Metformin Treatment Does Not Inhibit Growth of Pancreatic Cancer Patient-Derived Xenografts
Matthew B. Lipner; Raoud Marayati; Yangmei Deng; Xianxi Wang; Laura Raftery; Bert H. O’Neil; Jen Jen Yeh · 2016 · PLoS ONE
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
There is currently tremendous interest in developing anti-cancer therapeutics targeting cell signaling pathways important for both cancer cell metabolism and growth. Several epidemiological studies have shown that diabetic patients taking metformin have a decreased incidence of pancreatic cancer. This has prompted efforts to evaluate metformin, a drug with negligible toxicity, as a therapeutic modality in pancreatic cancer. Preclinical studies in cell line xenografts and one study in patient-derived xenograft (PDX) models were promising, while recently published clinical trials showed no benef
Abstract by Matthew B. Lipner; Raoud Marayati; Yangmei Deng; Xianxi Wang; Laura Raftery; Bert H. O’Neil; Jen Jen Yeh, PLoS ONE (2016) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1371/journal.pone.0147113