21,222 real negative results, null findings, and replication failures. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Isabel Comino, Ana Real, Javier Gil‐Humanes et al. · 2012 · Molecular Nutrition & Food Research
SCOPE: The only treatment available for coeliac disease (CD) is a strict diet in which the intake of wheat, barley, rye, or oats is avoided. Barley is a major cereal crop, grown mainly for its use in brewing, and it has high nutritional…
View details →Sue Y. McGorry · 2012 · Online Learning
Institutions of higher education are realizing the importance of service learning initiatives in developing awareness of students’ civic responsibilities, leadership and management skills, and social responsibility. These skills and…
View details →Odunayo David Adeniyi, Alexander Brenning, Alice Bernini et al. · 2023 · Land
Sustainable agricultural landscape management needs reliable and accurate soil maps and updated geospatial soil information. Recently, machine learning (ML) models have commonly been used in digital soil mapping, together with limited data, for various types of landscapes. In this study, we tested linear and nonlinear ML models in predicting and mapping soil properties in an agricultural lowland landscape of Lombardy region, Italy. We further evaluated the ability of an ensemble learning model, based on a stacking approach, to predict the spatial variation of soil properties, such as sand, sil
View details →Daniel M. Bagner, Michelle D. Berkovits, Stefany Coxe et al. · 2023 · JAMA Pediatrics
Importance: Early behavior problems in children with developmental delay (DD) are prevalent and impairing, but service barriers persist. Controlled studies examining telehealth approaches are limited, particularly for children with DD.…
View details →Jia Hoong Ong, Denis Burnham, Paola Escudero · 2015 · PLoS ONE
This study examines whether non-tone language listeners can acquire lexical tone categories distributionally and whether attention in the training phase modulates the effect of distributional learning. Native Australian English listeners were trained on a Thai lexical tone minimal pair and their performance was assessed using a discrimination task before and after training. During Training, participants either heard a Unimodal distribution that would induce a single central category, which should hinder their discrimination of that minimal pair, or a Bimodal distribution that would induce two
View details →Erik W. Ingwersen, Wessel T. Stam, Bono J.V. Meijs et al. · 2023 · Surgery
BACKGROUND: Machine learning is increasingly advocated to develop prediction models for postoperative complications. It is, however, unclear if machine learning is superior to logistic regression when using structured clinical data. Postoperative pancreatic fistula and delayed gastric emptying are the two most common complications with the biggest impact on patient condition and length of hospital stay after pancreatoduodenectomy. This study aimed to compare the performance of machine learning and logistic regression in predicting pancreatic fistula and delayed gastric emptying after pancreato
View details →Verônica Contini, Marcelo M. Victor, Guilherme Pinto Bertuzzi et al. · 2012 · Journal of Clinical Psychopharmacology
Results from pharmacogenetic investigations of methylphenidate (MPH) response in patients with ADHD are still inconsistent, especially among adults. This study investigates the role of genetic variants (SLC6A4, HTR1B, TPH2, DBH, DRD4,…
View details →Julie Justine Benoit, Eugenie Roudaia, Taylor Johnson et al. · 2020 · PeerJ
In the past 20 years, there has been growing research interest in the association between video games and cognition. Although many studies have found that video game players are better than non-players in multiple cognitive domains, other studies failed to replicate these results. Until now, the vast majority of studies defined video game players based on the number of hours an individual spent playing video games, with relatively few studies focusing on video game expertise using performance criteria. In the current study, we sought to examine whether individuals who play video games at a pro
View details →Tord Ranheim Sveen, Maria Viketoft, Jan Bengtsson et al. · 2025 · Nature Communications
Land abandonment is the single largest process of land-use change in the Global North driving succession and afforestation at continental scales, but assessing its impacts on soil microbial communities remains a challenge. Here, we establish a nationwide successional gradient of paired grassland and forest sites to track developments in microbial structure and functioning following land abandonment and gradual land-use change to forests. We show that microbes generally respond through threshold dynamics, leading to increasing functional but decreasing taxonomic diversity. Succession also entai
View details →Brahim Bergougui, Said Meziane · 2025 · Sustainability
Algeria’s resource-dependent economy faces significant challenges in balancing hydrocarbon reliance with environmental sustainability, yet existing research largely overlooks the comprehensive load capacity factor (LCF) metric in favor of traditional emissions analyses. This study examines the relationships between the LCF and key economic–environmental factors in Algeria from 1980 to 2023, including total natural resource rents, energy transition, technological innovation, GDP, primary energy consumption, and urbanization. Using ARDL and DARDL econometric approaches complemented by a kernel-b
View details →Magdalena Paplińska‐Goryca, Paulina Misiukiewicz‐Stępień, Monika Wróbel et al. · 2025 · Scientific Reports
Microplastic particles from the air are inhaled and accumulate in the lungs, potentially causing immunological reactions and airway tissue injury. This study aimed to evaluate the biological effects of polyamide fibres on nasal epithelium…
View details →Luke Hodgson, Jo Congleton, Richard Venn et al. · 2018 · Clinical Medicine
ABSTRACT The Royal College of Physicians (RCP) recently published the National Early Warning Score 2 (NEWS2), aiming to improve safety for patients with hypercapnic respiratory failure by suggesting a separate oxygen saturation (SpO2)…
View details →Yook Kit Ow-Yeong, Ibrahim H. Yeter, Farhan Ali · 2023 · International Journal of STEM Education
Abstract Background Data literacy is increasingly important in today’s data-driven world. Students across many educational systems first formally learn about data in elementary school not as a separate subject but via the mathematics curriculum. This experience can create tensions in the priorities of learning and assessment given the presence of other foundational mathematics content domains such as numbers, algebra, measurement, and geometry. There is a need to study data literacy in comparison to these other content domains in elementary mathematics. To address this need, we developed a met
View details →Elizabeth Y Long, Deborah L. Finke · 2014 · Environmental Entomology
Studies manipulating predator diversity and measuring the impact on herbivore abundance have found that enhancing predator species richness often increases the strength of prey suppression. This relationship may be due to mechanisms such…
View details →Lars Gamfeldt, Helmut Hillebrand · 2011 · PLoS ONE
The study of the interrelationship between productivity and biodiversity is a major research field in ecology. Theory predicts that if essential resources are heterogeneously distributed across a metacommunity, single species may dominate productivity in individual metacommunity patches, but a mixture of species will maximize productivity across the whole metacommunity. It also predicts that a balanced supply of resources within local patches should favor species coexistence, whereas resource imbalance would favor the dominance of one species. We performed an experiment with five freshwater al
View details →Thomas Galland, Carlos P. Carmona, Lars Götzenberger et al. · 2020 · Ecological Indicators
Functional redundancy is considered a major component of the insurance mechanism, which theoretically maintains ecosystem stability by preventing the loss of ecosystem functions with species loss. Over the past decades, examination of…
View details →Gareth Richards, Manuel C. Gomes, T. Ventura · 2018 · Journal of Developmental Origins of Health and Disease
Foetal sex hormones can have powerful and far-reaching effects on later phenotype. However, obtaining accurate measurements is difficult for ethical reasons, and researchers often employ proxy variables to examine their effects. The…
View details →Erkan Er, Eduardo Gómez‐Sánchez, Yannis Dimitriadis et al. · 2019 · Interactive Learning Environments
This paper presents the findings of a mixed-methods research that explored the potentials emerging from aligning learning design (LD) and learning analytics (LA) during the design of a predictive analytics solution and from involving the…
View details →Dhayana Dallmeier, Martin G. Larson, Na Wang et al. · 2012 · Journal of the American Heart Association
Background Prior studies have reported conflicting findings with regard to the association of biomarkers in the prediction of incident type 2 diabetes. We evaluated 12 biomarkers as possible diabetes predictors in the F ramingham H eart S…
View details →Xiaodong Huang, Xiaozhong Chen, Chong Zhao et al. · 2020 · Frontiers in Oncology
Purpose: To explore the efficacy of concomitant chemotherapy in intensity-modulated radiotherapy(IMRT) to treat stage II nasopharyngeal carcinoma (NPC). Methods and Materials: In this randomized phase 2 study (registered with ClinicalTrials.gov, (NCT01187238)), eligible patients with stage II (2010 UICC/AJCC) NPC were randomly assigned to either IMRT alone (RT group) or IMRT combined with concurrent cisplatin (40 mg/m2, weekly) (CCRT group). The primary endpoint was overall survival (OS). The second endpoints included local failure-free survival (LFFS), regional failure-free survival (RFFS), d
View details →Ilkka Koskivuo, Jukka Kemppainen, Salvatore Giordano et al. · 2016 · Acta Oncologica
BACKGROUND: Whole body positron emission tomography (PET)/computed tomography (CT) is a sensitive imaging technique in patients with metastatic melanoma, but its role in the follow-up of asymptomatic high-risk patients is unclear. The aim…
View details →Dhakshana Sivayoganathan, Deivanayagam Maruthini, Julie Glanville et al. · 2011 · Human Fertility
OBJECTIVE: This study aimed to compare the spectrum of polycystic ovary syndrome (PCOS) symptoms in patients from four different specialist clinics. DESIGN: A prospective cross-sectional observational study. SETTING: The study was…
View details →Matthew B. Lipner, Raoud Marayati, Yangmei Deng et al. · 2016 · PLoS ONE
There is currently tremendous interest in developing anti-cancer therapeutics targeting cell signaling pathways important for both cancer cell metabolism and growth. Several epidemiological studies have shown that diabetic patients taking metformin have a decreased incidence of pancreatic cancer. This has prompted efforts to evaluate metformin, a drug with negligible toxicity, as a therapeutic modality in pancreatic cancer. Preclinical studies in cell line xenografts and one study in patient-derived xenograft (PDX) models were promising, while recently published clinical trials showed no benef
View details →Michael Stewart, Raj K. Maturi, Vincent Chen et al. · 2014 · Clinical ophthalmology
AIMS: To determine if intravitreal bevacizumab combined with the dexamethasone intravitreal implant 0.7 mg improves visual acuity and macular thickness more than bevacizumab monotherapy in eyes with macular edema due to branch and central…
View details →Joel Wight, Mimi Yue, Colm Keane et al. · 2019 · British Journal of Haematology
De novo diffuse large B-cell lymphoma (DLBCL) presenting with synchronous central nervous system (CNS) and systemic disease (synDLBCL) is not well described and is excluded from clinical trials. We performed a retrospective analysis of 80…
View details →Melanie Nägeli, Patrick Scherler, Stephanie Witczak et al. · 2021 · Oecologia
The joint effects of interacting environmental factors on key demographic parameters can exacerbate or mitigate the separate factors' effects on population dynamics. Given ongoing changes in climate and land use, assessing interactions between weather and food availability on reproductive performance is crucial to understand and forecast population dynamics. By conducting a feeding experiment in 4 years with different weather conditions, we were able to disentangle the effects of weather, food availability and their interactions on reproductive parameters in an expanding population of the red
View details →Pasquale F. Innominato, Abdoulaye Karaboué, C. Focan et al. · 2020 · International Journal of Cancer
The triplet combination of irinotecan, oxaliplatin and fluorouracil is an active frontline regimen in metastatic colorectal cancer, but scarce data exist on its use as salvage treatment. We aimed at assessing its safety and efficacy profiles with its circadian-based administration (chronoIFLO5) as either first- or second-line treatment, within the time-finding EORTC 05011 trial. Five-day chronoIFLO5 was administered every 3 weeks in patients with PS 0, 1 or 2. It consisted of chronomodulated irinotecan (180 mg/sqm), oxaliplatin (80 mg/sqm) and fluorouracil-leucovorin (2800 and 1200 mg/sqm, res
View details →Kseniia Chernyshova, Keiichi Inoue, Shun‐ichi Yamashita et al. · 2019 · Investigative Ophthalmology & Visual Science
Purpose: Glaucoma results in progressive degeneration of the optic nerve and irreversible vision loss. Several mutations in the gene encoding optineurin (OPTN), the receptor for Parkin-dependent mitochondrial autophagy (mitophagy), are…
View details →Heather N. Taussig, Sara E. Culhane, Edward F. Garrido et al. · 2012 · Child Maltreatment
Physically neglected youth are at increased risk of mental health problems, but there are few interventions that have demonstrated efficacy in reducing mental health symptoms for this vulnerable population. The Fostering Healthy Futures…
View details →Rafiq Hamdi, Hans Van de Vyver, Piet Termonia · 2011 · International Journal of Climatology
Abstract We explore the use of high‐resolution dynamical downscaling as a means to simulate extreme values of summer maximum surface air temperature over Belgium ( T MAX ). We use the limited area version of the ARPEGE‐IFS model, ALADIN.…
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