Phase I/II trial of BMS-986,205 and nivolumab as first line therapy in hepatocellular carcinoma
Jasmine C. Huynh; May Cho; Arta M. Monjazeb; Ebaa Al-Obeidi; Amisha Singh; Kit Tam; Frances Lara; Anthony Martinez · 2023 · Investigational New Drugs
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: Indoleamine-2,3-dioxygenase (IDO) helps orchestrate immune suppression and checkpoint inhibitor resistance in hepatocellular carcinoma (HCC). BMS-986,205 is a novel oral drug that potently and selectively inhibits IDO. This Phase I/II study evaluated the safety and tolerability of BMS-986,205 in combination with nivolumab as first-line therapy in advanced HCC. METHODS: IV on Day 1 of each 14-day cycle). The primary objective was to determine the safety and tolerability of this combination; secondary objectives were to obtain preliminary efficacy. RESULTS: Eight patients received a
Abstract by Jasmine C. Huynh; May Cho; Arta M. Monjazeb; Ebaa Al-Obeidi; Amisha Singh; Kit Tam; Frances Lara; Anthony Martinez, Investigational New Drugs (2023) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1007/s10637-023-01416-w