Adding Concurrent Chemotherapy to Intensity-Modulated Radiotherapy Does Not Improve Treatment Outcomes for Stage II Nasopharyngeal Carcinoma: A Phase 2 Multicenter Clinical Trial
Xiaodong Huang; Xiaozhong Chen; Chong Zhao; Jingbo Wang; Kai Wang; Lin Wang; Jingjing Miao; Caineng Cao · 2020 · Frontiers in Oncology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Purpose: To explore the efficacy of concomitant chemotherapy in intensity-modulated radiotherapy(IMRT) to treat stage II nasopharyngeal carcinoma (NPC). Methods and Materials: In this randomized phase 2 study (registered with ClinicalTrials.gov, (NCT01187238)), eligible patients with stage II (2010 UICC/AJCC) NPC were randomly assigned to either IMRT alone (RT group) or IMRT combined with concurrent cisplatin (40 mg/m2, weekly) (CCRT group). The primary endpoint was overall survival (OS). The second endpoints included local failure-free survival (LFFS), regional failure-free survival (RFFS), d
Abstract by Xiaodong Huang; Xiaozhong Chen; Chong Zhao; Jingbo Wang; Kai Wang; Lin Wang; Jingjing Miao; Caineng Cao, Frontiers in Oncology (2020) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3389/fonc.2020.01314