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Browse the failure-mode index

21,239 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessSocial Sciences

More social, less material, more influenced by family ties: Why young women join political parties

Sofia Ammassari, Duncan McDonnell, Annika Werner et al. · 2026 · European Journal of Political Research

Abstract Do young women and men join political parties for different reasons? To investigate, we theorize the following: first, women will be more attracted by social incentives and men by material ones, while purposive incentives will be…

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Negative / Null Result ReportOpen accessPharmacology, Toxicology and Pharmaceutics

Innovative dual-functional hybrid cationic PEGylated proniosomes as a smart nano-platform for Boosted vaginal delivery: multi-level in-vitro, ex-vivo, microbiological, and in-vivo studies

Sadek Ahmed, Osama Saher, Heba Attia et al. · 2026 · Frontiers in Pharmacology

Introduction: Vaginal candidiasis remains a recurrent fungal infection affecting millions of women worldwide, necessitating innovative local delivery systems to overcome poor drug solubility and mucosal barriers. This study introduces Dual-Functional Hybrid Cationic PEGylated Proniosomes (DHCPP) as a smart nano-platform designed to boost the vaginal delivery of Fenticonazole Nitrate (FTN). Methods: DHCPP systems were fabricated via the coacervation phase separation method and optimized using a full 2 3 factorial design, achieving a high desirability value of 0.931. The optimized DHCPP exhibite

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Negative / Null Result ReportOpen accessMedicine

Computerized diagnostic decision support systems – a comparative performance study of Isabel Pro vs. ChatGPT4

Joe M. Bridges · 2024 · Diagnosis

OBJECTIVES: Validate the diagnostic accuracy of the Artificial Intelligence Large Language Model ChatGPT4 by comparing diagnosis lists produced by ChatGPT4 to Isabel Pro. METHODS: This study used 201 cases, comparing ChatGPT4 to Isabel Pro. Systems inputs were identical. Mean Reciprocal Rank (MRR) compares the correct diagnosis's rank between systems. Isabel Pro ranks by the frequency with which the symptoms appear in the reference dataset. The mechanism ChatGPT4 uses to rank the diagnoses is unknown. A Wilcoxon Signed Rank Sum test failed to reject the null hypothesis. RESULTS: Both systems p

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Molecular mechanisms underlying the lifespan and healthspan benefits of dietary restriction across species

Jialin Fan, Yunpeng Xu · 2026 · Frontiers in Genetics

Dietary restriction (DR), defined as reduced caloric intake or selective limitation of specific nutrients without malnutrition, is one of the most robust interventions known to extend lifespan and healthspan across species. Studies from yeast to mammals demonstrate that DR elicits conserved genetic, transcriptional, and epigenetic programs that promote cellular maintenance and stress resistance. At the molecular level, DR engages evolutionarily conserved nutrient-sensing pathways, including insulin/IGF-1 signaling (IIS), the mechanistic target of rapamycin (mTOR), AMP-activated protein kinase

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Stride Velocity 95 th Centile Detects Decline in Ambulatory Function Over Shorter Intervals than the 6-Minute Walk Test or North Star Ambulatory Assessment in Duchenne Muscular Dystrophy

Michael Rabbia, Maitea Guridi Ormazabal, Hannah Staunton et al. · 2024 · Journal of Neuromuscular Diseases

Background: Stride Velocity 95th Centile (SV95C) is the first wearable device-derived clinical outcome assessment (COA) to receive European Medicines Agency (EMA) qualification as a primary endpoint in ambulant patients with Duchenne muscular dystrophy (DMD) aged ≥4 years. Objective: To compare SV95C-in its first-ever clinical trial application as a secondary endpoint-with established motor function COAs used in the trial (Four-Stair Climb [4SC] velocity, North Star Ambulatory Assessment [NSAA], and Six-Minute Walk Distance [6MWD]). Methods: SV95C was a secondary endpoint in a subset (n = 47)

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Negative / Null Result ReportOpen accessImmunology and Microbiology

Endometrial Microbiome and Reproductive Receptivity: Diverse Perspectives

Galina Stoyancheva, Nikolina Mihaylova, Maria Gerginova et al. · 2025 · International Journal of Molecular Sciences

The human endometrium, previously considered a sterile environment, is now recognized as a low-biomass but biologically active microbial niche critical to reproductive health. Advances in sequencing technologies, particularly shotgun metagenomics, have provided unprecedented insights into the taxonomic and functional complexity of the endometrial microbiome. While 16S rRNA sequencing has delineated the distinction between Lactobacillus-dominant and non-dominant microbial communities, shotgun metagenomics has revealed additional diversity at the species and strain level, uncovering microbial si

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Negative / Null Result ReportOpen accessDecision Sciences

The suspension of morality in organisations: Conceptualising organisational moral disengagement and testing its role in relation to unethical behaviours and silence

Roberta Fida, Irene Skovgaard‐Smith, Claudio Barbaranelli et al. · 2024 · Human Relations

While considerable attention has been devoted to understanding how individual characteristics influence unethical actions, far less research has examined the role of social and organisational processes. We introduce the concept of organisational moral disengagement (OrgMD), drawing on Bandura’s moral agency theory, to explain how unethicality may be fostered in organisations. OrgMD is a multilevel construct, capturing perceptions of the mechanisms through which morality can be suspended in an organisation allowing unethical practices to flourish. Using four empirical studies, we validated OrgM

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Pancreatic cancer: molecular pathogenesis and emerging therapeutic strategies

Enrique Rozengurt, G. Eibl · 2026 · Signal Transduction and Targeted Therapy

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease for which there is no effective treatment. A deep understanding of the mechanisms underlying the molecular pathogenesis, signaling pathways and risk factors leading to PDAC is of paramount importance for identifying novel targets, prognostic markers, preventive strategies, and signature markers for use in specific and personalized therapeutic procedures. Activating somatic mutations in the KRAS oncogene play a critical role in PDAC initiation and maintenance. Here, we highlight the complex interplay between KRAS signaling, the tr

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Negative / Null Result Report

Did an Ultra-Low Emissions Policy on Coal-Fueled Thermal Power Reduce the Harmful Emissions? Evidence from Three Typical Air Pollutants Abatement in China

Penghao Ye, Senmao Xia, Yu Xiong et al. · 2020 · International Journal of Environmental Research and Public Health

Thermal power generation based on coal-fired power plants has the advantages of stability and controllability and has been the largest source of electricity supply in China. Coal-fired power plants, however, are also accompanied by high…

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Negative / Null Result ReportOpen accessMedicine

Interferon-α2b spray inhalation did not shorten virus shedding time of SARS-CoV-2 in hospitalized patients: a preliminary matched case-control study

Shao-rui Hao, Yan Ren, Shan-yan Zhang et al. · 2020 · Journal of Zhejiang University SCIENCE B

BACKGROUND: Currently, there are no drugs that have been proven to be effective against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Because of its broad antiviral activity, interferon (IFN) should be evaluated as a…

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Negative / Null Result Report

Skin‐to‐skin contact during eye examination did not reduce pain compared to standard care with parental support in preterm infants

Laila Kristoffersen, Ragnhild Støen, Håkon Bergseng et al. · 2019 · Acta Paediatrica

Abstract Aim We compared the pain relieving effect of skin‐to‐skin contact versus standard care in the incubator during screening for retinopathy of prematurity. Methods This randomised crossover study included 35 preterm infants of less…

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Negative / Null Result ReportOpen accessMedicine

Effect of high-volume hemofiltration on children with sepsis

Botao Ning, Sheng Ye, Yi Lyu et al. · 2020 · Translational Pediatrics

BACKGROUND: Sepsis has always been a challenge in pediatric intensive care unit (PICU) with poor prognosis. In order to evaluate the effect between routine continuous renal replacement therapy (CRRT) and high-volume hemofiltration (HVHF)…

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Negative / Null Result ReportOpen accessMedicine

Outcome is unchanged by adding vincristine upfront to the Malawi 28‐day protocol for endemic Burkitt lymphoma

Sarita Depani, Kondwani Joseph Banda, Simon Bailey et al. · 2015 · Pediatric Blood & Cancer

BACKGROUND: We previously reported a 28-day treatment protocol for children with endemic Burkitt lymphoma (BL) which included four doses of cyclophosphamide (CPM), intrathecal methotrexate and hydrocortisone (IT MTX/HC) at Queen Elizabeth…

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Negative / Null Result ReportOpen accessMedicine

Effects of Changes in the Levels of Damage-Associated Molecular Patterns Following Continuous Veno–Venous Hemofiltration Therapy on Outcomes in Acute Kidney Injury Patients With Sepsis

Jie Wu, Jianan Ren, Qinjie Liu et al. · 2019 · Frontiers in Immunology

Background: Continuous veno–venous hemofiltration (CVVH) could influence immunomodulation by cytokine removal. Damage-associated molecular patterns (DAMPs) are released by injured cells and have roles in sepsis. We investigated if the magnitude of DAMPs removal was associated with mortality in patients with sepsis undergoing CVVH. Methods: We conducted a prospective, observational study on patients acquiring CVVH at department of surgery, Jinling Hospital. Circulating levels of DAMPs (mitochondrial DNA [mtDNA]; nuclear DNA [nDNA]; heat shock protein [HSP]70) and cytokines were measured at the

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Negative / Null Result Report

Can we find the right balance in cause‐related marketing? Analyzing the boundaries of balance theory in evaluating brand‐cause partnerships

Joseph T. Yun, Brittany R. L. Duff, Patrick Vargas et al. · 2019 · Psychology & Marketing

Abstract Cause‐related marketing (CRM) refers to the phenomenon where brands partner with causes, such as nonprofit organizations. Consumers may see some CRM partnerships as less compatible than others, however the level of perceived…

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Negative / Null Result ReportOpen accessMedicine

The effects of midazolam or propofol plus fentanyl on ICU mortality: a retrospective study based on the MIMIC-IV database

Wen Sun, Yan Yang, Shidong Hu et al. · 2022 · Annals of Translational Medicine

Background: Patients in the intensive care unit (ICU) are often under stress and fail to cooperate well with invasive treatments. Analgesia and sedation are of great significance for reducing the suffering of patients and ensuring the…

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Negative / Null Result ReportOpen accessMedicine

Nebulized heparin and salbutamol versus salbutamol alone in acute exacerbations of chronic obstructive pulmonary disease requiring mechanical ventilation: a double-blind randomized controlled trial

Tarek Mohamed Ashoor, Ahmad Mahmoud Hasseb, Ibrahim M. Esmat · 2020 · Korean journal of anesthesiology

Background: Nebulized heparin has been effectively used in the management of many pulmonary diseases. However, its effect on mechanically ventilated patients with acute exacerbation chronic obstructive pulmonary disease (AECOPD) has never…

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Negative / Null Result ReportOpen accessMedicine

A comparison of different vitrification devices and the effect of blastocoele collapse on the cryosurvival of <i>in vitro</i> produced porcine embryos

Louise Katherine Bartolac, Jenna Lowe, George Koustas et al. · 2015 · Journal of Reproduction and Development

The aim of this study was to determine the optimum conditions for vitrifying in vitro produced day 7 porcine embryos using different vitrification devices and blastocoele collapse methods. Firstly embryos were collapsed by micro-pipetting,…

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Negative / Null Result ReportOpen accessMedicine

No significant association of serum klotho concentration with blood pressure and pulse wave velocity in a Chinese population

Wanying Liang, Lihong Wang, Jian‐Hang Wei et al. · 2021 · Scientific Reports

Klotho, an important anti-aging protein, may be related to elevated blood pressure (BP) and arterial stiffness. We aimed to investigate associations between the serum klotho concentration and peripheral/central BP and arterial stiffness based on the carotid-femoral pulse wave velocity (cfPWV) in a Chinese population. We invited all inhabitants aged ≥ 18 years in two Dali communities for participation. The SphygmoCor system was used to record radial arterial waveforms. Aortic waveforms were derived using a generalized transfer function. The central BP was assessed by calibrating the brachial BP

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