Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Sara Zehtabcheh, Hamed Soleimani Samarkhazan, Marjan Asadi et al. · 2025 · Biomarker Research
Acute myeloid leukemia (AML) with KMT2A rearrangements (KMT2A-r) represents a highly aggressive and prognostically unfavorable subtype of leukemia, often resistant to standard treatments and associated with high relapse rates. KMT2A-r, found in 3-10% of adult AML cases, disrupt epigenetic regulation by forming chimeric proteins that activate oncogenic pathways like HOXA and MEIS1. These fusion proteins recruit cofactors such as Menin and DOT1L, driving leukemogenesis through abnormal histone methylation. Diagnosing KMT2A-r AML requires precision, with traditional methods like FISH and RT-PCR b
View details →Negative / Null Result ReportOpen accessMedicine
Ruben A. Mesa, Jean‐Jacques Kiladjian, Srđan Verstovšek et al. · 2013 · Haematologica
Prior to Janus kinase inhibitors, available therapies for myelofibrosis were generally supportive and did not improve survival. This analysis compares efficacy outcomes of patients with myelofibrosis in the control arms (placebo [n=154]…
View details →Negative / Null Result ReportOpen accessMedicine
Virve I. Enne, Susan Stirling, Julie Barber et al. · 2025 · Intensive Care Medicine
PURPOSE: INHALE investigated the impact of seeking pathogens by PCR on antibiotic stewardship and clinical outcomes in hospital-acquired and ventilator-associated pneumonia (HAP and VAP). METHODS: This pragmatic multicentre, open-label RCT…
View details →Negative / Null Result Report
Shoichi Kuramitsu, Hitoshi Matsuo, Tomohiro Shinozaki et al. · 2020 · Circulation: Cardiovascular Interventions
Background: The safety of fractional flow reserve (FFR)-based deferral of revascularization remains to be fully established in real-world practice. We sought to assess clinical outcomes after deferral of revascularization based on FFR.…
View details →Negative / Null Result Report
Nicole Sneath · 2010 · Neonatal Network
Background: Peripherally inserted central catheters (PICCs) are commonly used in NICUs. Although they have many benefits, they also have many potential complications. Confirming catheter tip position is essential to decreasing…
View details →Negative / Null Result ReportOpen accessNeuroscience
Timo Stein, Deema Awad, Surya Gayet et al. · 2018 · Journal of Experimental Psychology General
Visual stimuli with social-emotional relevance have been claimed to gain preferential access to awareness. For example, recent studies used the breaking continuous flash suppression paradigm (b-CFS) to show that faces that are perceived as less dominant and more trustworthy are prioritized for awareness. Here we asked whether these effects truly reflect differences in social-emotional meaning or whether they can be equally explained by differences in low-level stimulus properties. In Experiment 1, we successfully replicated dominance- and untrustworthiness-related slowing for upright faces. Ho
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Rania Magadmi, Judit Mészáros, Zoheir A. Damanhouri et al. · 2019 · Frontiers in Cellular Neuroscience
Neuroimmune interactions are important in the pathophysiology of many chronic inflammatory diseases, particularly those associated with alterations in sensory processing and pain. Mast cells and sensory neuron nerve endings are found in areas of the body exposed to the external environment; both are specialized to sense potential damage by injury or pathogens and signal to the immune system and nervous system respectively, to elicit protective responses. Cell adhesion molecule 1 (CADM1), also known as SynCAM1, has previously been identified as an adhesion molecule which may couple mast cells t
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Theocharis Ispoglou, D. A. O’Kelly, Athanasia Angelopoulou et al. · 2015 · The Journal of Strength and Conditioning Research
Mouth rinsing with carbohydrate (CHO) solutions during cycling time trials results in performance enhancements; however, most studies have used approximately 6% CHO solutions. Therefore, the purpose of this study was to compare the…
View details →Negative / Null Result Report
Camille Lique, Michael Steele · 2012 · Journal of Geophysical Research: Oceans
Recent mooring observations in the Arctic Basin suggest the existence of a seasonality of Atlantic Water (AW) temperature. Here the DRAKKAR global ocean/sea‐ice model is used to examine the seasonal cycle amplitude of AW temperature within…
View details →Negative / Null Result ReportPsychology
Shengquan Ye, Ting Kin Ng, Kin Hang Yim et al. · 2015 · Journal of Personality Assessment
This study aimed at validating the Curiosity and Exploration Inventory-II (CEI-II; Kashdan et al., 2009 ) in a Chinese context. A total of 294 Chinese first-year undergraduate students in Hong Kong completed the CEI-II and measures of…
View details →Negative / Null Result ReportHealth Professions
Richard D. Lennox, David A. Sharar, Eileen Schmitz et al. · 2010 · Journal of Workplace Behavioral Health
This article describes the development and validation of a five-item scale Workplace Outcome Suite designed as an open access instrument aimed at facilitating empirical research on Employee Assistance Program (EAP) interventions. The suite…
View details →Negative / Null Result ReportOpen accessNeuroscience
David D. Aguilar, Robert E. Strecker, Radhika Basheer et al. · 2019 · Journal of Neurophysiology
The type 5 metabotropic glutamate receptor (mGluR5) represents a novel therapeutic target for schizophrenia and other disorders. Schizophrenia is associated with progressive abnormalities in cortical oscillatory processes including reduced…
View details →Negative / Null Result ReportOpen accessNeuroscience
Logan A. Pendergrast, L Lundell, Amy M. Ehrlich et al. · 2023 · Proceedings of the National Academy of Sciences
The circadian clock is a cell-autonomous transcription–translation feedback mechanism that anticipates and adapts physiology and behavior to different phases of the day. A variety of factors including hormones, temperature, food-intake,…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Sofia G. Seabra, Inês Fragata, Marta A. Antunes et al. · 2017 · Molecular Biology and Evolution
Experimental evolution is a powerful tool to understand the adaptive potential of populations under environmental change. Here, we study the importance of the historical genetic background in the outcome of evolution at the genome-wide level. Using the natural clinal variation of Drosophila subobscura, we sampled populations from two contrasting latitudes (Adraga, Portugal and Groningen, Netherlands) and introduced them in a new common environment in the laboratory. We characterized the genome-wide temporal changes underlying the evolutionary dynamics of these populations, which had previously
View details →Failed Experiment ReportOpen accessBiochemistry, Genetics and Molecular Biology
Shobana Raghunath, Siba K. Samal, Subbiah Elankumaran · 2013 · Journal of Virology
Oncolytic virus (OV) therapies of cancer are based on the use of replication-competent, tumor-selective viruses with limited toxicity. Newcastle disease virus (NDV), an avian paramyxovirus, is a promising OV and is inherently tumor…
View details →Negative / Null Result ReportEnvironmental Science
Robert N. Meroney, David E. Neff · 2010
Numerical calculations of wind loads on solar photovoltaic collectors were used to estimate drag, lift and overturning moments on different collector support systems. These results were compared with direct force measurement tests obtained…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Mehraj Ahmad Sheikh, Mushtaq Ahmad Malik, Rana Zehra Masood · 2020 · Asian Journal of Sustainability and Social Responsibility
Abstract Over the years, world market is integrating at much faster pace through increasing trade openness. Not being an unmixed blessing, consistent efforts have been made to examine impact of trade openness on economic, environmental and social welfare. This study is an attempt to empirically examine the implications of trade openness on sustainable development in India since liberalization policy 1991. We used the Autoregressive Distributed Lag (ARDL) model to test the relationship between sustainable development and trade openness along with other control variables that are supposed to aff
View details →Failed Experiment ReportOpen accessBiochemistry, Genetics and Molecular Biology
Emily J. Mockford, Rupert C. Marshall, Torben Dabelsteen · 2011 · PLoS ONE
Acoustic signals play a fundamental role in avian territory defence and mate attraction. Several studies have now shown that spectral properties of bird song differ between urban and rural environments. Previously this has been attributed to competition for acoustic space as a result of low-frequency noise present in cities. However, the physical structure of urban areas may have a contributory effect. Here we investigate the sound degradation properties of woodland and city environments using both urban and rural great tit song. We show that although urban surroundings caused significantly le
View details →Negative / Null Result ReportOpen accessMedicine
Hongbo Zhou, Jiping Zhu, Jiagang Tu et al. · 2010 · The Journal of Infectious Diseases
To study the effect of NS1 eIF4GI binding domain on virulence and pathogenicity of H5N1 influenza A virus, 5 recombinant H5N1 viruses encoding eIF4GI binding domain-truncated NS1 proteins and parental NS1 (NS1‐wt) were generated by an…
View details →Negative / Null Result ReportOpen accessPsychology
Francesco Bogliacino, Cristiano Codagnone, Felipe Montealegre et al. · 2021 · Scientific Reports
In the context of the current COVID-19 pandemic, households throughout the world have to cope with negative shocks. Previous research has shown that negative shocks impair cognitive function and change risk, time and social preferences. In this study, we analyze the results of a longitudinal multi-country survey conducted in Italy (N = 1652), Spain (N = 1660) and the United Kingdom (N = 1578). We measure cognitive function using the Cognitive Reflection Test and preferences traits (risk, time and social preferences) using an experimentally validated set of questions to assess the differences b
View details →Negative / Null Result ReportOpen accessNeuroscience
Christian Kieling, Mara Helena Hutz, Júlia Pasqualini Genro et al. · 2012 · Journal of Child Psychology and Psychiatry
BACKGROUND: The study of gene-environment interactions (G × E) is one of the most promising strategies to uncover the origins of mental disorders. Replication of initial findings, however, is essential because there is a strong possibility…
View details →Negative / Null Result ReportMedicine
Hye-Ryoung Kim, Choi-Ku Park, Jae‐Ku Oem et al. · 2010 · Journal of General Virology
We characterized low pathogenic avian influenza (LPAI) H5N2 and H9N2 viruses isolated in South Korea from 2008 to 2009. Genetic analysis of the H5N2 viruses isolated from wild birds and domestic ducks demonstrated that they were related to…
View details →Negative / Null Result ReportOpen accessMedicine
Cissy Kityo, Alexander J. Szubert, Abraham Siika et al. · 2018 · PLoS Medicine
BACKGROUND: In sub-Saharan Africa, individuals infected with HIV who are severely immunocompromised have high mortality (about 10%) shortly after starting antiretroviral therapy (ART). This group also has the greatest risk of morbidity and mortality associated with immune reconstitution inflammatory syndrome (IRIS), a paradoxical response to successful ART. Integrase inhibitors lead to significantly more rapid declines in HIV viral load (VL) than all other ART classes. We hypothesised that intensifying standard triple-drug ART with the integrase inhibitor, raltegravir, would reduce HIV VL fast
View details →Negative / Null Result ReportOpen accessHealth Professions
Kian Zarchi, S Latif, Vibeke B. Haugaard et al. · 2014 · Acta Dermato Venereologica
Wounds represent a growing healthcare problem due to an aging population. Nurses play a key role in wound management and their theoretical understanding of basic wound management may be expected to influence the quality of wound therapy…
View details →Negative / Null Result ReportOpen accessMedicine
Feiyu Niu, Yi‐Long Wu · 2014 · Experimental Hematology and Oncology
Since the recognition of epidermal growth factor receptor (EGFR) as a therapeutic target, EGFR tyrosine kinase inhibitors (TKIs) have been used in lung cancer patients with EGFR mutations, which has been a major breakthrough for lung cancer treatment.. The progression-free survival (PFS) of patients with EGFR mutations treated with EGFR TKIs is significantly prolonged compared with that of patients who underwent standard chemotherapy. However, all patients who initially respond to EGFR TKIs eventually develop acquired resistance (AR). Many small molecule agents and monoclonal antibodies (McAb)
View details →Negative / Null Result ReportOpen accessMedicine
Mads Lawaetz, Fatima Birch‐Johansen, Søren Friis et al. · 2016 · Acta Oncologica
Background The study was performed to determine the epidemiological, clinical, and histopathological characteristics and prognosis of primary mucosal melanoma of the head and neck (MMHN) in Denmark. Material and methods This was a national…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Stefania Napolitano, Nunzia Matrone, A. L. Muddassir et al. · 2019 · Journal of Experimental & Clinical Cancer Research
BACKGROUND: Molecular mechanisms driving acquired resistance to anti-EGFR therapies in metastatic colorectal cancer (mCRC) are complex but generally involve the activation of the downstream RAS-RAF-MEK-MAPK pathway. Nevertheless, even if inhibition of EGFR and MEK could be a strategy for overcoming anti-EGFR resistance, its use is limited by the development of MEK inhibitor (MEKi) resistance. METHODS: We have generated in vitro and in vivo different CRC models in order to underline the mechanisms of MEKi resistance. RESULTS: The three different in vitro MEKi resistant models, two generated by
View details →Replication FailureMedicine
Joyce O’Shaughnessy, D Paul, Christopher Stokoe et al. · 2010 · Cancer Research
Abstract Background: Combination regimens incorporating anthracyclines and taxanes are among the most effective for EBC and are particularly suitable for pts with high-risk disease. Significant efficacy benefit has been shown in phase III…
View details →Negative / Null Result ReportOpen accessMedicine
Christopher J. Hoffmann, Katherine Fielding, Salome Charalambous et al. · 2010 · AIDS
OBJECTIVE: To assess the effectiveness of cotrimoxazole preventive therapy (CPT) among individuals with CD4 cell count above 200 cells/microl and varying WHO clinical stages in reducing mortality during combination antiretroviral therapy…
View details →Negative / Null Result ReportNeuroscience
Annika Melinder, Svein Magnussen · 2014 · Psychology Crime and Law
Expert witnesses have various tasks that frequently include issues of memory. We tested if expert witnesses outperform other practitioners on memory issues of high relevance to clinical practice. We surveyed psychiatrists and psychologists…
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