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Browse the failure-mode index

21,691 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessEnvironmental Science

Does fox control improve red–legged partridge (Alectoris rufa) survival? An experimental study in Northern Spain

IREC, CSIC–UCLM–JCCM, Ciudad Real, Spain, Ainhoa Mateo-Moriones, Rafael Villafuerte et al. · 2012 · Animal Biodiversity and Conservation

This work evaluates the effectiveness of fox control as a method to improve the survival of red–legged partridge (Alectoris rufa). We radio–tracked 89 adult partridges and their chicks (62 few days old chicks and 46 over one–month–old chicks) and monitored their nests (N = 45) on two hunting estates in northern Spain over two years. Generalist predators (red fox, Vulpes vulpes, and magpie, Pica pica) were selectively controlled on one half of each estate during the first year, and on the other half in the second year. We estimated the effect of predator control on survival rates. Predator cont

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Androgen receptor‐positive, triple‐negative breast cancer

Ayca Gucalp, Tiffany A. Traina · 2017 · Cancer

Patients with triple-negative breast cancer (TNBC) generally are considered a single clinical subgroup, defined by the lack of receptor expression, and are uniformly treated with cytotoxic chemotherapy. However, the advent of molecular…

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Negative / Null Result ReportOpen accessMedicine

Impact of subglottic secretion drainage on microaspiration in critically ill patients: a prospective observational study

Guillaume Millot, Pauline Boddaert, Erika Parmentier-Decrucq et al. · 2018 · Annals of Translational Medicine

Background: Microaspiration is a major factor in ventilator-associated pneumonia (VAP) pathophysiology. Subglottic secretion drainage (SSD) aims at reducing its incidence. Methods: Single-center prospective observational study, performed…

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Negative / Null Result ReportOpen accessNeuroscience

Phase I/II trial of BMS-986,205 and nivolumab as first line therapy in hepatocellular carcinoma

Jasmine C. Huynh, May Cho, Arta M. Monjazeb et al. · 2023 · Investigational New Drugs

BACKGROUND: Indoleamine-2,3-dioxygenase (IDO) helps orchestrate immune suppression and checkpoint inhibitor resistance in hepatocellular carcinoma (HCC). BMS-986,205 is a novel oral drug that potently and selectively inhibits IDO. This Phase I/II study evaluated the safety and tolerability of BMS-986,205 in combination with nivolumab as first-line therapy in advanced HCC. METHODS: IV on Day 1 of each 14-day cycle). The primary objective was to determine the safety and tolerability of this combination; secondary objectives were to obtain preliminary efficacy. RESULTS: Eight patients received a

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Negative / Null Result Report

Sigma receptor type 1 knockout mice show a mild deficit in plasticity but no significant change in synaptic transmission in the CA 1 region of the hippocampus

Melissa A. Snyder, Kieran McCann, Maryline J. Lalande et al. · 2016 · Journal of Neurochemistry

Abstract The sigma‐1 receptor (σ‐1R) is a chaperone protein located at the endoplasmic reticulum ( ER ) mitochondrial interface with roles in neuroprotection and cognition. Increasing evidence suggests that loss of σ‐1R function could…

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Negative / Null Result Report

Why did life expectancy in Central and Eastern Europe suddenly improve in the 1990s? An analysis by cause of death

Johan P. Mackenbach, Marina Karanikolos, Jamie Lopez Bernal et al. · 2015 · Scandinavian Journal of Public Health

Background: The upturn of life expectancy in Central and Eastern Europe in the 1990s, after a period of stagnation or even decline, is one of the main events in European population history of the late 20th century, but has not been…

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Negative / Null Result Report

Association of clinically significant weight loss with number of patient visits and months of attendance at an Australian multidisciplinary weight management clinic

Juliana Chen, Harpreet Kaur, Joanna Jaques et al. · 2022 · Clinical Obesity

Summary Despite the obesity epidemic, there are relatively few multidisciplinary obesity services in Australia, and only limited data on the effectiveness of these services. The aim of this study was to evaluate the effectiveness of a…

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Negative / Null Result Report

Computer-Based Programmed Instruction Did Not Improve the Knowledge Retention of Medication Instructions of Individuals With Type 2 Diabetes Mellitus

Jorge G. Ruiz, Allen D. Andrade, Ramanakumar Anam et al. · 2013 · The Diabetes Educator

Purpose The purpose of this study was to investigate whether computer-based programmed instruction (CPI) with a dynamic avatar (DA) improves retention of medication information better than text (controls) or better than CPI with text…

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Negative / Null Result Report

Apremilast for moderate hidradenitis suppurativa: no significant change in lesional skin inflammatory biomarkers

A.R.J.V. Vossen, H.H. van der Zee, N. Davelaar et al. · 2018 · Journal of the European Academy of Dermatology and Venereology

Abstract Background Treatment with apremilast has recently demonstrated clinically meaningful improvement in moderate hidradenitis suppurativa ( HS ). Objective To evaluate the change in expression of inflammatory markers in lesional skin…

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Negative / Null Result Report

Effect of the change in antiviral therapy indication on identifying significant liver injury among chronic hepatitis B virus infections in the grey zone

Shan Ren, Wenjing Wang, Junfeng Lu et al. · 2022 · Frontiers in Immunology

Objective In clinical practice, a substantial proportion of chronic hepatitis B virus (HBV) infections that do not fit into any of the usual immune states are considered to be in the “grey zone (GZ)”. This study aimed to investigate the…

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Negative / Null Result Report

Association of the functionally significant polymorphisms of the MMP9 gene with H. pylori-positive gastric ulcer in the Caucasian population of Central Russia

Volodymyr Dvornyk, Irina Ponomarenko, Oksana Minyaylo et al. · 2021 · PLOS ONE

Background and purpose The study analyzed the association of functionally significant polymorphisms of matrix metalloproteinases ( MMPs ) genes with the development of gastric ulcer (GU) in Caucasians from Central Russia. Methods The 781…

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Negative / Null Result Report

Significant contributions of combustion‐related NH 3 and non‐fossil fuel NO x to elevation of nitrogen deposition in southwestern China over past five decades

Hao Huang, Wei Song, Xue‐Yan Liu · 2021 · Global Change Biology

Abstract Anthropogenic nitrogen (N) emissions and deposition have been increasing over past decades. However, spatiotemporal variations of N deposition levels and major sources remain unclear in many regions, which hinders making…

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Negative / Null Result Report

Eight Days of L-Citrulline or L-Arginine Supplementation Did Not Improve 200-m and 100-m Swimming Time Trials

Ozcan Esen, Mustafa Can Eser, Mekki Abdioglu et al. · 2022 · International Journal of Environmental Research and Public Health

The effects of L-citrulline or L-arginine supplementation on exercise performance are equivocal, and the effects on swimming performance are unclear. We aimed to assess whether 8-day supplementation with L-arginine or L-citrulline…

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Negative / Null Result Report

Physical activity and prenatal depression: going beyond statistical significance by assessing the impact of reliable and clinical significant change

Marina Vargas-Terrones, Taniya S. Nagpal, Maria Perales et al. · 2020 · Psychological Medicine

Abstract Background Previous literature supports exercise as a preventative agent for prenatal depression; however, treatment effects for women at risk for prenatal depression remain unexplored. The purpose of the study was to examine…

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Negative / Null Result Report

“The more you did, the more it made sense”: Problem‐based learning to improve early evidence‐based practice in an undergraduate physiotherapy professional programme

Olive Lennon, Deirdre Phelan, Deborah Wallace et al. · 2019 · Physiotherapy Research International

Abstract Background and Purpose Evidence‐based practice (EBP), which integrates clinical reasoning skills, research evidence, and patient preference, has become standard in curricula for health care professional programs. Students however…

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Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Response of broilers to supplementation of branched-chain amino acids blends with different valine contents in the starter period under summer conditions

Canan Kop Bozbay, Ahmet Akdag, Helin Atan et al. · 2020 · Animal Bioscience

OBJECTIVE: The objectives of this study were to compare the effects of normal and low protein content (PC) of starter diet supplemented or not with blends of branched-chain amino acids (BCAAs) on growth performance of broilers under summer conditions and to investigate whether these effects altered some quality traits and the characteristics of gastrointestinal tract. METHODS: A total of 768 mixed-sex broiler chicks (Ross 308, one-d-old) with an average initial body weight (BW) of 47.6±1.03 g were allocated into six treatments with four replications in 2×3 factorial arrangement. Factors were:

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