Negative / Null Result ReportOpen accessMedicine
Rishi Chanderraj, Brian Bartek, Kathleen A. Stringer et al. · 2026 · Journal of Clinical Investigation
BACKGROUNDSepsis encompasses considerable biological and clinical heterogeneity. Previously, 2 phenotypes ("hyperinflammatory" and "hypoinflammatory") have been consistently identified within sepsis via latent class analysis. These phenotypes differ in their biological features, clinical outcomes, and therapeutic responses to interventions. Prior studies of sepsis heterogeneity have focused primarily on the host response. Here, we investigate the potential influence of the causative pathogen on sepsis heterogeneity and pathobiology.METHODSWe performed a retrospective observational analysis of
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Anonymous, G. Baltus, Sarah Caudill et al. · 2026 · Physical review. D/Physical review. D.
We perform a search for binary black hole mergers with one sub-solar mass (SSM) black hole and a primary component above $\sim 2 M_\odot$ in data from the second observing run (O2) of the LIGO-Virgo detectors. Our analysis extends the parameter space explored by previous LIGO-Virgo Collaboration searches for binaries containing SSM components into a region of parameter space motivated by broad mass distributions of primordial black holes (PBHs) exhibiting a peak around $[2-3] M^{}_\odot$, which can arise from the reduction of the equation of state during the QCD phase transition in the early U
View details →Negative / Null Result ReportOpen accessSocial Sciences
Mukhlis Mukhlis, Ahmad Nabriz, Muhammad Eissawy Abu El Yazid et al. · 2026 · Integrated Education Journal
This study aims to comparatively analyze the perspectives, policies, implementation, and challenges of multicultural education in developed and developing countries. A qualitative approach was employed using library research, drawing on scholarly journal articles, academic books, educational policy documents, and relevant previous studies. Data were analyzed through comparative content analysis to identify patterns of similarities, differences, challenges, and implementation strategies across the two contexts. The findings indicate that developed countries generally demonstrate more systematic
View details →Negative / Null Result ReportOpen accessMedicine
Yimao Wu, Kaiyu Zhang, 夏新亚 et al. · 2026 · BMC Medicine
BACKGROUND: Breast cancer is the most commonly diagnosed malignancy in women worldwide, and its marked heterogeneity together with the complexity of the tumor microenvironment contributes to substantial variability in therapeutic…
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Nikolaos P.E. Kadoglou, Konstantinos G. Moulakakis, George Mantas et al. · 2022 · Angiology
Arterial stiffness and its valid index, the cardio-ankle vascular index (CAVI), have emerged as predictors of adverse cardiovascular outcomes. We investigated the relationship of the CAVI with significant carotid stenosis (> 50%) and the…
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Rachel Murchison, Catherine Gooday, Ketan Dhatariya · 2014 · Journal of the American Podiatric Medical Association
Medication to aid weight loss and weight loss surgery are becoming more commonly available for people with diabetes. As a result of profound weight loss, diabetes may go into remission and many biochemical and physical parameters improve.…
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Ozcan Esen, Mustafa Can Eser, Mekki Abdioglu et al. · 2022 · International Journal of Environmental Research and Public Health
The effects of L-citrulline or L-arginine supplementation on exercise performance are equivocal, and the effects on swimming performance are unclear. We aimed to assess whether 8-day supplementation with L-arginine or L-citrulline…
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Robert Pontius · 2018 · Land
The Verified Carbon Standard (VCS) recommends the Figure of Merit (FOM) as a possible metric to confirm models that simulate deforestation baselines for Reducing Emissions from Deforestation and forest Degradation (REDD). The FOM ranges…
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Anna Kuehne, Barbara Hauer, Bonita Brodhun et al. · 2018 · Eurosurveillance
Background Germany has a low tuberculosis (TB) incidence. A relevant and increasing proportion of TB cases is diagnosed among asylum seekers upon screening. Aim: We aimed to assess whether cases identified by screening asylum seekers had…
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Jiajia Du, Zhiyong Huang, Erlei Zhang · 2024 · Frontiers in Immunology
Background Immunotherapy based on immune checkpoint inhibitors (ICIs) has become the first-line treatment for unresectable hepatocellular carcinoma (uHCC). However, only a small portion of patients are responsive to ICIs. It is important…
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Marina Vargas-Terrones, Taniya S. Nagpal, Maria Perales et al. · 2020 · Psychological Medicine
Abstract Background Previous literature supports exercise as a preventative agent for prenatal depression; however, treatment effects for women at risk for prenatal depression remain unexplored. The purpose of the study was to examine…
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Olive Lennon, Deirdre Phelan, Deborah Wallace et al. · 2019 · Physiotherapy Research International
Abstract Background and Purpose Evidence‐based practice (EBP), which integrates clinical reasoning skills, research evidence, and patient preference, has become standard in curricula for health care professional programs. Students however…
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Canan Kop Bozbay, Ahmet Akdag, Helin Atan et al. · 2020 · Animal Bioscience
OBJECTIVE: The objectives of this study were to compare the effects of normal and low protein content (PC) of starter diet supplemented or not with blends of branched-chain amino acids (BCAAs) on growth performance of broilers under summer conditions and to investigate whether these effects altered some quality traits and the characteristics of gastrointestinal tract. METHODS: A total of 768 mixed-sex broiler chicks (Ross 308, one-d-old) with an average initial body weight (BW) of 47.6±1.03 g were allocated into six treatments with four replications in 2×3 factorial arrangement. Factors were:
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Charles M. Reigeluth, Peter Honebein · 2020 · Revista de Educación a Distancia (RED)
La mayoría de los investigadores que diseñan experiencias innovadoras de aprendizaje digital y luego realizan investigaciones que investigan la utilidad de esas experiencias de aprendizaje, no aplican completamente la teoría de la…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Mohamad Saad, Ayman El‐Menyar, Khalid Kunji et al. · 2022 · Circulation Genomic and Precision Medicine
Background: Enthusiasm for using polygenic risk scores (PRSs) in clinical practice is tempered by concerns about their portability to diverse ancestry groups, thus motivating genome-wide association studies in non-European ancestry…
View details →Negative / Null Result ReportMedicine
Neil A. Duncan, Sabina B. Bruehlmann, Christopher Hunter et al. · 2012 · Computer Methods in Biomechanics & Biomedical Engineering
Designing biomaterials to mimic and function within the complex mechanobiological conditions of connective tissues requires a detailed understanding of the micromechanical environment of the cell. The objective of our study was to measure…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Jonathan E. Ramsay, Eddie M. W. Tong, Joyce S. Pang et al. · 2016 · PLoS ONE
Religious priming has been found to have both positive and negative consequences, and recent research suggests that the activation of God-related and community-related religious cognitions may cause outgroup prosociality and outgroup derogation respectively. The present research sought to examine whether reminders of God and religion have different effects on attitudes towards ingroup and outgroup members. Over two studies, little evidence was found for different effects of these two types of religious primes. In study 1, individuals primed with the words "religion", "God" and a neutral contro
View details →Negative / Null Result ReportOpen accessMedicine
Colleen Lacey, Lisa Ohlhauser, Jodie R. Gawryluk · 2019 · Frontiers in Neurology
Background Clarifying the neuropathology of depression as a symptom of Parkinson's disease (PD) has been the goal of recent neuroimaging studies; however, results have been conflicting and lack replication. The purpose of the current study was to replicate recent methods that have used diffusion tensor imaging (DTI) to compare individuals with PD with and without depression and to extend previous findings to allow for a better understanding of the results. Methods Thirty-seven participants with de novo PD were retrieved from the Parkinson's Progression Marker's Initiative (PPMI) and were separ
View details →Negative / Null Result ReportPsychology
R. Garrett, Daniel Sude, Paolo Riva · 2019 · Political Communication
Research suggests that ostracism could promote endorsement of partisan falsehoods. Socially excluded individuals are uniquely attentive to distinctions between in-groups and out-groups, and act in ways intended to promote group belonging,…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Jacqueline Ramı́rez, Tae Won Kim, Wanqing Liu et al. · 2013 · Pharmacogenetics and Genomics
XK469 (NSC 697887) is a selective topoisomerase II β inhibitor eliminated mainly by aldehyde oxidase I (AOX1). We performed a candidate gene study to investigate whether AOX1 genetic variation contributes to interindividual variability in…
View details →Negative / Null Result ReportAgricultural and Biological Sciences
Patrick R.J. Fortuna, Helle Bielefeldt‐Ohmann, Dmitry A. Ovchinnikov et al. · 2018 · Stem Cells and Development
Horses are susceptible to a number of neurotropic viruses, including West Nile virus (WNV), which is a pathogen of global significance in both horses and humans. However, there are no in vitro models with which to study infectious…
View details →Negative / Null Result ReportOpen accessMedicine
Rachel Charlton, Anita McGrogan, Julia Snowball et al. · 2017 · Drug Safety
Electronic healthcare data have several advantages over prospective observational studies, but the sensitivity of data on neurodevelopmental outcomes and its comparability with data generated through other methodologies is unknown. The…
View details →Negative / Null Result ReportOpen accessMedicine
Adam Stevens, Philip Murray, Jérôme Wojcik et al. · 2016 · European Journal of Endocrinology
OBJECTIVE: Single-nucleotide polymorphisms (SNPs) associated with the response to recombinant human growth hormone (r-hGH) have previously been identified in growth hormone deficiency (GHD) and Turner syndrome (TS) children in the PREDICT long-term follow-up (LTFU) study (Nbib699855). Here, we describe the PREDICT validation (VAL) study (Nbib1419249), which aimed to confirm these genetic associations. DESIGN AND METHODS: Children with GHD (n = 293) or TS (n = 132) were recruited retrospectively from 29 sites in nine countries. All children had completed 1 year of r-hGH therapy. 48 SNPs previou
View details →Negative / Null Result ReportPsychology
Karen R. Gouze, John V. Lavigne, Joyce Hopkins et al. · 2012 · Infant Mental Health Journal
Temperamental negative affectivity (NA) and effortful control (EC) have long been of interest to psychologists, but sensory regulation (SR) has received less attention. Using confirmatory factor analysis, the present study reexamined the…
View details →Negative / Null Result ReportOpen accessComputer Science
Wilhelmiina Hämäläinen · 2010 · Työväentutkimus Vuosikirja
Analyzing statistical dependencies is a fundamental problem in all empirical science. Dependencies help us understand causes and effects, create new scientific theories, and invent cures to problems. Nowadays, large amounts of data is…
View details →Negative / Null Result ReportOpen accessMedicine
Lu Zhao, Caroline Mwaliko, Evans Atoni et al. · 2019 · Frontiers in Microbiology
Globally, mosquitoes are known to be competent vectors to various arboviruses that cause serious and debilitating diseases to humans and animals. Conversely, mosquitoes harbor a wide array of insect specific viruses (ISVs) that are generally neglected. Extensive characterization of these ISVs is important in understanding their persistence infection effect on host behavior and arbovirus transmission. Herein, we report first time isolation of Tanay virus (TANAV) isolate YN15_103_01 in Anopheles sinensis mosquitoes from Yunnan Province, China. Phylogenetically, the isolate’s nucleotide identity
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Abby E. Davis, Kaitlin R. Deutsch, Alondra M. Torres et al. · 2021 · Scientific Reports
Flowers can be transmission platforms for parasites that impact bee health, yet bees share floral resources with other pollinator taxa, such as flies, that may be hosts or non-host vectors (i.e., mechanical vectors) of parasites. Here, we assessed whether the fecal-orally transmitted gut parasite of bees, Crithidia bombi, can infect Eristalis tenax flower flies. We also investigated the potential for two confirmed solitary bee hosts of C. bombi, Osmia lignaria and Megachile rotundata, as well as two flower fly species, Eristalis arbustorum and E. tenax, to transmit the parasite at flowers. We
View details →Negative / Null Result ReportOpen accessSocial Sciences
Melissa Chapple, Philip Davis, Josie Billington et al. · 2022 · Frontiers in Psychology
Dominant theoretical models of autism and resultant research enquiries have long centered upon an assumed autism-specific empathy deficit. Associated empirical research has largely relied upon cognitive tests that lack ecological validity and associate empathic skill with heuristic-based judgments from limited snapshots of social information. This artificial separation of thought and feeling fails to replicate the complexity of real-world empathy, and places socially tentative individuals at a relative disadvantage. The present study aimed to qualitatively explore how serious literary fiction,
View details →Failed Experiment ReportOpen accessBiochemistry, Genetics and Molecular Biology
Angeliki Argyriadou, Athanasios Ι. Gelasakis, Georgios Banos et al. · 2020 · Journal of the Hellenic Veterinary Medical Society
The objective of the study was twofold: (i) to review the genetics of production and resilience traits of indigenous Greek small ruminant breeds as well as the evolution of national breeding programs, and (ii) explore innovative and…
View details →Negative / Null Result ReportOpen accessMedicine
Nicolas Laverde, Christian Grévisse, Sandra Ximena Jaramillo-Rincón et al. · 2025 · Computational and Structural Biotechnology Journal
Effective communication is crucial for trust-building, accurate information gathering, and clinical decision-making in healthcare. Despite its emphasis in medical curricula, traditional training methods, such as role-playing with…
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