Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Osval A. Montesinos‐López, J. Cricelio Montesinos-López, P. K. Singh et al. · 2020 · G3 Genes Genomes Genetics
The paradigm called genomic selection (GS) is a revolutionary way of developing new plants and animals. This is a predictive methodology, since it uses learning methods to perform its task. Unfortunately, there is no universal model that can be used for all types of predictions; for this reason, specific methodologies are required for each type of output (response variables). Since there is a lack of efficient methodologies for multivariate count data outcomes, in this paper, a multivariate Poisson deep neural network (MPDN) model is proposed for the genomic prediction of various count outcome
View details →Negative / Null Result ReportOpen accessMedicine
Ellen W. Demerath, Nikki Lynn Rogers, Derek Reed et al. · 2010 · Annals of Human Biology
BACKGROUND: Elevated visceral adiposity is strongly predictive of cardiometabolic disease, but, due to the high cost of biomedical imaging, assessment of factors contributing to normal variation in visceral (VAT) and subcutaneous (SAT)…
View details →Negative / Null Result ReportOpen accessMedicine
Kotaro Matsumoto, Katsuya Suzuki, Keiko Yoshimoto et al. · 2019 · Arthritis Research & Therapy
Abstract Background Large vessel vasculitis (LVV) is a type of vasculitis characterized by granulomatous inflammation of medium- and large-sized arteries. Clinical assessment of acute phase reactants has been conventionally used to diagnose and monitor diseases; however, accurate assessment of vascular disease activity status can be difficult. In this study, we investigated comprehensive immuno-phenotyping to explore useful biomarkers associated with clinical characteristics. Methods Consecutive patients with newly diagnosed LVV who visited our institution between May 2016 and May 2019 were en
View details →Negative / Null Result Report
E. Gautier, J. Savarino, J. Erbland et al. · 2016 · Climate of the Past
Abstract. Current volcanic reconstructions based on ice core analysis have significantly improved over the past few decades by incorporating multiple-core analyses with a high temporal resolution from different parts of the polar regions…
View details →Negative / Null Result Report
Klaus‐Holger Knorr, Marcus A. Horn, Werner Borken · 2015 · Global Change Biology
Abstract Nitrogen (N) nutrition in pristine peatlands relies on the natural input of inorganic N through atmospheric deposition or biological dinitrogen (N 2 ) fixation. However, N 2 fixation and its significance for N cycling, plant…
View details →Negative / Null Result Report
Ahuva Y. Segal, Tracey L. Sletten, Erin E. Flynn-Evans et al. · 2016 · Journal of Biological Rhythms
While previous studies have demonstrated short-wavelength sensitivity to the acute alerting effects of light during the biological night, fewer studies have assessed the alerting effect of light during the daytime. This study assessed the…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Yanyan Lu, Ran Meng, Xiangyu Wang et al. · 2019 · Nature Communications
Acute graft-versus-host disease (GVHD) remains a major obstacle for the wider usage of allogeneic hematopoietic stem cell transplantation (allo-HSCT), which is an effective therapy for hematopoietic malignancy. Here we show that caspase-11, the cytosolic receptor for bacterial endotoxin (lipopolysaccharide: LPS), enhances GVHD severity. Allo-HSCT markedly increases the LPS-caspase-11 interaction, leading to the cleavage of gasdermin D (GSDMD). Caspase-11 and GSDMD mediate the release of interleukin-1α (IL-1α) in allo-HSCT. Deletion of Caspase-11 or Gsdmd, inhibition of LPS-caspase-11 interacti
View details →Negative / Null Result ReportOpen accessMedicine
Khrongwong Musikatavorn, Poj Plitawanon, Suthaporn Lumlertgul et al. · 2021 · Western Journal of Emergency Medicine
INTRODUCTION: The ultrasound measurement of inferior vena cava (IVC) diameter change during respiratory phase to guide fluid resuscitation in shock patients is widely performed, but the benefit on reducing the mortality of sepsis patients is questionable. The study objective was to evaluate the 30-day mortality rate of patients with sepsis-induced tissue hypoperfusion (SITH) and septic shock (SS) treated with ultrasound-guided fluid management (UGFM) using ultrasonographic change of the IVC diameter during respiration compared with those treated with the usual-care strategy. METHODS: This was
View details →Negative / Null Result ReportOpen accessMedicine
Kenji Fujiwara, May Tun Saung, Hao Jing et al. · 2020 · Journal for ImmunoTherapy of Cancer
Background Radiation therapy (RT) has the potential to enhance the efficacy of immunotherapy, such as checkpoint inhibitors, which has dramatically altered the landscape of treatments for many cancers, but not yet for pancreatic ductal…
View details →Negative / Null Result ReportOpen accessMedicine
Lisa Eidenschink Brodersen, Robert B. Gerbing, María Laura Pardo et al. · 2020 · Blood Advances
Risk stratification for acute myeloid leukemia (AML) uses molecular and cytogenetic abnormalities identified at diagnosis. Response to therapy informs risk, and morphology continues to be used more frequently than flow cytometry. Herein,…
View details →Negative / Null Result ReportOpen accessDentistry
Zeynep Başağaoğlu Demirekin, Muhammed Hilmi Büyükçavuş · 2022 · BMC Medical Education
BACKGROUND: The long-term psychological effects of COVID-19 on dental students are unclear. The aim of this cross-sectional online study was to investigate the psychological effects of the COVID-19 pandemic on dental students. METHOD: The Quality of Life Scale (WHOQOL-BREF) was sent to all dental students through Google Forms to evaluate their quality of life (QoL), and the DASS-21 scale was used to evaluate their psychosocial status due to distance learning during the COVID-19 pandemic. The answers were analyzed both on the basis of year of education and type of education (online versus class
View details →Negative / Null Result ReportOpen accessMedicine
Dafna Ben Yaakov, Yana Shadkchan, Nathaniel D. Albert et al. · 2017 · Journal of Antimicrobial Chemotherapy
Objectives: Over the last 30 years, the number of invasive fungal infections among immunosuppressed patients has increased significantly, while the number of effective systemic antifungal drugs remains low. The aim of this study was to…
View details →Replication FailureOpen accessMedicine
Jing You, Shuchai Zhu, Jiancheng Li et al. · 2022 · International Journal of Radiation Oncology*Biology*Physics
PurposeThe standard dose (SD) of definitive concurrent chemoradiotherapy (dCRT) remains 50.4 Gy in patients with esophageal cancer; a higher dose, when applied with conventional radiation therapy techniques, increases toxicities without…
View details →Negative / Null Result ReportOpen accessMedicine
Woo‐Ri Shin, Hyun Tae Lee, Heejin Lim et al. · 2018 · Nature Communications
BAFF, a member of the TNF superfamily, has been recognized as a good target for autoimmune diseases. Belimumab, an anti-BAFF monoclonal antibody, was approved by the FDA for use in treating systemic lupus erythematosus. However, the molecular basis of BAFF neutralization by belimumab remains unclear. Here our crystal structure of the BAFF-belimumab Fab complex shows the precise epitope and the BAFF-neutralizing mechanism of belimumab, and demonstrates that the therapeutic activity of belimumab involves not only antagonizing the BAFF-receptor interaction, but also disrupting the formation of th
View details →Negative / Null Result ReportOpen accessMedicine
Julia Katharina Schwarze, Jens Tijtgat, Gil Awada et al. · 2022 · Journal for ImmunoTherapy of Cancer
Background Intratumoral (IT) myeloid dendritic cells (myDCs) play a pivotal role in initiating antitumor immune responses and relicensing of anti-tumor cytotoxic T lymphocytes within the tumor microenvironment. Talimogene laherparepvec…
View details →Negative / Null Result ReportMaterials Science
Huan Zhang, Shicheng Zhao, Xin Yu et al. · 2019 · Journal of Polymer Science Part B Polymer Physics
ABSTRACT The physical properties of ultrahigh molecular weight polyethylene (UHMWPE) are generally highly dependent on its molecular weight. However, in our study, it was found that two UHMWPE samples of similar molecular weight, SLL‐5 and…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Toni Weinhage, Timo Wirth, Paula Schütz et al. · 2020 · Frontiers in Immunology
Background. The receptor for advanced glycation end products (RAGE) is a multiligand receptor involved in a number of processes and disorders. While it is known that RAGE-signaling can contribute to toxic liver damage and fibrosis, its role in acute inflammatory liver injury and septic multiorgan failure is yet undefined. We examined RAGE in lipopolysaccharide (LPS) induced acute liver injury of D-galN sensitized mice as a classical model for tumor necrosis factor alpha (TNF-α) dependent inflammatory organ damage. Methods. Mice (Rage-/- and C57BL/6) were intraperitoneally injected with D galN
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Delson Chikobvu, Retius Chifurira · 2015 · South African Journal of Science
We modelled the mean annual rainfall for data recorded in Zimbabwe from 1901 to 2009. Extreme value theory was used to estimate the probabilities of meteorological droughts. Droughts can be viewed as extreme events which go beyond and/or below normal rainfall occurrences, such as exceptionally low mean annual rainfall. The duality between the distribution of the minima and maxima was exploited and used to fit the generalised extreme value distribution (GEVD) to the data and hence find probabilities of extreme low levels of mean annual rainfall. The augmented Dickey Fuller test confirmed that r
View details →Negative / Null Result ReportOpen accessMedicine
Valery Matthys, Elena E. Gorbunova, Irina N. Gavrilovskaya et al. · 2011 · Journal of Virology
Hantaviruses primarily infect the endothelial cell lining of capillaries and cause two vascular permeability-based diseases. The ability of pathogenic hantaviruses to regulate the early induction of interferon determines whether…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Jorge Aníbal Restrepo Morales, Osmar Leandro Loaiza, Juan Gabriel Vanegas López · 2019 · Journal of Economics Finance and Administrative Science
Purpose This paper aims to study the influence of innovation on micro, small and medium-sized enterprises (MSME) performance in Colombia through the 403 MSMES survey analysis. In particular, this paper measures the effect of participation in R&D alliances, product innovation and process innovation on it. Design/methodology/approach MSME performance is measured through a composite index, estimated through principal components analysis using polychoric correlations, which is based on eight self-reported assessments of MSME performance. Then, this measure of performance is related to MSME par
View details →Negative / Null Result ReportOpen accessMedicine
Wouter Claeys, Lien Van Hoecke, Anja Geerts et al. · 2022 · Scientific Reports
Hepatic encephalopathy (HE) is a common complication of chronic liver disease, characterized by an altered mental state and hyperammonemia. Insight into the brain pathophysiology of HE is limited due to a paucity of well-characterized HE models beyond the rat bile duct ligation (BDL) model. Here, we assess the presence of HE characteristics in the mouse BDL model. We show that BDL in C57Bl/6j mice induces motor dysfunction, progressive liver fibrosis, liver function failure and hyperammonemia, all hallmarks of HE. Swiss mice however fail to replicate the same phenotype, underscoring the import
View details →Negative / Null Result ReportPsychology
Krista R. Mehari, Albert D. Farrell · 2013 · Journal of Research on Adolescence
This study examined the moderating effects of individual ethnicity and school ethnic composition on the relation between peer victimization and adolescents' well‐being. Participants were 4,593 sixth grade students attending 36 schools…
View details →Negative / Null Result ReportOpen accessMedicine
James West, Bryan Voss, Leo Pavliv et al. · 2016 · Pulmonary Circulation
Right ventricular (RV) failure is the primary cause of death in pulmonary arterial hypertension (PAH) and is a significant cause of morbidity and mortality in other forms of pulmonary hypertension. There are no approved therapies directed…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Josine L. Min, Jennifer M. Taylor, J. Brent Richards et al. · 2011 · PLoS ONE
The integrated analysis of genotypic and expression data for association with complex traits could identify novel genetic pathways involved in complex traits. We profiled 19,573 expression probes in Epstein-Barr virus-transformed lymphoblastoid cell lines (LCLs) from 299 twins and correlated these with 44 quantitative traits (QTs). For 939 expressed probes correlating with more than one QT, we investigated the presence of eQTL associations in three datasets of 57 CEU HapMap founders and 86 unrelated twins. Genome-wide association analysis of these probes with 2.2 m SNPs revealed 131 potential
View details →Negative / Null Result ReportOpen accessPsychology
Kalina J. Michalska, Jean Decety, Thomas A. Zeffiro et al. · 2014 · NeuroImage Clinical
Because the disruptive behavior disorders are highly impairing conditions, it is important to determine if structural variations in brain are associated early in life with these problems among children. Structural MRI data were acquired…
View details →Negative / Null Result ReportOpen accessMedicine
Bruno Borghese, Jörg Tost, Magalie de Surville et al. · 2015 · BioMed Research International
Characterizing genetic contributions to endometriosis might help to shorten the time to diagnosis, especially in the most severe forms, but represents a challenge. Previous genome-wide association studies (GWAS) made no distinction between peritoneal endometriosis (SUP), endometrioma (OMA), and deep infiltrating endometriosis (DIE). We therefore conducted a pooled sample-based GWAS and distinguished histologically confirmed endometriosis subtypes. We performed an initial discovery step on 10-individual pools (two pools per condition). After quality control filtering, a Monte-Carlo simulation w
View details →Negative / Null Result ReportMedicine
Qi Tang, Cédric Julien, Robert Eveleigh et al. · 2015 · Spine
In Brief Study Design. A replication association study that used genomic data generated from French-Canadian case and control cohorts. Objectives. To determine whether the 53 single nucleotide polymorphisms (SNPs) that were previously…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Simplice Asongu, Samba Diop, Joseph Nnanna · 2020 · Journal of Public Affairs
This study has: (a) analysed the economic impact of the Covid‐19 pandemic, (b) evaluated the effectiveness and relevance of different measures against the pandemic and (c) examined nexuses between the corresponding measures and economic…
View details →Negative / Null Result ReportOpen accessMedicine
Matthijs Kant, Wilton A. van Klei, Markus W. Hollmann et al. · 2025 · JAMA
Importance: Intraoperative hypotension is associated with adverse postoperative outcomes, but whether a proactive strategy to prevent intraoperative hypotension improves outcomes is uncertain. Objective: To determine whether intraoperative…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
James Raftery, Hywel C Williams, Aileen Clarke et al. · 2020 · BMJ Open
OBJECTIVES: Randomised controlled trials in healthcare increasingly include economic evaluations. Some show small differences which are not statistically significant. Yet these sometimes come to paradoxical conclusions such as: 'the…
View details →