Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Clara Collart, Christo P. Christov, James C. Smith et al. · 2011 · Molecular and Cellular Biology
Noncoding Y RNAs are essential for the initiation of chromosomal DNA replication in mammalian cell extracts, but their role in this process during early vertebrate development is unknown. Here, we use antisense morpholino nucleotides (MOs)…
View details →Negative / Null Result ReportOpen accessMedicine
Michael Scott Doyle, Bethany N. Swope, Jerome A. Hogsette et al. · 2011 · Journal of Medical Entomology
In 2006-2007, stable flies, Stomoxys calcitrans (L.) (Diptera: Muscidae), were suspected of being enzootic vectors of West Nile virus (family Flaviviridae, genus Flavivirus, WNV) during a die-off of American white pelicans (Pelecanus…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Imogen Wadlow, Clare Paton‐Walsh, Hugh Forehead et al. · 2019 · Atmosphere
Motivated by public interest, the Clean Air and Urban Landscapes (CAUL) hub deployed instrumentation to measure air quality at a roadside location in Sydney. The main aim was to compare concentrations of fine particulate matter (PM2.5) measured along a busy road section with ambient regional urban background levels, as measured at nearby regulatory air quality stations. The study also explored spatial and temporal variations in the observed PM2.5 concentrations. The chosen area was Randwick in Sydney, because it was also the subject area for an agent-based traffic model. Over a four-day campai
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Sophie Q. van Rijssel, Guusje J. Koorneef, G. F. Veen et al. · 2025 · Science
Organic farming is often considered to be more sustainable than conventional farming. However, both farming systems comprise highly variable management practices. In this study, we show that in organic and conventional arable fields, the…
View details →Negative / Null Result ReportOpen accessMedicine
Kosuke Kitamura, Toshiyuki China, Mayuko Kanayama et al. · 2018 · Prostate International
To determine the clinical predictive factors affecting the recovery from postoperative urinary incontinence after robot-assisted radical prostatectomy (RARP). We consecutively analyzed 320 patients who underwent RARP between January 2012…
View details →Negative / Null Result ReportOpen accessMedicine
Stephen J. Nicholls · 2012 · Cleveland Clinic Journal of Medicine
The AIM-HIGH trial (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides: Impact on Global Health Outcomes) found, in an interim analysis, no cardiovascular benefit from taking extended-release niacin…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Duc Tin Tran, Sri Nagarjun Batchu, Andrew Advani · 2024 · Frontiers in Cardiovascular Medicine
Interferons (IFNs) and IFN-related pathways play key roles in the defence against microbial infection. However, these processes may also be activated during the pathogenesis of non-infectious diseases, where they may contribute to organ injury, or function in a compensatory manner. In this review, we explore the roles of IFNs and IFN-related pathways in heart disease. We consider the cardiac effects of type I IFNs and IFN-stimulated genes (ISGs); the emerging role of the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway; the seemingly paradoxical effects of the type
View details →Negative / Null Result ReportOpen accessMedicine
Guodong Sun, Yang Zhang, Shanshan Mo et al. · 2021 · International Journal of General Medicine
PURPOSE: To analyze the risk factors of multiple organ dysfunction syndromes (MODS) caused by sepsis. PATIENTS AND METHODS: A total of 180 patients with sepsis admitted to The First Affiliated Hospital of Harbin Medical University (No. 23,…
View details →Negative / Null Result ReportOpen accessMedicine
Gil Cunha De Santis, Luciana Correa Oliveira de Oliveira, Pedro Manuel Marques Garibaldi et al. · 2022 · Emerging infectious diseases
To assess whether high-dose coronavirus disease (COVID-19) convalescent plasma (CCP) transfusion may benefit patients with severe COVID-19, we conducted a multicenter randomized trial in Brazil. Patients with severe COVID-19 who were within 10 days of initial symptom onset were eligible. Patients in the CCP group received 3 daily doses of CCP (600 mL/d) in addition to standard treatment; control patients received standard treatment only. Primary outcomes were death rates at days 30 and 60 of study randomization. Secondary outcomes were ventilator-free days and hospital-free days. We enrolled 1
View details →Negative / Null Result ReportOpen accessNursing
Tatiana Galvão, Bethany H. Brown, Peter Hecker et al. · 2011 · Cardiovascular Research
AIMS: The impact of a high-fat diet on the failing heart is unclear, and the differences between polyunsaturated fatty acids (PUFA) and saturated fat have not been assessed. Here, we compared a standard low-fat diet to high-fat diets…
View details →Negative / Null Result ReportOpen accessMedicine
Stefan D. Anker, Javed Butler, Muhammad Usman et al. · 2022 · Nature Medicine
Abstract The EMPEROR-Preserved trial showed that the sodium–glucose co-transporter 2 inhibitor empagliflozin significantly reduces the risk of cardiovascular death or hospitalization for heart failure (HHF) in heart failure patients with left ventricular ejection fraction (LVEF) > 40%. Here, we report the results of a pre-specified analysis that separately evaluates these patients stratified by LVEF: preserved (≥ 50%) ( n = 4,005; 66.9%) or mid-range (41–49%). In patients with LVEF ≥ 50%, empagliflozin reduced the risk of cardiovascular death or HHF (the primary endpoint) by 17% versus plac
View details →Negative / Null Result Report
Karin Isler · 2011 · BioEssays
Abstract Recently, Weisbecker and Goswami presented the first comprehensive comparative analysis of brain size, metabolic rate, and development periods in marsupial mammals. In this paper, a strictly energetic perspective is applied to…
View details →Negative / Null Result Report
Manju Dhandapani, Sivashanmugam Dhandapani, Meena Agarwal et al. · 2013 · Journal of Clinical Nursing
Aims and objectives To assess the factors associated with development of pressure ulcer in patients with severe traumatic brain injury ( TBI ) and study its prognostic significance with respect to neurological outcome at three months.…
View details →Negative / Null Result Report
Aaron Yerke, Daisy Fry Brumit, Anthony A. Fodor · 2024 · Microbiome
Abstract Background Normalization, as a pre-processing step, can significantly affect the resolution of machine learning analysis for microbiome studies. There are countless options for normalization scheme selection. In this study, we…
View details →Negative / Null Result Report
Zhonghao Xin, Lingling Pu, Weina Gao et al. · 2017 · Scientific Reports
Abstract Riboflavin deficiency is widespread in many regions over the world, especially in underdeveloped countries. In this study, we investigated the effects of riboflavin deficiency on protein expression profiles in HepG2 cells in order…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
J. Casellas, Rodrigo Gularte‐Mérida, Charles R. Farber et al. · 2012 · Genetics
Transmission ratio distortion (TRD) is the departure from the expected genotypic frequencies under Mendelian inheritance. This departure can be due to multiple physiological mechanisms during gametogenesis, fertilization, fetal and…
View details →Negative / Null Result ReportOpen accessNeuroscience
Anna Maria Matziorinis, Christian Gaser, Stefan Koelsch · 2022 · Brain Structure and Function
Music-making and engagement in music-related activities have shown procognitive benefits for healthy and pathological populations, suggesting reductions in brain aging. A previous brain aging study, using Brain Age Gap Estimation (BrainAGE), showed that professional and amateur-musicians had younger appearing brains than non-musicians. Our study sought to replicate those findings and analyze if musical training or active musical engagement was necessary to produce an age-decelerating effect in a cohort of healthy individuals. We scanned 125 healthy controls and investigated if musician status,
View details →Negative / Null Result ReportMedicine
Albert J. Arias, Joel Gelernter, Ralitza Gueorguieva et al. · 2014 · American Journal on Addictions
BACKGROUND: Disulfiram and naltrexone were evaluated in treatment of individuals with co-occurring alcohol dependence and other Axis I disorders (e.g., Major Depression). We explored pharmacogenetic interactions in genotyped subjects.…
View details →Negative / Null Result ReportOpen accessNeuroscience
Tao Yu, Hui Gao, Benjamin Ackerman et al. · 2016 · BMC Genomics
BACKGROUND: Restricted and Repetitive Behaviors (RRB), one of the core symptom categories for Autism Spectrum Disorders (ASD), comprises heterogeneous groups of behaviors. Previous research indicates that there are two or more factors (subcategories) within the RRB domain. In an effort to identify common variants associated with RRB, we have carried out a genome-wide association study (GWAS) using the Autism Genetic Resource Exchange (AGRE) dataset (n = 1,335, all ASD probands of European ancestry) for each identified RRB subcategory, while allowing for comparisons of associated single nucleot
View details →Negative / Null Result ReportOpen accessMedicine
Silvia Tietz, Marcel Zwahlen, Neda Haghayegh Jahromi et al. · 2016 · European Journal of Immunology
Considering the 3R rules of animal experimentation, we asked if refined scoring of experimental autoimmune encephalomyelitis (EAE) in mice improves documentation of clinical EAE allowing to perform a more powerful statistical analysis.…
View details →Negative / Null Result ReportPhysics and Astronomy
A. Malagoli, Fumitake Kametani, Jianyi Jiang et al. · 2011 · Superconductor Science and Technology
It is well known that the critical current density Jc of multifilamentary Bi-2212 wires tends to decline as the wire length increases, but the reasons for and the magnitude of this decline remain obscure and quantitatively unpredictable.…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Yitong Li, Erika S. Wittchen, Elizabeth Monaghan-Benson et al. · 2019 · PLoS ONE
As a key homeostasis regulator in mammals, the MERTK receptor tyrosine kinase is crucial for efferocytosis, a process that requires remodeling of the cell membrane and adjacent actin cytoskeleton. Membrane and cytoskeletal reorganization also occur in endothelial cells during inflammation, particularly during neutrophil transendothelial migration (TEM) and during changes in permeability. However, MERTK's function in endothelial cells remains unclear. This study evaluated the contribution of endothelial MERTK to neutrophil TEM and endothelial barrier function. In vitro experiments using primary
View details →Negative / Null Result ReportOpen accessNeuroscience
Sook-Lei Liew, Tziporah Thompson, Joel Ramirez et al. · 2018 · Frontiers in Neuroscience
We routinely make fine motor adjustments to maintain optimal motor performance. These adaptations have been attributed to both implicit, error-based mechanisms, and explicit, strategy-based mechanisms. However, little is known about the neural basis of implicit vs. explicit learning. Here, we aimed to use anodal transcranial direct current stimulation (tDCS) to probe the relationship between different brain regions and learning mechanisms during a visuomotor adaptation task in humans. We hypothesized that anodal tDCS over the cerebellum (CB) should increase implicit learning while anodal tDCS
View details →Negative / Null Result ReportOpen accessMedicine
Sergiusz Jóźwiak, Pierangelo Veggiotti, J. Moreira et al. · 2018 · Epilepsy & Behavior
PURPOSE: This was a phase-II, randomized, double-blind (DB), placebo-controlled study aimed to evaluate neurocognitive effects of eslicarbazepine acetate (ESL) as adjunctive therapy in pediatric patients with refractory focal-onset…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Zhaonan Sun, Yu Zhu · 2012 · Bioinformatics
MOTIVATION: Further advancement of RNA-Seq technology and its application call for the development of effective normalization methods for RNA-Seq data. Currently, different normalization methods are compared and validated by their…
View details →Negative / Null Result Report
Mary E Braine, Neal Cook · 2016 · Journal of Clinical Nursing
Aims and objectives This paper aims to critically consider the evidence since the Glasgow Coma Scale was first launched, reflecting on how that evidence has shaped practice. It illustrates the lack of clarity and consensus about the use of…
View details →Methods Dead-EndOpen accessMedicine
Umile Giuseppe Longo, Rocco Papalia, Sergio De Salvatore et al. · 2023 · Journal of Clinical Medicine
Insufficiently treated shoulder pain may cause mental disturbances, including depression and anxiety. The Hospital Anxiety and Depression Scale (HADS) is a patient-reported outcome measure (PROM) that aims to identify depression and anxiety in patients in nonpsychiatric wards. The aim of this study was to identify the minimum clinically important difference (MCID) and patient acceptable symptom state (PASS) scores for the HADS in a cohort of individuals with rotator cuff disease. Using the HADS, participants' degrees of anxiety and depression were assessed at inception and at their final asses
View details →Negative / Null Result Report
Leher Singh · 2018 · Child Development
Abstract Prior research suggests that bilingualism may endow infants with greater phonological flexibility. This study investigated whether this flexibility facilitates word learning in additional languages (n = 96). Experiment 1 compared…
View details →Replication FailureOpen accessMedicine
John Lowe, David Gillespie, Ali F. Aboklaish et al. · 2024 · The Lancet Respiratory Medicine
BACKGROUND: Systematic reviews have reported conflicting evidence on whether macrolide antibiotics reduce rates of chronic lung disease of prematurity (CLD) in at-risk preterm infants born at less than 30 weeks' gestation, including in those colonised with pulmonary Ureaplasma spp. Since an adequately powered trial has been lacking, we aimed to assess if the macrolide azithromycin improved survival without the development of physiologically defined moderate or severe CLD in preterm infants. METHODS: AZTEC was a multicentre, double-blind, randomised, placebo-controlled trial conducted in 28 ter
View details →Negative / Null Result ReportEnvironmental Science
Jamie Thompson, David A. Beauchamp · 2014 · Transactions of the American Fisheries Society
Abstract We evaluated freshwater growth and survival from juvenile (ages 0–3) to smolt (ages 1–5) and adult stages in wild steelhead Oncorhynchus mykiss sampled in different precipitation zones of the Skagit River basin, Washington. Our…
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