Negative / Null Result ReportOpen accessMedicine
Akio Kôyama, Toshiro Fujita, Fumitake Gejyo et al. · 2015 · BMC Nephrology
BACKGROUND: Evidence increasingly points to the importance of chronic hypoxia in the tubulointerstitium as a final common pathway to end-stage renal disease (ESRD). Beraprost sodium (BPS) is an orally active prostacyclin (PGI2) analogue demonstrating prevention of the progression of chronic kidney disease (CKD) in various animal models by maintaining renal blood flow and attenuating renal ischemic condition. METHODS: This multicenter, randomized, double-blind, placebo-controlled, phase II trial was designed to determine the recommended dose of the sustained-release form of BPS (TRK-100STP 120
View details →Negative / Null Result Report
Ian G Barr, Cleve Rynehart, Paul Whitney et al. · 2020 · Eurosurveillance
The advent of COVID-19, has posed a risk that human respiratory samples containing human influenza viruses may also contain SARS-CoV-2. This potential risk may lead to SARS-CoV-2 contaminating conventional influenza vaccine production…
View details →Negative / Null Result ReportOpen accessMedicine
Curtis J. Henry, Rebecca L. Sedjo, Andrii I. Rozhok et al. · 2015 · BMC Cancer
BACKGROUND: Inflammatory cytokines in the colonic microenvironment have been shown to increase with advance colorectal cancer disease state. However, the contribution of inflammatory cytokines to pre-malignant disease, such as the formation of adenomas, is unclear. METHODS: Using the Milliplex® MAP Human Cytokine/ Chemokine Magnetic Bead Panel Immunoassay, serum cytokine and chemokine profiles were assayed among participants without an adenoma (n = 97) and those with an adenoma (n = 97) enrolled in the NCI-funded Insulin Resistance Atherosclerosis Colon Study. The concentrations of interleukin
View details →Negative / Null Result ReportMedicine
Wen-Jyi Lo, Wen Shin Chang, Han-Fang Hsu et al. · 2017 · PubMed
Mounting evidence supports the notion that inflammatory processes play a role in carcinogenesis, and interleukin-10 (IL10) is an important inflammatory cytokine. This study aimed to evaluate the contribution of IL10 A-1082G (rs1800896),…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Caroline R. Amendola, William T. Cordell, Colin M. Kneucker et al. · 2023 · Metabolic Engineering
Pseudomonas putida KT2440 is a robust, aromatic catabolic bacterium that has been widely engineered to convert bio-based and waste-based feedstocks to target products. Towards industrial domestication of P. putida KT2440, rational genome…
View details →Negative / Null Result Report
Jamal T. Maalouf, James Combs, William E. Gillis et al. · 2020 · Journal of Knowledge Management
Purpose The purpose of this paper is to introduce strategy as a factor that explains when franchisors – through the franchisees they select – seek to replicate routines exactly versus allow local adaptation of routines.…
View details →Negative / Null Result ReportOpen accessComputer Science
Shervin Malmasi · 2016 · Figshare
The prediction of an author's native language using only their second language writing -- a task called Native Language Identification (NLI) -- is usually tackled using supervised classification. This is underpinned by the presupposition…
View details →Negative / Null Result ReportOpen accessNeuroscience
Amit Walia, Matthew Shew, Jordan Varghese et al. · 2023 · JAMA Otolaryngology–Head & Neck Surgery
Importance: Cochlear implantation produces remarkable results in postlingual deafness, although auditory outcomes vary. Electrocochleography (ECochG) has emerged as a valuable tool for assessing the cochlear-neural substrate and evaluating…
View details →Negative / Null Result ReportMedicine
Haruo Ohtani, Hiroyasu Ishida, Yuka Ito et al. · 2011 · Pathology International
Autoimmune pancreatitis (AIP) (also called IgG4-related sclerosing pancreatitis (IgG4-SP)) and IgG4-related sclerosing cholangitis (IgG4-SC) are frequently associated with each other. It is generally believed that association of these…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Liza C. Villaruz, Grace Huang, Marjorie Romkes et al. · 2015 · Clinical Epigenetics
BACKGROUND: Carboplatin/paclitaxel (CP), with or without sorafenib, result in objective response rates of 18-20 % in unselected chemotherapy-naïve patients. Molecular predictors of survival and response to CP-based chemotherapy in metastatic melanoma (MM) are critical to improving the therapeutic index. Intergroup trial E2603 randomized MM patients to CP with or without sorafenib. Expression data were collected from pre-treatment formalin-fixed paraffin-embedded (FFPE) tumor tissues from 115 of 823 patients enrolled on E2603. The selected patients were balanced across treatment arms, BRAF stat
View details →Negative / Null Result ReportOpen accessMedicine
Manish A. Shah, Kohei Shitara, Florian Lordick et al. · 2022 · Clinical Cancer Research
PURPOSE: To compare napabucasin (generator of reactive oxygen species) plus paclitaxel with paclitaxel only in patients with second-line advanced gastric or gastroesophageal junction (GEJ) adenocarcinoma. EXPERIMENTAL DESIGN: In the…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Nathalie Goemans, M. Tulinius, Anna‐Karin Kroksmark et al. · 2016 · Neuromuscular Disorders
Duchenne muscular dystrophy is a rare genetic disorder with life-limiting pathology. Drisapersen induces exon 51 skipping, thereby producing a shorter but functional dystrophin protein. The longest available data are from an open-label…
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Patricia Burns, Gabriel Vinderola, Jorge Reinheimer et al. · 2011 · Journal of Dairy Research
The capacity of lactic acid bacteria to produce exopolysaccharides (EPS) conferring microorganisms a ropy phenotype could be an interesting feature from a technological point of view. Progressive adaptation to bile salts might render some…
View details →Failed Experiment ReportOpen accessMedicine
Kalpana Rajanala, Farokh Dotiwala, Arun K. Upadhyay · 2023 · Frontiers in Ophthalmology
Geographic atrophy (GA) is an advanced stage of age-related macular degeneration (AMD) that leads to gradual and permanent vision loss. GA is characterized by the loss of photoreceptor cells and retinal pigment epithelium (RPE), leading to distinct atrophic patches in the macula, which tends to increase with time. Patients with geographic atrophy often experience a gradual and painless loss of central vision, resulting in difficulty reading, recognizing faces, or performing activities that require detailed vision. The primary risk factor for the development of geographic atrophy is advanced ag
View details →Negative / Null Result ReportOpen accessMedicine
Bishwajit Bhowmik, Tasnima Siddiquee, Ibrahimu Mdala et al. · 2021 · Diabetes Research and Clinical Practice
AIM: To assess the efficacy of vitamin D3 or B12 supplementation during pregnancy. METHODS: Pregnant women at 6-14 weeks in the intervention arm received oral high dose intermittent vitamin D3 and/or low dose B12 supplementation if they…
View details →Negative / Null Result ReportOpen accessMedicine
Graham Jackson, Charlotte Pawlyn, David A. Cairns et al. · 2020 · British Journal of Haematology
Second-generation immunomodulatory agents, such as lenalidomide, have a more favourable side-effect profile than the first-generation thalidomide, but their optimum combination and duration for patients with newly diagnosed transplant-ineligible myeloma (ND-TNE-MM) has not been defined. The most appropriate delivery and dosing regimens of these therapies for patients at advanced age and frailty status is also unclear. The Myeloma XI study compared cyclophosphamide, thalidomide and dexamethasone (CTDa) to cyclophosphamide, lenalidomide and dexamethasone (CRDa) as induction therapy, followed by
View details →Failed Experiment ReportOpen accessMedicine
Maria Fortunata Lofiego, Francesca Piazzini, Francesca Pia Caruso et al. · 2024 · Journal of Translational Medicine
BACKGROUND: Glioblastoma multiforme (GBM) is a highly aggressive primary brain tumor, that is refractory to standard treatment and to immunotherapy with immune-checkpoint inhibitors (ICI). Noteworthy, melanoma brain metastases (MM-BM), that share the same niche as GBM, frequently respond to current ICI therapies. Epigenetic modifications regulate GBM cellular proliferation, invasion, and prognosis and may negatively regulate the cross-talk between malignant cells and immune cells in the tumor milieu, likely contributing to limit the efficacy of ICI therapy of GBM. Thus, manipulating the tumor
View details →Negative / Null Result ReportAgricultural and Biological Sciences
Zuzana Sýkorová, Jana Rydlová, Renata Slavíková et al. · 2015 · Restoration Ecology
An extensive field trial was established on a fly ash deposit (1) to evaluate whether the inoculation with arbuscular mycorrhizal fungi ( AMF ) and/or ectomycorrhizal fungi ( EcMF ) improves growth and survival of 13 planted tree species…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Beau J. Fenner, Jonathan F. Russell, Arlene V. Drack et al. · 2023 · Frontiers in Medicine
Introduction X-linked retinoschisis (XLRS) is an inherited retinal disease (IRD) caused by pathogenic mutations in the retinoschisin gene, RS1 . Affected individuals develop retinal layer separation, leading to loss of visual acuity (VA). Several XLRS gene therapy trials have been attempted but none have met their primary endpoints. An improved understanding of XLRS natural history and clinical outcomes may better inform future trials. Here, we report the long-term functional and structural outcomes of XLRS and the relevance of RS1 genotypes to the visual prognosis of affected individuals. Met
View details →Negative / Null Result ReportOpen accessMedicine
Jianli Lv, Bo Han, Cuiyan Wang et al. · 2019 · Frontiers in Pediatrics
Objective To investigate the clinical features and the diagnostic and follow-up value of acute fulminant myocarditis (AFM) in children. Methods 20 children diagnosed with AFM admitted to our department were reviewed, and the clinical manifestations; pathogenic examination results; myocardial injury biomarkers; and electrocardiography, echocardiogram and cardiovascular magnetic resonance (CMR) results were analyzed. Results The initial symptoms were abdominal pain, vomiting, fatigue, syncope, and convulsions. All children had significantly increased hs-cTnT and NT-pro BNP. In addition to nonspe
View details →Negative / Null Result ReportOpen accessMedicine
Sarah S. Mougalian, Ronda Copher, Jonathan Kish et al. · 2018 · Cancer Medicine
INTRODUCTION: Real-world data are critical to demonstrate the consistency of evidence and external generalizability of randomized controlled trials (RCTs). This study examined characteristics and outcomes of metastatic triple-negative breast cancer (mTNBC) patients treated with eribulin mesylate at community oncology practices in the United States. METHODS: Physicians identified mTNBC patients initiating eribulin between 1 January 2011 and 1 January 2014 and abstracted data into an electronic case report form (eCRF). Eribulin treatment in the metastatic setting was categorized as early use (EU
View details →Negative / Null Result ReportOpen accessMedicine
Robert Stuver, Steven M. Horwitz, Ranjana H. Advani et al. · 2023 · British Journal of Haematology
There remains no one standard induction for nodal-based peripheral T-cell lymphoma (PTCL). We conducted a phase II study of lenalidomide plus CHOEP as a novel induction strategy. Patients received CHOEP at standard doses in combination…
View details →Negative / Null Result ReportOpen accessMedicine
Jayson L. Parker, Zoe Yi Zhang, Rena Buckstein · 2011 · Journal of Pharmacy & Pharmaceutical Sciences
PURPOSE: To quantify the clinical trial risk of new drug development in Non-Hodgkin's lymphoma (NHL). Risk estimates for this disease have not been reported before. METHODS: We undertook a retrospective review of clinical trials in (NHL) in four subtypes to compare the success rate with the industry average. Our inclusion criteria required that a drug must initiate its phase I trial in one of the four NHL subtypes between 1998 and June 2008 in the US. In addition, clinical trials of new drug candidates that pertain to four subtypes of NHL were retrieved from clinicaltrial.gov. Drug candidates
View details →Negative / Null Result ReportOpen accessNursing
Gilberto Friedman, Cecilia Lopes Flávia Couto, Maicon Becker · 2015 · Indian Journal of Critical Care Medicine
BACKGROUND AND AIMS: Studies comparing jejunal and gastric nutrition show inconsistent results regarding pneumonia. The aim of this study was to evaluate the incidence of pneumonia comparing gastric with jejunal nutrition. Secondarily, we…
View details →Negative / Null Result ReportOpen accessMedicine
Kota Ogawa, Akiko Noda, Jun Ueda et al. · 2020 · Cellular & Molecular Biology Letters
BACKGROUND: Animal model studies show that reductive stress is involved in cardiomyopathy and myopathy, but the exact physiological relevance remains unknown. In addition, the microRNAs miR-143 and miR-145 have been shown to be upregulated in cardiac diseases, but the underlying mechanisms associated with these regulators have yet to be explored. METHODS: We developed transgenic mouse lines expressing exogenous miR-143 and miR-145 under the control of the alpha-myosin heavy chain (αMHC) promoter/enhancer. RESULTS: The two transgenic lines showed dilated cardiomyopathy-like characteristics and
View details →Negative / Null Result Report
Jacques Demongeot, Hervé Seligmann · 2020 · Scientific Reports
Abstract Ribosomal RNAs are complex structures that presumably evolved by tRNA accretions. Statistical properties of tRNA secondary structures correlate with genetic code integration orders of their cognate amino acids. Ribosomal RNA…
View details →Negative / Null Result Report
Naiyue Hu, Chenghang Du, Wanqing Zhang et al. · 2022 · Agronomy
Grain yield and quality of wheat are both important components for food security. Great effort has been made in the genetic improvement of wheat grain yield in China. However, wheat grain quality (i.e., protein concentration and protein…
View details →Negative / Null Result Report
Christoph Alexander Rüst, Romuald Lepers, Thomas Rosemann et al. · 2014 · SpringerPlus
Abstract This study investigated the change in sex differences across years in ultra-distance swimming performances at the 36-km ‘Maratona del Golfo Capri-Napoli’ race held from 1954 to 2013. Changes in swimming performance of 662 men and…
View details →Negative / Null Result Report
Christina Thunberg, Mari S. Messel, Liisa Raud et al. · 2020 · Scientific Reports
Abstract The ability to cancel an already initiated response is central to flexible behavior. While several different behavioral and neural markers have been suggested to quantify the latency of the stopping process, it remains unclear if…
View details →Negative / Null Result Report
Elisa Molinari, Shalabh Srivastava, Rebecca M. Dewhurst et al. · 2020 · BMC Nephrology
Abstract Background PKHD1 is the main genetic cause of autosomal recessive polycystic kidney disease (ARPKD), a hereditary hepato-renal fibrocystic disorder which is the most important cause of end-stage renal disease during early…
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