Hematopoietic cell-mediated dissemination of murine cytomegalovirus is regulated by NK cells and immune evasion.
Shunchuan Zhang; Lauren E Springer; Han-Zhi Rao; Renee G Espinosa Trethewy; Lindsey M Bishop; Meaghan H Hancock; Finn Grey; Christopher M Snyder · 2021 · PLoS Pathogens
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Cytomegalovirus (CMV) causes clinically important diseases in immune compromised and immune immature individuals. Based largely on work in the mouse model of murine (M)CMV, there is a consensus that myeloid cells are important for disseminating CMV from the site of infection. In theory, such dissemination should expose CMV to cell-mediated immunity and thus necessitate evasion of T cells and NK cells. However, this hypothesis remains untested. We constructed a recombinant MCMV encoding target sites for the hematopoietic specific miRNA miR-142-3p in the essential viral gene IE3. This virus diss
Abstract by Shunchuan Zhang; Lauren E Springer; Han-Zhi Rao; Renee G Espinosa Trethewy; Lindsey M Bishop; Meaghan H Hancock; Finn Grey; Christopher M Snyder, PLoS Pathogens (2021) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1371/journal.ppat.1009255