CRISPR–Cas technologies in neurodegenerative disorders: mechanistic insights, therapeutic potential, and translational challenges
Raya Kh. Yashooa; Ari Q. Nabi; Shukur Wasman Smail; Sarkar Sardar Azeez; Wissam Albeer Nooh; Suhad A. Mustafa; Abd Al-Bar Al-Farha; Nazzareno Capitanio · 2026 · Frontiers in Neurology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
CRISPR-Cas genome-editing technologies have emerged as powerful tools for precise DNA and RNA modulation, offering promising therapeutic strategies for neurodegenerative disorders such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS). This review critically evaluates current CRISPR/Cas applications in neurodegeneration, with emphasis on mechanistic insights, therapeutic outcomes, and translational feasibility. Preclinical and early translational studies demonstrate that CRISPR-Cas platforms can correct pathogenic mutation
Abstract by Raya Kh. Yashooa; Ari Q. Nabi; Shukur Wasman Smail; Sarkar Sardar Azeez; Wissam Albeer Nooh; Suhad A. Mustafa; Abd Al-Bar Al-Farha; Nazzareno Capitanio, Frontiers in Neurology (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3389/fneur.2025.1737468