Negative / Null Result ReportOpen accessMathematics
Konrad Neumann, Ulrike Grittner, Sophie K. Piper et al. · 2017 · PLoS Biology
Despite the potential benefits of sequential designs, studies evaluating treatments or experimental manipulations in preclinical experimental biomedicine almost exclusively use classical block designs. Our aim with this article is to bring the existing methodology of group sequential designs to the attention of researchers in the preclinical field and to clearly illustrate its potential utility. Group sequential designs can offer higher efficiency than traditional methods and are increasingly used in clinical trials. Using simulation of data, we demonstrate that group sequential designs have t
View details →Negative / Null Result ReportOpen accessMedicine
Tom Koeman, Pauline Slottje, Leo J. Schouten et al. · 2017 · Occupational and Environmental Medicine
OBJECTIVE: To prospectively study suspected occupational risk factors for amyotrophic lateral sclerosis (ALS). METHODS: For this case-cohort analysis within the prospective Netherlands Cohort Study, 58 279 men and 62 573 women aged 55-69…
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I. A. G. Snellen, L. Guzman-Ramirez, M. R. Hogerheijde et al. · 2020 · Astronomy & Astrophysics
Context. ALMA observations of Venus at 267 GHz that show the apparent presence of phosphine (PH 3 ) in its atmosphere have been presented in the literature. Phosphine currently has no evident production routes on the planet’s surface or in…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Patrick Kline, Christopher Walters · 2021 · Econometrica
This paper develops methods for detecting discrimination by individual employers using correspondence experiments that send fictitious resumes to real job openings. We establish identification of higher moments of the distribution of…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Susan C. Kleiman, Emily Bulik-Sullivan, Elaine M. Glenny et al. · 2017 · PLoS ONE
OBJECTIVE: This study examined associations between the composition and diversity of the intestinal microbiota and measures of depression, anxiety, eating disorder psychopathology, stress, and personality in a group of healthy adult females. METHODS: Female participants (n = 91) ages 19-50 years with BMI 18.5-25 kg/m2 were recruited from central North Carolina between July 2014 and March 2015. Participants provided a single fecal sample and completed an online psychiatric questionnaire that included five measures: (i) Beck Anxiety Inventory; (ii) Beck Depression Inventory-II; (iii) Eating Diso
View details →Negative / Null Result ReportOpen accessMedicine
Sae‐Won Han, Hyun‐Jung Lee, Jeong Mo Bae et al. · 2012 · International Journal of Cancer
The prognostic impact of CpG island methylator phenotype (CIMP) and microsatellite instability (MSI) on the treatment outcome of colon cancer patients receiving adjuvant 5-fluorouracil/leucovorin/oxaliplatin (FOLFOX) is unclear. We…
View details →Negative / Null Result ReportOpen accessMedicine
Shoji Kawakami, Yoshio Tahara, Teruo Noguchi et al. · 2016 · Circulation Journal
BACKGROUND: Prehospital ECG improves survival following ST-segment elevation myocardial infarction (STEMI). Although a new International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment…
View details →Negative / Null Result ReportOpen accessMedicine
Shigeyuki Tamura, Atsushi Takeno, Hirofumi Miki · 2011 · International Journal of Surgical Oncology
Gastric cancer is one of the most common causes of cancer-related death worldwide. Surgical resection with lymph node dissection is the only potentially curative therapy for gastric cancer. However, the appropriate extent of lymph node dissection accompanied by gastrectomy for cancer remains controversial. In East Asian countries, especially in Japan and Korea, D2 lymph node dissection has been regularly performed as a standard procedure. In Western countries, surgeons perform gastrectomy with D1 dissection only because D2 is associated with high mortality and morbidity compared to those assoc
View details →Negative / Null Result ReportOpen accessHealth Professions
Ton Wang, Brooke C. Bredbeck, Brandy Sinco et al. · 2021 · JAMA Surgery
Importance: Through the Choosing Wisely campaign, surgical specialties identified 4 low-value breast cancer operations. Preliminary data suggest varying rates of deimplementation and have identified patient-level and clinician-level…
View details →Negative / Null Result ReportMedicine
Hyehyun Jeong, Kyu‐pyo Kim, Jae Ho Jeong et al. · 2023 · Hepatology
BACKGROUND AND AIMS: The effectiveness of gemcitabine-based adjuvant chemotherapy is unclear in cholangiocarcinoma. We investigated the role of adjuvant gemcitabine plus cisplatin (GemCis) in a homogeneous group of high-risk patients with…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Heidi Lynch, Matthew P. Buman, Jared M. Dickinson et al. · 2020 · International Journal of Environmental Research and Public Health
There are conflicting reports regarding the efficacy of plant versus animal-derived protein to support muscle and strength development with resistance training. The purpose of this study was to determine whether soy and whey protein supplements matched for leucine would comparably support strength increases and muscle growth following 12 weeks of resistance training. Sixty-one untrained young men (n = 19) and women (n = 42) (18–35 year) enrolled in this study, and 48 completed the trial (17 men, 31 women). All participants engaged in supervised resistance training 3×/week and consumed 19 grams
View details →Negative / Null Result ReportPsychology
Joseph F. Sobanko, Julia Dai, Joel M. Gelfand et al. · 2018 · Dermatologic Surgery
BACKGROUND: Minimally invasive cosmetic injectable procedures are increasingly common. However, a few studies have investigated changes in psychosocial functioning following these treatments. OBJECTIVE: To assess changes in body image,…
View details →Negative / Null Result ReportMedicine
Kevin J. McHale, Joshua C. Rozell, Andrew H. Milby et al. · 2016 · The American Journal of Sports Medicine
BACKGROUND: Tarsometatarsal (Lisfranc) joint injuries commonly occur in National Football League (NFL) competition; however, the career effect of these injuries is unknown. PURPOSE: To define the time to return to competition for NFL…
View details →Negative / Null Result ReportMedicine
Ann M. Farese, Cassandra R. Brown, Cassandra P. Smith et al. · 2013 · Health Physics
The identification of the optimal administration schedule for an effective medical countermeasure is critical for the effective treatment of individuals exposed to potentially lethal doses of radiation. The efficacy of filgrastim…
View details →Negative / Null Result ReportSocial Sciences
Richard Stansfield, Thomas J. Mowen, Thomas P. O’Connor et al. · 2016 · Journal of Research in Crime and Delinquency
Objective: Research on the relationship between religion and criminal recidivism has produced encouraging but ultimately inconclusive findings. This study offers a new direction for studying the role of religious support in reentry,…
View details →Negative / Null Result ReportOpen accessMedicine
David J. Cohen, Tara A. Lavelle, Ben van Hout et al. · 2011 · Catheterization and Cardiovascular Interventions
OBJECTIVES: To evaluate the cost-effectiveness of alternative approaches to revascularization for patients with three-vessel or left main coronary artery disease (CAD). BACKGROUND: Previous studies have demonstrated that, despite higher…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Małgorzata Bulkowska, Agata Rybicka, Kerem Mert Senses et al. · 2017 · BMC Cancer
BACKGROUND: MicroRNAs may act as oncogenes or tumour suppressor genes, which make these small molecules potential diagnostic/prognostic factors and targets for anticancer therapies. Several common oncogenic microRNAs have been found for canine mammary cancer and human breast cancer. On account of this, large-scale profiling of microRNA expression in canine mammary cancer seems to be important for both dogs and humans. METHODS: Expression profiles of 317 microRNAs in 146 canine mammary tumours of different histological type, malignancy grade and clinical history (presence/absence of metastases)
View details →Negative / Null Result ReportOpen accessMedicine
Kristi McIntyre, Joyce O’Shaughnessy, Lee S. Schwartzberg et al. · 2014 · Breast Cancer Research and Treatment
Eribulin mesylate, a novel non-taxane microtubule dynamics inhibitor, is approved for treatment of metastatic breast cancer (MBC) in patients who have previously received at least 2 chemotherapeutic regimens for MBC that should have…
View details →Negative / Null Result ReportMedicine
Juliana C.N. Chan, Béatrice Sauvé, Sonya Tokmakejian et al. · 2014 · Experimental and Clinical Endocrinology & Diabetes
OBJECTIVE: Hair analysis has been demonstrated to accurately reflect exposure to drug abuse, environmental toxins and exogenous hormones. We tested the feasibility of measuring cortisol and testosterone in hair of healthy and obese…
View details →Negative / Null Result ReportMedicine
Abhishek Mathur, Sharona Ross, Kenneth Luberice et al. · 2014 · The American Surgeon
Negative margins are the goal with pancreaticoduodenectomy for pancreatic adenocarcinoma. Thereby, margins are assessed intraoperatively with frozen section analysis and negative margins are pursued. This study was undertaken to determine…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Haijie Liu, Yang Hu, Yan Zhang et al. · 2022 · Alzheimer s Research & Therapy
BACKGROUND: Until now, Mendelian randomization (MR) studies have investigated the causal association of risk factors with Alzheimer's disease (AD) using large-scale AD genome-wide association studies (GWAS), GWAS by proxy (GWAX), and meta-analyses of GWAS and GWAX (GWAS+GWAX) datasets. However, it currently remains unclear about the consistency of MR estimates across these GWAS, GWAX, and GWAS+GWAX datasets. METHODS: Here, we first selected 162 independent educational attainment genetic variants as the potential instrumental variables (N = 405,072). We then selected one AD GWAS dataset (N = 63
View details →Negative / Null Result ReportOpen accessHealth Professions
Guillém López i Casasnovas, Marina Soley‐Bori · 2014 · International Journal of Environmental Research and Public Health
In times of economic crisis, most countries face the dual challenge of fighting unemployment while restraining social expenditures and closing budget deficits. The spending cuts and lack of employment affect a large number of decisions that have a direct or indirect impact on health. This impact is likely to be unevenly distributed among different groups within the population, and therefore not only health levels may be at risk, but also their distribution. The main purpose of this paper is to explore links between unemployment, economic growth, inequality, and health. We regress a measure of
View details →Negative / Null Result ReportOpen accessPsychology
Magdalena Łuniewska, Katarzyna Chyl, Agnieszka Dębska et al. · 2018 · Scientific Reports
The prevalence and long-term consequences of dyslexia make it crucial to look for effective and efficient ways of its therapy. Action video games (AVG) were implied as a possible remedy for difficulties in reading in Italian and English-speaking children. However, the studies examining the effectiveness of AVG application in dyslexia suffered from significant methodological weaknesses such as small sample sizes and lack of a control group with no intervention. In our study, we tested how two forms of training: based on AVG and on phonological non-action video games (PNAVG), affect reading in a
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Anvar Khosravi · 2010 · American Journal of Applied Sciences
Problem statement: It is important for policy makers to find affect of monetary and fiscal policy on economic growth and to know how those impacts on growth to present a effective policies. Approach: We apply the bounds testing (ARDL) approach and to cointegration which is more appropriate for estimation in small sample studies. The data span for the study is from 1960-2006, the empirical results found a cointegration relations between Growth, monetary policy and fiscal policy in Iran. Results: The results indicated the impact of Exchange rate and inflation on growth was negative, government e
View details →Negative / Null Result ReportOpen accessMedicine
Pras Pathmanathan, Gary R. Mirams, James Southern et al. · 2011 · International Journal for Numerical Methods in Biomedical Engineering
Abstract Finite element (FE) cardiac electro‐physiology solvers commonly have ionic current determined at mesh nodes but required element interiors. We consider two interpolation approaches: (i) ionic current interpolation (ICI), where nodal ionic currents are linearly interpolated into the element and (ii) state variable interpolation (SVI), where cell model state variables are interpolated instead, from which the ionic current is evaluated. We explain why SVI leads to a method which is massively more computationally demanding than ICI (more than might originally be expected), and then demons
View details →Negative / Null Result ReportOpen accessMedicine
Marco Colombo, Stuart J. McGurnaghan, Luke A. K. Blackbourn et al. · 2020 · Diabetologia
Abstract Aims/hypothesis We examined whether candidate biomarkers in serum or urine can improve the prediction of renal disease progression in type 1 diabetes beyond prior eGFR, comparing their performance with urinary albumin/creatinine ratio (ACR). Methods From the population-representative Scottish Diabetes Research Network Type 1 Bioresource (SDRNT1BIO) we sampled 50% and 25% of those with starting eGFR below and above 75 ml min −1 [1.73 m] −2 , respectively ( N = 1629), and with median 5.1 years of follow-up. Multiplexed ELISAs and single molecule array technology were used to measure nin
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Mary Ann McColl, Celine Boyer Denis, Kate-Lin Douglas et al. · 2023 · Canadian Journal of Occupational Therapy
Background. The Canadian Occupational Performance Measure (COPM) assists occupational therapists to identify occupational performance problems using a client-centred approach. Since its first publication in 1991, there has been abundant…
View details →Negative / Null Result ReportOpen accessMedicine
Elaine Ku, Dawei Xie, Michael G. Shlipak et al. · 2015 · Journal of the American Society of Nephrology
Measured GFR (mGFR) has long been considered the gold standard measure of kidney function, but recent studies have shown that mGFR is not consistently superior to eGFR in explaining CKD-related comorbidities. The associations between…
View details →Negative / Null Result ReportOpen accessMedicine
Seulkee Lee, Seonyoung Kang, Yeonghee Eun et al. · 2021 · Arthritis Research & Therapy
BACKGROUND: Few studies on rheumatoid arthritis (RA) have generated machine learning models to predict biologic disease-modifying antirheumatic drugs (bDMARDs) responses; however, these studies included insufficient analysis on important features. Moreover, machine learning is yet to be used to predict bDMARD responses in ankylosing spondylitis (AS). Thus, in this study, machine learning was used to predict such responses in RA and AS patients. METHODS: Data were retrieved from the Korean College of Rheumatology Biologics therapy (KOBIO) registry. The number of RA and AS patients in the traini
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N Gedney, C Huntingford, E Comyn-Platt et al. · 2019 · Environmental Research Letters
Abstract Emissions from wetlands are the single largest source of the atmospheric greenhouse gas (GHG) methane (CH 4 ). This may increase in a warming climate, leading to a positive feedback on climate change. For the first time, we extend…
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