Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Mansour S Almetwazi, Ahmad O Noor, Diena M Almasri et al. · 2017 · Saudi Pharmaceutical Journal
Objective: To evaluate the association between the level of vitamin D and glycemic control among patients with diabetes. Research design and method: We analyzed data collected from NHANES 2003–2006. We included only non-pregnant adult diabetic persons 18 years or older. Participants who had vitamin D level less than 20 ng/ml were considered as having vitamin D deficiency. Participants were considered to have a glucose control if the HbA1c level was less than 7% [53 mmol/L]. We used student’s t test to compare the difference in HbA1c means between people with Diabetes with and without a vitamin
View details →Negative / Null Result ReportOpen accessMedicine
Xin Zhao, Chaoxuan Wang, Jian Wang et al. · 2026 · Scientific Reports
Abstract Sarcopenia, the progressive loss of muscle mass and function, is a significant health concern in middle-aged and older adults, potentially linked to adverse outcomes like falls and fractures. A cohort study was conducted utilizing participants aged ≥ 45 years from CHARLS. Sarcopenia was defined using established criteria. Primary outcomes were isolated falls, isolated hip fractures, and composite outcomes. Associations were assessed using multivariable Cox regression (adjusted for confounders), propensity score matching (PSM), and inverse probability weighting (IPW), reporting hazard
View details →Negative / Null Result ReportOpen accessPsychiatry
Ahmed Kamil Toman, Ahmed Kamil Toman, Ahmed Kamil Toman et al. · 2025 · Frontiers in Psychiatry
IntroductionCo-occurring conditions are common in children with autism spectrum disorder (ASD) and have important negative impacts on the children and their families. For Iraqi children, local healthcare systems tend to place more emphasis on the management of ASD itself while neglecting co-occurring conditions.ObjectivesThis study aims to investigate the prevalence, characteristics, and potential risk factors of co-occurring epilepsy, sleep, and weight issues among Iraqi children with ASD.MethodsA multicenter cross-sectional study was conducted from January 24 to August 7, 2024, including chi
View details →Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Sharmin Chowdhury, Sheikh Joly Ferdous Ara, Shirazum Monira Mili et al. · 2022 · Advances in Cancer Biology - Metastasis
Background: Colorectal carcinoma (CRC) is the third most common cancer in the world and incidences are on the rise in Bangladesh. KRAS, NRAS, BRAF, PIK3CA, and AKTI gene mutations are predictive markers of biological therapies, monoclonal antibodies targeting EGFR. The purpose of this study was to detect KRAS, NRAS, BRAF, PIK3CA, and AKT1 genes mutation in CRC patients by multiplex real-time Polymerase Chain Reaction (PCR) and evaluate the association of the mutations with clinicopathological features. Methodology: This cross-sectional study was carried out in the Department of Microbiology &
View details →Negative / Null Result ReportMedicine
H. Henjum, Karoline Mo Feten, Erlend Hartvigsen et al. · 2025 · Acta oncologica
Background and purpose Proton Arc Therapy (PAT) is an emerging proton therapy treatment modality with the potential to reduce radiation exposure to healthy tissues compared to conventional Intensity-Modulated Proton Therapy (IMPT) with…
View details →Negative / Null Result ReportOpen accessMedicine
Nihal Al Riyami, Intisar Al-Ruheili, Fatma Al-Shezawi et al. · 2013 · Oman Medical Journal
Objectives: Preterm premature rupture of membranes (PPROM) is defined as a rupture of the amniotic membranes occurring before 37 weeks of gestation and before the onset of labor. Extreme PPROM occurs prior to 26 weeks gestation and contributes to an increased risk of prematurity, leading to maternal and fetal complications. This study aims to estimate the risk factors associated with various maternal complications and to determine the worst outcomes in Omani females with extreme PPROM.Methods: A retrospective cohort study was conducted on 44 women with extreme PPROM, who delivered at Sultan Qa
View details →Negative / Null Result ReportOpen accessOrthopedic surgery
Jaehyung Lee, Janghyun Kim, Sungkuk Chae et al. · 2024 · Foot & Ankle Orthopaedics
Category: Diabetes; Other Introduction/Purpose: Foot ulcers and subsequent amputations are disabling complications in diabetic patients, and major amputations, including below-knee amputations, leave patients with catastrophic disabilities. Diabetes is the most common cause of causing end-stage renal disease which results in hemodialysis, and patients with diabetes on hemodialysis have a higher prevalence of several co-morbidities compared to those without diabetes. The purpose of this study is to compare survival rates after below knee amputation in patients with diabetes who are on hemodialy
View details →Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Ko Yoon, Won Hye, Jeon Eun et al. · 2011 · BMC Cancer
Abstract Background CD44s is a cell adhesion molecule known to mediate cellular adhesion to the extracellular matrix, a prerequisite for tumor cell migration. CD44s plays an important role in invasion and metastasis of various cancers. In the present study, we sought to determine whether CD44s is involved in clinical outcomes of patients with resected non-small cell lung cancer (NSCLC). Methods Using immunohistochemical staining, we investigated CD44s protein expression using tissue array specimens from 159 patients with resected NSCLC (adenocarcinoma (AC; n = 82) and squamous cell carcinoma (
View details →Negative / Null Result ReportOpen accessPublic aspects of medicine
Siqi Luo, Bingquan Xiong, Yuling Chen et al. · 2026 · Critical Public Health
Engagement in physical activity (PA) is a key health-promoting behavior in the prevention and management of chronic kidney disease (CKD). However, evidence regarding the associations between domain-specific PA and CKD remains limited. This study examined the relationships between different PA domains and CKD. Data were obtained from a large population-based survey. PA was self-reported and categorized into transportation-related (TPA), occupational (OPA), and leisure-time PA (LTPA). Multivariable logistic regression, restricted cubic spline models, and subgroup analyses were used to assess ass
View details →Negative / Null Result ReportOpen accessMedicine
Dana S Forcey, Jane S Hocking, Sepehr N Tabrizi et al. · 2014 · PLoS ONE
BACKGROUND: We investigated the detection of chlamydia at different stages of the menstrual cycle. METHODS: Electronic medical records for women attending Melbourne Sexual Health Centre between March 2011 and 31(st) December 2012, who were tested for chlamydia by nucleic acid amplification of high vaginal, cervical, or urinary samples, and who recorded a date of last normal menstrual period (LNMP) between 0-28 days were included in the analysis. Logistic regression was used to calculate adjusted odds ratio (aOR) and 95% confidence intervals (CI) for the association of chlamydia with menstrual
View details →Negative / Null Result ReportOpen accessOther systems of medicine
Nuha Shawarb, Manal Badrasawi, Hassan Abu Qaoud et al. · 2023 · BMC Complementary Medicine and Therapies
Abstract Background The medicinal application of natural plant remedies is well established. These medicinal plants are still in use within the Palestinian community to treat several illnesses. This research is intended to study the use of natural plants to treat different types of respiratory tract disorders. Method This ethno botanical study focused on the medicinal plants that are used to treat respiratory diseases in the northern part of Palestine; Nablus, Tulkarm, Qalqilia, and Jenin. A questionnaire was distributed to 120 respondents. The data obtained included names of the plants used,
View details →Negative / Null Result ReportOpen accessMedicine
Liugang Xu, Yajun Wang, Hongyun Ji et al. · 2024 · PLoS ONE
Background Numerous observational studies have reported an association between frailty and atherosclerosis. However, the causal relationship between frailty and the occurrence of atherosclerosis in different anatomical sites remains unclear. we conducted a bidirectional Mendelian randomization (MR) study to evaluate the causal relationship between the frailty index (FI), and both systemic atherosclerosis and lipids. Methods We obtained summary statistics from large-scale genome-wide association studies (GWAS) of various phenotypes, including frailty (n = 175,226), coronary atherosclerosis (n =
View details →Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Mahdieh Hosseinzadeh, Niloufar Saber, Sakineh Shab Bidar et al. · 2024 · BMC Endocrine Disorders
Abstract Background Type 2 diabetes mellitus (T2DM) is often linked to chronic inflammation, which can be influenced by both lifestyle and dietary choices. However, the relationship between the inflammatory potential of diet and lifestyle factors and the risk of developing T2DM remains unclear. The present study aimed to investigate the associations of the empirical dietary inflammatory index (EDII), dietary inflammatory score (DIS), and lifestyle inflammatory score (LIS) with the risk of T2DM among Iranian adults. Methods The current study was conducted on 5714 individuals from Yazd Health St
View details →Negative / Null Result ReportOpen accessMedicine
Hajibagheri K, Abaszade A, Afrasiabian Sh et al. · 2018 · مجله علمی دانشگاه علوم پزشکی کردستان
Background and Aim: Genital wart is the most common sexually transmitted infection and its role in cervical cancer has been confirmed. The aim of this study was to determine the presence of human papillomavirus (HPV) and the frequency of its genotypes in the patients with genital lesions referring to the clinics in Sanandaj, Iran. Material and Method: This descriptive analytical study included 50 women with genital lesions referring to the clinics in Sanandaj City from February 2016 to February 2017. Biopsy samples were examined for four genotypes (HPV 16, 18 (high risk) and HPV 11, 6 (Low ris
View details →Negative / Null Result ReportOpen accessDentistry
Leena Verma, Ravi Sharma, Sidhi Passi et al. · 2023 · Journal of South Asian Association of Pediatric Dentistry
Aim: To evaluate the correlation between dental caries and obesity in 8–10 years school children of Chandigarh, India. Materials and methods: Around 100 children of the age range of 8–10 years who attended the Pediatrics OPD of Dr Harvansh Singh Judge Institute of Dental Sciences & Hospital, Chandigarh, India were selected. Four groups were made group I—25 healthy teeth and nonobese (HNO) children, group II—25 carious teeth and nonobese (CNO) children, group III—25 healthy teeth and obese (HO) children, and group IV—carious teeth and obese (CO) children. Caries score was recorded after careful
View details →Negative / Null Result ReportOpen accessMedicine (General)
Daniela Cristina Batista Pieroni, Naylla do Carmo Carlins, Pamela Polato et al. · 2017 · O Mundo da Saúde
Aging is associated with a decline in sensory acuity that may lead to impaired nutritional status. Thus, the study aimed to evaluate gustatory sensitivity in relation to the nutritional status of elderly women participating in an Activity Center for the Elderly (ACE). For that, an observational, analytical cross-sectional study was performed with elderly participants of an ACE, in Curitiba, PR. An anamnesis was applied to know and characterize the evaluated population, then an evaluation of the nutritional status was made through anthropometry. The taste sensitivity evaluation was carried out
View details →Negative / Null Result ReportOpen accessEnvironmental sciences
El Sobky, Abeer, F, El Bokhary, M, AwadAllah, Hala, I et al. · 2018 · Journal of Environmental Science
This study was conducted to highlight the significant environmental factors that may have impacts on breast benign and malignant diseases. This study was carried out on one hundred females who came to radiology department to perform mammographic examination. A complete personal and family history of patients was taken, clinical examination was done, all cases were asked to fill a questionnaire about how often they deal with each item of the environmental factors including (alcohol, caffeine, smoking, use of some material that are commonly used in daily life and known to have estrogenic effect
View details →Negative / Null Result ReportOpen accessAgriculture
Dirk Hays, Steve Hague, Seth C. Murray et al. · 2013 · Agronomy
To identify and develop drought tolerant maize (Zea mays L.), high-throughput and cost-effective screening methods are needed. In dicot crops, measuring survival and recovery of seedlings has been successful in predicting drought tolerance but has not been reported in C4 grasses such as maize. Seedlings of sixty-two diverse maize inbred lines and their hybrid testcross progeny were evaluated for germination, survival and recovery after a series of drought cycles. Genotypic differences among inbred lines and hybrid testcrosses were best explained approximately 13 and 18 days after planting, res
View details →Negative / Null Result ReportOpen accessChemistry
Tóth Štefan, Olexa Peter, Hertelyová Zdenka et al. · 2020 · Open Chemistry
The aim of this study was to detect the concentrations of PCSK9 in various subclinical stages of atherosclerosis and to highlight its relationship with inflammation. One hundred and fifty-nine healthy patients were divided into three groups, based on the extent of atherosclerotic changes in the carotid artery: a group without identifiable atherosclerosis, cIMT>75‰ and an asymptomatic plaque group. The PCSK9 was measured by ELISA and hsCRP by the immunoturbidimetric method. Vascular changes were identified by a carotid ultrasound. PCSK9 was elevated, when comparing the healthy group with the cI
View details →Negative / Null Result ReportOpen accessMedicine (General)
Indra Hidayat, Erna Setiawati, Tanti Ajoe Kesoema et al. · 2023 · Jurnal Kedokteran Diponegoro
Background: Smartphone with all of its benefits make the majority of its users become too attached with the device that can fulfil their various needs. Due to its accessibility, an increase of daily screen time has also been observed which may have negative impacts on health, one of them being De Quervain’s Syndrome. De Quervain’s Syndrome is a type of Repetitive Strain Injury, affecting the thumb and wrist caused by a repetitious activity that puts burden or trauma to the aforementioned body parts. Objective: To assess the correlation between duration of screen time and method of handling sma
View details →Negative / Null Result ReportOpen accessHistory of scholarship and learning. The humanities
Salih Gülen, İsmail Dönmez, Fatma Betül Şengönül et al. · 2025 · SAGE Open
STEM education aims to develop 21st-century skills, support economic growth and promote gender equality in STEM fields. It is known that gender stereotypes play a significant role in the formation of STEM identity. The most important factor preventing some high school-level female students from pursuing STEM careers is their lack of participation in STEM activities. Female students in high schools have limited opportunities to explore or learn about STEM careers due to the emphasis on verbal and religious courses in their curriculum. However, it is known that women can work more autonomously i
View details →Negative / Null Result ReportOpen accessMedicine
Memota Laishram, Krishnagopal Srikanth, AR Rajalakshmi et al. · 2017 · Journal of Clinical and Diagnostic Research
Introduction: Macular disease is the leading cause of low vision in the Western world. Drusen and pigmentary irregularities are common among the rural Northern Indian population. The disease process leads to loss of central vision, metamorphopsia, macropsia or micropsia and colour vision defect. Aim: To study the retinal sensitivity changes in macular diseases using microperimetry. Materials and Methods: It was an observational study, conducted in the Department of Ophthalmology at a rural tertiary care hospital. This study was started from December 2014 until June 2016, in all patients with m
View details →Negative / Null Result ReportOpen accessDiseases of the respiratory system
Amika K. Sood, Allison J. Burbank, Michael Lawson et al. · 2019 · Respiratory Research
Abstract Background Endotoxin is a component of particulate matter linked to respiratory disease. Our group has shown that experimental endotoxin inhalation challenge reproducibly triggers neutrophilic inflammation in the airways and in peripheral blood. Sputum induction is currently the only available method for assessing airway neutrophilia but is laborious and time-consuming. This analysis examined the correlation between systemic and airway inflammatory responses to endotoxin to determine if peripheral blood could serve as a surrogate marker for neutrophilic airway inflammation. Methods We
View details →Negative / Null Result ReportOpen accessNuclear engineering. Atomic power
Jun Yeong Jo, Chi Bum Bahn, Hwasung Yeom · 2024 · Nuclear Engineering and Technology
The dissolved oxygen in a coolant can affect the oxidation properties of structural materials. A desirable oxide phase formation is achieved by manipulating the oxygen level in the coolant, which can mitigate structural material degradation in nuclear power plants. Therefore, the role of dissolved oxygen in the corrosion of structural materials in aqueous environments needs to be understood. In this study, a short-term corrosion test (up to 300 h) of Ferritic/Martensitic steels (F/M steels; FeCrW model alloys), namely, Fe12Cr1W, Fe9Cr1W, and Fe9Cr, in stagnant water at 360 °C was performed in
View details →Negative / Null Result ReportOpen accessAnimal culture
C.D. Araújo, G.S. Sanches, F. Borek et al. · 2023 · Arquivo Brasileiro de Medicina Veterinária e Zootecnia
ABSTRACT KIT protein is associated with the etiology of canine mast cell tumors (MCT); however, the expression patterns of KIT are highly variable. The aim of this study was to determine if KIT patterns are related with eosinophil count in MCT. Hematoxylin eosin and May Grünwald-Giemsa stain techniques were applied, histological grading and eosinophil counting were performed in 48 MCT samples. Immunohistochemical evaluation was performed with IL-5, VEGFr, and c-KIT antibodies. The percentage of immunolabeling with IL-5 and VEGFr was determined, and the samples incubated with c-KIT were graded
View details →Negative / Null Result ReportOpen accessMedicine (General)
Manoochehr Nakhjavani, Firouzeh Asgarani, Fatemeh Esfahanian et al. · 2009 · Acta Medica Iranica
Accumulating evidence suggest that in patients with diabetes mellitus, increased rate of lipoprotein oxidation and oxidative stress have important role in diabetic angiopathy, including nephropathy. To evaluate the association of oxidized low- density lipoprotein (ox-LDL) with the development of diabetic nephropathy, plasma level of ox-LDL were measured in 70 diabetic patients with macro and 63 patients with normoalbuminuria. The plasma oxidized- LDL level in patients with macroalbuminuria was higher than those in normoalbuminuric group, (85.72 ± 32.92 mu/L versus 75.07 ± 26.46 u/L, P= 0.041).
View details →Negative / Null Result ReportOpen accessDentistry
Dewi Kania Intan Permatasari, Tenny Setiani Dewi, Dewi Marhaeni Diah Herawati · 2021 · Dental Journal
Background: Taste disorders often occur in the elderly, which can have serious consequences on their health status. Zinc and saliva volume have a role in maintaining taste acuity, especially in the elderly. Purpose: This study was to determine the correlation between salivary zinc levels, salivary volume, and taste disorders in elderly patients. Methods: This was a cross-sectional research. Elderly patients with and without taste disorders were included in this study. Salivary zinc levels were measured using the Atomic Absorption Spectrometry (AAS) method. Salivary volume was measured using th
View details →Negative / Null Result ReportOpen accessInfectious and parasitic diseases
Dou Qu, Xiaoni Zhong, Guiyuan Xiao et al. · 2018 · International Journal of Infectious Diseases
Objective: To evaluate adherence to pre-exposure prophylaxis (PrEP) in a clinical trial of a population of men who have sex with men (MSM), to explore the influence of social psychology and objective factors (e.g., forgetting, too busy) on adherence, and to provide evidence for subsequent PrEP research. Methods: This study analyzed the data from the daily medication group within a PrEP study (a randomized placebo-controlled trial of oral tenofovir among MSM in Western China from April 2013 to March 2015). A total of 331 participants were analyzed. PrEP adherence was self-reported by the subjec
View details →Negative / Null Result ReportOpen accessMedicine
Fatemeh Moghadasi-Boroujeni, Mansoureh Adel Ghahraman · 2020 · مجله پژوهش در علوم توانبخشی
Introduction: Romberg test is one of the balance screening tests. Since this test does not require special equipment, it is widely used in the evaluation of people suffering from balance disorders. This study aimed to determine the sensitivity of the Romberg test for the diagnosis of peripheral vestibular dysfunction compared with the caloric test that is the gold standard for the diagnosis of horizontal semicircular canal/superior vestibular nerve disorders.Materials and Methods: This study was a cross-sectional-comparative study and the sample was selected from those who referred to the audi
View details →Negative / Null Result ReportOpen accessMedicine (General)
Joel Del Bel Pádua, Carolline Fontes Alves Mariano, Alexandre Todorovic Fabro et al. · 2024 · Biomarker Insights
Background: Immunohistochemical prognostic significance of the homologous recombination-related proteins RAD51, ATM, BRCA1, and BRCA2 is known in gastric adenocarcinoma, one of the deadliest cancers. Objective and design: This retrospective cohort study aimed to evaluate mRNA expression and promoter methylation of some homologous recombination-related genes in this neoplasm. Methods: We evaluated mRNA expression and methylation of RAD51 , ATM , ATR , BRCA1 , and BRCA2 in tumor and non-tumor frozen samples from gastrectomy specimens by RT-qPCR and MS-HRM, correlating our results with previous i
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