An International Study of Factors Affecting Variability of Dosimetry Calculations, Part 4: Impact of Fitting Functions in Estimated Absorbed Doses
Sara Kurkowska; Julia Brosch-Lenz; Yuni K. Dewaraja; Eric C. Frey; John J. Sunderland; Carlos Uribe · 2025 · Journal of Nuclear Medicine
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Individualized radiopharmaceutical therapies guided by patient-specific absorbed dose (AD) assessments using nuclear medicine imaging have the potential to improve both efficacy and safety. Understanding sources of variability in AD calculations is critical for standardization. The Society of Nuclear Medicine and Molecular Imaging Dosimetry Task Force launched the 177Lu Dosimetry Challenge to evaluate variability across steps within the dosimetry workflow. This work aimed to assess the variability in ADs due to different fitting and integration methods. Methods: Anonymized datasets from 2 pati
Abstract by Sara Kurkowska; Julia Brosch-Lenz; Yuni K. Dewaraja; Eric C. Frey; John J. Sunderland; Carlos Uribe, Journal of Nuclear Medicine (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.2967/jnumed.124.268612