Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Alex Grier, Xing Qiu, Sanjukta Bandyopadhyay et al. · 2017 · Microbiome
BACKGROUND: Identification of factors that influence the neonatal gut microbiome is urgently needed to guide clinical practices that support growth of healthy preterm infants. Here, we examined the influence of nutrition and common practices on the gut microbiota and growth in a cohort of preterm infants. RESULTS: With weekly gut microbiota samples spanning postmenstrual age (PMA) 24 to 46 weeks, we developed two models to test associations between the microbiota, nutrition and growth: a categorical model with three successive microbiota phases (P1, P2, and P3) and a model with two periods (ea
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Jenna R. Krall, James A. Mulholland, Armistead G. Russell et al. · 2016 · Environmental Health Perspectives
BACKGROUND: Short-term exposure to ambient fine particulate matter (PM2.5) concentrations has been associated with increased mortality and morbidity. Determining which sources of PM2.5 are most toxic can help guide targeted reduction of PM2.5. However, conducting multicity epidemiologic studies of sources is difficult because source-specific PM2.5 is not directly measured, and source chemical compositions can vary between cities. OBJECTIVES: We determined how the chemical composition of primary ambient PM2.5 sources varies across cities. We estimated associations between source-specific PM2.5
View details →Negative / Null Result ReportOpen accessMedicine
Aletta P. I. Houwink, Saskia Rijkenberg, Rob J. Bosman et al. · 2016 · Critical Care
BACKGROUND: During resuscitation in severe sepsis and septic shock, several goals are set. However, usually not all goals are equally met. The aim of this study is to determine the relative importance of the different goals, such as mean arterial pressure (MAP), lactate, central venous oxygen saturation (ScvO2) and central to forefoot temperature (delta-T), and how they relate to intensive care unit (ICU) and hospital mortality. METHODS: In a retrospective cohort study in a 20-bed mixed medical and surgical ICU of a teaching hospital we studied consecutive critically ill patients who were admi
View details →Negative / Null Result ReportMedicine
Moira Strand Hutchinson, Guri Grimnes, Ragnar M. Joakimsen et al. · 2010 · European Journal of Endocrinology
OBJECTIVE: Ecologic and observational studies have suggested an association between serum 25-hydroxyvitamin D (25(OH)D) levels and cardiovascular disease (CVD) risk factors, CVD mortality, and cancer mortality. Based on this, low serum…
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Masayuki Hirukawa, Masako Ueda · 2011 · Pacific Economic Review
Abstract Policy‐makers typically interpret positive relations between venture capital (VC) investments and innovations as evidence that VC investments stimulate innovation ( VC‐first hypothesis ). This interpretation is, however, one‐sided…
View details →Negative / Null Result ReportOpen accessHealth Professions
Anthony Montgomery, Florina Spânu, Adriana Băban et al. · 2015 · Burnout Research
According to the Job Demands-Resources (JD-R) model, burnout and engagement are psychological reactions that develop when individual characteristics interact with work characteristics. This study tests the JD-R model using multilevel…
View details →Negative / Null Result ReportOpen accessNeuroscience
Dongshan Yang, Chuan-En Wang, Bentian Zhao et al. · 2010 · Human Molecular Genetics
Neurodegeneration is a hallmark of many neurological diseases, including Alzheimer's, Parkinson's and the polyglutamine diseases, which are all caused by misfolded proteins that accumulate in neuronal cells of the brain. Although apoptosis…
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Ahmad Juwaini, Gusli Chidir, Dewiana Novitasari et al. · 2022 · International Journal of Data and Network Science
This study aims to determine the effect of e-service quality on customer e-satisfaction, the effect of e-trust on customer e-satisfaction, the effect of e-service quality on customer e-loyalty, the effect of e-trust on customer e-loyalty and finally, the effect of e-satisfaction on online shop customer e-loyalty. The type of research used in this research is correlational research with a quantitative approach and testing the research hypothesis was carried out by using the Structural Equation Model (SEM) approach based on Partial Least Square (PLS). The sample or respondent used in this study
View details →Negative / Null Result ReportOpen accessNeuroscience
Christopher Summerfield, Valentin Wyart, Vanessa M. Johnen et al. · 2011 · Frontiers in Human Neuroscience
Repetitions of a sensory event elicit lower levels of brain activity than its initial presentation ("repetition suppression," RS). According to one view, RS depends on the biophysics of neuronal discharge, and is thus an automatic consequence of stimulus processing ("fatigue" model). Another account suggests that RS depends on the statistical structure of the environment, and occurs when repeated stimuli are less surprising than novel stimuli ("surprise reduction" model). In support of the latter view, functional magnetic resonance imaging studies have shown that RS is modulated by the local p
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Giovanna Paolone, Christopher C. Angelakos, Paul Meyer et al. · 2013 · Journal of Neuroscience
Some rats [sign-trackers (STs)] are especially prone to attribute incentive salience to reward cues, relative to others [goal-trackers (GTs)]. Thus, reward cues are more likely to promote maladaptive reward-seeking behavior in STs than…
View details →Negative / Null Result ReportMaterials Science
Jonathan E. Sutton, Dionisios G. Vlachos · 2012 · ACS Catalysis
We present a theoretical and computational analysis to elucidate the relation of the Brønsted–Evans–Polanyi (BEP) and transition state scaling (TSS) correlations. We find that the TSS correlation is an approximation of the BEP correlation.…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Sara O.I. Ramirez-Gomez, Carlos A. Torres-Vitolas, Kate Schreckenberg et al. · 2015 · Ecosystem Services
Over the last two decades indigenous peoples in the lower Caquetá River basin in Colombia have experienced detrimental changes in the provision of important ecosystem services in ways that have significant implications for the maintenance of their traditional livelihoods. To assess these changes we conducted eight participatory mapping activities and convened 22 focus group discussions. We focused the analysis on two types of change: (1) changes in the location of ecosystem services provisioning areas and (2) changes in the stock of ecosystem services. The focal ecosystem services include serv
View details →Negative / Null Result ReportDecision Sciences
Gloria Mark, Shamsi T. Iqbal, Mary Czerwinski et al. · 2016
While email provides numerous benefits in the workplace, it is unclear how patterns of email use might affect key workplace indicators of productivity and stress. We investigate how three email use patterns: duration, interruption habit,…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Alec Stone Sweet, Thomas L. Brunell · 2012 · American Political Science Review
In an article previously published by the APSR , Carrubba, Gabel, and Hankla claim that the decision making of the European Court of Justice (ECJ) has been constrained—systematically—by the threat of override on the part of member state…
View details →Negative / Null Result ReportSocial Sciences
Samuel Bazzi, Arya Gaduh, Alexander D. Rothenberg et al. · 2016 · American Economic Review
We use a natural experiment in Indonesia to provide causal evidence on the role of location-specific human capital and skill transferability in shaping the spatial distribution of productivity. From 1979–1988, the Transmigration Program…
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Chris Forman, Nicolas van Zeebroeck · 2012 · Management Science
How did the diffusion of the Internet influence research collaborations within firms? We examine the relationship between business use of basic Internet technology and the size and geographic composition of industrial research teams…
View details →Negative / Null Result ReportAgricultural and Biological Sciences
Kazushi Takahashi, Christopher B. Barrett · 2013 · American Journal of Agricultural Economics
Abstract The yield potential of a set of improved rice management practices, known as the System of Rice Intensification (SRI), has attracted much attention. Yet we know surprisingly little about SRI's socio‐economic impact. Using data…
View details →Negative / Null Result ReportEconomics, Econometrics and Finance
Menzie Chinn, Olivier Coibion · 2013 · Journal of Futures Markets
Abstract This study examines the predictive content of futures prices for energy, agricultural, precious and base metal commodities. In particular, we examine whether futures prices are (1) unbiased and/or (2) accurate predictors of…
View details →Negative / Null Result ReportOpen accessNeuroscience
Stephen B. R. E. Brown, Henk van Steenbergen, Guido P. H. Band et al. · 2012 · Frontiers in Human Neuroscience
The late positive potential (LPP) is an event-related potential (ERP) component over visual cortical areas that is modulated by the emotional intensity of a stimulus. However, the functional significance of this neural modulation remains elusive. We conducted two experiments in which we studied the relation between LPP amplitude, subsequent perceptual sensitivity to a non-emotional stimulus (Experiment 1) and visual cortical excitability, as reflected by P1/N1 components evoked by this stimulus (Experiment 2). During the LPP modulation elicited by unpleasant stimuli, perceptual sensitivity was
View details →Negative / Null Result ReportOpen accessMedicine
Adam C. Naj, Gary W. Beecham, Eden R. Martin et al. · 2010 · PLoS Genetics
Genome-wide association studies (GWAS) of late-onset Alzheimer disease (LOAD) have consistently observed strong evidence of association with polymorphisms in APOE. However, until recently, variants at few other loci with statistically significant associations have replicated across studies. The present study combines data on 483,399 single nucleotide polymorphisms (SNPs) from a previously reported GWAS of 492 LOAD cases and 496 controls and from an independent set of 439 LOAD cases and 608 controls to strengthen power to identify novel genetic association signals. Associations exceeding the ex
View details →Negative / Null Result ReportOpen accessMedicine
Zvinka Z. Zlatar, Martha C. Muniz, Douglas Galasko et al. · 2016 · The Journals of Gerontology Series B
Objectives: Subjective cognitive decline (SCD) is common in older adults; however, its utility in clinic-based samples remains controversial given its strong associations with mood symptoms. Methods: Five hundred nineteen individuals aged…
View details →Negative / Null Result ReportOpen accessMedicine
Anja Laschkolnig, Barbara Kollerits, Claudia Lamina et al. · 2014 · Cardiovascular Research
AIMS: The relevance of lipoprotein(a) [Lp(a)] concentrations and low-molecular-weight (LMW) apo(a) phenotypes in peripheral arterial disease (PAD) has only been investigated by few studies. Therefore, we analysed this association in three…
View details →Negative / Null Result ReportOpen accessPsychology
Emily S. Kappenman, Annmarie MacNamara, Greg Hajcak · 2014 · Social Cognitive and Affective Neuroscience
Threatening stimuli have been shown to preferentially capture attention using a range of tasks and measures. However, attentional bias to threat has not typically been found in unselected individuals using behavioral measures in the…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Luuk van Hooren, Alessandra Vaccaro, Mohanraj Ramachandran et al. · 2021 · Nature Communications
Abstract Gliomas are brain tumors characterized by an immunosuppressive microenvironment. Immunostimulatory agonistic CD40 antibodies (αCD40) are in clinical development for solid tumors, but are yet to be evaluated for glioma. Here, we demonstrate that systemic delivery of αCD40 in preclinical glioma models induces the formation of tertiary lymphoid structures (TLS) in proximity of meningeal tissue. In treatment-naïve glioma patients, the presence of TLS correlates with increased T cell infiltration. However, systemic delivery of αCD40 induces hypofunctional T cells and impairs the response t
View details →Negative / Null Result ReportBusiness, Management and Accounting
Henry Laurion, Alastair Lawrence, James Ryans · 2016 · The Accounting Review
ABSTRACT We investigate the effects of audit partner rotation among U.S. publicly listed firms, utilizing the fact that audit partners are periodically copied by name in public correspondence between issuers and the Securities and Exchange…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Edda Humprecht, Laia Castro, Sina Blassnig et al. · 2022 · Journal of Communication
Abstract Media systems have changed significantly as a result of the development of information technologies. However, typologies of media systems that incorporate aspects of digitalization are rare. This study fills this gap by…
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
R. Cotesta, G. Carullo, Emanuele Berti et al. · 2022 · Physical Review Letters
We analyze GW150914 postmerger data to understand if ringdown overtone detection claims are robust. We find no evidence in favor of an overtone in the data after the waveform peak. Around the peak, the Bayes factor does not indicate the…
View details →Negative / Null Result ReportSocial Sciences
Pamela Stone, Lisa Ackerly Hernandez · 2013 · Journal of Social Issues
Using a model of the stigmatization of flexible work based on status legitimation theory, we analyze the experiences of a sample of 54 mothers who “opted out” of professional jobs. Qualitative text analysis reveals that features of women's…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Arnaud Bataille, Scott D. Cashins, Laura F. Grogan et al. · 2015 · Proceedings of the Royal Society B Biological Sciences
The pathogenic chytrid fungus Batrachochytrium dendrobatidis (Bd) can cause precipitous population declines in its amphibian hosts. Responses of individuals to infection vary greatly with the capacity of their immune system to respond to the pathogen. We used a combination of comparative and experimental approaches to identify major histocompatibility complex class II (MHC-II) alleles encoding molecules that foster the survival of Bd-infected amphibians. We found that Bd-resistant amphibians across four continents share common amino acids in three binding pockets of the MHC-II antigen-binding
View details →Negative / Null Result ReportOpen accessMedicine
Daniel Gelfond, Sonya L. Heltshe, Chang‐Xing Ma et al. · 2017 · Clinical and Translational Gastroenterology
OBJECTIVES: A defect in bicarbonate secretion contributes to the pathophysiology of gastrointestinal complications in patients with cystic fibrosis (CF). We measured gastrointestinal pH, clinical outcomes, and intestinal transit profiles…
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