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Browse the failure-mode index

21,222 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result Report

Did Access to Care Improve Since Passage of the Veterans Choice Act?

Deborah Gurewich, Michael Shwartz, Erin Beilstein-Wedel et al. · 2021 · Medical Care

Background: The 2014 Veterans Choice Program aimed to improve care access for Veterans through expanded availability of community care (CC). Increased access to CC could particularly benefit rural Veterans, who often face obstacles in…

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Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

The Impact of Covid-19 Pandemic on Stock Market Return Volatility: Evidence from Malaysia and Singapore

Jordan Ngu Chuan Yong, Sayyed Mahdi Ziaei, Kenneth Szulczyk · 2021 · Asian Economic and Financial Review

In this study, the volatility of two Asian stock markets, Bursa Malaysia and Singapore Exchange, is estimated. The analysis used data on daily closing prices of the indices of the respective stock markets between July 1, 2019 and August…

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Negative / Null Result ReportOpen accessMedicine

Reduced Frontoparietal Activity in Schizophrenia Is Linked to a Specific Deficit in Goal Maintenance: A Multisite Functional Imaging Study

Andrew Poppe, Deanna M. Barch, Cameron S. Carter et al. · 2016 · Schizophrenia Bulletin

Patients with schizophrenia (SZ) previously demonstrated specific deficits in an executive function known as goal maintenance, associated with reduced middle frontal gyrus (MFG) activity. This study aimed to validate a new tool-the Dot…

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Negative / Null Result ReportOpen accessEnvironmental Science

Exposure to Phthalates Affects Calcium Handling and Intercellular Connectivity of Human Stem Cell-Derived Cardiomyocytes

Nikki Gillum Posnack, Rabia Idrees, Hao Ding et al. · 2015 · PLoS ONE

BACKGROUND: The pervasive nature of plastics has raised concerns about the impact of continuous exposure to plastic additives on human health. Of particular concern is the use of phthalates in the production of flexible polyvinyl chloride (PVC) products. Di-2-ethylhexyl-phthalate (DEHP) is a commonly used phthalate ester plasticizer that imparts flexibility and elasticity to PVC products. Recent epidemiological studies have reported correlations between urinary phthalate concentrations and cardiovascular disease, including an increased risk of high blood pressure and coronary risk. Yet, there

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Negative / Null Result ReportOpen accessMedicine

Maternal and fetal genetic contribution to gestational weight gain

Nicole M. Warrington, Rebecca C. Richmond, Bjarke Fenstra et al. · 2017 · International Journal of Obesity

BACKGROUND: Clinical recommendations to limit gestational weight gain (GWG) imply high GWG is causally related to adverse outcomes in mother or offspring, but GWG is the sum of several inter-related complex phenotypes (maternal fat deposition and vascular expansion, placenta, amniotic fluid and fetal growth). Understanding the genetic contribution to GWG could help clarify the potential effect of its different components on maternal and offspring health. Here we explore the genetic contribution to total, early and late GWG. PARTICIPANTS AND METHODS: A genome-wide association study was used to

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Negative / Null Result ReportOpen accessEngineering

Respirable Silica Dust Suppression During Artificial Stone Countertop Cutting

Jared H Cooper, David L. Johnson, Margaret Phillips · 2014 · The Annals of Occupational Hygiene

PURPOSE: To assess the relative efficacy of three types of controls in reducing respirable silica exposure during artificial stone countertop cutting with a handheld circular saw. APPROACH: A handheld worm drive circular saw equipped with…

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Negative / Null Result ReportOpen accessDecision Sciences

Determinants of bank’s efficiency in an emerging economy: A data envelopment analysis approach

Saif Ullah, Abdul Majeed, József Popp · 2023 · PLoS ONE

This study aims to assess the influence of internal and external factors on the Efficiency of banks in Pakistan using the Data Envelopment Analysis Approach (DEA). Bank's Efficiency is measured through DEA Model using input and output variables. The input variable includes the number of employees, number of branches, administration expenses, non-interest expenses, and loan loss provisions. In contrast, the output variable consists of net interest income, net commissions, and total other income. This study considers the internal determinants of the bank's Efficiency as corporate governance, ent

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Negative / Null Result ReportOpen accessPsychology

Effectiveness of a Web-based and Mobile Therapy Chatbot on Anxiety and Depressive Symptoms in Subclinical Young Adults: Randomized Controlled Trial

Stanisław Karkosz, Robert Szymański, Katarzyna Sanna et al. · 2023 · JMIR Formative Research

BACKGROUND: There has been an increased need to provide specialized help for people with depressive and anxiety symptoms, particularly teenagers and young adults. There is evidence from a 2-week intervention that chatbots (eg, Woebot) are effective in reducing depression and anxiety, an effect that was not detected in the control group that was provided self-help materials. Although chatbots are a promising solution, there is limited scientific evidence for the efficacy of agent-guided cognitive behavioral therapy (CBT) outside the English language, especially for highly inflected languages. O

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Negative / Null Result ReportOpen accessMedicine

Metabolic cost of level, uphill, and downhill running in highly cushioned shoes with carbon-fiber plates

Clarissa S. Whiting, Wouter Hoogkamer, Rodger Kram · 2021 · Journal of sport and health science/Journal of Sport and Health Science

BACKGROUND: Compared to conventional racing shoes, Nike Vaporfly 4% running shoes reduce the metabolic cost of level treadmill running by 4%. The reduction is attributed to their lightweight, highly compliant, and resilient midsole foam…

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Negative / Null Result ReportOpen accessMedicine

Identification of complications that have a significant effect on length of stay after spine surgery and predictive value of 90-day readmission rate

Sanjay Yadla, George M. Ghobrial, Peter G. Campbell et al. · 2015 · Journal of Neurosurgery Spine

OBJECT: Complications after spine surgery have an impact on overall outcome and health care expenditures. The increased cost of complications is due in part to associated prolonged hospital stays. The authors propose that certain…

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Negative / Null Result ReportMedicine

Blood Serotonin in Schizophrenie Children

Meredith F. Campbell, Eitan Friedman, William H. Green et al. · 2017 · International Pharmacopsychiatry

Blood serotonin levels were measured in schizophrenic children, all of whom showed manifestations of illness in the first 2 years of life, and controls. Serotonin levels were higher in patients (mean = 0.267 mug/ml) than in controls (mean…

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Failed Experiment ReportOpen accessMedicine

Efficacy and biodistribution analysis of intracerebroventricular administration of an optimized scAAV9-SMN1 vector in a mouse model of spinal muscular atrophy

Nicole Armbruster, Annalisa Lattanzi, M. Jeavons et al. · 2016 · Molecular Therapy — Methods & Clinical Development

Spinal muscular atrophy (SMA) is an autosomal recessive disease of variable severity caused by mutations in the SMN1 gene. Deficiency of the ubiquitous SMN function results in spinal cord α-motor neuron degeneration and proximal muscle…

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Negative / Null Result ReportOpen accessMedicine

Platelet-Rich Plasma (PRP): Molecular Mechanisms, Actions and Clinical Applications in Human Body

Wen-Shan Wu, Li-Ru Chen, Kuo-Hu Chen · 2025 · International Journal of Molecular Sciences

Platelet-rich plasma (PRP) is an autologous blood-derived concentrate increasingly utilized in regenerative medicine for its ability to accelerate healing and tissue repair. PRP is broadly classified by leukocyte content, fibrin architecture, and platelet concentration, with classification systems developed to standardize characterization. Preparation methods, including single- or double-spin centrifugation and buffy coat techniques, influence the final composition of PRP, determining the relative proportions of platelets, leukocytes, plasma proteins, and extracellular vesicles. These componen

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Negative / Null Result ReportOpen accessMedicine

Is Doppler ultrasound of additional value to gray-scale ultrasound in differentiating malignant and benign thyroid nodules?

Pedro Weslley Rosário, Alexandre Lemos Silva, Michelle Aparecida Ribeiro Borges et al. · 2015 · Archives of Endocrinology and Metabolism

The objective of this study was to evaluate whether Doppler ultrasound (DUS) is of additional value to gray-scale ultrasound (GSUS) in predicting the benign or malignant nature of thyroid nodules. A total of 1,502 solid thyroid nodules ≥ 10 mm were evaluated. Suspicious vascularity (predominantly or exclusively central blood flow) was observed in only 5% of the nodules. This finding showed 96% specificity, but only 15% sensitivity. GSUS alone showed sensitivity and specificity of 88.7% and 68.2%, respectively, which did not improve with the addition of DUS (sensitivity of 89.4% and specificity

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Negative / Null Result ReportEconomics, Econometrics and Finance

Deposit Insurance Creates a Need for Bank Regulation

Mark J. Flannery · 2026

Many bank managers and owners have long complained that they are over-regulated by a plethora of government agencies. The thrust of their complaint is that they could do a better job - i.e. become more profitable or increase their bank’s…

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Negative / Null Result ReportOpen accessMedicine

Durvalumab Plus Olaparib in Previously Untreated, Platinum-Ineligible Patients With Metastatic Urothelial Carcinoma: A Multicenter, Randomized, Phase II Trial (BAYOU)

Jonathan E. Rosenberg, Se Hoon Park, Vadim Kozlov et al. · 2022 · Journal of Clinical Oncology

PURPOSE: Homologous recombination repair gene mutations (HRRm) are common in urothelial carcinoma (UC), rendering tumor cells sensitive to poly (ADP-ribose) polymerase (PARP) inhibition. We assessed efficacy and safety of durvalumab…

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Negative / Null Result ReportOpen accessMedicine

Traditional Chinese medicine <em>Astragalus </em>polysaccharide enhanced antitumor effects of the angiogenesis inhibitor apatinib in pancreatic cancer cells on proliferation, invasiveness, and apoptosis

Jun Wu, Jing Wang, Qiang Su et al. · 2018 · OncoTargets and Therapy

Background: Traditional chemotherapy and molecular targeted therapy have shown modest effects on the survival of patients with pancreatic cancer. The current study aimed to investigate the antitumor effects of apatinib, Astragalus…

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Negative / Null Result ReportMedicine

Significant Association of Annual Hospital Volume With the Risk of Inhospital Stroke or Death Following Carotid Endarterectomy but Likely Not After Carotid Stenting

Andreas Kuehnl, Pavlos Tsantilas, Christoph Knappich et al. · 2016 · Circulation Cardiovascular Interventions

BACKGROUND: Associations between hospital volume and the risk of stroke or death following carotid endarterectomy (CEA) and carotid artery stenting (CAS) on a national level in Germany were analyzed. METHODS AND RESULTS: Secondary data…

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Negative / Null Result ReportSocial Sciences

When are victims unlikely to cooperate with the police?

Richard B. Felson, Brendan Lantz · 2015 · Aggressive Behavior

Data from the National Incident-Based Reporting System (NIBRS) are used to examine the tendency for victims of physical assault, sexual assault, and robbery to refuse to cooperate with the police (N= 3,856,171). Analyses of physical…

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Negative / Null Result ReportOpen accessDecision Sciences

A Model for Improving E-Tax Systems Adoption in Rural Zambia Based on the TAM Model

Patience Njina Soneka, Jackson Phiri · 2019 · Open Journal of Business and Management

The objective of this study was to assess the factors that influence the level of e-tax systems adoption in Zambia. The study focused on TaxOnline system used by domestic taxes division in Zambia. The study was conducted in rural Zambia. In this study, the researcher used Technology Acceptance Model (TAM). The sample size was purposively selected from various taxpayers who were coming through to Zambia Revenue Authority Solwezi internet bureau. 100 semi structured survey questionnaires were distributed with 100% response. The data collected was analyzed using descriptive statistics. The result

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Negative / Null Result ReportOpen accessMedicine

Alcohol use and cardiometabolic risk in the UK Biobank: A Mendelian randomization study

Joanna Lankester, Daniela Zanetti, Erik Ingelsson et al. · 2021 · PLoS ONE

Observational studies suggest alcohol use promotes the development of some adverse cardiometabolic traits but protects against others including outcomes related to coronary artery disease. We used Mendelian randomization (MR) to explore causal relationships between the degree of alcohol consumption and several cardiometabolic traits in the UK Biobank. Using the well-established ADH1B Arg47His variant (rs1229984) and up to 24 additional SNPs recently found to be associated with alcohol consumption in an independent dataset as instruments, we conducted two-stage least squares and inverse weighte

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Negative / Null Result ReportOpen accessSocial Sciences

Failure to CAPTCHA Attention: Null Results from an Honesty Priming Experiment in Guatemala

Stewart Kettle, Marco Hernandez, Mike Sanders et al. · 2017 · Behavioral Sciences

We report results from a large online randomised tax experiment in Guatemala. The trial involves short messages and choices presented to taxpayers as part of a CAPTCHA pop-up window immediately before they file a tax return, with the aim of priming honest declarations. In total our sample includes 627,242 taxpayers and 3,232,430 tax declarations made over four months. Treatments include: honesty declaration; information about public goods; information about penalties for dishonesty, questions allowing a taxpayer to choose which public good they think tax money should be spent on; or questions

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Prospective associations of plasma phospholipids and mild cognitive impairment/dementia among African Americans in the ARIC Neurocognitive Study

Danni Li, Jeffrey R. Misialek, Eric Boerwinkle et al. · 2016 · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring

INTRODUCTION: The objective of this study was to investigate whether 10 phospholipids/metabolites previously identified as prospectively predictive of mild cognitive impairment (MCI) or dementia in whites would also be predictive in a…

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Negative / Null Result ReportOpen accessNeuroscience

The Statistical Analysis of Multi-Voxel Patterns in Functional Imaging

Kai Schreiber, Bart Krekelberg · 2013 · PLoS ONE

The goal of multi-voxel pattern analysis (MVPA) in BOLD imaging is to determine whether patterns of activation across multiple voxels change with experimental conditions. MVPA is a powerful technique, its use is rapidly growing, but it poses serious statistical challenges. For instance, it is well-known that the slow nature of the BOLD response can lead to greatly exaggerated performance estimates. Methods are available to avoid this overestimation, and we present those here in tutorial fashion. We go on to show that, even with these methods, standard tests of significance such as Students' T

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