Systemic inflammatory response to inhaled endotoxin does not correlate with airway response
Amika K. Sood; Allison J. Burbank; Michael Lawson; Haibo Zhou; Heather B. Wells; David B. Peden; Michelle L. Hernandez · 2019 · Respiratory Research
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Background Endotoxin is a component of particulate matter linked to respiratory disease. Our group has shown that experimental endotoxin inhalation challenge reproducibly triggers neutrophilic inflammation in the airways and in peripheral blood. Sputum induction is currently the only available method for assessing airway neutrophilia but is laborious and time-consuming. This analysis examined the correlation between systemic and airway inflammatory responses to endotoxin to determine if peripheral blood could serve as a surrogate marker for neutrophilic airway inflammation. Methods We
Abstract by Amika K. Sood; Allison J. Burbank; Michael Lawson; Haibo Zhou; Heather B. Wells; David B. Peden; Michelle L. Hernandez, Respiratory Research (2019) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1186/s12931-019-1227-3