Negative / Null Result ReportAgricultural and Biological Sciences
Patrick R.J. Fortuna, Helle Bielefeldt‐Ohmann, Dmitry A. Ovchinnikov et al. · 2018 · Stem Cells and Development
Horses are susceptible to a number of neurotropic viruses, including West Nile virus (WNV), which is a pathogen of global significance in both horses and humans. However, there are no in vitro models with which to study infectious…
View details →Negative / Null Result ReportOpen accessMedicine
Rachel Charlton, Anita McGrogan, Julia Snowball et al. · 2017 · Drug Safety
Electronic healthcare data have several advantages over prospective observational studies, but the sensitivity of data on neurodevelopmental outcomes and its comparability with data generated through other methodologies is unknown. The…
View details →Negative / Null Result ReportOpen accessMedicine
Adam Stevens, Philip Murray, Jérôme Wojcik et al. · 2016 · European Journal of Endocrinology
OBJECTIVE: Single-nucleotide polymorphisms (SNPs) associated with the response to recombinant human growth hormone (r-hGH) have previously been identified in growth hormone deficiency (GHD) and Turner syndrome (TS) children in the PREDICT long-term follow-up (LTFU) study (Nbib699855). Here, we describe the PREDICT validation (VAL) study (Nbib1419249), which aimed to confirm these genetic associations. DESIGN AND METHODS: Children with GHD (n = 293) or TS (n = 132) were recruited retrospectively from 29 sites in nine countries. All children had completed 1 year of r-hGH therapy. 48 SNPs previou
View details →Negative / Null Result ReportPsychology
Karen R. Gouze, John V. Lavigne, Joyce Hopkins et al. · 2012 · Infant Mental Health Journal
Temperamental negative affectivity (NA) and effortful control (EC) have long been of interest to psychologists, but sensory regulation (SR) has received less attention. Using confirmatory factor analysis, the present study reexamined the…
View details →Negative / Null Result ReportOpen accessComputer Science
Wilhelmiina Hämäläinen · 2010 · Työväentutkimus Vuosikirja
Analyzing statistical dependencies is a fundamental problem in all empirical science. Dependencies help us understand causes and effects, create new scientific theories, and invent cures to problems. Nowadays, large amounts of data is…
View details →Negative / Null Result ReportOpen accessMedicine
Lu Zhao, Caroline Mwaliko, Evans Atoni et al. · 2019 · Frontiers in Microbiology
Globally, mosquitoes are known to be competent vectors to various arboviruses that cause serious and debilitating diseases to humans and animals. Conversely, mosquitoes harbor a wide array of insect specific viruses (ISVs) that are generally neglected. Extensive characterization of these ISVs is important in understanding their persistence infection effect on host behavior and arbovirus transmission. Herein, we report first time isolation of Tanay virus (TANAV) isolate YN15_103_01 in Anopheles sinensis mosquitoes from Yunnan Province, China. Phylogenetically, the isolate’s nucleotide identity
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Abby E. Davis, Kaitlin R. Deutsch, Alondra M. Torres et al. · 2021 · Scientific Reports
Flowers can be transmission platforms for parasites that impact bee health, yet bees share floral resources with other pollinator taxa, such as flies, that may be hosts or non-host vectors (i.e., mechanical vectors) of parasites. Here, we assessed whether the fecal-orally transmitted gut parasite of bees, Crithidia bombi, can infect Eristalis tenax flower flies. We also investigated the potential for two confirmed solitary bee hosts of C. bombi, Osmia lignaria and Megachile rotundata, as well as two flower fly species, Eristalis arbustorum and E. tenax, to transmit the parasite at flowers. We
View details →Negative / Null Result ReportOpen accessSocial Sciences
Melissa Chapple, Philip Davis, Josie Billington et al. · 2022 · Frontiers in Psychology
Dominant theoretical models of autism and resultant research enquiries have long centered upon an assumed autism-specific empathy deficit. Associated empirical research has largely relied upon cognitive tests that lack ecological validity and associate empathic skill with heuristic-based judgments from limited snapshots of social information. This artificial separation of thought and feeling fails to replicate the complexity of real-world empathy, and places socially tentative individuals at a relative disadvantage. The present study aimed to qualitatively explore how serious literary fiction,
View details →Failed Experiment ReportOpen accessBiochemistry, Genetics and Molecular Biology
Angeliki Argyriadou, Athanasios Ι. Gelasakis, Georgios Banos et al. · 2020 · Journal of the Hellenic Veterinary Medical Society
The objective of the study was twofold: (i) to review the genetics of production and resilience traits of indigenous Greek small ruminant breeds as well as the evolution of national breeding programs, and (ii) explore innovative and…
View details →Negative / Null Result ReportOpen accessMedicine
Nicolas Laverde, Christian Grévisse, Sandra Ximena Jaramillo-Rincón et al. · 2025 · Computational and Structural Biotechnology Journal
Effective communication is crucial for trust-building, accurate information gathering, and clinical decision-making in healthcare. Despite its emphasis in medical curricula, traditional training methods, such as role-playing with…
View details →Negative / Null Result ReportOpen accessMedicine
Gregory A. Hawkins, David J. Friedman, Lingyi Lu et al. · 2015 · American Journal of Nephrology
<b><i>Background:</i></b> In African Americans (AAs), <i>APOL1</i> G1 and G2 nephropathy risk variants are associated with non-diabetic end-stage kidney disease (ESKD) in an autosomal recessive pattern.…
View details →Negative / Null Result ReportOpen accessMedicine
Christos Koros, Athina‐Maria Simitsi, Dimitra Papadimitriou et al. · 2020 · Journal of Parkinson s Disease
BACKGROUND: Blood uric acid level represents an emerging biomarker in Parkinson's disease (PD). Whether uric acid levels change in genetic forms of PD is just beginning to be explored. OBJECTIVE: The aim of the present study was to assess differences in serum uric acid level among PD patients harboring the p.A53T mutation in the alpha-synuclein gene, idiopathic PD, and healthy controls. METHODS: Longitudinal 5-year serum uric acid measurement data of 369 de novo idiopathic PD patients and 174 age- and gender-matched healthy controls have been downloaded from the Parkinson's Progression Markers
View details →Negative / Null Result ReportComputer Science
Jundong Li, Osmar R. Zaı̈ane · 2017 · Intelligent Data Analysis
Established associative classification algorithms have shown to be very effective in handling categorical data such as text data. The learned model is a set of rules that are easy to understand and can be edited. However, they still suffer…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Selina Banda, Florence Phiri, Jack Kaale et al. · 2023
Bloom’s Taxonomy is crucial in any teaching and learning environment because it determines direction for a course of study. This study assessed application of Bloom’s Taxonomy in courses of study offered in colleges in Lusaka District. Objectives were: Assess the application of Bloom’s Taxonomy in setting learning outcomes for the courses; Assess reflection of Bloom’s Taxonomy in activities set for course participants; Ascertain significance attached to Bloom’s Taxonomy in courses of study designed for participants. The study employed a mixed methodology, in particular employing a descriptive
View details →Negative / Null Result ReportMedicine
Maryam Masouminia, R. Gelfand, Istvan Kovanecz et al. · 2018 · The Journal of Sexual Medicine
BACKGROUND: Previous work showed that muscle-derived stem cells (MDSCs) exposed long-term to the milieu of uncontrolled type 2 diabetes (UC-T2D) in male obese Zucker (OZ) rats, were unable to correct the associated erectile dysfunction and…
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Charlie Curtsinger, Emery D. Berger · 2013 · ACM SIGARCH Computer Architecture News
Researchers and software developers require effective performance evaluation. Researchers must evaluate optimizations or measure overhead. Software developers use automatic performance regression tests to discover when changes improve or…
View details →Failed Experiment ReportOpen accessMedicine
Miguel Oliveira Santos, Mamede de Carvalho · 2024 · Expert Review of Neurotherapeutics
INTRODUCTION: Amyotrophic lateral sclerosis (ALS) is a rapidly progressive motor neuron disorder with a fatal outcome 3-5 years after disease onset due to respiratory complications. Superoxide dismutase 1 (SOD1) mutations are found in…
View details →Negative / Null Result ReportAgricultural and Biological Sciences
Carlos M. Herrera · 2021 · Ecology
Pollinators can mediate facilitative or competitive relationships between plant species, but the relative importance of these two conflicting phenomena in shaping community-wide pollinator resource use remains unexplored. This article…
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
George Gitonga Inoti · 2014 · Journal of Finance and Accounting
This study sought to determine whether acquisitions enhance corporate financial performance. The general objective of the study was to assess the effects of acquisitions on the financial performance of the acquiring companies in Kenya. The…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Evan A. Valdes, James H. Liu, Matt N Williams · 2022 · Asian Journal Of Social Psychology
The status‐legitimacy hypothesis proposes that those who are most disadvantaged by unequal social systems are even more likely than members of more advantaged groups to provide ideological support for the very social system that is responsible for their disadvantages. Li, Yang, Wu, and Kou (2020, Personality and Social Psychology Bulletin ) sought to expand the generalizability of this hypothesis by testing it in China, addressing inconsistencies surrounding the empirical support for this hypothesis by postulating that the construct of status should be separated into an objective and subjectiv
View details →Negative / Null Result ReportMedicine
Cezar H. Lorenzi, Douglas Teixeira Leffa, Rodrigo A. Bressan et al. · 2022 · Journal of Child Psychology and Psychiatry
BACKGROUND: Very few predictive models in Psychiatry had their performance validated in independent external samples. A previously developed multivariable demographic model for attention-deficit/hyperactivity disorder (ADHD) accurately…
View details →Negative / Null Result ReportOpen accessMedicine
Helena Lam, Nakul Katyal, Catherine D. Parker et al. · 2018 · Cureus
Thromboelastography with platelet mapping (TEG-PM) is a modality to measure platelet function, especially in patients taking antiplatelet medications. It consists of two components: arachidonic acid (AA), which is sensitive to aspirin, and adenosine diphosphate (ADP), which is sensitive to clopidogrel. In patients with spontaneous intracerebral hemorrhages (sICH), the clinical interpretation of platelet mapping is unclear. The objective of this study was to evaluate TEG-PM in patients with sICH on aspirin and/or clopidogrel who receive platelet transfusions. This study was an IRB-approved, ret
View details →Negative / Null Result ReportOpen accessMedicine
Markus Karlsson, Tino Kurz · 2016 · Acta Ophthalmologica
PURPOSE: Oxidative stress-related damage to retinal pigment epithelial (RPE) cells is an important feature in the development of age-related macular degeneration. Iron-catalysed intralysosomal production of hydroxyl radicals is considered…
View details →Negative / Null Result ReportOpen accessMedicine
В. Т. Ивашкин, М. V. Maevskaya, Е. Н. Широкова et al. · 2021 · Drugs - Real World Outcomes
While no “gold-standard” pharmacotherapy for nonalcoholic fatty liver disease (NAFLD) is yet established, essential phospholipids (EPLs) are reported to decrease steatosis and improve laboratory parameters. This analysis evaluated…
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Bjoern Zante, Katja Erne, Marie-Madlen Jeitziner · 2022 · Scientific Reports
Abstract To help reduce the spread of the SARS-CoV-2 virus during the COVID-19 pandemic, ICU visits were banned or restricted. Therefore, family-centered care as usually practiced was not feasible Video calls were recommended to meet…
View details →Negative / Null Result ReportOpen accessMedicine
Marina da Costa Rosa, Alex Shimura Yamashita, Gregory J. Riggins · 2021 · Neuro-Oncology
BACKGROUND: Isocitrate Dehydrogenase 1/2 (IDH1/2) mutations are diagnostic for Astrocytoma or Oligodendroglioma, IDH-mutant. In these IDH-mutant gliomas, retinoic acid-related gene expression is commonly silenced by DNA hypermethylation.…
View details →Negative / Null Result ReportOpen accessMedicine
James M. Heun, Axel Grothey, Megan E. Branda et al. · 2011 · The Oncologist
Abstract Learning Objectives After completing this course, the reader will be able to: Explain the difference in survival prediction between response criteria (WHO) when used as a two-level variable (CR/PR vs. other) and as a three-level…
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Dominika Szalewska, Renata Główczyńska, Ryszard Piotrowicz et al. · 2021 · ESC Heart Failure
AIMS: The aim of our study was to analyse the benefits of a 9 week hybrid comprehensive telerehabilitation (HCTR) programme in heart failure (HF) patients according to aetiology, as a subanalysis of the Telerehabilitation in Heart Failure…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Miki Takemura, Rio Nakamura, Merime Ota et al. · 2023 · Antimicrobial Agents and Chemotherapy
ABSTRACT Achromobacter spp. and Burkholderia cepacia complex (Bcc) are rare but diverse opportunistic pathogens associated with serious infections, which are often multidrug resistant. This study compared the in vitro antibacterial activity of the siderophore antibiotic cefiderocol against Achromobacter spp. and Bcc isolates with that of other approved antibacterial drugs, including ceftazidime-avibactam, ciprofloxacin, colistin, imipenem-relebactam, and meropenem-vaborbactam. Isolates were collected in the SIDERO multinational surveillance program. Among 334 Achromobacter spp. isolates [76.6%
View details →Failed Experiment ReportOpen accessMedicine
Fiona Carty, Hazel Dunbar, Ian J. Hawthorne et al. · 2021 · Stem Cells Translational Medicine
Cell-based therapy for the treatment of inflammatory disorders has focused on the application of mesenchymal stromal cells (MSCs) and multipotent adult progenitor cells (MAPCs). Despite the recent positive findings in industry-sponsored…
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