Negative / Null Result Report
Nicole Stegmeier, Sameer R. Oak, Colin O’Rourke et al. · 2017 · Sports Health: A Multidisciplinary Approach
Background: Two versions of the International Knee Documentation Committee (IKDC) Subjective Knee Evaluation form currently exist: the original version (1999) and a recently modified pediatric-specific version (2011). Comparison of the…
View details →Negative / Null Result ReportOpen accessMedicine
Iván Chérrez-Ojeda, Emanuel Vanegas, Valeria L. Mata et al. · 2019 · Allergy Asthma and Clinical Immunology
Little is known about the association of urticarial vasculitis (UV) with thyroid autoimmunity. The latter has been mostly described in the setting of patients with chronic spontaneous urticaria (CSU). In this letter to the editor, we compare UV and CSU through retrospective analyses, which reveal that 41.7% patients with UV presented antithyroperoxidase (anti-TPO) and/or antithyroglobulin antibody (ATA) above the reference range, while only 4% patients with CSU had these antibodies elevated. There is a moderately strong association assessed by the Phi coefficient (φ = 0.420, p = 0.004). Furthe
View details →Negative / Null Result ReportNeuroscience
Tiago Pereira, Ana María Abreu, Alexandre Castro‐Caldas · 2013 · Perceptual and Motor Skills
This study aimed to assess how the capacity to acquire, form and consolidate motor memories might vary across different tasks and different groups (with and without motor expertise). 20 athletes and 21 non-athletes were tested on five…
View details →Negative / Null Result ReportOpen accessMedicine
Jana Uhlinova, Anne Kuudeberg, Kaja Metsküla et al. · 2022 · BMC Nephrology
INTRODUCTION: Chronic kidney disease-mineral and bone disorders (CKD-MBD) is characterised by generalised vascular calcification (VC) and impaired bone health. We aimed to investigate the relationship between VC and bone mineral density (BMD) in CKD patients. METHODS: We performed a cross-sectional study of patients with different stages of CKD. For assessment of VC of abdominal aorta lateral lumbar X-rays (Kauppila score), the ankle-brachial index (ABI) and echocardiography were used. Total body densitometry provided BMD. RESULTS: Ninety patients (41% male, median age 64 years (range 29-87))
View details →Negative / Null Result ReportEngineering
Shuo Li, Peiliang Cong, Demei Yu et al. · 2019 · Transportation Research Record Journal of the Transportation Research Board
High friction surface treatment (HFST) has been proactively used as a solution to extreme friction demands at locations such as horizontal curves, ramps, bridge decks, and intersections. Considerable efforts have been made to evaluate the…
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A. Ross Otto · 2010 · Cognitive Science
Abstract Cunha and Caldieraro (2009) investigated whether sunk‐cost effects, which are well documented in hypothetical situations involving monetary investments, also occur in choice situations with purely behavioral investments. Their…
View details →Negative / Null Result ReportOpen accessMedicine
Patrick Royer, Elias Björnson, Martin Adiels et al. · 2024 · American Heart Journal
BACKGROUND AND AIMS: Recent developments in high-throughput proteomic technologies enable the discovery of novel biomarkers of coronary atherosclerosis. The aims of this study were to test if plasma protein subsets could detect coronary artery calcifications (CAC) in asymptomatic individuals and if they add predictive value beyond traditional risk factors. METHODS: Using proximity extension assays, 1,342 plasma proteins were measured in 1,827 individuals from the Impaired Glucose Tolerance and Microbiota (IGTM) study and 883 individuals from the Swedish Cardiopulmonary BioImage Study (SCAPIS)
View details →Negative / Null Result ReportOpen accessMedicine
Sabiq Muhtadi, Rezwana R. Razzaque, Ahmad Chowdhury et al. · 2023 · Journal of Medical Imaging
Purpose: We evaluate texture quantified from ultrasound Nakagami parametric images for non-invasive characterization of breast tumors, as Nakagami images can more faithfully represent intrinsic tumor characteristics than standard B-mode…
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Mo Sadique, Sapna Ratan Shah, Sunil Kumar Sharma et al. · 2023 · Mathematics
Synovial joints are unique biological tribo-systems that allow for efficient mobility. Most of the synovial joint activities in the human body are accomplished due to the presence of synovial fluid. As a biological lubricant, synovial…
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Fatih Kuzu · 2018 · Pakistan Journal of Medical Sciences
Background & Objectives: In diabetics, cardiac microvascular circulation disorder increases the risk of arrhythmia and sudden cardiac death. Tpeak-Tend (Tp-e) interval, Tp-e dispersion, and Tp-e/QT and Tp-e/QTc ratios measured by surface…
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Minh Tam Thi BUI, Trinh Quang Long · 2021 · Journal of risk and financial management
This paper identifies whether there was a performance difference among micro, small and medium enterprises (MSMEs) led by men and by women in Vietnam during the period 2005–2013 and aims to provide explanations for the differences, if any, in various performance indicators. The paper adopts a quantitative approach using a firm-level panel dataset in the manufacturing sector in 10 provinces/cities in Vietnam in five waves from 2005 to 2013. Fixed effect models are estimated to examine the influence of firm variables and demographic, human capital characteristics of owners/managers on firms’ val
View details →Negative / Null Result ReportPsychology
Josephine Terry, Jia Hoong Ong, Paola Escudero · 2015 · ICPhS
Distributional learning studies investigating the acquisition of the Dutch contrast /ɑ/-/a:/ by nonnative Dutch learners have reported mixed results. The present study extends the literature by examining whether (i) naive listeners are…
View details →Negative / Null Result ReportOpen accessPsychology
Amy D. Herschell, David J. Kolko, Ashley T. Scudder et al. · 2021 · Journal of Clinical Child & Adolescent Psychology
OBJECTIVE: This study (NIMH RO1 MH095750; ClinicalTrials.gov Identifier: NCT02543359) evaluated the effectiveness of three training models to implement a well-established evidence-based treatment, Parent-Child Interaction Therapy (PCIT).…
View details →Negative / Null Result ReportOpen accessMedicine
Angkana T. Huang, Henrik Salje, Ana Coello Escoto et al. · 2022 · PLoS Pathogens
Neutralizing antibodies are important correlates of protection against dengue. Yet, determinants of variation in neutralization across strains within the four dengue virus serotypes (DENV1-4) is imperfectly understood. Studies focus on structural DENV proteins, especially the envelope (E), the primary target of anti-DENV antibodies. Although changes in immune recognition (antigenicity) are often attributed to variation in epitope residues, viral processes influencing conformation and epitope accessibility also affect neutralizability, suggesting possible modulating roles of nonstructural prote
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Guangfu Hu, Guangxia Hu, Chengjiao Zhang et al. · 2020 · BMC Cancer
BACKGROUND: The benefit of adjuvant chemotherapy in invasive lobular carcinoma (ILC) is still unclear. The objective of the current study was to elucidate the effectiveness of adjuvant chemotherapy in hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, pT1b-c/N0-1/M0 ILC. METHODS: Based on Surveillance, Epidemiology, and End-Results (SEER) database, we identified original 12,334 HR-positive, HER2-negative, pT1b-c/N0-1/M0 ILC patients, who were then divided into adjuvant chemotherapy group and control group. End-points were overall survival (OS) and breast
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Mila Vulchanova, Valentin Vulchanov · 2022 · Frontiers in Communication
Problems with the processing and understanding of figurative language have been systematically observed in individuals on the autism spectrum despite preserved structural language skills. In this qualitative review we discuss theoretical…
View details →Negative / Null Result ReportOpen accessMedicine
Rachel Silvany Quadros Guimarães, Igor D. Bandeira, Bianca Lima Barretto et al. · 2024 · Frontiers in Psychiatry
Introduction: Although pharmacological treatment for Attention-Deficit/Hyperactivity Disorder (ADHD) has demonstrated efficacy, several individuals persist in experiencing social and academic impairment. Additionally, the occurrence of significant side effects may render the use of psychotropic medications untenable. However, Transcranial Direct Current Stimulation (tDCS), a non-invasive brain stimulation technique, shows promising results in treating ADHD. Objectives: To investigate the efficacy and safety of tDCS on the performance of children and adolescents with ADHD in neuropsychological
View details →Negative / Null Result ReportMedicine
Allison Gedney, Pascale C. Salah, Jennifer A. Mahoney et al. · 2022 · Veterinary and Comparative Oncology
Canine splenic hemangiosarcoma (HSA) is an aggressive tumour of vascular endothelium that carries a grave prognosis following standard of care treatment with surgery and doxorubicin. A previous pilot study revealed potential anti-tumour…
View details →Negative / Null Result ReportOpen accessMedicine
Maurice de Wit, Ya Gao, Darlene Mercieca et al. · 2020 · EBioMedicine
BACKGROUND: Clinical responses to EGFR tyrosine kinase inhibitors (TKIs) are restricted to tumors harboring specific activating mutations and even then, not all tyrosine kinase inhibitors provide clinical benefit. All TKIs however,…
View details →Negative / Null Result ReportOpen accessMedicine
Kevin Lynch, Gabriella C. Squeo, William J. Kane et al. · 2021 · International Journal of Cancer
Abstract Checkpoint‐blockade therapy (CBT) is approved for select colorectal cancer (CRC) patents, but additional immunotherapeutic options are needed. We hypothesized that vaccination with carcinoembryonic antigen (CEA) and Her2/neu…
View details →Negative / Null Result ReportOpen accessMedicine
Ming-Ci Cai, Shu Cheng, Xin Wang et al. · 2020 · Genome Medicine
Abstract Background Cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP)/CHOP-like chemotherapy is widely used in peripheral T cell lymphoma (PTCL). Here we conducted a phase 2, multicenter, randomized, controlled trial, comparing the efficacy and safety of CEOP/IVE/GDP alternating regimen with CEOP in newly diagnosed PTCL. Methods PTCL patients, except for anaplastic large cell lymphoma-anaplastic lymphoma kinase positive, were 1:1 randomly assigned to receive CEOP/IVE/GDP (CEOP, cyclophosphamide 750 mg/m 2 , epirubicin 70 mg/m 2 , vincristine 1.4 mg/m 2 [maximum 2 mg] on day 1
View details →Negative / Null Result ReportOpen accessMedicine
K. Lance Gould, Nils P. Johnson, Amanda E. Roby et al. · 2025 · European Heart Journal
BACKGROUND AND AIMS: The randomized CENTURY trial tested the hypothesis that a comprehensive strategy integrating intense lifestyle modification and aggressive medical management to goals with revascularization reserved for severely reduced coronary flow capacity (CFC) by positron emission tomography (PET) would reduce risk factors, subsequent revascularization, death and myocardial infarction (MI) compared with standard of care in chronic stable coronary artery disease (CAD). METHODS: Participants were randomly assigned to standard or comprehensive care groups. Rest-stress PET quantified CFC
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Maximilian J. Mair, Aysegül Ilhan‐Mutlu, Sahra Pajenda et al. · 2021 · Cancer Immunology Immunotherapy
PURPOSE: In primary brain tumors, the efficacy of immune-modulating therapies is still under investigation as inflammatory responses are restricted by tight immunoregulatory mechanisms in the central nervous system. Here, we measured soluble PD-L1 (sPD-L1) in the plasma of patients with recurrent glioblastoma (GBM) and recurrent WHO grade II-III glioma treated with bevacizumab-based salvage therapy. METHODS: Thirty patients with recurrent GBM and 10 patients with recurrent WHO grade II-III glioma were treated with bevacizumab-based salvage therapy at the Medical University of Vienna. Prior to
View details →Negative / Null Result ReportOpen accessMedicine
Akiko Ioka, Masami Inoue, Akihiro Yoneda et al. · 2015 · Journal of Epidemiology
BACKGROUND: In 2004, the Japanese government halted the 6-month mass screening program for neuroblastoma. We investigated whether its cessation had led to an increase not only in mortality due to this disease but also in the incidence of advanced-stage disease among older children. METHODS: Study subjects were neuroblastoma patients retrieved from the population-based Osaka Cancer Registry. Trends of incidence and mortality from neuroblastoma were analyzed by calendar year and birth cohort. Prognostic factors, including stage and v-myc avian myelocytomatosis viral oncogene neuroblastoma derive
View details →Negative / Null Result ReportOpen accessMedicine
Somnath Bandyopadhyay, Seán Connolly, Omar Jabado et al. · 2017 · Lupus Science & Medicine
OBJECTIVE: To characterise patients with active SLE based on pretreatment gene expression-defined peripheral immune cell patterns and identify clusters enriched for potential responders to abatacept treatment. METHODS: This post hoc…
View details →Negative / Null Result ReportOpen accessMedicine
Rohit Nathani, Meena B. Bansal · 2023 · PubMed
Tremendous effort has been put forth over the past 2 decades in understanding the pathophysiology of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NAFLD/NASH). Although multiple potential targets for drug development…
View details →Negative / Null Result ReportOpen accessMedicine
Panpan Zhang, Wei Wang, Ming Lu et al. · 2018 · Cancer Medicine
BACKGROUND: Gastroesophageal Junction neuroendocrine neoplasms (GEJ-NENs) are rare and heterogeneous tumors. We aim to analyze the clinicopathlogical features and prognostic factors of GEJ-NENs and to compare the outcome of GEJ-NENs with other gastric NENs. METHODS: A total of 297 GEJ-NENs patients were enrolled from 10 Chinese hospitals and 3152 gastric NENs patients, including 274 GEJ-NENs, were retrieved from Surveillance, Epidemiology, and End Results (SEER) database. RESULTS: The clinical characteristics of GEJ-NENs among different races were different. All Chinese patients had GEJ-NENs o
View details →Negative / Null Result ReportMedicine
Josephine Berger-Groch, Johannes M. Rueger, Patrick Czorlich et al. · 2021 · Prehospital Emergency Care
Background: The role of pelvic circumferential compression devices (PCCD) is to temporarily stabilize the pelvic ring, reduce its volume and to tamponade bleeding. The purpose of this study was to evaluate the effect of PCCDs on mortality…
View details →Negative / Null Result ReportOpen accessMedicine
Bethan Goulden, David Isenberg · 2020 · Expert Opinion on Biological Therapy
INTRODUCTION: The type 1 interferon pathway is known to play a role in the immunopathology of systemic lupus erythematosus (SLE). As a result, biologic agents targeting this pathway have been developed and are currently being investigated…
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Qihan Ma, Jianbo Wang, Ming Xiong et al. · 2023 · Remote Sensing
The lockdowns from the coronavirus disease of 2019 (COVID-19) have led to a reduction in anthropogenic activities and have hence reduced primary air pollutant emissions, which were reported to have helped air quality improvements. However,…
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