Susceptibility of amphibians to chytridiomycosis is associated with MHC class II conformation
Arnaud Bataille; Scott D. Cashins; Laura F. Grogan; Lee F. Skerratt; David Hunter; Michael McFadden; Benjamin C. Scheele; Laura A. Brannelly · 2015 · Proceedings of the Royal Society B Biological Sciences
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
The pathogenic chytrid fungus Batrachochytrium dendrobatidis (Bd) can cause precipitous population declines in its amphibian hosts. Responses of individuals to infection vary greatly with the capacity of their immune system to respond to the pathogen. We used a combination of comparative and experimental approaches to identify major histocompatibility complex class II (MHC-II) alleles encoding molecules that foster the survival of Bd-infected amphibians. We found that Bd-resistant amphibians across four continents share common amino acids in three binding pockets of the MHC-II antigen-binding
Abstract by Arnaud Bataille; Scott D. Cashins; Laura F. Grogan; Lee F. Skerratt; David Hunter; Michael McFadden; Benjamin C. Scheele; Laura A. Brannelly, Proceedings of the Royal Society B Biological Sciences (2015) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1098/rspb.2014.3127