The Use of Genome-Wide eQTL Associations in Lymphoblastoid Cell Lines to Identify Novel Genetic Pathways Involved in Complex Traits
Josine L. Min; Jennifer M. Taylor; J. Brent Richards; Tim Watts; Fredrik Pettersson; John Broxholme; Kourosh R. Ahmadi; Gabriela Surdulescu · 2011 · PLoS ONE
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Abstract
The integrated analysis of genotypic and expression data for association with complex traits could identify novel genetic pathways involved in complex traits. We profiled 19,573 expression probes in Epstein-Barr virus-transformed lymphoblastoid cell lines (LCLs) from 299 twins and correlated these with 44 quantitative traits (QTs). For 939 expressed probes correlating with more than one QT, we investigated the presence of eQTL associations in three datasets of 57 CEU HapMap founders and 86 unrelated twins. Genome-wide association analysis of these probes with 2.2 m SNPs revealed 131 potential
Abstract by Josine L. Min; Jennifer M. Taylor; J. Brent Richards; Tim Watts; Fredrik Pettersson; John Broxholme; Kourosh R. Ahmadi; Gabriela Surdulescu, PLoS ONE (2011) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1371/journal.pone.0022070