The integrated analysis of genotypic and expression data for association with complex traits could identify novel genetic pathways involved in complex traits. We profiled 19,573 expression probes in Epstein-Barr virus-transformed lymphoblastoid cell lines (LCLs) from 299 twins and correlated these with 44 quantitative traits (QTs). For 939 expressed probes correlating with more than one QT, we investigated the presence of eQTL associations in three datasets of 57 CEU HapMap founders and 86 unrelated twins. Genome-wide association analysis of these probes with 2.2 m SNPs revealed 131 potential
View details →Negative / Null Result ReportOpen accessPsychology
Kalina J. Michalska, Jean Decety, Thomas A. Zeffiro et al. · 2014 · NeuroImage Clinical
Because the disruptive behavior disorders are highly impairing conditions, it is important to determine if structural variations in brain are associated early in life with these problems among children. Structural MRI data were acquired…
View details →Negative / Null Result ReportOpen accessMedicine
Bruno Borghese, Jörg Tost, Magalie de Surville et al. · 2015 · BioMed Research International
Characterizing genetic contributions to endometriosis might help to shorten the time to diagnosis, especially in the most severe forms, but represents a challenge. Previous genome-wide association studies (GWAS) made no distinction between peritoneal endometriosis (SUP), endometrioma (OMA), and deep infiltrating endometriosis (DIE). We therefore conducted a pooled sample-based GWAS and distinguished histologically confirmed endometriosis subtypes. We performed an initial discovery step on 10-individual pools (two pools per condition). After quality control filtering, a Monte-Carlo simulation w
View details →Negative / Null Result ReportMedicine
Qi Tang, Cédric Julien, Robert Eveleigh et al. · 2015 · Spine
In Brief Study Design. A replication association study that used genomic data generated from French-Canadian case and control cohorts. Objectives. To determine whether the 53 single nucleotide polymorphisms (SNPs) that were previously…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Simplice Asongu, Samba Diop, Joseph Nnanna · 2020 · Journal of Public Affairs
This study has: (a) analysed the economic impact of the Covid‐19 pandemic, (b) evaluated the effectiveness and relevance of different measures against the pandemic and (c) examined nexuses between the corresponding measures and economic…
View details →Negative / Null Result ReportOpen accessMedicine
Matthijs Kant, Wilton A. van Klei, Markus W. Hollmann et al. · 2025 · JAMA
Importance: Intraoperative hypotension is associated with adverse postoperative outcomes, but whether a proactive strategy to prevent intraoperative hypotension improves outcomes is uncertain. Objective: To determine whether intraoperative…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
James Raftery, Hywel C Williams, Aileen Clarke et al. · 2020 · BMJ Open
OBJECTIVES: Randomised controlled trials in healthcare increasingly include economic evaluations. Some show small differences which are not statistically significant. Yet these sometimes come to paradoxical conclusions such as: 'the…
View details →Negative / Null Result ReportOpen accessMedicine
Jai Chand Patel, Meenakshi Shukla, Manish Shukla et al. · 2025 · Frontiers in Bioengineering and Biotechnology
Mesenchymal stem cells (MSCs) are emerging as a powerful tool in regenerative medicine due to their ability to differentiate into mesenchymal lineages, such as bone, cartilage, and fat, along with their low immunogenicity and strong immunomodulatory properties. Unlike traditional cell therapies that rely on engraftment, MSCs primarily function through paracrine signaling-secreting bioactive molecules like vascular endothelial growth factor (VEGF), transforming growth factor-beta (TGF-β), and exosomes. These factors contribute to tissue repair, promote angiogenesis, and modulate immune response
View details →Negative / Null Result ReportOpen accessMedicine
Cédric Peleman, Stig Hellemans, Geraldine Veeckmans et al. · 2024 · Cell Death and Differentiation
There is an unmet clinical need for pharmacologic treatment for metabolic dysfunction-associated steatotic liver disease (MASLD). Hepatocyte cell death is a hallmark of this highly prevalent chronic liver disease, but the dominant type of cell death remains uncertain. Here we report that ferroptosis, an iron-catalyzed mode of regulated cell death, contributes to MASLD. Unsupervised clustering in a cohort of biopsy-proven MASLD patients revealed a subgroup with hepatic ferroptosis signature and lower glutathione peroxidase 4 (GPX4) levels. Likewise, a subgroup with reduced ferroptosis defenses
View details →Negative / Null Result ReportOpen accessMedicine
Mairi Ziaka, Aristomenis K. Exadaktylos · 2024 · Critical Care
Acute respiratory distress syndrome (ARDS) represents a life-threatening inflammatory reaction marked by refractory hypoxaemia and pulmonary oedema. Despite advancements in treatment perspectives, ARDS still carries a high mortality rate, often due to systemic inflammatory responses leading to multiple organ dysfunction syndrome (MODS). Indeed, the deterioration and associated mortality in patients with acute lung injury (LI)/ARDS is believed to originate alongside respiratory failure mainly from the involvement of extrapulmonary organs, a consequence of the complex interaction between initial
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
K. Masuda, Joshua N. Winn · 2017 · The Astronomical Journal
Abstract We revisit the null result of the Hubble Space Telescope search for transiting planets in the globular cluster 47 Tucanae, in the light of improved knowledge of planet occurrence from the Kepler mission. Gilliland and co-workers…
View details →Negative / Null Result ReportOpen accessEarth and Planetary Sciences
Alexis Rojas, Pedro Patarroyo, Liang Mao et al. · 2017 · Geology
Large-scale biogeographic provinces of Cretaceous ammonoids, as currently defined in the literature, were delimited using qualitative assessments of taxonomic inventories. Using aggregated species occurrences in the Paleobiology Database, we generated a geographic network to quantify connectivity of Albian epicontinental basins and used the flow-based Infomap algorithm to delineate bioprovinces. Despite taxonomic, stratigraphic, and geographic limitations of the data, the Infomap bioprovinces are largely concordant with the traditional, qualitatively derived biogeographic model, including the
View details →Negative / Null Result ReportOpen accessMedicine
Luciana Mascia, Vito Fanelli, Alice Mistretta et al. · 2024 · American Journal of Respiratory and Critical Care Medicine
Abstract Rationale Lung-protective strategies using low Vt and moderate positive end-expiratory pressure (PEEP) are considered best practice in critical care, but interventional trials have never been conducted in patients with acute brain…
View details →Negative / Null Result ReportOpen accessDecision Sciences
Paul Monsarrat, Jean‐Noël Vergnes · 2017 · GigaScience
Background: In medicine, effect sizes (ESs) allow the effects of independent variables (including risk/protective factors or treatment interventions) on dependent variables (e.g., health outcomes) to be quantified. Given that many public health decisions and health care policies are based on ES estimates, it is important to assess how ESs are used in the biomedical literature and to investigate potential trends in their reporting over time. Results: Through a big data approach, the text mining process automatically extracted 814 120 ESs from 13 322 754 PubMed abstracts. Eligible ESs were risk
View details →Negative / Null Result ReportMedicine
Sergio Leonardi, Pierluigi Tricoci, HD White et al. · 2013 · European Heart Journal
AIMS: The TRA·CER trial compared vorapaxar, a novel platelet protease-activated receptor (PAR)-1 antagonist, with placebo in 12 944 patients with high-risk non-ST-segment elevation acute coronary syndromes (NSTE ACS). In this analysis, we…
View details →Negative / Null Result ReportOpen accessMedicine
Sriram Ramgopal, Cameron Dezfulian, Robert W. Hickey et al. · 2019 · JAMA Network Open
Importance: A high Pao2, termed hyperoxemia, is postulated to have deleterious health outcomes. To date, the association between hyperoxemia during the ongoing management of critical illness and mortality has been incompletely evaluated in children. Objective: To examine whether severe hyperoxemia events are associated with mortality among patients admitted to a pediatric intensive care unit (PICU). Design, Setting, and Participants: A retrospective cohort study was conducted over a 10-year period (January 1, 2009, to December 31, 2018); all 23 719 PICU encounters at a quaternary children's ho
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Inmaculada Martínez‐Zarzoso, Martina Vidovic, Anca M. Voicu · 2016 · The Journal of Environment & Development
The aim of this article is to investigate the relationship between environmental stringency and intra–European Union (EU) trade flows. Two main hypotheses are tested. First, we test whether the stringency of a country's environmental…
View details →Negative / Null Result ReportMedicine
Alicia K. Klanecky, Dennis E. McChargue, Lindsay Bruggeman · 2012 · American Journal on Addictions
Alcohol use to replace inadequate dissociative capabilities, or chemical dissociation, has been linked to college students with childhood or adolescent sexual abuse (CASA). Insofar as CASA-exposed persons experience a restricted range of…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Hector Roux de Bézieux, Koen Van den Berge, Kelly Street et al. · 2024 · Nature Communications
In single-cell RNA sequencing (scRNA-Seq), gene expression is assessed individually for each cell, allowing the investigation of developmental processes, such as embryogenesis and cellular differentiation and regeneration, at unprecedented resolution. In such dynamic biological systems, cellular states form a continuum, e.g., for the differentiation of stem cells into mature cell types. This process is often represented via a trajectory in a reduced-dimensional representation of the scRNA-Seq dataset. While many methods have been suggested for trajectory inference, it is often unclear how to h
View details →Negative / Null Result ReportOpen accessPsychology
Victoria Whitelock, Suzanne Higgs, Jeffrey M. Brunstrom et al. · 2018 · Appetite
Focusing attention on food during a meal has been shown to reduce later snack consumption. We report the results of two studies that aimed to replicate this effect and to elucidate the underlying mechanisms. We hypothesised that focused attention during a lunchtime meal would improve visual memory and/or memory for the satiating effects of the meal, and that this would reduce later food intake. In Study 1, participants (N = 108, 52.8% female, BMI M = 25.75 kg/m2) were randomly allocated to eat a fixed lunchtime meal while listening to instructions that encouraged them to pay attention to the s
View details →Null Dataset
Hatice Büşra Lüleci, Alper Yılmaz · 2022 · BioData Mining
Abstract Objectives In this study, we aimed to identify tissue-specific genes for various human tissues/organs more robustly and rigorously by extending the tau score algorithm. Introduction Tissue-specific genes are a class of genes whose…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Miroslav Petr, Petr Šťastný, Ondřej Pecha et al. · 2014 · PLoS ONE
To date, polymorphisms in several genes have been associated with a strength/power performance including alpha 3 actinin, ciliary neurotrophic factor, vitamin D receptor, or angiotensin I converting enzyme, underlining the importance of genetic component of the multifactorial strength/power-related phenotypes. The single nucleotide variation in peroxisome proliferator-activated receptor alpha gene (PPARA) intron 7 G/C (rs4253778; g.46630634G>C) has been repeatedly found to play a significant role in response to different types of physical activity. We investigated the effect of PPARA intron 7
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