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Browse the failure-mode index

21,253 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result Report

Additional Decitabine Did Not Improve Outcomes of Elder Acute Myeloid Leukemia Patients Based on Microtransplantation with Cytarabine and Anthracycline Chemotherapy

Kaixun Hu, Yajing Huang, Huisheng Ai et al. · 2015 · Blood

Abstract Acute myeloid leukemia (AML) of older patients is an aggressive malignancy. Despite decitabine is performed some clinic trials in these patients, however there is little data on efficacy and is more controversial on it. Recent…

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Negative / Null Result Report

Did multiagent chemotherapy improve clinical outcomes of advanced pancreatic cancer? A single center experience of 408 cases.

Yousuke Nakai, Hiroyuki Isayama, Kazunaga Ishigaki et al. · 2016 · Journal of Clinical Oncology

293 Background: We previously reported the introduction of S-1 improved overall survival (OS) in advanced pancreatic cancer (PC), but in a pooled analysis of 3 RCTs, a combination of gemcitabine and S-1 (GS) improved OS in locally advanced…

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Negative / Null Result Report

Delaying Shoulder Motion and Strengthening and Increasing Achilles Allograft Thickness for Glenoid Resurfacing Did Not Improve the Outcome for a 30-Year-Old Patient with Postarthroscopic Glenohumeral Chondrolysis

John G. Skedros, Tanner R. Henrie, Chad S. Mears · 2014 · Case Reports in Orthopedics

Although interposition soft-tissue (biologic) resurfacing of the glenoid with humeral hemiarthroplasty has been considered an option for end-stage glenohumeral arthritis, the results of this procedure are highly unsatisfactory in patients…

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Negative / Null Result Report

Postoperative Doxycycline Did Not Improve Early Postoperative Outcomes in Hip Arthroscopy Patients: A Retrospective Cohort Study

Zeeshan M. Akhtar, Emily R. Hunt, Brooks N. Platt et al. · 2021 · The Journal of Hip Surgery

Abstract Doxycycline has been shown to reduce fibroblast activity in the treatment of multiple pathologies, and was utilized as part of the postoperative medication protocol to help prevent adhesions from developing after hip arthroscopy.…

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Negative / Null Result Report

Did the 2017 wage increase improve job satisfaction of academic staff? A case study of the university of Nigeria, Nsukka

Abdullahi Abubakar, Boniface Denis Umoh · 2023 · Caleb International Journal of Development Studies

Many employees are merely holding on to their current jobs for lack of alternatives. Such staff members are no longer deriving satisfaction from their current jobs. Lack of satisfaction impinges on workers productivity and attitude to work…

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Negative / Null Result Report

P0603 Early tumour necrosis factor inhibitor initiation is associated with increased persistence in Crohn’s Disease but not Ulcerative Colitis, whereas early ustekinumab, vedolizumab and tofacitinib did not improve persistence

B Gu, J Chetwood, A Pudipeddi et al. · 2026 · Journal of Crohn’s and Colitis

Abstract Background Emerging evidence suggests early initiation of advanced therapies (AT) may improve outcomes, but optimal timing remains unclear. We aimed to assess the impact of AT timing on persistence. Methods We interrogated the…

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Negative / Null Result Report

A Novel Honey Powder-Based Supplement Containing Carbohydrate and Protein Did Not Improve Endurance Performance in Recreationally Trained Cyclists

Taíse Toniazzo, Rafael de Almeida Azevedo, Tamires Nunes Oliveira et al. · 2025 · International Journal of Sport Nutrition and Exercise Metabolism

Sports supplements composed of carbohydrate and protein are widely used by endurance athletes and recreational practitioners, mostly aimed at improving performance. This study investigated the effect of a novel carbohydrate + protein honey…

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Negative / Null Result ReportMedicine

Inhibitory Effects of Oxytocin on Jejunal Migrating Myoelectric Complex Activity in Fasted Rats: Role of Oxytocin and GLP-1 Receptors.

Balcı, Saltık, Aktemur et al. · 2026 · Life (Basel, Switzerland)

The migrating myoelectric complex (MMC) is the electrical basis of fasting small intestinal motility. Although oxytocin (OT) regulates gastrointestinal functions through oxytocin receptors (OTRs), its effect on jejunal MMC activity during…

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Negative / Null Result Report

Utility of platelet indices as a diagnostic indicator of hemodynamically significant PDA in preterm infants: a comparative cross-sectional study

Samar Mahmoud Elbahy, Ola Galal Ali, Sara Soliman Ali et al. · 2024 · Egyptian Pediatric Association Gazette

Abstract Background Among preterm babies, patent ductus arteriosus (PDA) is a prevalent condition, and hemodynamically significant patent ductus arteriosus (hsPDA) constitutes an important problem that impacts their outcome. There has…

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Negative / Null Result Report

OA09 Significant association between disease duration in axial spondyloarthritis and the occurrence of uveitis and inflammatory bowel disease, with no such association found for psoriasis

Brona Dinneen, Marcus Kenyon, Finbar O'Shea · 2024 · Rheumatology

Abstract Background/Aims Axial spondyloarthritis is a chronic inflammatory condition primarily impacting the spine and sacroiliac joints. In addition to spinal inflammation and peripheral symptoms, it frequently presents with…

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Negative / Null Result Report

Association between global longitudinal strain and coronary artery calcium in the diagnosis of significant coronary artery disease

M Shvydka, M Lutay, I Golikova · 2026 · European Heart Journal - Cardiovascular Imaging

Abstract Introduction Non-invasive diagnostic methods for coronary artery disease (CAD) are gaining increasing importance due to their accessibility, diagnostic value, safety, and cost-effectiveness. Both global longitudinal strain (GLS)…

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Negative / Null Result Report

Evaluation of the departmental inter-rater reliability when scoring thyroid nodules according to the British Thyroid Association Ultrasound-classification model: Is there significant disagreement?

Nabil Rtam · 2023 · Ultrasound

Introduction: The British Thyroid Association Ultrasound-classification is a risk stratification model which grades thyroid nodules in U2–5 based on their sonographic appearance. Existence of variability between the ultrasound operators…

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Negative / Null Result Report

The Association between a Recorded Diagnosis of Obesity and Clinically Significant Weight Loss in the Primary Care Setting: A Nationwide Registry

Michal Kasher Meron, Nira Koren-Morag, Dan Oieru · 2024 · Obesity Facts

Introduction: Overweight and obesity (OW/OB) are underdiagnosed. The primary aim was to assess whether a diagnosis of OW/OB recorded by a primary care physician (PCP) is associated with clinically significant weight loss, compared to a…

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Negative / Null Result Report

A Study on the Job Training Support Experience of Job Coach for the Vocational Rehabilitation Support Project for the People with a Significant Disability

Min-Sik Kim, Young-Ran Kim · 2024 · The K Association of Education Research

This study focuses on experience of Job Coach in Occupational Rehabilitation Support Projects that is offered by the field at the Field-Centric Occupational Rehabilitation Centers. The purpose of the study is to present better support to…

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Negative / Null Result Report

Abstract 4364710: Association Between Pre-Operative History of Significant Bleeding and Post-Operative Cardiovascular Events Following Lower Extremity Revascularization

David Bresnahan, Yuhe Xia, Elliot Luttrell-Williams et al. · 2025 · Circulation

Background and Hypothesis: Patients with symptomatic peripheral artery disease (PAD) frequently undergo lower extremity revascularization (LER) but remain at increased risk of major adverse cardiovascular and limb events following the…

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Negative / Null Result Report

Is There a Significant Association Between Body Image and Psychological Health in Moroccan Postmenopausal Women? A Cross-Sectional Study

Sara Esseffar, Said Bellahcen, Ghizlane Azizi et al. · 2025 · The Open Public Health Journal

Background Menopause and its consequences, sometimes complex, can generate discomfort in well-being and consequently affect the quality of women’s lives. Objective The present study was carried out to examine the quality of life of…

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