Development of a digital twin of a tablet that mimics a real solid dosage form: Differences in the dissolution profile in conventional mini-USP II and a biorelevant colon model
Michael Schütt; Konstantinos Stamatopoulos; Hannah Batchelor; Mark Simmons; Alessio Alexiadis · 2022 · European Journal of Pharmaceutical Sciences
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
The performance of colon-targeted solid dosage forms is commonly assessed using standardised pharmacopeial dissolution apparatuses like the USP II or the miniaturised replica, the mini-USP II. However, these fail to replicate the hydrodynamics and shear stresses in the colonic environment, which is crucial for the tablet's drug release process. In this work, computer simulations are used to create a digital twin of a dissolution apparatus and to develop a method to create a digital twin of a tablet that behaves realistically. These models are used to investigate the drug release profiles and s
Abstract by Michael Schütt; Konstantinos Stamatopoulos; Hannah Batchelor; Mark Simmons; Alessio Alexiadis, European Journal of Pharmaceutical Sciences (2022) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1016/j.ejps.2022.106310