Negative / Null Result ReportOpen accessMedicine
Charanpreet Singh, Sanjay Jain, Veena Dhawan et al. · 2020 · Archives of Endocrinology and Metabolism
OBJECTIVE: We conducted a study to examine the association of endothelial dysfunction and oxidative stress with uric acid levels in patients of metabolic syndrome. METHODS: One hundred and two patients of Metabolic Syndrome (International Diabetes Federation definition) were included in the study. Anthropometric measurements, serum uric acid levels, fasting blood sugar levels and lipid levels, as well as malondialdehyde and reactive nitrogen intermediates were measured after an 8-hour fasting period. Flow mediated vasodilation (FMD) of the brachial artery was measured and endothelial dysfuncti
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Adélaïde Doussau, Paul Perez, Maryse Puntous et al. · 2013 · Transfusion
Background During on‐pump cardiac surgery, hemorrhagic complications occur frequently. Fresh‐frozen plasma ( FFP ) is widely transfused to provide coagulation factors. Yet, no randomized clinical trial has demonstrated its benefits on…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Diego Chemello, Luís Eduardo Paim Rohde, Kátia Gonçalves dos Santos et al. · 2010 · EP Europace
AIMS: We investigated whether the combination of beta(1)-Gly389Arg and GNB3 C825T, two genetic polymorphisms strictly related to adrenergic system modulation, could act as predictors of appropriate therapies in patients with heart failure…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Micah J. McCauley, Ioulia Rouzina, Jasmine Li et al. · 2020 · Viruses
Retroviral nucleocapsid (NC) proteins are nucleic acid chaperones that play distinct roles in the viral life cycle. During reverse transcription, HIV-1 NC facilitates the rearrangement of nucleic acid secondary structures, allowing the transactivation response (TAR) RNA hairpin to be transiently destabilized and annealed to a complementary RNA hairpin. In contrast, during viral assembly, NC, as a domain of the group-specific antigen (Gag) polyprotein, binds the genomic RNA and facilitates packaging into new virions. It is not clear how the same protein, alone or as part of Gag, performs such d
View details →Negative / Null Result ReportOpen accessMedicine
Robert S. Wallis · 2014 · Open Forum Infectious Diseases
OBJECTIVES: There is increasing interest in the potential role of adjunctive anti-inflammatory therapy to accelerate tuberculosis (TB) treatment. Sputum culture conversion is an important biomarker predictor of durable TB cure. METHODS:…
View details →Negative / Null Result ReportOpen accessMedicine
Mark Seow Khoon Chong, Jing Lim, Junwei Goh et al. · 2014 · Molecular Pharmaceutics
In spite of recognized limitations in capturing species-specific responses and high costs, rodent models remain commonly used in prostate cancer metastasis research, due largely to the lack of available alternatives. We aim to develop an…
View details →Negative / Null Result ReportOpen accessNeuroscience
Aung Naing, Alain P. Algazi, Gerald S. Falchook et al. · 2022 · Cancer
BACKGROUND: Targeting programmed cell death protein 1 (PD-1) and indoleamine 2,3-dioxygenase (IDO1) pathways is an appealing option for cancer treatment. METHODS: The open-label, phase 1/2 ECHO-203 study evaluated the safety, tolerability,…
View details →Negative / Null Result ReportOpen accessMedicine
Etsuro Ogata, Masafumi Fukagawa, Hideki Hirakata et al. · 2016 · Clinical and Experimental Nephrology
BACKGROUND: Calcium (Ca)-based phosphate (P) binders, compared to non-Ca-based P binders, contribute to vascular calcification, which is associated with cardiovascular events. METHODS: The LANDMARK study is a multicenter, randomized, open-label, parallel comparative study of lanthanum carbonate (LC) and calcium carbonate (CC) in hemodialysis patients. Stable hemodialysis patients with intact parathyroid hormone ≤240 pg/mL meeting ≥1 of the following criteria (age >65 years, postmenopause, diabetes mellitus) were randomized into the LC and CC groups. LC group patients initially received LC 750
View details →Negative / Null Result ReportOpen accessMedicine
Mary A.M. Rogers, Kathleen Ward, Tanya R. Gure et al. · 2011 · Diabetes Care
OBJECTIVE: The goals of this study were to examine trajectories of blood pressure (BP) in adults with diabetes and investigate the association of trajectory patterns with mortality. RESEARCH DESIGN AND METHODS: A nonconcurrent longitudinal…
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Kristina B Beck, Ben C Sheldon, Josh A Firth · 2023 · eLife
The emergence and spread of novel behaviours via social learning can lead to rapid population-level changes whereby the social connections between individuals shape information flow. However, behaviours can spread via different mechanisms…
View details →Negative / Null Result ReportOpen accessMedicine
Paul Sondo, Biébo Bihoun, Marc Christian Tahita et al. · 2021 · Malaria Journal
BACKGROUND: Multi-genotype malaria infections are frequent in endemic area, and people commonly harbour several genetically distinct Plasmodium falciparum variants. The influence of genetic multiplicity and whether some specific genetic variants are more or less likely to invest into gametocyte production is not clearly understood. This study explored host and parasite-related risk factors for gametocyte carriage, and the extent to which some specific P. falciparum genetic variants are associated with gametocyte carriage. METHODS: Gametocytes and asexual forms were detected by light microscopy
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Aidan E. Gilchrist, Brendan A. C. Harley · 2022 · Advanced Healthcare Materials
Abstract Hematopoietic stem cells are the progenitors of the blood and immune system and represent the most widely used regenerative therapy. However, their rarity and limited donor base necessitate the design of ex vivo systems that…
View details →Negative / Null Result ReportOpen accessEngineering
Peter D. Dunning · 2020 · Structural and Multidisciplinary Optimization
Abstract This paper investigates the application of the co-rotational method to solve geometrically nonlinear topology optimization problems. The main benefit of this approach is that the tangent stiffness matrix is naturally positive definite, which avoids some numerical issues encountered when using other approaches. Three different methods for constructing the tangent stiffness matrix are investigated: a simplified method, where the linear elastic stiffness matrix is simply rotated; the consistent method, where the tangent stiffness is derived by differentiating residual forces by displacem
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Xiangxu Zou, Hui Zhang, Jie Zuo et al. · 2016 · Scientific Reports
Abstract To identify the facilitation effect of a cool-season aquatic macrophyte (FE am ) for use in effluent purification via constructed floating wetlands (CFWs) and to determine the possible pathways used during a winter period with an…
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Christopher W. Belter, Neal K. Kaske · 2016 · College & Research Libraries
Although cited reference studies are common in the library and information science literature, they are rarely performed in nonacademic institutions or in the atmospheric and oceanic sciences. In this paper, we analyze more than 400,000…
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Aimée C. Colbath, Steven W. Dow, Leone S. Hopkins et al. · 2020 · Equine Veterinary Journal
Abstract Background Allogeneic and autologous bone marrow‐derived mesenchymal stem cells (BMDMSCs) have been administered in equine joints for their anti‐inflammatory effects. However, allogeneic BMDMSC offer multiple clinical and…
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Rachel Charlton, Christine Damase‐Michel, Caroline Hurault‐Delarue et al. · 2019 · Pharmacoepidemiology and Drug Safety
Abstract Objectives In November 2014, the CMDh (a regulatory body representing EU Member States) advised doctors not to prescribe sodium valproate for epilepsy or bipolar disorder in preg nant women, in women who can become pregnant, or in…
View details →Negative / Null Result ReportOpen accessDentistry
Kittisak Sanon, Takashi Hatayama, Antonín Tichý et al. · 2022 · Dental Materials Journal
This study investigated the influence of application/wash-out times of sodium hypochlorite (NaOCl) and hypochlorous acid (HOCl) on dentin bond strength of one-step self-etch adhesives (1-SEAs). Human coronal dentin discs with a…
View details →Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
Da‐Tian Bau · 2011 · The Chinese Journal of Physiology
Many articles have reported the caveolin-1 gene to be down-regulated thus suggesting that it might be a candidate tumor suppressor gene in many tumors. However, its involvement in bladder cancer is not clear and may be depending on…
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Tracy Leskey, Heather Andrews, Angelika Bády et al. · 2021 · Journal of Economic Entomology
Brown marmorated stink bug, Halyomorpha halys, is native to Asia and has invaded North America and Europe inflicting serious agricultural damage to specialty and row crops. Tools to monitor the spread of H. halys include traps baited with…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Andrea J. Savio, Mathieu Lemire, Miralem Mrkonjic et al. · 2012 · PLoS ONE
Single nucleotide polymorphisms (SNPs) are the most common form of genetic variation. We previously demonstrated that SNPs (rs1800734, rs749072, and rs13098279) in the MLH1 gene region are associated with MLH1 promoter island methylation, loss of MLH1 protein expression, and microsatellite instability (MSI) in colorectal cancer (CRC) patients. Recent studies have identified less CpG-dense "shore" regions flanking many CpG islands. These shores often exhibit distinct methylation profiles between different tissues and matched normal versus tumor cells of patients. To date, most epigenetic studie
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RuoLi Chen, Mohammad Alkataan Ahmed, Nicholas Robert Forsyth · 2022 · Biomolecules
Cells respond to reduced oxygen availability predominately by activation of the hypoxia-inducible factor (HIF) pathway. HIF activation upregulates hundreds of genes that help cells survive in the reduced oxygen environment. The aim of this…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
David Funosas, Esther Sebastián‐González, Jon Morant et al. · 2026 · Ecological Indicators
Abstract Recent advances in machine learning have accelerated automated species detection across diverse ecological domains, enabling large-scale, non-invasive monitoring of biodiversity. In ornithological research, coupling passive acoustic monitoring (PAM) with rapidly-developing novel identification tools such as BirdNET—a deep learning–based sound recognition algorithm—offers new opportunities for surveying vocally active bird communities. Yet, BirdNET performance across diverse ecological and biogeographic contexts remains to be quantified. Here, we present the first worldwide evaluation
View details →Negative / Null Result ReportOpen accessComputer Science
Thomas A. Buckley, James A. Diao, Cam N. Srivastava et al. · 2026 · Nature Communications
Multimodal foundation models have shown compelling but conflicting performance in medical image interpretation. However, the ways in which these models integrate and prioritize different data modalities, including images and text, remain…
View details →Negative / Null Result ReportOpen accessMedicine
Akshay Khunte, Veer Sangha, Evangelos K. Oikonomou et al. · 2026 · European Heart Journal - Digital Health
ABSTRACT Background Timely and accurate assessment of electrocardiograms (ECGs) is crucial for diagnosing, triaging, and clinically managing patients. Current workflows rely on computerized ECG interpretation tools built into ECG signal…
View details →Negative / Null Result ReportOpen accessArts and Humanities
Bianca Brown, Botagoz Tusmagambet, Valentino Rahming et al. · 2023 · Applied Psycholinguistics
Abstract This study conceptually replicated and extended Reid, Trofimovich, and O’Brien (2019), who found that native English speakers could be biased positively (or negatively) relative to a control condition in terms of how they rate non-native English speech. Our internet-based study failed to replicate Reid et al. across a wider population sample of “native” speakers ( n = 189). Listeners did not change how they rated non-native English speech after social bias orientations and performed similarly across all five measures of speech and across age and race (Asian, Black, and Caucasian). We
View details →Negative / Null Result ReportOpen accessMedicine
Yasir Almuhanna · 2025 · Journal of Clinical Medicine
Wound healing is a complex and multistage process that incorporates precise cellular and molecular coordination. The presence of biofilms in chronic wounds adversely affects the wound healing process, as it prolongs the closure of the wound, thus sustaining chronic inflammation. Current data suggest that biofilms are present in almost all chronic wounds, which leads to significant challenges in diagnosis and treatment. Traditional detection methods, such as cultures and light microscopy, often fail to detect biofilms; however, sophisticated molecular and imaging techniques are constrained by t
View details →Negative / Null Result ReportOpen accessMedicine
Stijntje Dijk, Claudia Wollny, Jörg Barkhausen et al. · 2025 · JAMA
Importance: Given the widespread use of medical imaging, evaluating the effectiveness of interventions to improve appropriateness is crucial for optimizing health care resources and patient outcomes. Objective: To assess the effects of…
View details →Negative / Null Result ReportOpen accessNeuroscience
Onurcan Yılmaz, Hasan G. Bahçekapılı · 2015 · PLoS ONE
Scientific and religious thinking compete with each other on several levels. For example, activating one generally weakens the other. Since priming religion is known to increase moral behaviour and moral sensitivity, priming science might be expected to have the opposite effect. However, it was recently demonstrated that, on the contrary, science priming increases moral sensitivity as well. The present set of studies sought to replicate this effect and test two explanations for it. Study 1 used a sentence unscrambling task for implicitly priming the concept of science but failed to replicate i
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Iliana Medina, Alice Exnerová, Klára Daňková et al. · 2025 · Science
Natural selection has repeatedly led to the evolution of two alternative antipredator color strategies-camouflage to avoid detection and aposematism to advertise unprofitability-but we lack understanding of how ecological context favors one strategy over the other. We conducted a globally replicated predation experiment at 21 sites on six continents to test how predator community, prey community, and visual environment influenced the predation risk of 15,018 artificial paper "moth" prey with cryptic or warning coloration. Results indicated that aposematic strategies fare better in environments
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