Diagnosis value of targeted and metagenomic sequencing in respiratory tract infection
Yukun Kuang; Weiping Tan; Chaohui Hu; Zehan Dai; Lihong Bai; Ji‐Yu Wang; Huai Liao; Haihong Chen · 2024 · Frontiers in Cellular and Infection Microbiology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
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Abstract
Background: Targeted next-generation sequencing (tNGS) has become a trending tool in the field of infection diagnosis, but concerns are also raising about its performance compared with metagenomic next-generation sequencing (mNGS). This study aims to explore the clinical feasibility of a tNGS panel for respiratory tract infection diagnosis and compare it with mNGS in the same cohort of inpatients. Methods: 180 bronchoalveolar lavage fluid samples were collected and sent to two centers for mNGS and tNGS blinded tests, respectively. The concordance between pathogen reports of both methods and th
Abstract by Yukun Kuang; Weiping Tan; Chaohui Hu; Zehan Dai; Lihong Bai; Ji‐Yu Wang; Huai Liao; Haihong Chen, Frontiers in Cellular and Infection Microbiology (2024) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3389/fcimb.2024.1498512