Systemic Activation of TLR3-Dependent TRIF Signaling Confers Host Defense against Gram-Negative Bacteria in the Intestine
Jose Ruiz; Saravana Kanagavelu; Claudia Flores; Laura Romero; Reldy Riveron; David Q. Shih; Masayuki Fukata · 2016 · Frontiers in Cellular and Infection Microbiology
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Abstract
Recognition of Gram-negative bacteria by toll-like receptor (TLR)4 induces MyD88 and TRIF mediated responses. We have shown that TRIF-dependent responses play an important role in intestinal defense against Gram-negative enteropathogens. In the current study, we examined underlying mechanisms of how systemic TRIF activation enhances intestinal immune defense against Gram-negative bacteria. First we confirmed that the protective effect of poly I:C against enteric infection of mice with Yersinia enterocolitica was dependent on TLR3-mediated TRIF signaling by using TLR3-deficient mice. This prote
Abstract by Jose Ruiz; Saravana Kanagavelu; Claudia Flores; Laura Romero; Reldy Riveron; David Q. Shih; Masayuki Fukata, Frontiers in Cellular and Infection Microbiology (2016) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3389/fcimb.2015.00105