21,222 real negative results, null findings, and replication failures. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Tzu‐Hsing Kuo, Julie A. Williams · 2014 · SLEEP
STUDY OBJECTIVES: Sleep is known to increase as an acute response to infection. However, the function of this behavioral response in host defense is not well understood. To address this problem, we evaluated the effect of acute sleep…
View details →Maxwell Akanbi, Chad J. Achenbach, Babafemi Taiwo et al. · 2017 · BMC Pulmonary Medicine
BACKGROUND: Xpert MTB/Rif (Xpert) is described as a game changer in tuberculosis (TB) control. We evaluated the impact of Xpert on diagnosis, time to treatment, and treatment outcome among patients with HIV associated TB in Nigeria. METHODS: Adults with HIV being evaluated for pulmonary TB (PTB) were consecutively enrolled into the study cohort. At baseline, expectorated sputa were examined using Xpert and smear microscopy for Mycobacterium tuberculosis (MTB) and acid fast bacilli, respectively. Patients diagnosed with TB were followed-up until 6 months post TB diagnosis. TB was defined as spu
View details →Catarina S. Lobo, Maria Inês P. Mendes, Diogo A. Pereira et al. · 2023 · Scientific Reports
Photodynamic therapy (PDT) with redaporfin stimulates colon carcinoma (CT26), breast (4T1) and melanoma (B16F10) cells to display high levels of CD80 molecules on their surfaces. CD80 overexpression amplifies immunogenicity because it increases same cell (cis) CD80:PD-L1 interactions, which (i) disrupt binding of T-cells PD-1 inhibitory receptors with their ligands (PD-L1) in tumour cells, and (ii) inhibit CTLA-4 inhibitory receptors binding to CD80 in tumour cells. In some cancer cells, redaporfin-PDT also increases CTLA-4 and PD-L1 expressions and virtuous combinations between PDT and immune
View details →Sabine Rauth, Dominik Hinz, Michael A. Borger et al. · 2016 · Biochemical Journal
Amyloid beta (Aβ) peptides, in particular Aβ42 and Aβ40, exert neurotoxic effects and their overproduction leads to amyloid deposits in the brain, thus constituting an important biomolecular target for treatments of Alzheimer's disease…
View details →Jason L. Pugh, Alona S. Sukhina, Thomas M. Seed et al. · 2014 · The Journal of Immunology
Lymphocytes are sensitive to ionizing radiation and naive lymphocytes are more radiosensitive than their memory counterparts. Less is known about radiosensitivity of memory cell subsets. We examined the radiosensitivity of naive (TN),…
View details →Tomáš Suchý, Martin Bartoš, Radek Sedláček et al. · 2021 · Materials
This study aims to point out the main drawback with respect to the design of simulated body environments. Three media commonly used for the simulation of the identical body environment were selected, i.e., Kokubo's simulated body fluid that simulates the inorganic component of human blood plasma, human blood plasma, and phosphate buffer saline. A comparison was performed of the effects of the media on collagen scaffolds. The mechanical and structural effects of the media were determined via the application of compression mechanical tests, the determination of mass loss, and image and micro-CT
View details →Stephanie Seneff, Robert Davidson, Jingjing Liu · 2012 · Entropy
Autism is a condition characterized by impaired cognitive and social skills, associated with compromised immune function. The incidence is alarmingly on the rise, and environmental factors are increasingly suspected to play a role. This…
View details →Marlin D Figgins, Trevor Bedford · 2026 · eLife
Accurately estimating relative transmission rates of SARS-CoV-2 variants remains a scientific and public health priority. Recent studies have used the sample proportions of different variants from genetic sequence data to describe variant frequency dynamics and relative transmission rates, but frequencies alone cannot capture the rich epidemiological behavior of SARS-CoV-2. Here, we extend methods for inferring the effective reproduction number of an epidemic using confirmed case data to jointly estimate variant-specific effective reproduction numbers and frequencies of co-circulating variants
View details →Felicia C. Goldstein, Angela F. Caveney, Vicki Hertzberg et al. · 2016 · Journal of Neurotrauma
A Phase III, double-blind, placebo-controlled trial (ProTECT III) found that administration of progesterone did not reduce mortality or improve functional outcome as measured by the Glasgow Outcome Scale Extended (GOSE) in subjects with…
View details →M. Roupret, Aurélie Bertaut, G. Pignot et al. · 2025 · Annals of Oncology
BACKGROUND: Standard treatment of high-risk non-muscle-invasive bladder cancer (NMIBC) after transurethral resection of bladder tumor is intravesical instillation with Bacillus Calmette-Guérin (BCG) (induction and maintenance regimens);…
View details →Yongliang Wang, Yumeng Guo · 2026 · Journal of Computer Assisted Learning
ABSTRACT Background The rise of artificial intelligence (AI) has reshaped English as Foreign Language (EFL) instruction, offering new opportunities for language learning. While much of the existing research focuses on AI integration in…
View details →Christof A. Leicht, Victoria L. Goosey‐Tolfrey, Nicolette C. Bishop · 2026 · PubMed
A spinal cord injury (SCI) can increase the risk of infection by impacting on many aspects of immune function; one particularly well-documented observation is a reduction in lymphocyte numbers. The vast majority of lymphoid cells express…
View details →Joost de Winter, Sebastiaan M. Petermeijer, Lars Kooijman et al. · 2021 · International Journal of Psychophysiology
Several papers by Eckhard Hess from the 1960s and 1970s report that the pupils dilate or constrict according to the interest value, arousing content, or mental demands of visual stimuli. However, Hess mostly used small sample sizes and undocumented luminance control. In a first experiment (N = 182) and a second preregistered experiment (N = 147), we replicated five studies of Hess using modern equipment. Our experiments (1) did not support the hypothesis of gender differences in pupil diameter change with respect to baseline (PC) when viewing stimuli of different interest value, (2) showed tha
View details →Chao Gao, Bin Zhu, Fan Ouyang et al. · 2025 · BMJ
Abstract Objectives To investigate whether a less intense antiplatelet regimen could be used for people receiving drug coated balloons. Design Multicentre, randomised, open label, assessor blind, non-inferiority trial (REC-CAGEFREE II).…
View details →Oisín Ryan, Jonas M B Haslbeck, Lourens Waldorp · 2025 · Multivariate Behavioral Research
Time series analysis is increasingly popular across scientific domains. A key concept in time series analysis is stationarity, the stability of statistical properties of a time series. Understanding stationarity is crucial to addressing frequent issues in time series analysis such as the consequences of failing to model non-stationarity, how to determine the mechanisms generating non-stationarity, and consequently how to model those mechanisms (i.e., by differencing or detrending). However, many empirical researchers have a limited understanding of stationarity, which can lead to the use of in
View details →Ahmed Samour, Riza Radmehr, Ernest Baba Ali et al. · 2024 · Heliyon
Given the alarming level of climate change, policymakers across the globe are seeking strategies to mitigate environmental pollution to achieve sustainable development. In this context, renewable energy and technological advancements have…
View details →Anne Lohr, Michael Sailer, Matthias Stadler et al. · 2024 · Teaching and Teacher Education
We investigated factors that are potentially associated with teaching and learning with digital technology, by replicating and extending Sailer, Murböck, and Fischer's (2021) study with a representative sample of 407 German secondary school teachers. In line with the replicated study, teachers' technology-related teaching skills were crucial for different forms of students' active learning, whereas the digital technology equipment available in a school was less important. School support was positively related to successful digital teaching and learning at schools. The success of Bring-Your-Own
View details →Mark E. Steiner, L. Ryan Smart · 2012 · Arthroscopy
Purpose This study evaluated the ability of flexible instruments compared with rigid instruments to place anatomic femoral tunnels in anterior cruciate ligament reconstructions by use of both transtibial drilling and anteromedial drilling…
View details →Leah Wetherill, Manav Kapoor, Arpana Agrawal et al. · 2013 · Alcoholism Clinical and Experimental Research
BACKGROUND: Despite the high heritability of alcohol dependence (AD), the genes found to be associated with it account for only a small proportion of its total variability. The goal of this study was to identify and analyze phenotypes…
View details →Laiana Schneider, A C Colar da Silva, Luiz Carlos Werres et al. · 2015 · Lupus
OBJECTIVES: To evaluate the expression of Th1, Th2, and Th17 cytokines in patients with systemic lupus erythematosus (SLE), and verify the association between serum cytokine levels and vitamin D concentration. METHODS: The sample consisted…
View details →Tracy L. Finch, Joan Mackintosh, Alex Petrou et al. · 2022 · PLOS ONE
Autistic children grow to become autistic adults, and autism is increasingly diagnosed in adulthood and later life. This qualitative study aimed to understand experiences of autism throughout adulthood. A national cohort study of autistic…
View details →Valentina Nachtigall, Katja Serova, Nikol Rummel · 2020 · Instructional Science
Abstract The current work builds on research demonstrating the effectiveness of Productive Failure (PF) for learning. While the effectiveness of PF has been demonstrated for STEM learning, it has not yet been investigated whether PF is also beneficial for learning in non-STEM domains. Given this need to test PF for learning in domains other than mathematics or science, and the assumption that features embodied in a PF design are domain-independent, we investigated the effect of PF on learning social science research methods. We conducted two quasi-experimental studies with 212 and 152 10th gra
View details →Jutta R. de Jong, Anouk Keizer, Manja M. Engel et al. · 2017 · Experimental Brain Research
The sense of how we experience our physical body as our own represents a fundamental component of human self-awareness. Body ownership can be studied with bodily illusions which are generated by inducing a visuo-tactile conflict where individuals experience illusionary ownership over a fake body or body part, such as a rubber hand. Previous studies showed that different types of touch modulate the strength of experienced ownership over a rubber hand. Specifically, participants experienced more ownership after the rubber hand illusion was induced through affective touch vs non-affective touch.
View details →Kenia Martínez, Sarah K. Madsen, Anand A. Joshi et al. · 2015 · Human Brain Mapping
People differ in their cognitive functioning. This variability has been exhaustively examined at the behavioral, neural and genetic level to uncover the mechanisms by which some individuals are more cognitively efficient than others.…
View details →Toru Hashimoto, Vidhya Sivakumaran, Ricardo Carnicer et al. · 2016 · Journal of the American Heart Association
BACKGROUND: Nitric oxide synthase uncoupling occurs under conditions of oxidative stress modifying the enzyme's function so it generates superoxide rather than nitric oxide. Nitric oxide synthase uncoupling occurs with chronic pressure…
View details →Jinbo Bi, Jiangwen Sun, Yu‐Wei Wu et al. · 2013 · ACM Transactions on Intelligent Systems and Technology
Alcohol misuse is one of the most serious public health problems facing adolescents and young adults in the United States. National statistics shows that nearly 90% of alcohol consumed by youth under 21 years of age involves binge drinking…
View details →Nararuk Boonyanam · 2014 · International Journal of Financial Research
Monetary variables contain information to forecast stock price is still controversial. This paper examines the relationship between stock price and monetary variables in Thailand which is an Asian small open emerging economy. Monetary variables are consumer price index, nominal bilateral exchange rate in term of bath per US dollar, narrow money, and 14 days repurchased rate, employing a multivariate cointegration, VECM, variance decomposition and impulse response analysis covering the period of January 1999 to December 2012 with 168 observations. The study found a long run relationship between
View details →Takeo Ishii, Takashi Angata, Emily S. Wan et al. · 2016 · Respirology
BACKGROUND AND OBJECTIVE: The exacerbation-prone phenotype of COPD is particularly important, as exacerbations lead to poor quality of life and disease progression. We previously found that COPD patients who lack Siglec-14, a myeloid cell…
View details →Jeanne E. Barthold, Kaitlin P. McCreery, Jaylene Martinez et al. · 2022 · Biofabrication
Abstract Articular cartilage is a layered tissue with a complex, heterogeneous structure and lubricated surface which is challenging to reproduce using traditional tissue engineering methods. Three-dimensional printing techniques have…
View details →Beibei Zhao, Xianghui Li, Yonglun Zeng et al. · 2016 · BMC Microbiology
BACKGROUND: The opportunistic bacterial pathogen Legionella pneumophila uses substrate effectors of Dot/Icm type IVB secretion system (T4BSS) to accomplish survival and replication in amoebae cells and mammalian alveolar macrophages. During the conversion between its highly resistant, infectious dormant form and vigorously growing, uninfectious replicative form, L. pneumophila utilizes a complicated regulatory network in which proteolysis may play a significant role. As a highly conserved core protease, ClpP is involved in various cellular processes as well as virulence in bacteria, and has be
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