Dementia Revealed: Novel Chromosome 6 Locus for Late-Onset Alzheimer Disease Provides Genetic Evidence for Folate-Pathway Abnormalities
Adam C. Naj; Gary W. Beecham; Eden R. Martin; Paul J. Gallins; Eric Powell; Ioanna Konidari; Patrice L. Whitehead; Guiqing Cai · 2010 · PLoS Genetics
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Genome-wide association studies (GWAS) of late-onset Alzheimer disease (LOAD) have consistently observed strong evidence of association with polymorphisms in APOE. However, until recently, variants at few other loci with statistically significant associations have replicated across studies. The present study combines data on 483,399 single nucleotide polymorphisms (SNPs) from a previously reported GWAS of 492 LOAD cases and 496 controls and from an independent set of 439 LOAD cases and 608 controls to strengthen power to identify novel genetic association signals. Associations exceeding the ex
Abstract by Adam C. Naj; Gary W. Beecham; Eden R. Martin; Paul J. Gallins; Eric Powell; Ioanna Konidari; Patrice L. Whitehead; Guiqing Cai, PLoS Genetics (2010) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1371/journal.pgen.1001130