Systemic Influences of Mammary Cancer on Monocytes in Mice
Amy Robinson; Matthew Burgess; Sheila Webb; Pieter A. Louwe; Zhengyu Ouyang; Dylan Skola; Claudia Z. Han; Nizar N. Batada · 2022 · Cancers
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
There is a growing body of evidence that cancer causes systemic changes. These influences are most evident in the bone marrow and the blood, particularly in the myeloid compartment. Here, we show that there is an increase in the number of bone marrow, circulating and splenic monocytes by using mouse models of breast cancer caused by the mammary epithelial expression of the polyoma middle T antigen. Cancer does not affect ratios of classical to non-classical populations of monocytes in the circulation nor does it affect their half-lives. Single cell RNA sequencing also indicates that cancer doe
Abstract by Amy Robinson; Matthew Burgess; Sheila Webb; Pieter A. Louwe; Zhengyu Ouyang; Dylan Skola; Claudia Z. Han; Nizar N. Batada, Cancers (2022) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3390/cancers14030833