Negative / Null Result ReportOpen accessImmunologic diseases. Allergy
Shunchuan Zhang, Lauren E Springer, Han-Zhi Rao et al. · 2021 · PLoS Pathogens
Cytomegalovirus (CMV) causes clinically important diseases in immune compromised and immune immature individuals. Based largely on work in the mouse model of murine (M)CMV, there is a consensus that myeloid cells are important for disseminating CMV from the site of infection. In theory, such dissemination should expose CMV to cell-mediated immunity and thus necessitate evasion of T cells and NK cells. However, this hypothesis remains untested. We constructed a recombinant MCMV encoding target sites for the hematopoietic specific miRNA miR-142-3p in the essential viral gene IE3. This virus diss
View details →Failed Experiment ReportOpen accessImmunologic diseases. Allergy
Jessica J. Harrison, Wilson Nguyen, Mahali S. Morgan et al. · 2024 · npj Vaccines
Abstract In 2022, a genotype IV (GIV) strain of Japanese encephalitis virus (JEV) caused an unprecedented and widespread outbreak of disease in pigs and humans in Australia. As no veterinary vaccines against JEV are approved in Australia and all current approved human and veterinary vaccines are derived from genotype (G) III JEV strains, we used the recently described insect-specific Binjari virus (BinJV) chimeric flavivirus vaccine technology to produce a JEV GIV vaccine candidate. Herein we describe the production of a chimeric virus displaying the structural prM and E proteins of a JEV GIV
View details →Failed Experiment ReportOpen accessNeurology. Diseases of the nervous system
Baker David, Giovannoni Gavin, Jackson Samuel J · 2011 · Journal of Neuroinflammation
Abstract Introduction Microglial activation in multiple sclerosis has been postulated to contribute to long-term neurodegeneration during disease. Fingolimod has been shown to impact on the relapsing remitting phase of disease by modulating autoreactive T-cell egress from lymph organs. In addition, it is brain penetrant and has been shown to exert multiple effects on nervous system cells. Methods In this study, the impact of fingolimod and other sphingosine-1-phosphate receptor active molecules following lysophosphotidyl choline-induced demyelination was examined in the rat telencephalon reagg
View details →Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Lars Hausfeld, Lars Hausfeld, Niels R. Disbergen et al. · 2021 · Frontiers in Neuroscience
Numerous neuroimaging studies demonstrated that the auditory cortex tracks ongoing speech and that, in multi-speaker environments, tracking of the attended speaker is enhanced compared to the other irrelevant speakers. In contrast to speech, multi-instrument music can be appreciated by attending not only on its individual entities (i.e., segregation) but also on multiple instruments simultaneously (i.e., integration). We investigated the neural correlates of these two modes of music listening using electroencephalography (EEG) and sound envelope tracking. To this end, we presented uniquely com
View details →Negative / Null Result ReportOpen accessMedicine
Karen E Mulak, Hannah S Sarvasy, Alba Tuninetti et al. · 2021 · PLoS ONE
Adapting laboratory psycholinguistic methods to fieldwork contexts can be fraught with difficulties. However, successful implementation of such methods in the field enhances our ability to learn the true extent and limitations of human behavior. This paper reports two attempts to run word learning experiments with the small community of Nungon speakers in Towet village in the Saruwaged Mountains, Papua New Guinea. A first attempt involved running a cross-situational task in which word-object pairings were presented ambiguously in each trial, and an explicit word learning task in which pairings
View details →Negative / Null Result ReportOpen accessAstrophysics
Mohit Bhardwaj, Victoria M. Kaspi, K. W. Masui et al. · 2025 · The Astrophysical Journal
Despite hundreds of detected fast radio bursts (FRBs), the faint-end slope ( γ ) of their energy distribution remains poorly constrained, hindering understanding of whether bright, cosmological FRBs and faint, Galactic magnetar SGR 1935+2154-like bursts share a common origin. In this study, we constrain this faint-end slope, modeled with a Schechter-like distribution, by searching for potential associations between bursts from the CHIME/FRB Catalog-1 and galaxies in the Local Volume. We crossmatched CHIME/FRB Catalog-1 FRBs with 495 Local Volume galaxies within 21 Mpc, identified from the HECA
View details →Replication FailureOpen accessNuclear and particle physics. Atomic energy. Radioactivity
The CMS collaboration, A. Hayrapetyan, A. Tumasyan et al. · 2025 · Journal of High Energy Physics
Abstract Results are presented for a test of the compositeness of the heaviest charged lepton, τ, using data collected by the CMS experiment in proton-proton collisions at a center-of-mass energy of 13 TeV at the CERN LHC. The data were collected in 2016–2018 and correspond to an integrated luminosity of 138 fb −1. This analysis searches for tau lepton pair production in which one of the tau leptons is produced in an excited state and decays to a ground state tau lepton and a photon. The event selection consists of two isolated tau lepton decay candidates and a high-energy photon. The mass of
View details →Replication FailureOpen accessAstrophysics
J. Ming, M. A. Papa, H.-B. Eggenstein et al. · 2024 · The Astrophysical Journal
We perform a search for continuous nearly monochromatic gravitational waves from the central compact objects associated with the supernova remnants Vela Jr. and G347.3. Over 10 ^18 different waveforms are considered, covering signal frequencies between 20 and 1300 Hz (20 and 400 Hz) for G347.3-0.5 (Vela Jr.) and a very broad range of frequency derivatives. The data set used for this first search is from the second observing run of LIGO (O2). Thousands of volunteers donating compute cycles through the computing project Einstein@Home have made this endeavor possible. Following the Einstein@Home
View details →Replication FailureOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
N. V. Dmitrieva, M. V. Eidelshtein, V. V. Aginova et al. · 2019 · Сибирский онкологический журнал
The purpose of the study was to evaluate the frequency of isolation of multi-resistant Pseudomonas aeruginosa and identify the mechanisms of resistance to carbapenems.Material and methods. We analyzed 866 strains of Pseudomonos aeruginosaisolated from clinical samples from cancer patients in the period 2014–2016. the level of resistance to piperacillin/tazobactam, ceftazidime, cefepime, imipenem, meropenem, ciprofloxacin, amikacin in dynamics was determined. carbapenem-resistant (car-R) strains were examined for the presence of enzymes.Results. Between 2014 and 2016, the number of strains resi
View details →Methods Dead-EndOpen accessMedicine
Rukhsana Tumrani, S. Sabahat Haider, Mehvish Sana · 2024 · Pakistan Journal of Medical Research
Background: Serum electrolytes are one of the most frequently requested tests in patients from critical care settings. Methodsfor estimation of serum electrolytes include direct and indirect ion selective electrode (ISE). In case of indirect ISE, the pre-analytical dilution step can result in pseudonormonatremia or pseudohypernatremia in setting of hypoalbuminemia. Discrepancy in sodium results can lead to the misdiagnosis and mismanagement of critically ill patients. Objective: To evaluate the difference of mean serum sodium level measured by direct and indirect ISE in critically ill patients
View details →Negative / Null Result ReportOpen access
Miftahul Jannah, Zulpikar Zulpikar, Muliani Muliani · 2021 · Acta Aquatica
Tilapia (Oreochromis niloticus) is a type of freshwater fish that is widely cultivated by Indonesians. The problem that often arises in cultivation is lack of water quality. One of the ways to improve water quality is by using aquaponics…
View details →Replication FailureOpen accessDiseases of the digestive system. Gastroenterology
Ben-Gang Zhou, Ming-Wen Guo, Li-Juan Zhang et al. · 2024 · Therapeutic Advances in Gastroenterology
Background: The efficacy of the 14-day esomeprazole–amoxicillin (EA) dual therapy in eradicating Helicobacter pylori ( H. pylori ) has been widely discussed previously. Vonoprazan, a novel potassium-competitive acid blocker, presents rapid, potent, and long-lasting acid inhibitory effects compared to esomeprazole. However, there is currently a scarcity of direct comparisons between the 10-day vonoprazan–amoxicillin (VA) and the 14-day EA dual therapy for H. pylori eradication. Objectives: This study aimed to compare the efficacy and safety of the 10-day VA and the 14-day EA dual therapy for H.
View details →Negative / Null Result ReportOpen accessMedicine
Teerachate Nantakeeratipat · 2026 · Frontiers in Digital Health
BackgroundLarge Language Models (LLMs) in healthcare holds immense promise yet carries the risk of perpetuating social biases. While artificial intelligence (AI) fairness is a growing concern, a gap exists in understanding how these models perform under conditions of clinical ambiguity, a common feature in real-world practice.MethodsWe conducted a study using an ambiguity-probe methodology with a set of 42 sociodemographic personas and 15 clinical vignettes based on the 2018 classification of periodontal diseases. Ten were clear-cut scenarios with established ground truths, while five were int
View details →Negative / Null Result ReportOpen accessGynecology and obstetrics
Jingting Liu, Yijun Dong, Yawei Zhou et al. · 2024 · BMC Pregnancy and Childbirth
Abstract Background Observational epidemiological studies suggested that immunological dysregulation and inflammation play a significant role in the placental and renal dysfunction that leads to maternal hypertension. The immunophenotypes' possible causalities with hypertensive disease of pregnancy remain ambiguous. We performed two-sample Mendelian randomization (MR) analyses to comprehensively investigate the causal effect of immunophenotypes on hypertensive disorder of pregnancy (HDP). Methods The large-scale genome-wide association studies (GWASs) data on immunological traits was taken fro
View details →Negative / Null Result ReportOpen accessMedicine (General)
Emily Sheppard, MScPT, Michael Smyth, MSc, Todd Dow, BSc et al. · 2020 · Archives of Rehabilitation Research and Clinical Translation
Objective: To assess the effect the Pre-clerkship Residency Exploration Program (PREP) had on student career interest and improving understanding of physical medicine and rehabilitation (PMR). Design: During a 2-week program, students were exposed to a PMR elective, workshop, career presentation, and panel discussion with PMR residents. Interest and understanding were assessed using pre- and postprogram questionnaires. Setting: PREP was held at a Canadian medical school during the summer between the second and third years of undergraduate medical training. Participants: Second-year medical stu
View details →Negative / Null Result ReportOpen accessEducation (General)
Wonseok Chang, Yura Kim, Hye Jin Park · 2024 · Korean Journal of Medical Education
Purpose Although interest in various forms of learning media is increasing due to the coronavirus disease 2019 (COVID-19) pandemic there is relatively little research on influencing student motivation by intervening in cognitive processing. The purpose of this study was to present the optimal form of learning materials provided to medical students. Methods This study provided learning materials in class at a level according to social cues (script, video [artificial intelligence (AI) voice], video [professor voice]) based on the principle of voices among the principles of personalization, voice
View details →Negative / Null Result ReportOpen accessNutrition. Foods and food supply
Dan Liang, Chang Liu, Xingyu Zhang · 2026 · Food, Nutrition and Health
Abstract Background This study aimed to investigate the relationship between dietary iron intake and risk of abdominal aortic calcification (AAC) in middle-aged and older US adults. Methods We analyzed data from the 2013-2014 National Health and Nutrition Examination Survey (NHANES). Multivariate linear and logistic regression models were employed to evaluate the association between dietary iron intake and AAC score, as well as the likelihood of both AAC and severe AAC. To investigate potential non-linear dose-response relationships, we performed restricted cubic spline (RCS) modeling. In addi
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Yinuo Li, Xi Liu, Qian Hong et al. · 2024 · Frontiers in Cardiovascular Medicine
BackgroundRecent epidemiological studies have indicated a correlation between platelet indices and pulmonary arterial hypertension (PAH), yet the causality between them remains unclear. To explore the causal relationship between four platelet indices and PAH, with the aim of providing a theoretical basis for clinical prevention and treatment.MethodsSingle-nucleotide polymorphisms (SNPs) associated with platelet-related traits were selected as exposure factors from published genome-wide association studies (GWAS), including: platelet count (PLT), plateletcrit (PCT), mean platelet volume (MPV),
View details →Negative / Null Result ReportOpen accessMedicine
Bohan Jia, Junyi Sun, Di Zhu et al. · 2025 · Scientific Reports
Abstract Cancer significantly contributes to the unfavorable prognosis of coronavirus disease 2019 (COVID-19) patients. The efficacy and safety of azvudine and nirmatrelvir/ritonavir (Paxlovid) in cancer patients with COVID-19 remain uncertain. Therefore, we designed a comprehensive retrospective study encompassing clinical data of 32,864 hospitalized COVID-19 patients, 691 of whom were cancer patients treated with azvudine and 200 were cancer patients treated with Paxlovid. After 2:1 propensity score matching, 397 patients in the azvudine group and 199 patients in the Paxlovid group were enro
View details →Negative / Null Result ReportOpen accessDentistry
Disha Kumar, Anant Gopal Nigam, Nikhil Marwah et al. · 2018 · Journal of Indian Society of Pedodontics and Preventive Dentistry
Background and Objectives: The aim of this study was to examine the arch dimensions of beta thalassemia major patients in comparison with normal individuals. Materials and Methods: Dental arch dimensions were compared between thalassemic patients and normal individuals in the age group of 12–16 years in the maxillary and mandibular arch corresponding to each other regarding age, sex and Angle's molar relationship. A total number of sixty cases in each group were taken. Maxillary and mandibular impressions were made with alginate for all the sixty participants in each group and poured with die
View details →Negative / Null Result ReportOpen accessMedicine (General)
M.A. Arbex, L.C. Martins, L.A.A. Pereira et al. · 2007 · Brazilian Journal of Medical and Biological Research
Studies of cooking-generated NO2 effects are rare in occupational epidemiology. In the present study, we evaluated the lung function of professional cooks exposed to NO2 in hospital kitchens. We performed spirometry in 37 cooks working in four hospital kitchens and estimated the predicted FVC, FEV1 and FEF25-75, based on age, sex, race, weight, and height, according to Knudson standards. NO2 measurements were obtained for 4 consecutive days during 4 different periods at 20-day intervals in each kitchen. Measurements were performed inside and outside the kitchens, simultaneously using Palm diff
View details →Negative / Null Result ReportOpen accessOphthalmology
Ahmed S Abdel-Wanes, Abelrahman G Salman, Azza M.A Said et al. · 2020 · Journal of the Egyptian Ophthalmological Society
Aim To determine the risk factors responsible for opaque bubble layer (OBL) formation in femtosecond-laser-assisted in situ keratomileusis (FSL-LASIK). Patients and methods A retrospective, comparative study was carried out from January 2015 to January 2017 in El-Watany Eye Hospital. Two hundred eyes who were eligible for FSL-laser-assisted in situ keratomileusis (FSL was done using FS200, wavelight, Germany SR/1025-1-380) were classified into two groups. Group I: the study group with OBL formation during surgery (100 eye) and group (II): the control group without OBL formation during surgery
View details →Negative / Null Result ReportOpen accessMedicine
Zagorac Slaviša, Bumbaširević Marko, Lešić Aleksandar et al. · 2008 · Srpski Arhiv za Celokupno Lekarstvo
Introduction Multiple trauma is one of the leading causes of mortality and morbidity in the population of people under 45 years of age. The consequences of multiple trauma have huge epidemiological, social and economic significance. Objective The aim of the paper was to analyze the conclusive treatment outcome of multiply traumatized patients with respect to their sex, age, injury mechanism and type. METHOD This retrospective study included 100 patients with multiple injuries (ISS>16) treated in the Emergency Room of the Clinical Centre of Serbia in the course of 2004. Clinical, X-ray, laborat
View details →Negative / Null Result ReportOpen accessMedicine
Levent Cigerim, Erkan Feslihan · 2019 · Journal of Oral Health and Oral Epidemiology
BACKGROUND AND AIM: Alterations in blood pressure (BP) and variability of heart rate (HR) throughout dental procedures were not clearly understood. The aim of this study is to evaluate the effects of body mass index (BMI) on BP and HR in patients undergoing tooth extraction. METHODS: Based on BMI, 831 patients who underwent single tooth extraction were divided into two groups; group 1: underweight and normal-weight patients, group 2: overweight and obese patients. BP and HR were monitored before local anesthesia and after tooth extraction. For statistical analysis of the data, Number Cruncher
View details →Negative / Null Result ReportOpen accessSports medicine
Tim Wang MD, Van Krueger, Roslyn Kackman et al. · 2025 · Orthopaedic Journal of Sports Medicine
Objectives: Osteochondral allograft (OCA) transplantation is an effective treatment method for articular cartilage damage in the knee. The mid- and long-term outcomes of patellofemoral OCA transplantation has been less frequently reported compared to those of the medial and lateral compartments of the knee, and these grafts often show lower survival rates and worse patient-reported outcomes. The unique morphology and biomechanics of the patellofemoral compartment leads to different pathologies than other areas of the knee. The purpose of this study was to assess graft survivorship and patient-
View details →Negative / Null Result ReportOpen accessAnesthesiology
Marzieh khalaji, Mohadese Babaie, Fatemeh Bayat et al. · 2025 · BMC Anesthesiology
Abstract Aim This study aims at comparing the impact of Magnesium Sulfate and Lidocaine sprays on hemodynamic changes after laryngoscopy and tracheal intubation. Design This double-blind clinical trial (code IRCT20230719058846N1) was conducted on the patients undergoing elective surgery in the city of Karaj. Methods A total of 100 patients, aged 18 to 40 years and classified as ASA I or II, who were candidates for elective surgery, were randomly assigned to two equal groups. Prior to intubation, patients received lidocaine spray (5 puffs of Lidocaine 10%) in one group, and magnesium sulfate sp
View details →Failed Experiment ReportOpen accessMedicine
Omole-ohonsi A, Ashimi AO · 2008 · Ibom Medical Journal
Objective: To evaluate the feasibility and outcome of caesarean myomectomy. Patients and Methods: A retrospective study of cases of caesarean myomectomy at the Aminu Kano Teaching Hospital, Kano, Nigeria, a tertiary health facility in a developing country between January 1998 and December 2004. Outcome Measures: Age and parity of the women, number, size and location of fibroids, duration of operation, estimated blood loss, postoperative complications and duration of hospital stay. Results: Sixteen cases of caesarean myomectomy were done during the study period using the tourniquet method. It i
View details →Failed Experiment ReportOpen accessMedicine
Yi Zhan, Huiming Yang, Jiangtao Wang et al. · 2024 · Scientific Reports
Abstract Based on the characteristics of Kummell’s disease (KD) and related anatomical structures of the thoracolumbar spine, a novel bone cement screw system has been designed to effectively avoid the cement loosening and displacement. This experiment aimed to assess the biological effects of the novel bone cement screw system in KD on fresh cadaveric thoracolumbar spine specimens, thereby discussing its potential application value and providing a foundation for clinical implementation. This study employed a total of 50 fresh female adult cadaver specimens. Each specimen underwent extraction
View details →Negative / Null Result ReportOpen accessDentistry
Polavarapu Venkata Ravi Chandra, Vemisetty Hari Kumar, Surakanti Jayaprada Reddy et al. · 2015 · Dental Research Journal
Background: The aim of this study was to evaluate and compare the in vitro biofilm forming capacity of Enterococcus faecalis on Gutta-percha points disinfected with four disinfectants. Materials and Methods: A total of 50 Gutta-percha points used in this study were divided into four test groups based on disinfectant (5.25% sodium hypochlorite, 2% chlorhexidine gluconate, 20% neem, 13% benzalkonium chloride [BAK]), and one control group. The Gutta-percha points were initially treated with corresponding disinfectants followed by anaerobic incubation in Brain Heart Infusion broth suspended with h
View details →Negative / Null Result ReportOpen accessMedicine (General)
Fatemeh Zanganeh, Amir Jalali, Hamid Galehdari et al. · 2014 · Iranian South Medical Journal
Background: Cytochrome P450 2E1 (CYP2E1) is a main enzyme which plays a major role in activating and detoxifying many xenobiotics, carcinogens and drugs. Available studies suggest that CYP2E1 single nucleotide polymorphisms (SNPs) are involved in the risk of developing certain cancers after exposure to carcinogens. The purpose of the present study was to assess genotype and allele frequencies of polymorphic CYP2E1*5B in the Iranian population. Material and Methods: This study was performed on 200 healthy individuals (female: 100, male: 100) in medical laboratories of Ahvaz during 2011. The CYP
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