21,222 real negative results, null findings, and replication failures. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Tyler Greer, Qiang Hao, Mengguo Jing et al. · 2019
This replication study aims at both quantifying the effects of active learning classrooms in introductory programming courses (CS1) and overcoming some design and methodological limits of prior studies on this topic. 156 students enrolled…
View details →Uğur Demirel, Handan Çam, Ramazan Ünlü · 2020 · GAZI UNIVERSITY JOURNAL OF SCIENCE
Stock market prediction in financial and commodity markets is a major challenge for speculators, investors, and companies but also profitable with an accurate prediction. Thus, obtaining accurate prediction results becomes extremely…
View details →Joseph Rigdon, Sanjay Basu · 2019 · BMJ Open
OBJECTIVES: We aimed to test whether or not adding (1) nutrition predictor variables and/or (2) using machine learning models improves cardiovascular death prediction versus standard Cox models without nutrition predictor variables.…
View details →Kevin van Schie, Arne Leer · 2019 · Clinical Psychological Science
In this direct replication of Houben, Otgaar, Roelofs, and Merckelbach ( Clinical Psychological Science, 6, 610–616, 2018), we tested whether making eye movements during memory recall increases susceptibility to creating false memories.…
View details →Matthew Rueben, Frank J. Bernieri, Cindy Grimm et al. · 2017
Privacy-sensitive robotics is an emerging area of HRI research. Judgments about privacy would seem to be context-dependent, but none of the promising work on contextual "frames" has focused on privacy concerns. This work studies the impact…
View details →Simon Ruch, Flavio Jean Schmidig, Leona Knüsel et al. · 2022 · NeuroImage
Slow-wave sleep is the deep non-rapid eye-movement (NREM) sleep stage that is most relevant for the recuperative function of sleep. Its defining property is the presence of slow oscillations (<2 Hz) in the scalp electroencephalogram (EEG). Slow oscillations are generated by a synchronous back and forth between highly active UP-states and silent DOWN-states in neocortical neurons. Growing evidence suggests that closed-loop sensory stimulation targeted at UP-states of EEG-defined slow oscillations can enhance the slow oscillatory activity, increase sleep depth, and boost sleep's recuperative fun
View details →Ahmed M. Eissa, Flavio Barros, Pavle Vrljicak et al. · 2018 · Biomacromolecules
Novel approaches for culturing primary human cells in vitro are increasingly needed to study cell and tissue physiology and to grow replacement tissue for regenerative medicine. Conventional 2D monolayer cultures of endometrial epithelial…
View details →Xinwu Qian, Lijun Sun, Satish V. Ukkusuri · 2021 · Scientific Reports
Improved mobility not only contributes to more intensive human activities but also facilitates the spread of communicable disease, thus constituting a major threat to billions of urban commuters. In this study, we present a multi-city investigation of communicable diseases percolating among metro travelers. We use smart card data from three megacities in China to construct individual-level contact networks, based on which the spread of disease is modeled and studied. We observe that, though differing in urban forms, network layouts, and mobility patterns, the metro systems of the three cities
View details →Thit Mynster Kronborg, Robert Schierwagen, Kajetan Trôst et al. · 2023 · Hepatology Communications
BACKGROUND: Patients with cirrhosis and portal hypertension face a high risk of complications. Besides their anti-inflammatory and antifibrotic effects, statins may reduce portal pressure and thus the risk of complications and mortality.…
View details →Ruhul Salim, Kamrul Hassan, Sanzidur Rahman · 2019 · Applied Economics
This study aims to investigate dynamic relationships between research and development (R&D) expenditure, climate change (measured by annual rainfall and temperature variations), human capital (proxied by literacy) and total factor…
View details →Quentin J. Leclerc, Jodi A. Lindsay, Gwenan M. Knight · 2022 · PLoS Computational Biology
Bacteriophage (phage) are bacterial predators that can also spread antimicrobial resistance (AMR) genes between bacteria by generalised transduction. Phage are often present alongside antibiotics in the environment, yet evidence of their joint killing effect on bacteria is conflicted, and the dynamics of transduction in such systems are unknown. Here, we combine in vitro data and mathematical modelling to identify conditions where phage and antibiotics act in synergy to remove bacteria or drive AMR evolution. We adapt a published model of phage-bacteria dynamics, including transduction, to add
View details →Mark J. Ducey, John Gunn, Andrew A. Whitman · 2013 · Forests
Restoration of old-growth forest structure is an emerging silvicultural goal, especially in those regions where old-growth abundance falls below the historic range of variability. However, longitudinal studies of old-growth dynamics that can inform silvicultural and policy options are few. We analyzed the change in structure, including stand density, diameter distribution, and the abundance of large live, standing dead, and downed dead trees on 58 late-successional and old-growth plots in Maine, USA, and compared these to regional data from the U.S. Forest Inventory and Analysis program. Struc
View details →Alan L. Ho, Eric J. Sherman, Shrujal S. Baxi et al. · 2016 · Journal of Clinical Oncology
6096 Background: Recurrent/metastatic adenoid cystic carcinoma (R/M ACC) is incurable. Regorafenib (BAY 73-4506; Bayer) is a tyrosine kinase inhibitor (TKI) that targets receptor tyrosine kinases (RTKs), including vascular endothelial…
View details →Tugba Nilay Kulaksız, Şükran Nazan Koşar, Süleyman Bulut et al. · 2016 · Nutrients
The carbohydrate (CHO) concentration of a mouth rinsing solution might influence the CHO sensing receptors in the mouth, with consequent activation of brain regions involved in reward, motivation and regulation of motor activity. The purpose of the present study was to examine the effects of maltodextrin mouth rinsing with different concentrations (3%, 6% and 12%) after an overnight fast on a 20 km cycling time trial performance. Nine recreationally active, healthy males (age: 24 ± 2 years; V ˙ O 2 m a x : 47 ± 5 mL·kg(-1)·min(-1)) participated in this study. A double-blind, placebo-controlled
View details →Rokshana Parvin, Jan Schinkoethe, Christian Grund et al. · 2020 · Veterinary Research
An intravenous pathogenicity index (IVPI) of > 1.2 in chickens or, in case of subtypes H5 and H7, expression of a polybasic hemagglutinin cleavage site (HACS), signals high pathogenicity (HP). Viruses of the H9N2-G1 lineage, which spread across Asia and Africa, are classified to be of low pathogenicity although, in the field, they became associated with severe clinical signs and epizootics in chickens. Here we report on a pre-eminent trait of recent H9N2-G1 isolates from Bangladesh and India, which express a tribasic HACS (motif PAKSKR-GLF; reminiscent of an HPAIV-like polybasic HACS) and comp
View details →Ludo Waltman, Vincent A. Traag · 2021 · F1000Research
Most scientometricians reject the use of the journal impact factor for assessing individual articles and their authors. The well-known San Francisco Declaration on Research Assessment also strongly objects against this way of using the…
View details →Yukiko Morimoto, Gertraud Maskarinec, Song‐Yi Park et al. · 2014 · British Journal Of Nutrition
Given the high intake levels of soya and low incidence rates of breast cancer in Asian countries, isoflavones, substances with an oestrogen-like structure occurring principally in soyabeans, are postulated to be cancer protective. In the…
View details →Habiba S. Al Safar, Heather J. Cordell, Osman Jafer et al. · 2013 · Annals of Human Genetics
Twenty percent of people aged 20 to 79 have type 2 diabetes (T2D) in the United Arab Emirates (UAE). Genome-wide association studies (GWAS) to identify genes for T2D have not been reported for Arab countries. We performed a discovery GWAS…
View details →Nana Ama Amissah, Sophie Gryseels, Nicholas J. Tobias et al. · 2014 · PLoS neglected tropical diseases
BACKGROUND: The reservoir and mode of transmission of Mycobacterium ulcerans, the causative agent of Buruli ulcer, still remain a mystery. It has been suggested that M. ulcerans persists with difficulty as a free-living organism due to its natural fragility and inability to withstand exposure to direct sunlight, and thus probably persists within a protective host environment. METHODOLOGY/PRINCIPAL FINDINGS: We investigated the role of free-living amoebae as a reservoir of M. ulcerans by screening the bacterium in free-living amoebae (FLA) cultures isolated from environmental specimens using re
View details →Thomas Muelleman, Jeremy Peterson, Naweed I. Chowdhury et al. · 2015 · Journal of Neurological Surgery Part B Skull Base
Objectives To determine the utility of three-dimensional (3D) printed models in individualized petroclival tumor resection planning by measuring the fidelity of printed anatomical structures and comparing tumor exposure afforded by…
View details →Adrian T. Davis, Heidi Israel, Lisa K. Cannada et al. · 2012 · Journal of Orthopaedic Trauma
OBJECTIVES: The purpose of this study was to test the biomechanical properties of locking and nonlocking plates using one-third tubular and periarticular plate designs in an osteoporotic distal fibula fracture model. METHODS: Twenty-four…
View details →Tomoya Mizuno, Takao Kamai, Hideyuki Abe et al. · 2015 · BMC Cancer
BACKGROUND: The relationship between the clinicopathological features and molecular changes associated with standardized uptake value (SUV) determined by Positron emission tomography (PET) with [18F] fluorodeoxyglucose (18F-FDG PET) in human renal cell carcinoma (RCC) has not been elucidated. On the other hand, overactivation of the phosphatidylinositol 3'kinase (PI3K), serine/threonine kinase Akt, and mammalian target of rapamycin (mTOR) pathway has been detected in a variety of human cancers, including RCC. So far, little is known about the relationship between the SUV and these proteins in
View details →Yukie Fujimoto, Natsuko Inoue, Koji Morimoto et al. · 2019 · Cancer Science
Analysis of anticancer immunity aids in assessing the prognosis of patients with breast cancer. From 250 operated breast cancers, we focused on serum levels of C-C motif chemokine ligand 5 (CCL5), which is involved in cancer immune…
View details →Andrew B. Speer, Neil Douglas Christiansen, Chet Robie et al. · 2021 · Journal of Applied Psychology
The use of personality measures to predict work-related outcomes has been of great interest over the past several decades. The present study used machine learning (ML) to examine the optimal level in the personality hierarchy to use in…
View details →Weijun Wang, Zong‐Han Liu, Kang Wang et al. · 2023 · Cancer Medicine
BACKGROUND: There is no consensus on the optimal regimen for unresectable recurrent hepatocellular carcinoma (HCC), so this retrospective study aimed to evaluate the efficacy and safety of transarterial chemoembolization (TACE) combined with lenvatinib and PD-1 inhibitors (T-L-P) versus TACE combined with lenvatinib (T-L) or TACE alone. METHOD: Data were collected from 204 patients with unresectable recurrent HCC who received T-L-P, T-L, or TACE alone at three medical centers from January, 2019 to December, 2020 for analysis. The survival outcomes, tumor response, and adverse events were compa
View details →Lucinda L. van Stee, Sarah E. Boston, Ameet Singh et al. · 2015 · Veterinary Surgery
OBJECTIVE: To assess the outcome of canine splenic lymphoma treated with splenectomy and to evaluate prognostic factors, including involvement of other sites, adjuvant chemotherapy, and the effect of World Health Organization (WHO)…
View details →Javier Pereda, Salvador Pérez, Javier Escobar et al. · 2012 · PLoS ONE
BACKGROUND: Obesity is a prognostic factor for severity in acute pancreatitis in humans. Our aim was to assess the role of oxidative stress and abdominal fat in the increased severity of acute pancreatitis in obese rats. METHODOLOGY: Taurocholate-induced acute pancreatitis was performed in lean and obese Zucker rats. Levels of reduced glutathione, oxidized glutathione, L-cysteine, cystine, and S-adenosylmethionine were measured in pancreas as well as the activities of serine/threonine protein phosphatases PP1 and PP2A and tyrosin phosphatases. Isoprostane, malondialdehyde, triglyceride, and fr
View details →Naveen Gupta, Ranjeet Sinha, Anna Krasnodembskaya et al. · 2018 · Stem Cells
Bone marrow derived mesenchymal stromal cells have been shown to have significant therapeutic effects in experimental models of pneumonia and lung injury. The current study examined the roles of the toll like receptor 4 (TLR4) and protease…
View details →James L. Alexander, Hajir Ibraheim, Bhavisha P. Sheth et al. · 2021 · Journal for ImmunoTherapy of Cancer
INTRODUCTION: Immune checkpoint inhibitors (CPIs) have changed the treatment landscape for many cancers, but also cause severe inflammatory side effects including enterocolitis. CPI-induced enterocolitis is treated empirically with corticosteroids, and infliximab (IFX) is used in corticosteroid-refractory cases. However, robust outcome data for these patients are scarce. METHODS: We conducted a multicenter (six cancer centers), cohort study of outcomes in patients treated with IFX for corticosteroid-refractory CPI-induced enterocolitis between 2007 and 2020. The primary outcome was corticoster
View details →Shota Hamada, Martin Gulliford · 2016 · Journal of the American Geriatrics Society
OBJECTIVES: To evaluate whether low glycosylated hemoglobin (HbA1c), blood pressure (BP), and total cholesterol (TC) are associated with lower risk of all-cause mortality in very old individuals with type 2 diabetes mellitus. DESIGN:…
View details →