Platelet indices and the risk of pulmonary arterial hypertension: a two-sample and multivariable Mendelian randomization study
Yinuo Li; Xi Liu; Qian Hong; Rui Xu · 2024 · Frontiers in Cardiovascular Medicine
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BackgroundRecent epidemiological studies have indicated a correlation between platelet indices and pulmonary arterial hypertension (PAH), yet the causality between them remains unclear. To explore the causal relationship between four platelet indices and PAH, with the aim of providing a theoretical basis for clinical prevention and treatment.MethodsSingle-nucleotide polymorphisms (SNPs) associated with platelet-related traits were selected as exposure factors from published genome-wide association studies (GWAS), including: platelet count (PLT), plateletcrit (PCT), mean platelet volume (MPV),
Abstract by Yinuo Li; Xi Liu; Qian Hong; Rui Xu, Frontiers in Cardiovascular Medicine (2024) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.3389/fcvm.2024.1395245