Exploring genetic associations between immune cells and hypertensive disorder of pregnancy using Mendelian randomization
Jingting Liu; Yijun Dong; Yawei Zhou; Wendi Wang; Yan Li; Jianying Pei · 2024 · BMC Pregnancy and Childbirth
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Background Observational epidemiological studies suggested that immunological dysregulation and inflammation play a significant role in the placental and renal dysfunction that leads to maternal hypertension. The immunophenotypes' possible causalities with hypertensive disease of pregnancy remain ambiguous. We performed two-sample Mendelian randomization (MR) analyses to comprehensively investigate the causal effect of immunophenotypes on hypertensive disorder of pregnancy (HDP). Methods The large-scale genome-wide association studies (GWASs) data on immunological traits was taken fro
Abstract by Jingting Liu; Yijun Dong; Yawei Zhou; Wendi Wang; Yan Li; Jianying Pei, BMC Pregnancy and Childbirth (2024) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1186/s12884-024-06950-w