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Browse the failure-mode index

21,245 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

In vitro and in vivo activity of cefiderocol against Achromobacter spp. and Burkholderia cepacia complex, including carbapenem-non-susceptible isolates

Miki Takemura, Rio Nakamura, Merime Ota et al. · 2023 · Antimicrobial Agents and Chemotherapy

ABSTRACT Achromobacter spp. and Burkholderia cepacia complex (Bcc) are rare but diverse opportunistic pathogens associated with serious infections, which are often multidrug resistant. This study compared the in vitro antibacterial activity of the siderophore antibiotic cefiderocol against Achromobacter spp. and Bcc isolates with that of other approved antibacterial drugs, including ceftazidime-avibactam, ciprofloxacin, colistin, imipenem-relebactam, and meropenem-vaborbactam. Isolates were collected in the SIDERO multinational surveillance program. Among 334 Achromobacter spp. isolates [76.6%

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Failed Experiment ReportOpen accessMedicine

IFN-γ and PPARδ Influence the Efficacy and Retention of Multipotent Adult Progenitor Cells in Graft vs Host Disease

Fiona Carty, Hazel Dunbar, Ian J. Hawthorne et al. · 2021 · Stem Cells Translational Medicine

Cell-based therapy for the treatment of inflammatory disorders has focused on the application of mesenchymal stromal cells (MSCs) and multipotent adult progenitor cells (MAPCs). Despite the recent positive findings in industry-sponsored…

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Negative / Null Result ReportEnvironmental Science

Stream Mesocosm Experiments Show Significant Differences in Sensitivity of Larval and Emerging Adults to Metals

Christopher J. Kotalik, William H. Clements · 2019 · Environmental Science & Technology

Evaluations of aquatic insect responses to contaminants typically use larval life stages to characterize taxa sensitivity, but the effects of contaminants to emerging terrestrial adults have received less attention. We present the results…

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Negative / Null Result ReportOpen accessEarth and Planetary Sciences

Brief Episodes of Nocturnal Hypoxia and Acidification Reduce Survival of Economically Important Blue Crab (Callinectes sapidus) Larvae

Stephen J. Tomasetti, Jeffrey R. Kraemer, Christopher J. Gobler · 2021 · Frontiers in Marine Science

Many shallow coastal systems experience diel fluctuations in dissolved oxygen (DO) and pH that can intensify throughout the summer season and expose estuarine organisms to repeated episodes of coastal hypoxia and acidification. In temperate regions, larval release of the economically important blue crab Callinectes sapidus occurs in the summer, and while the earliest stage (zoea I) larvae are susceptible to persistent low DO and low pH conditions, their sensitivity to diel fluctuations is unknown. Here, a series of short-term (≤96 h) experiments were conducted to investigate the survival of C.

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Chronic intermittent hypoxia accelerates cardiac dysfunction and cardiac remodeling during cardiac pressure overload in mice and can be alleviated by PHD3 overexpression

Xuan Xu, Penghao Zhen, Fuchao Yu et al. · 2022 · Frontiers in Cardiovascular Medicine

Obstructive sleep apnea (OSA) accelerates the progression of chronic heart failure (CHF). OSA is characterized by chronic intermittent hypoxia (CIH), and CIH exposure accelerates cardiac systolic dysfunction and cardiac remodeling in a cardiac afterload stress mouse model. Mechanistic experiments showed that long-term CIH exposure activated hypoxia-inducible factor 1α (HIF-1α) expression in the mouse heart and upregulated miR-29c expression and that both HIF-1α and miR-29c simultaneously inhibited sarco-/endoplasmic reticulum calcium ATPase 2a (SERCA2a) expression in the mouse heart. Cardiac H

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Negative / Null Result ReportOpen accessMedicine

Gastric electrical stimulation treatment of type 2 diabetes: effects of implantation versus meal-mediated stimulation. A randomized blinded cross-over trial

Harold E. Lebovitz, Bernhard Ludvik, Jarosław Kozakowski et al. · 2015 · Physiological Reports

Gastric electrical stimulation with the implanted DIAMOND device has been shown to improve glycemic control and decrease weight and systolic blood pressure in patients with type 2 diabetes inadequately controlled with oral antidiabetic agents. The objective of this study was to determine if device implantation alone (placebo effect) contributes to the long-term metabolic benefits of DIAMOND(®) meal-mediated gastric electrical stimulation in patients with type 2 diabetes. The study was a 48 week randomized, blinded, cross-over trial in university centers comparing glycemic improvement of DIAMON

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Negative / Null Result ReportOpen accessMedicine

Lingual Lymph Node Metastases as a Prognostic Factor in Oral Squamous Cell Carcinoma—A Retrospective Multicenter Study

Masahiro Kikuchi, Hiroyuki Harada, Ryo Asato et al. · 2021 · Medicina

Backgrounds and Objectives: The epidemiology and prognostic role of lingual lymph node (LLN) metastasis in patients with oral squamous cell carcinoma (OSCC) remain unclear. Here, we aimed to analyze the clinicopathological features, risk factors, and prognostic role of LLN metastasis in patients with OSCC. Materials and Methods: In total, 945 patients with OSCC were retrospectively analyzed. Clinicopathological features were compared between patients with and without LLN metastasis. The risk factors of LLN metastasis and its effects on survival outcomes were evaluated using multi-variate analy

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Negative / Null Result Report

The advanced machine learner XGBoost did not reduce prehospital trauma mistriage compared with logistic regression: a simulation study

Anna Larsson, Johanna Berg, Mikael Gellerfors et al. · 2021 · BMC Medical Informatics and Decision Making

Abstract Background Accurate prehospital trauma triage is crucial for identifying critically injured patients and determining the level of care. In the prehospital setting, time and data are often scarce, limiting the complexity of triage…

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Negative / Null Result ReportOpen accessMedicine

Using infective mosquitoes to challenge monkeys with Plasmodium knowlesi in malaria vaccine studies

Jittawadee Murphy, Walter R. Weiss, David J. Fryauff et al. · 2014 · Malaria Journal

BACKGROUND: When rhesus monkeys (Macaca mulatta) are used to test malaria vaccines, animals are often challenged by the intravenous injection of sporozoites. However, natural exposure to malaria comes via mosquito bite, and antibodies can neutralize sporozoites as they traverse the skin. Thus, intravenous injection may not fairly assess humoral immunity from anti-sporozoite malaria vaccines. To better assess malaria vaccines in rhesus, a method to challenge large numbers of monkeys by mosquito bite was developed. METHODS: Several species and strains of mosquitoes were tested for their ability

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Negative / Null Result ReportOpen accessMedicine

Cost-effectiveness of weekly adaptive radiotherapy versus standard IMRT in head and neck cancer alongside the ARTIX trial

Lionel Perrier, Frédéric Balusson, Magali Morelle et al. · 2024 · Radiotherapy and Oncology

BACKGROUND AND PURPOSE: We performed a cost-effectiveness analysis (CEA) comparing an adaptive radiotherapy (ART) strategy, based on weekly replanning, aiming to correct the parotid gland overdose during treatment and expecting therefore…

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Negative / Null Result ReportOpen accessMedicine

Polaprezinc for prevention of oral mucositis in patients receiving chemotherapy followed by hematopoietic stem cell transplantation: A multi‐institutional randomized controlled trial

Junichi Kitagawa, Ryo Kobayashi, Yasuyuki Nagata et al. · 2020 · International Journal of Cancer

Oral mucositis is a common and distressing complication in patients receiving high-dose chemotherapy followed by hematopoietic stem cell transplantation (HSCT). We reported previously in a single-center retrospective analysis that…

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Negative / Null Result ReportOpen accessMedicine

Phase II clinical trial of sequential treatment with systemic chemotherapy and intraperitoneal paclitaxel for gastric and gastroesophageal junction peritoneal carcinomatosis - STOPGAP trial

Maheswari Senthil, Farshid Dayyani · 2023 · BMC Cancer

BACKGROUND: Studies from Asia indicate that normothermic intraperitoneal chemotherapy (NIPEC) may confer survival benefit in patients with gastric peritoneal carcinomatosis (PC). However, data regarding this approach is lacking in western population. The current STOPGAP trial is intended to assess 1-year progression-free survival benefit of sequential systemic chemotherapy and paclitaxel NIPEC in patients with gastric/ gastroesophageal junction (GEJ) adenocarcinoma PC. METHODS: This is a prospective, single center, single arm, phase II investigator-initiated clinical trial. Patients with histo

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Negative / Null Result ReportPsychology

Impact of a Student Success Course on Undergraduate Academic Outcomes

Leah D. Hoops, Shirley L. Yu, Andrea Burridge et al. · 2015 · Journal of College Reading and Learning

Both community colleges and four-year institutions offer Student Success Courses (SSCs) to promote student engagement (self-regulated learning, SRL) and performance (grades, retention, and graduation). However, little work has been done to…

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Unraveling tumor specific neoantigen immunogenicity prediction: a comprehensive analysis

Guadalupe Nibeyro, Verónica M. Baronetto, Juan I. Folco et al. · 2023 · Frontiers in Immunology

Introduction: Identification of tumor specific neoantigen (TSN) immunogenicity is crucial to develop peptide/mRNA based anti-tumoral vaccines and/or adoptive T-cell immunotherapies; thus, accurate in-silico classification/prioritization proves critical for cost-effective clinical applications. Several methods were proposed as TSNs immunogenicity predictors; however, comprehensive performance comparison is still lacking due to the absence of well documented and adequate TSN databases. Methods: Here, by developing a new curated database having 199 TSNs with experimentally-validated MHC-I present

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Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

Skill-relatedness and employment growth of firms in times of prosperity and crisis in an oil-dependent region

John-Erik Rørheim, Ron Boschma · 2021 · Environment and Planning A Economy and Space

Many studies have shed light on the positive side of relatedness, but little attention has yet been devoted to possible downsides of relatedness for firm performance in regions. We found in a case study of the oil-dependent Stavanger region in Norway that plants in industries that are skill-related to the dominant oil and gas industry showed lower employment growth than plants in other industries. This was the case both in the boom and the crisis periods, even when controlling for supply linkages to the oil and gas sector. However, we also found that plants skill-related to the oil and gas ind

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Negative / Null Result ReportOpen accessMedicine

Evaluating deep learning methods in detecting and segmenting different sizes of brain metastases on 3D post-contrast T1-weighted images

Youngjin Yoo, Pascal Ceccaldi, Siqi Liu et al. · 2021 · Journal of Medical Imaging

Purpose: We investigate the impact of various deep-learning-based methods for detecting and segmenting metastases with different lesion volume sizes on 3D brain MR images. Approach: A 2.5D U-Net and a 3D U-Net were selected. We also…

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Negative / Null Result ReportOpen accessImmunology and Microbiology

Significant association of CD4+CD25+Foxp3+ regulatory T cells with clinical findings in patients with systemic lupus erythematosus

Xiaofan Yang, Weiwen Wang, Juan Xu et al. · 2019 · Annals of Translational Medicine

Background: Regulatory T (Treg) cells are one of the important mechanisms in maintaining self-tolerance and immune homeostasis. CD4+CD25+Foxp3+Treg is considered to have a role in the pathogenesis of systemic lupus erythematosus (SLE).…

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Negative / Null Result ReportAgricultural and Biological Sciences

A genome‐wide significant association on chromosome 2 for footrot resistance/susceptibility in Swiss White Alpine sheep

Allegra Niggeler, Jens Tetens, Anna Stäuble et al. · 2017 · Animal Genetics

Footrot is one of the most important causes of lameness in global sheep populations and is characterized by a bacterial infection of the interdigital skin. As a multifactorial disease, its clinical representation depends not only on…

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Negative / Null Result ReportMedicine

Results of the Kigali Imbereheza Project: A 2-Arm Individually Randomized Trial of TI-CBT Enhanced to Address ART Adherence and Mental Health for Rwandan Youth Living With HIV

Geri R. Donenberg, Jessica Fitts, Charles Ingabire et al. · 2022 · JAIDS Journal of Acquired Immune Deficiency Syndromes

Background: Adolescents living with HIV have elevated mental distress and suboptimal antiretroviral therapy (ART) adherence. Setting: Two urban clinics in Kigali, Rwanda. Methods: A 2-arm individual randomized controlled trial compared…

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Negative / Null Result ReportAgricultural and Biological Sciences

Stay cool, travel far: cold‐acclimated oriental fruit moth females have enhanced flight performance but lay fewer eggs

Aurélie Ferrer, Dominique Mazzi, Silvia Dorn · 2014 · Entomologia Experimentalis et Applicata

Abstract Acclimation to a particular environment may provide organisms with advantages in that environment. In species with multiple generations per year, acclimation may cause life‐history traits to vary with season and between…

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Negative / Null Result Report

Saline versus Saline with Blood as a Contrast Agent for Right‐to‐left Shunt Diagnosis by Transcranial Doppler: Is There a Significant Difference?

Marcos Christiano Lange, Viviane Flumignan Zétola, Élcio J Piovesan et al. · 2010 · Journal of Neuroimaging

ABSTRACT BACKGROUND AND PURPOSE Agitated saline solution (AS) is the contrast agent (CA) of choice for the diagnosis of right‐to‐left shunt (RLS). The aim of this study was to compare AS to AS with blood (ASb) in the diagnosis and…

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