Ten-day vonoprazan–amoxicillin dual therapy versus 14-day esomeprazole–amoxicillin dual therapy for first-line eradication: a prospective multicenter randomized controlled trial
Ben-Gang Zhou; Ming-Wen Guo; Li-Juan Zhang; Zhi-Dong Liu; Chun-Hua Liu; Xue-Feng Li; Shun-Song Li; Peng Xiao · 2024 · Therapeutic Advances in Gastroenterology
WASTE classifies this as Replication Failure · AI classification, approximate
A previously reported effect did not replicate here — verify it holds before you build on it.
Abstract
Background: The efficacy of the 14-day esomeprazole–amoxicillin (EA) dual therapy in eradicating Helicobacter pylori ( H. pylori ) has been widely discussed previously. Vonoprazan, a novel potassium-competitive acid blocker, presents rapid, potent, and long-lasting acid inhibitory effects compared to esomeprazole. However, there is currently a scarcity of direct comparisons between the 10-day vonoprazan–amoxicillin (VA) and the 14-day EA dual therapy for H. pylori eradication. Objectives: This study aimed to compare the efficacy and safety of the 10-day VA and the 14-day EA dual therapy for H.
Abstract by Ben-Gang Zhou; Ming-Wen Guo; Li-Juan Zhang; Zhi-Dong Liu; Chun-Hua Liu; Xue-Feng Li; Shun-Song Li; Peng Xiao, Therapeutic Advances in Gastroenterology (2024) — licensed CC BY 4.0.
About to run something similar?
Run an AI Precheck on your own design to catch failure modes like this one before you spend the time. Your first desk check is free.
Related failures
Avaliação da qualidade de vida e toxicidades em pacientes com câncer colorretal tratados com quimioterapia adjuvante baseada em fluoropirimidinas Evaluation of the toxicity and quality of life in patients with colorectal cancer treated with chemotherapy
Negative / Null Result ReportRandomized clinical trial comparing sodium picosulfate with mannitol on the preparation FOR colonoscopy in hospitalized patients Ensaio clínico randomizado comparando picosulfato de sódio com manitol no preparo para colonoscopia em pacientes hospitalizados
Negative / Null Result ReportImpact of peritoneal lavage on intra-abdominal abscess after laparoscopic appendectomy for perforated appendicitis: a propensity score matching analysis
Negative / Null Result ReportA randomized control trial to assess the effectiveness of a brief educational intervention on colonoscopy preparation and experience in patients with inflammatory bowel disease
Negative / Null Result ReportPATTERNS OF ALCOHOL CONSUMPTION AND MENTAL HEALTH IN HCV-INFECTED PATIENTS: IMPLICATIONS FOR ANTIVIRAL ELIGIBILITY
Negative / Null Result ReportReducing diagnostic delays of extraintestinal manifestations in inflammatory bowel disease: a comparative study of a multidisciplinary outpatient clinic versus conventional referral specialists
WASTE indexes this work — it does not host or republish it. Failure-type classification is automated and approximate.
Metadata source: DOAJ · DOI 10.1177/17562848241309870