Electrospun PLA/PVP K90 Biphasic-Release Sublingual Film for Motion Sickness Treatment
Wenwen Zhang; Qilin Wang; Wei Yi; Hongxi Wang; Deng-Guang Yu; Tao Yi · 2026 · Biomolecules
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
To overcome the limitations of traditional motion sickness medications—slow onset of action, short duration of efficacy, and poor patient compliance—this study employed coaxial electrospinning technology. Poly(lactic acid) (PLA) and polyvinylpyrrolidone K90 (PVP K90) were used as composite carrier materials. The sheath layer is composed of highly hydrophilic PVP K90, loaded with the antihistamine diphenhydramine (DPH). The core layer, composed of biodegradable PLA with excellent sustained-release properties, carries the anticholinergic drug scopolamine hydrobromide (SH). This core–sheath nanos
Abstract by Wenwen Zhang; Qilin Wang; Wei Yi; Hongxi Wang; Deng-Guang Yu; Tao Yi, Biomolecules (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3390/biom16030363