Negative / Null Result ReportOpen accessMedicine
Paul Sondo, Biébo Bihoun, Marc Christian Tahita et al. · 2021 · Malaria Journal
BACKGROUND: Multi-genotype malaria infections are frequent in endemic area, and people commonly harbour several genetically distinct Plasmodium falciparum variants. The influence of genetic multiplicity and whether some specific genetic variants are more or less likely to invest into gametocyte production is not clearly understood. This study explored host and parasite-related risk factors for gametocyte carriage, and the extent to which some specific P. falciparum genetic variants are associated with gametocyte carriage. METHODS: Gametocytes and asexual forms were detected by light microscopy
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Aidan E. Gilchrist, Brendan A. C. Harley · 2022 · Advanced Healthcare Materials
Abstract Hematopoietic stem cells are the progenitors of the blood and immune system and represent the most widely used regenerative therapy. However, their rarity and limited donor base necessitate the design of ex vivo systems that…
View details →Negative / Null Result ReportOpen accessEngineering
Peter D. Dunning · 2020 · Structural and Multidisciplinary Optimization
Abstract This paper investigates the application of the co-rotational method to solve geometrically nonlinear topology optimization problems. The main benefit of this approach is that the tangent stiffness matrix is naturally positive definite, which avoids some numerical issues encountered when using other approaches. Three different methods for constructing the tangent stiffness matrix are investigated: a simplified method, where the linear elastic stiffness matrix is simply rotated; the consistent method, where the tangent stiffness is derived by differentiating residual forces by displacem
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Xiangxu Zou, Hui Zhang, Jie Zuo et al. · 2016 · Scientific Reports
Abstract To identify the facilitation effect of a cool-season aquatic macrophyte (FE am ) for use in effluent purification via constructed floating wetlands (CFWs) and to determine the possible pathways used during a winter period with an…
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Christopher W. Belter, Neal K. Kaske · 2016 · College & Research Libraries
Although cited reference studies are common in the library and information science literature, they are rarely performed in nonacademic institutions or in the atmospheric and oceanic sciences. In this paper, we analyze more than 400,000…
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Aimée C. Colbath, Steven W. Dow, Leone S. Hopkins et al. · 2020 · Equine Veterinary Journal
Abstract Background Allogeneic and autologous bone marrow‐derived mesenchymal stem cells (BMDMSCs) have been administered in equine joints for their anti‐inflammatory effects. However, allogeneic BMDMSC offer multiple clinical and…
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Rachel Charlton, Christine Damase‐Michel, Caroline Hurault‐Delarue et al. · 2019 · Pharmacoepidemiology and Drug Safety
Abstract Objectives In November 2014, the CMDh (a regulatory body representing EU Member States) advised doctors not to prescribe sodium valproate for epilepsy or bipolar disorder in preg nant women, in women who can become pregnant, or in…
View details →Negative / Null Result ReportOpen accessDentistry
Kittisak Sanon, Takashi Hatayama, Antonín Tichý et al. · 2022 · Dental Materials Journal
This study investigated the influence of application/wash-out times of sodium hypochlorite (NaOCl) and hypochlorous acid (HOCl) on dentin bond strength of one-step self-etch adhesives (1-SEAs). Human coronal dentin discs with a…
View details →Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
Da‐Tian Bau · 2011 · The Chinese Journal of Physiology
Many articles have reported the caveolin-1 gene to be down-regulated thus suggesting that it might be a candidate tumor suppressor gene in many tumors. However, its involvement in bladder cancer is not clear and may be depending on…
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Tracy Leskey, Heather Andrews, Angelika Bády et al. · 2021 · Journal of Economic Entomology
Brown marmorated stink bug, Halyomorpha halys, is native to Asia and has invaded North America and Europe inflicting serious agricultural damage to specialty and row crops. Tools to monitor the spread of H. halys include traps baited with…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Andrea J. Savio, Mathieu Lemire, Miralem Mrkonjic et al. · 2012 · PLoS ONE
Single nucleotide polymorphisms (SNPs) are the most common form of genetic variation. We previously demonstrated that SNPs (rs1800734, rs749072, and rs13098279) in the MLH1 gene region are associated with MLH1 promoter island methylation, loss of MLH1 protein expression, and microsatellite instability (MSI) in colorectal cancer (CRC) patients. Recent studies have identified less CpG-dense "shore" regions flanking many CpG islands. These shores often exhibit distinct methylation profiles between different tissues and matched normal versus tumor cells of patients. To date, most epigenetic studie
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RuoLi Chen, Mohammad Alkataan Ahmed, Nicholas Robert Forsyth · 2022 · Biomolecules
Cells respond to reduced oxygen availability predominately by activation of the hypoxia-inducible factor (HIF) pathway. HIF activation upregulates hundreds of genes that help cells survive in the reduced oxygen environment. The aim of this…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Josef Biber, Catharina Gandor, Elvir Bećirović et al. · 2025 · Pharmacology & Therapeutics
Gene therapy is an innovative medical approach that offers new treatment options for congenital and acquired diseases by transferring, correcting, inactivating or regulating genes to supplement, replace or modify a gene function. The approval of voretigene neparvovec (Luxturna), a gene therapy for RPE65-associated retinopathy, has marked a milestone for the field of retinal gene therapy, but has also helped to accelerate the development of gene therapies for genetic diseases affecting other organs. Voretigene neparvovec is a vector based on adeno-associated virus (AAV) that delivers a function
View details →Negative / Null Result ReportOpen accessNeuroscience
Onurcan Yılmaz, Hasan G. Bahçekapılı · 2015 · PLoS ONE
Scientific and religious thinking compete with each other on several levels. For example, activating one generally weakens the other. Since priming religion is known to increase moral behaviour and moral sensitivity, priming science might be expected to have the opposite effect. However, it was recently demonstrated that, on the contrary, science priming increases moral sensitivity as well. The present set of studies sought to replicate this effect and test two explanations for it. Study 1 used a sentence unscrambling task for implicitly priming the concept of science but failed to replicate i
View details →Negative / Null Result ReportOpen accessMedicine
Yasir Almuhanna · 2025 · Journal of Clinical Medicine
Wound healing is a complex and multistage process that incorporates precise cellular and molecular coordination. The presence of biofilms in chronic wounds adversely affects the wound healing process, as it prolongs the closure of the wound, thus sustaining chronic inflammation. Current data suggest that biofilms are present in almost all chronic wounds, which leads to significant challenges in diagnosis and treatment. Traditional detection methods, such as cultures and light microscopy, often fail to detect biofilms; however, sophisticated molecular and imaging techniques are constrained by t
View details →Negative / Null Result ReportOpen accessMedicine
Ryan Shean, Tathya Shah, Aditya Pandiarajan et al. · 2025 · Scientific Reports
The ability of large language models (LLMs) to accurately answer medical board-style questions reflects their potential to benefit medical education and real-time clinical decision-making. With the recent advance to reasoning models, the latest LLMs excel at addressing complex problems in benchmark math and science tests. This study assessed the performance of first-generation reasoning models-DeepSeek's R1 and R1-Lite, OpenAI's o1 Pro, and Grok 3-on 493 ophthalmology questions sourced from the StatPearls and EyeQuiz question banks. o1 Pro achieved the highest overall accuracy (83.4%), signifi
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Mboneye Anselme, Huafeng He, Chengyang Lai et al. · 2025 · Journal of Translational Medicine
In the realm of cellular biochemistry, mitochondria have been increasingly recognized for their critical role in both cellular metabolism and the etiology of various diseases. Mitochondrial transporters (MTs) are essential for maintaining…
View details →Negative / Null Result ReportOpen accessEngineering
Filippo Laganà, Danilo Pratticò, Marco F. Quattrone et al. · 2026 · Eng—Advances in Engineering
Defects in printed circuit boards (PCBs), if not detected promptly, may persist over time until they cause the failure of critical components. Traditional monitoring methods, which are limited to simulations or superficial measurements, obstruct predictive maintenance and real-time fault detection. To address these issues and enhance real-time diagnostics of thermal anomalies in PCBs, this work proposes an integrated system that combines infrared thermography (IRT), artificial intelligence (AI) algorithms, and Taguchi–ANOVA statistical techniques. IR thermography was employed to identify therm
View details →Negative / Null Result ReportOpen accessSocial Sciences
Chloe Wittenberg, Ziv Epstein, Gabrielle Péloquin-Skulski et al. · 2025 · PNAS Nexus
Abstract Recent advancements in generative AI have raised widespread concern about the use of this technology to spread audio and visual misinformation. In response, there has been a major push among policymakers and technology companies to label AI-generated media appearing online. It remains unclear, however, what types of labels are most effective for this purpose. Here, we evaluate two (potentially complementary) strategies for labeling AI-generated content online: (i) a process-based approach, aimed at clarifying how content was made and (ii) a harm-based approach, aimed at highlighting c
View details →Negative / Null Result ReportOpen accessComputer Science
Michael S. Vitevitch, Gavin J. D. Mullin · 2021 · Brain Sciences
Cognitive network science is an emerging approach that uses the mathematical tools of network science to map the relationships among representations stored in memory to examine how that structure might influence processing. In the present study, we used computer simulations to compare the ability of a well-known model of spoken word recognition, TRACE, to the ability of a cognitive network model with a spreading activation-like process to account for the findings from several previously published behavioral studies of language processing. In all four simulations, the TRACE model failed to retr
View details →Negative / Null Result ReportOpen accessMedicine
Stijntje Dijk, Claudia Wollny, Jörg Barkhausen et al. · 2025 · JAMA
Importance: Given the widespread use of medical imaging, evaluating the effectiveness of interventions to improve appropriateness is crucial for optimizing health care resources and patient outcomes. Objective: To assess the effects of…
View details →Negative / Null Result ReportOpen accessNeuroscience
Patrick Vermersch, Laura Airas, Thomas Berger et al. · 2025 · Frontiers in Immunology
Background: Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system (CNS), characterized by inflammation and neurodegeneration. The pathophysiology of MS, especially its progressive forms, involves various cellular components, including microglia, the primary resident immune cells of the CNS. This review discusses the role of microglia in neuroinflammation, tissue repair, and neural homeostasis, as well as their involvement in MS and explores potential therapeutic strategies targeting microglial function. Methods: A literature search conducted in August 202
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Marta Arroyo‐Izaga, Concepción Martínez de la Pera, Laura Ansotegui et al. · 2026 · Archivos Latinoamericanos de Nutrición
The objective of this study was to determine whether a short training program, using real foods, would decreased their portion-size estimation errors after training. 90 student volunteers (20.18+/-0.44 y old) of the University of the…
View details →Negative / Null Result ReportSocial Sciences
Wesley Myers, Kristin M. Lloyd, Jillian J. Turanovic et al. · 2018 · Journal of Contemporary Criminal Justice
There is a growing “replication crisis” in the social and behavioral sciences, where original research across a wide array of substantive areas has failed to replicate when conducted by others. This problem highlights the importance of…
View details →Negative / Null Result ReportOpen accessArts and Humanities
Bianca Brown, Botagoz Tusmagambet, Valentino Rahming et al. · 2023 · Applied Psycholinguistics
Abstract This study conceptually replicated and extended Reid, Trofimovich, and O’Brien (2019), who found that native English speakers could be biased positively (or negatively) relative to a control condition in terms of how they rate non-native English speech. Our internet-based study failed to replicate Reid et al. across a wider population sample of “native” speakers ( n = 189). Listeners did not change how they rated non-native English speech after social bias orientations and performed similarly across all five measures of speech and across age and race (Asian, Black, and Caucasian). We
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Qiyao Zhang, Zhen Cao, Shangcheng Yan et al. · 2025 · Journal of Translational Medicine
Pancreatic cancer, specifically pancreatic ductal adenocarcinoma (PDAC), is notorious for its aggressive nature and dismal prognosis, ranking as a leading cause of cancer-related mortality worldwide. Despite advancements in surgical…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Piers Forster, Tristram Walsh, Chris Smith et al. · 2026 · Earth system science data
Abstract. In a rapidly changing climate, evidence-based decision-making benefits from up-to-date and timely information. We track twelve key sets of indicators of the state of the climate system, closely following Intergovernmental Panel on Climate Change (IPCC) Sixth Assessment report (AR6) methods, to produce our fourth annual publication. One of the indicators, the Earth's energy imbalance (EEI) provides a crucial integrative measure of the overall heating of the planet and the pace of climate change – this has more than doubled since the 1976–1995 period. A newly added indicator of tempera
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Atif Mahmood, Asad Mehmood, Simone Terzani et al. · 2025 · Management Decision
Purpose The environmental, social and governance (ESG) topic has recently received increasing attention from scholars due to increasing regulations for firms’ non-financial disclosure with respect to environmental and social issues. For instance, the European Union (EU) recently issued the Corporate Sustainability Reporting Directive (CSRD) in December 2022 and implemented it starting in 2024 in member states. Non-financial disclosure is relevant for various stakeholders and could affect firm value. Therefore, this study aims to examine the effect of ESG disclosure on firm value in the EU cont
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Xiaoxiao Ma · 2023 · Green and Low-Carbon Economy
Facing severe air pollution, the Chinese government has introduced bottom-up public participation in environmental policy. The increase in public environmental attention can promote the participation of all people in environmental…
View details →Negative / Null Result ReportOpen accessDecision Sciences
Roberta Fida, Irene Skovgaard‐Smith, Claudio Barbaranelli et al. · 2024 · Human Relations
While considerable attention has been devoted to understanding how individual characteristics influence unethical actions, far less research has examined the role of social and organisational processes. We introduce the concept of organisational moral disengagement (OrgMD), drawing on Bandura’s moral agency theory, to explain how unethicality may be fostered in organisations. OrgMD is a multilevel construct, capturing perceptions of the mechanisms through which morality can be suspended in an organisation allowing unethical practices to flourish. Using four empirical studies, we validated OrgM
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