Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Raissa Relator, Aika Terada, Jun Sese · 2018 · BMC Medical Genomics
BACKGROUND: Survival analysis methods have been widely applied in different areas of health and medicine, spanning over varying events of interest and target diseases. They can be utilized to provide relationships between the survival time of individuals and factors of interest, rendering them useful in searching for biomarkers in diseases such as cancer. However, some disease progression can be very unpredictable because the conventional approaches have failed to consider multiple-marker interactions. An exponential increase in the number of candidate markers requires large correction factor
View details →Negative / Null Result ReportOpen accessSocial Sciences
Kate Ambler, Kelly Jones, Michael O’Sullivan · 2025 · Journal of Development Economics
We conduct a randomized controlled trial to test a novel intervention for increasing women’s empowerment in Uganda. The intervention includes a within-household transfer of a productive asset, which has a lower cost than an external…
View details →Negative / Null Result ReportOpen accessMedicine
Dominik Lewandowski, Mateusz Konieczny, Agata Różycka et al. · 2025 · International Journal of Molecular Sciences
Cathepsins, a family of lysosomal proteases, play critical roles in maintaining cellular homeostasis through protein degradation and modulation of immune responses. In the central nervous system (CNS), their functions extend beyond classical proteolysis, influencing neuroinflammation, synaptic remodeling, and neurodegeneration. Emerging evidence underscores the crucial role of microglial cathepsins in the pathophysiology of several neurological disorders. This review synthesizes current knowledge on the involvement of cathepsins in a spectrum of CNS diseases, including Parkinson's disease, Alz
View details →Negative / Null Result ReportOpen accessMedicine
Yuning Chen, Ying Fang, Zibai Lyu et al. · 2026 · Journal of Biomedical Science
The microbiome has emerged as a critical, context-dependent regulator of tumorigenesis and anticancer immunity, capable of either promoting cancer progression or protecting against malignancy. This dual role is mediated by multiple interconnected mechanisms-including chronic inflammation, modulation of immune responses, and alterations in host metabolic signaling. These microbiome-cancer interactions vary across organs, influencing malignancies in the colon, breast, lung, and beyond. Clinically, the microbiome significantly affects patient responses to cancer therapies, particularly immunother
View details →Negative / Null Result ReportOpen accessMaterials Science
Qiuyun Guo, He Lv, Ran Dong et al. · 2026 · Polymers
Batch production of nanomaterials is highly desired for developing commercial nanoproducts. Here, a brand-new electrospinning method, termed hole electrospinning, was developed for batch production of drug-loaded polymeric nanofibers. Using resveratrol and polyvinylpyrrolidone as model drug and filament-forming matrix, respectively, both hole and single-needle electrospinning were conducted. The resultant nanofibrous films were compared in terms of morphology, physical and thermal properties, mechanical performance, fast-dissolution rate, and antioxidant activity. Analytical and characterizati
View details →Negative / Null Result ReportOpen accessMedicine
Tanayott Thaweethai, Sarah E. Donohue, Jeffrey N. Martin et al. · 2025 · Nature Communications
Longitudinal trajectories of Long COVID remain ill-defined, yet are critically needed to advance clinical trials, patient care, and public health initiatives for millions of individuals with this condition. Long COVID trajectories were…
View details →Negative / Null Result ReportOpen accessMaterials Science
Wenwen Zhang, Qilin Wang, Wei Yi et al. · 2026 · Biomolecules
To overcome the limitations of traditional motion sickness medications—slow onset of action, short duration of efficacy, and poor patient compliance—this study employed coaxial electrospinning technology. Poly(lactic acid) (PLA) and polyvinylpyrrolidone K90 (PVP K90) were used as composite carrier materials. The sheath layer is composed of highly hydrophilic PVP K90, loaded with the antihistamine diphenhydramine (DPH). The core layer, composed of biodegradable PLA with excellent sustained-release properties, carries the anticholinergic drug scopolamine hydrobromide (SH). This core–sheath nanos
View details →Negative / Null Result ReportOpen accessSocial Sciences
Junjie Dong, Zhidan Tan, Y Zhang et al. · 2025 · BMC Psychology
BACKGROUND: With the advancement of globalization and technology, remote work has gradually become a feasible and popular work model, particularly with the rapid adoption of working from home driven by the COVID-19 pandemic. This shift not…
View details →Negative / Null Result ReportOpen accessMedicine
Bernardo G. Collaco, Syed Ali Haider, Srinivasagam Prabha et al. · 2026 · npj Digital Medicine
Agentic AI represents a promising evolution of artificial intelligence in healthcare, with systems capable of operating autonomously to achieve defined clinical goals. However, the literature lacks conceptual clarity in distinguishing AI…
View details →Negative / Null Result ReportOpen accessComputer Science
Remita Austin, R. Parvathi · 2025 · Scientific Reports
The absence of reliable early treatment serves as one of the main causes of cervical cancer. Hence, it is crucial to detect cervical cancer early. The biggest challenge in diagnosing cervical cancer early is that it is asymptomatic until it develops into invasive carcinoma. In medical applications, the use of machine learning and deep learning is successful as a classifier in the preliminary identification of cancerous cells in the cervical region. In our study, we present a CNN-based method for the classification of cervical cancer cells. We present a method for accurately classifying Pap sme
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Sara Kurkowska, Julia Brosch-Lenz, Yuni K. Dewaraja et al. · 2025 · Journal of Nuclear Medicine
Individualized radiopharmaceutical therapies guided by patient-specific absorbed dose (AD) assessments using nuclear medicine imaging have the potential to improve both efficacy and safety. Understanding sources of variability in AD calculations is critical for standardization. The Society of Nuclear Medicine and Molecular Imaging Dosimetry Task Force launched the 177Lu Dosimetry Challenge to evaluate variability across steps within the dosimetry workflow. This work aimed to assess the variability in ADs due to different fitting and integration methods. Methods: Anonymized datasets from 2 pati
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Yukun Kuang, Weiping Tan, Chaohui Hu et al. · 2024 · Frontiers in Cellular and Infection Microbiology
Background: Targeted next-generation sequencing (tNGS) has become a trending tool in the field of infection diagnosis, but concerns are also raising about its performance compared with metagenomic next-generation sequencing (mNGS). This study aims to explore the clinical feasibility of a tNGS panel for respiratory tract infection diagnosis and compare it with mNGS in the same cohort of inpatients. Methods: 180 bronchoalveolar lavage fluid samples were collected and sent to two centers for mNGS and tNGS blinded tests, respectively. The concordance between pathogen reports of both methods and th
View details →Replication FailureOpen accessMedicine
Nichola Cooper, James B. Bussel, Maciej Kaźmierczak et al. · 2024 · British Journal of Haematology
Summary Primary immune thrombocytopenia (ITP) is an antiplatelet‐antibody‐mediated disorder with accelerated platelet clearance and decreased platelet production. Rozanolixizumab, a monoclonal IgG4 anti‐FcRn antibody, blocks IgG recycling and decreases IgG levels. We report efficacy and safety of rozanolixizumab in adults with persistent/chronic ITP in 24‐week phase 3 studies (TP0003; TP0006), and their 52‐week open‐label extension (OLE). Primary end‐point was durable clinically meaningful platelet response (DCMPR) of ≥50 × 10 9 /L for 8/12 weeks during Weeks 13–25 in the double‐blind studies.
View details →Negative / Null Result ReportOpen accessNeuroscience
Maliha Ashraf, Alexandre Chapiro, Rafał Mantiuk · 2025 · Nature Communications
As large engineering efforts go towards improving the resolution of mobile, augmented reality (AR), and virtual reality (VR) displays, it is important to know the maximum resolution at which further improvements bring no noticeable benefit. This limit is often referred to as the retinal resolution, although the limiting factor may not necessarily be attributed to the retina. To determine the ultimate resolution at which an image appears sharp to our eyes with no perceivable blur, we created an experimental setup with a sliding display, which allows for continuous control of the resolution. The
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Raya Kh. Yashooa, Ari Q. Nabi, Shukur Wasman Smail et al. · 2026 · Frontiers in Neurology
CRISPR-Cas genome-editing technologies have emerged as powerful tools for precise DNA and RNA modulation, offering promising therapeutic strategies for neurodegenerative disorders such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS). This review critically evaluates current CRISPR/Cas applications in neurodegeneration, with emphasis on mechanistic insights, therapeutic outcomes, and translational feasibility. Preclinical and early translational studies demonstrate that CRISPR-Cas platforms can correct pathogenic mutation
View details →Negative / Null Result ReportOpen accessPsychology
Nobel Glas · 2026 · Zenodo (CERN European Organization for Nuclear Research)
EA-GLAS-02 v1.0. A self-contained empirical white paper presenting the measurement program for the Semantic Deviation Principle (Sharks 2026). Defines meaning as the time-integrated divergence a sign induces from the most probable trajectory of a semantic field, extending the Bar-Hillel and Carnap (1953) program into distributional and temporal domains. Two primary operationalizations. (F1) Closed-system trajectory deviation within a frozen language model, where the counterfactual baseline is read from logits, building on surprisal theory (Hale 2001; Levy 2008) and decomposing it into signed d
View details →Negative / Null Result ReportOpen accessMaterials Science
Malek Msheik, Sylvain Rodat, Stéphane Abanades · 2024 · Journal of Analytical and Applied Pyrolysis
Solar methane pyrolysis in different molten media and reactor configurations was experimented to improve hydrogen production . Pure Sn, Ni 0.18 Sn 0.82 , Cu 0.45 Bi 0.55 , and KCl melts were compared at three different temperatures…
View details →Negative / Null Result ReportOpen accessComputer Science
Rabab Ali Abumalloh, Mehrbakhsh Nilashi, Osama Halabi et al. · 2024 · Journal of Innovation & Knowledge
Recommendation agents (RAs) have proven to be effective decision-making tools for customers, as they can boost trust and loyalty when customers shop online. They can analyse large amounts of data using machine learning algorithms and…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Maria Nikogհosyan, Siras Hakobyan, Anahit Hovhannisyan et al. · 2019 · Frontiers in Genetics
Background: During last decades a number of genome-wide association studies (GWAS) has identified numerous single nucleotide polymorphisms (SNPs) associated with different complex diseases. However, associations reported in one population are often conflicting and did not replicate when studied in other populations. One of the reasons could be that most of GWAS employ case-control design in one or a limited number of populations, but little attention was paid to global distribution of disease associated alleles across different populations. Moreover, the majority of GWAS have been performed on
View details →Negative / Null Result ReportOpen accessComputer Science
Robert Ranisch, Joschka Haltaufderheide · 2025 · Digital Society
Abstract Conversational agents are increasingly used in healthcare, with Large Language Models (LLMs) significantly enhancing their capabilities. When integrated into social robots, LLMs offer the potential for more natural interactions. However, while LLMs promise numerous benefits, they also raise critical ethical concerns, particularly regarding hallucinations and deceptive patterns. In this case study, we observed a critical pattern of deceptive behavior in commercially available LLM-based care software integrated into robots. The LLM-equipped robot falsely claimed to have medication remin
View details →Negative / Null Result ReportOpen accessPsychology
Sofience · 2026 · Zenodo (CERN European Organization for Nuclear Research)
SΔϕ-60 introduces the Utilitarian Subject-Splitting Index, USSI, within the Sofience-Δϕ Formalism. The paper examines whether utilitarian calculation merely evaluates the happiness of already-existing majorities and minorities, or whether such calculation can first produce the operational boundary between majority and minority by redistributing Transition Completion Cost, TCC. The document begins with the Sofience Subject Thought Experiment. A person is imagined as capable of detaching and reattaching any part of the body while the detached parts remain alive, neurologically connected, and phy
View details →Negative / Null Result ReportOpen accessMedicine
Yusuke Kamatsuki, Marie Synnøve Qvale, Kathrin Steffen et al. · 2024 · The American Journal of Sports Medicine
Background: Anterior cruciate ligament (ACL) injury is one of the most severe injuries for athletes. It is important to identify risk factors because a better understanding of injury causation can help inform athletes about risk and increase their understanding of and motivation for injury prevention. Purpose: To investigate the relationship between anatomic factors and risk for future noncontact ACL injuries. Study Design: Cohort study; Level of evidence, 2. Methods: A total of 870, excluding 9 players with a new contact ACL injury and a player with a new noncontact ACL injury just before the
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Zahraa S. Al-tameemi, Alejandra Rodríguez‐Verdugo · 2024 · mSystems
ABSTRACT Microbial communities are incredibly diverse. Yet, the eco-evolutionary processes originating and maintaining this diversity remain understudied. Here, we investigate the patterns of diversification for Pseudomonas putida evolving in isolation and with Acinetobacter johnsonii leaking resources used by P. putida . We experimentally evolved four experimental replicates in monoculture and co-culture for 200 generations. We observed that P. putida diversified into two distinct morphotypes that differed from their ancestor by single-point mutations. One of the most prominent mutations hit
View details →Negative / Null Result ReportOpen accessComputer Science
Sarah Kettley · 2026 · Edinburgh Napier Research Repository (Edinburgh Napier University)
The purpose of the research described in this thesis was to develop a design methodology for Wearable Computing concepts that could potentially embody authenticity. The Wearables community, still firmly rooted in the disciplines of engineering and ergonomics, had made clear its aspirations to the mainstream market (DeVaul et al 2001). However, at this point, there was a distinct lack of qualitative studies on user perceptions of Wearable products. A review of the market research literature revealed significant consumer demand for authenticity in goods and services, and it was this need that dr
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Ignacio J. Melero‐Jiménez, Yael Sorokin, Ami Merlin et al. · 2025 · Nature Communications
Populations facing lethal environmental change can escape extinction through rapid genetic adaptation, a process known as evolutionary rescue. Despite extensive study, evolutionary rescue is largely unexplored in mutualistic communities, where it is likely constrained by the less adaptable partner. Here, we explored empirically the likelihood, population dynamics, and genetic mechanisms underpinning evolutionary rescue in an obligate mutualism involving cross-feeding of amino acids between auxotrophic Escherichia coli strains. We found that over 80% of populations overcame a severe decline whe
View details →Negative / Null Result ReportOpen accessNeuroscience
Shao-Chin Hung, Aaron R. Seitz · 2011 · PLoS ONE
Consolidation, a process that stabilizes memory trace after initial acquisition, has been studied for over a century. A number of studies have shown that a skill or memory must be consolidated after acquisition so that it becomes resistant to interference from new information. Previous research found that training on a peripheral 3-dot hyperacuity task could retrogradely interfere with earlier training on the same task but with a mirrored stimulus configuration. However, a recent study failed to replicate this finding. Here we address the controversy by replicating both patterns of results, ho
View details →Negative / Null Result ReportOpen accessMathematics
Changye Wu, Pierre Pudlo, Christian P. Robert et al. · 2026 · Statistics and Computing
stands for empirical, leverages importance sampling to construct an empirical distribution on discretization parameters, thereby eliminating the need for manual burn-in diagnostics and online adaptation. The proposal distribution used in the calibration stage is obtained via a Population Monte Carlo scheme with tempering and relies on flexible parametric variational families such as normalizing flows. Once the calibration stage complete, the resulting algorithm defines a homogeneous Markov chain via a mixture of HMC kernels with a fixed mixing distribution, and hence preserves the target distr
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Sean Myers · 2026 · The Review of Economic Studies
Abstract This paper studies how municipal governments jointly manage spending, credit market borrowing, and a public employee pension system. I model governments as levered investors who must meet non-defaultable pension obligations and…
View details →Negative / Null Result ReportOpen accessMedicine
Ulla Lång, Johanna Metsälä, Hugh Ramsay et al. · 2025 · American Journal of Psychiatry
OBJECTIVE: As many as half of individuals who develop psychosis had attended child and adolescent psychiatric services at some stage in childhood, highlighting substantial opportunities for prevention within these services if an effective preventive intervention were identified. The authors hypothesized that adolescent psychiatric patients exposed to doxycycline, an antibiotic with putative neuroprotective properties, would have a lower risk of developing schizophrenia. METHODS: This was an emulated target trial using nationwide Finnish health register data on all individuals born between 1987
View details →Negative / Null Result ReportOpen accessMedicine
Shu-Shu Han, Qin Liu, Zhiming Zeng et al. · 2026 · Cardiovascular Diabetology
BACKGROUND: Cardiovascular-kidney-metabolic (CKM) syndrome imposes a substantial global health burden, with most adults clustered in early stages 0-3. Insulin resistance (IR), as a core manifestation of metabolic dysfunction, is thought to…
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