Mutational profile of KRAS, NRAS, BRAF, PIK3CA, and AKT1 genes in colorectal cancer patients in a tertiary care hospital, Dhaka
Sharmin Chowdhury; Sheikh Joly Ferdous Ara; Shirazum Monira Mili; Tahani Momotaz; Md Maruf Ahmed Molla; Shaheda Anwar; Ahmed Abu Saleh · 2022 · Advances in Cancer Biology - Metastasis
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Background: Colorectal carcinoma (CRC) is the third most common cancer in the world and incidences are on the rise in Bangladesh. KRAS, NRAS, BRAF, PIK3CA, and AKTI gene mutations are predictive markers of biological therapies, monoclonal antibodies targeting EGFR. The purpose of this study was to detect KRAS, NRAS, BRAF, PIK3CA, and AKT1 genes mutation in CRC patients by multiplex real-time Polymerase Chain Reaction (PCR) and evaluate the association of the mutations with clinicopathological features. Methodology: This cross-sectional study was carried out in the Department of Microbiology &
Abstract by Sharmin Chowdhury; Sheikh Joly Ferdous Ara; Shirazum Monira Mili; Tahani Momotaz; Md Maruf Ahmed Molla; Shaheda Anwar; Ahmed Abu Saleh, Advances in Cancer Biology - Metastasis (2022) — licensed CC BY 4.0.
About to run something similar?
Run an AI Precheck on your own design to catch failure modes like this one before you spend the time. Your first desk check is free.
Related failures
Effects of Src on Proliferation and Invasion of Lung Cancer Cells
Negative / Null Result ReportSecretory Function of Kupffer Cells in Liver Cancer After Cryoablation
Negative / Null Result ReportEffect of antiangiogenic-based treatment and systemic inflammatory factors on outcomes in patients with BRAF v600-mutated metastatic colorectal cancer: a real-world study in Spain
Negative / Null Result ReportImpact of the interval between neoadjuvant immunochemotherapy and surgery on surgical–pathological outcomes in non-small cell lung cancer
Negative / Null Result ReportImpact of innate lymphoid cell type 2 in chronic lymphocytic leukemia on the function of treg and CD8+ T cells through IL-9
Negative / Null Result ReportAnti-ceramide antibody and sphingosine-1-phosphate as potential biomarkers of unresectable non-small cell lung cancer
WASTE indexes this work — it does not host or republish it. Failure-type classification is automated and approximate.
Metadata source: DOAJ · DOI 10.1016/j.adcanc.2022.100054