Caspase-11 signaling enhances graft-versus-host disease
Yanyan Lu; Ran Meng; Xiangyu Wang; Yajing Xu; Yiting Tang; Jianfeng Wu; Qianqian Xue; Songlin Yu · 2019 · Nature Communications
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Acute graft-versus-host disease (GVHD) remains a major obstacle for the wider usage of allogeneic hematopoietic stem cell transplantation (allo-HSCT), which is an effective therapy for hematopoietic malignancy. Here we show that caspase-11, the cytosolic receptor for bacterial endotoxin (lipopolysaccharide: LPS), enhances GVHD severity. Allo-HSCT markedly increases the LPS-caspase-11 interaction, leading to the cleavage of gasdermin D (GSDMD). Caspase-11 and GSDMD mediate the release of interleukin-1α (IL-1α) in allo-HSCT. Deletion of Caspase-11 or Gsdmd, inhibition of LPS-caspase-11 interacti
Abstract by Yanyan Lu; Ran Meng; Xiangyu Wang; Yajing Xu; Yiting Tang; Jianfeng Wu; Qianqian Xue; Songlin Yu, Nature Communications (2019) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41467-019-11895-2